Metabolist – November 2014

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Cancer metabolism
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A Role for the Mitochondrial Pyruvate Carrier as a Repressor of the Warburg Effect and Colon Cancer Cell Growth
John C. Schell, Kristofor A. Olson, Lei Jiang, Amy J. Hawkins, Jonathan G. Van Vranken, Jianxin Xie, Robert A. Egnatchik, Espen G. Earl, Ralph J. DeBerardinis, Jared Rutter
http://www.cell.com/molecular-cell/abstract/S1097-2765(14)00783-7

Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport
Chendong Yang, Bookyung Ko, Christopher T. Hensley, Lei Jiang, Ajla T. Wasti, Jiyeon Kim, Jessica Sudderth, Maria Antonietta Calvaruso, Lloyd Lumata, Matthew Mitsche, Jared Rutter, Matthew E. Merritt, Ralph J. DeBerardinis
http://www.cell.com/molecular-cell/abstract/S1097-2765(14)00782-5

Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier
Nathaniel M. Vacanti, Ajit S. Divakaruni, Courtney R. Green, Seth J. Parker, Robert R. Henry, Theodore P. Ciaraldi, Anne N. Murphy, Christian M. Metallo
http://www.cell.com/molecular-cell/abstract/S1097-2765(14)00781-3

Characterization of the Usage of the Serine Metabolic Network in Human Cancer
Mahya Mehrmohamadi, Xiaojing Liu, Alexander A. Shestov, Jason W. Locasale
http://www.cell.com/cell-reports/abstract/S2211-1247(14)00880-8

IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo
Avinashnarayan Venkatanarayan, Payal Raulji, William Norton, Deepavali Chakravarti, Cristian Coarfa, Xiaohua Su, Santosh K. Sandur, Marc S. Ramirez, Jaehuk Lee, Charles V. Kingsley, Eliot F. Sananikone, Kimal Rajapakshe, Katherine Naff, Jan Parker-Thornburg, James A. Bankson, Kenneth Y. Tsai, Preethi H. Gunaratne & Elsa R. Flores
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13910.html?WT.ec_id=NATURE-20141120

Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch
J B Tennakoon, Y Shi, J J Han, E Tsouko, M A White, A R Burns, A Zhang, X Xia, O R Ilkayeva, L Xin, M M Ittmann, F G Rick, A V Schally and D E Frigo
http://www.nature.com/onc/journal/v33/n45/abs/onc2013463a.html

l-2-Hydroxyglutarate: An Epigenetic Modifier and Putative Oncometabolite in Renal Cancer
Eun-Hee Shim, Carolina B. Livi, Dinesh Rakheja, Jubilee Tan, Daniel Benson, Vishwas Parekh, Eun-Young Kho, Arindam P. Ghosh, Richard Kirkman,Sadanan Velu, Shilpa Dutta, Balachandra Chenna, Shane L. Rea, Robert J. Mishur, Qiuhua Li, Teresa L. Johnson-Pais, Lining Guo, Sejong Bae, Shi Wei, Karen Block, and Sunil Sudarshan
http://cancerdiscovery.aacrjournals.org/content/4/11/1290.abstract?etoc

Metabolic and transcriptional profiling reveals pyruvate dehydrogenase kinase 4 as a mediator of epithelial-mesenchymal transition and drug resistance in tumor cells
Sun  Y, Daemen  A, Hatzivassiliou  G, Arnott  D, Wilson  C, Zhuang  G, Gao  M, Liu  P, Boudreau  A, Johnson  L, Settleman  J
http://www.cancerandmetabolism.com/content/2/1/20/abstract

Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer
Keren Yizhak, Edoardo Gaude, Sylvia Le Dévédec, Yedael Y Waldman, Gideon Y Stein, Bob van de Water, Christian Frezza and Eytan Ruppin
http://elifesciences.org/content/3/e03641

PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells
Yuhui Jiang, Yugang Wang, Ting Wang, David H. Hawke, Yanhua Zheng, Xinjian Li, Qin Zhou, Sadhan Majumder, Erfei Bi, David X. Liu, Suyun Huang and Zhimin Lu
http://www.nature.com/ncomms/2014/141121/ncomms6566/full/ncomms6566.html?WT.ec_id=NCOMMS-20141126

Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis
T Liu, R J Kishton, A N Macintyre, V A Gerriets, H Xiang, X Liu, E D Abel, D Rizzieri, J W Locasale and J C Rathmell
http://www.nature.com/cddis/journal/v5/n10/abs/cddis2014431a.html?WT.ec_id=CDDIS-201410

β-alanine suppresses malignant breast epithelial cell aggressiveness through alterations in metabolism and cellular acidity in vitro.
Vaughan RA, Gannon NP, Garcia-Smith R, Licon-Munoz Y, Barberena MA, Bisoffi M, Trujillo KA
http://www.molecular-cancer.com/content/13/1/14

Selective Inhibition of Mutant Isocitrate Dehydrogenase 1 (IDH1) via Disruption of a Metal Binding Network by an Allosteric Small Molecule
Gejing Deng, Junqing Shen, Ming Yin, Jessica McManus, Magali Mathieu, Patricia Gee, Timothy He, Chaomei Shi, Olivier Bedel, Larry R. McLean, Frank Le-Strat, Ying Zhang, Jean-Pierre Marquette, Qiang Gao, Bailin Zhang, Alexey Rak, Dietmar Hoffmann, Eamonn Rooney, Aurelie Vassort, Walter Englaro, Yi Li, Vinod Patel, Francisco Adrian, Stefan Gross, Dmitri Wiederschain, Hong Cheng, and Stuart Licht
http://www.jbc.org/content/early/2014/11/12/jbc.M114.608497.abstract

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Starvation
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Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex
Anita Parmigiani, Aida Nourbakhsh, Boxiao Ding, Wei Wang, Young Chul Kim, Konstantin Akopiants, Kun-Liang Guan, Michael Karin, Andrei V. Budanov
http://www.cell.com/cell-reports/abstract/S2211-1247(14)00873-0

PIP4kγ is a substrate for mTORC1 that maintains basal mTORC1 signaling during starvation
Ashley M. Mackey, Deborah A. Sarkes, Ian Bettencourt, John M. Asara, and Lucia E. Rameh
http://stke.sciencemag.org/content/7/350/ra104.abstract

Transcriptional regulation of autophagy by an FXR–CREB axis
Sunmi Seok, Ting Fu, Sung-E Choi, Yang Li, Rong Zhu, Subodh Kumar, Xiaoxiao Sun, Gyesoon Yoon, Yup Kang, Wenxuan Zhong, Jian Ma, Byron Kemper & Jongsook Kim Kemper
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13949.html?WT.ec_id=NATURE-20141113

Nutrient-sensing nuclear receptors coordinate autophagy
Jae Man Lee, Martin Wagner, Rui Xiao, Kang Ho Kim, Dan Feng, Mitchell A. Lazar & David D. Moore
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13961.html?WT.ec_id=NATURE-20141113

Metabolic-Stress-Induced Rearrangement of the 14-3-3ζ Interactome Promotes Autophagy via a ULK1- and AMPK-Regulated 14-3-3ζ Interaction with Phosphorylated Atg9
Vajira K. Weerasekara, David J. Panek, David G. Broadbent, Jeffrey B. Mortenson, Andrew D. Mathis, Gideon N. Logan, John T. Prince, David M. Thomson, J. Will Thompson, and Joshua L. Andersen
http://mcb.asm.org/content/34/24/4379.abstract?etoc

The effect of glucose concentration and sodium phenylbutyrate treatment on mitochondrial bioenergetics and ER stress in 3T3-L1 adipocytes
Ross M. Tanis, Gerardo G. Piroli, Stani D. Day, Norma Frizzell
http://www.sciencedirect.com/science/article/pii/S0167488914003711

OPA1‐dependent cristae modulation is essential for cellular adaptation to metabolic demand
David A Patten, Jacob Wong, Mireille Khacho, Vincent Soubannier, Ryan J Mailloux, Karine Pilon‐Larose, Jason G MacLaurin, David S Park, Heidi M McBride, Laura Trinkle‐Mulcahy, Mary‐Ellen Harper, Marc Germain, and Ruth S Slack
http://EMBOJ.embopress.org/content/33/22/2676?etoc

p53-mediated Regulation of Phosphoglycerate Dehydrogenase (PHGDH) is crucial for the Apoptotic Response Upon Serine Starvation
Yang Ou, Shang-Jui Wang, Le Jiang, Bin Zheng, and Wei Gu
http://www.jbc.org/content/early/2014/11/17/jbc.M114.616359.abstract

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mTOR / AMPK
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mTORC1-mediated translational elongation limits intestinal tumour initiation and growth
William J. Faller, Thomas J. Jackson, John R. P. Knight, Rachel A. Ridgway, Thomas Jamieson, Saadia A. Karim, Carolyn Jones, Sorina Radulescu, David J. Huels, Kevin B. Myant, Kate M. Dudek, Helen A. Casey, Alessandro Scopelliti, Julia B. Cordero, Marcos Vidal, Mario Pende, Alexey G. Ryazanov, Nahum Sonenberg, Oded Meyuhas, Michael N. Hall, Martin Bushell, Anne E. Willis & Owen J. Sansom
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13896.html

Rab1A Is an mTORC1 Activator and a Colorectal Oncogene
Janice D. Thomas, Yan-Jie Zhang, Yue-Hua Wei, Jun-Hung Cho, Laura E. Morris, Hui-Yun Wang, X.F. Steven Zheng
http://www.cell.com/cancer-cell/abstract/S1535-6108(14)00371-7

TORC2-dependent protein kinase Ypk1 phosphorylates ceramide synthase to stimulate synthesis of complex sphingolipids
Alexander Muir, Subramaniam Ramachandran, Françoise M Roelants, Garrett Timmons and Jeremy Thorner
http://elifesciences.org/content/3/e03779

AMPKα1 deficiency promotes cellular proliferation and DNA damage via p21 reduction in mouse embryonic fibroblasts
Hairong Xu, Yanhong Zhou, Kathleen A. Coughlan, Ye Ding, Shaobin Wang, Yue Wu, Ping Song, Ming-Hui Zou
http://www.biomedcentral.com/1741-7007/12/82

Role of AMP-activated protein kinase in cross-talk between apoptosis and autophagy in human colon cancer
X Song, S-Y Kim, L Zhang, D Tang, D L Bartlett, Y T Kwon and Y J Lee
http://www.nature.com/cddis/journal/v5/n10/abs/cddis2014463a.html?WT.ec_id=CDDIS-201410

Pre-clinical study of drug combinations that reduce breast cancer burden due to aberrant mTOR and metabolism promoted by LKB1 loss
Rafaela Andrade-Vieira, Donna Goguen, Heidi A. Bentley, Chris V. Bowen and Paola A. Marignani
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=2818

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Hypoxia / ischemia
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Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
Edward T. Chouchani, Victoria R. Pell, Edoardo Gaude, Dunja Aksentijević, Stephanie Y. Sundier, Ellen L. Robb, Angela Logan, Sergiy M. Nadtochiy, Emily N. J. Ord, Anthony C. Smith, Filmon Eyassu, Rachel Shirley, Chou-Hui Hu, Anna J. Dare, Andrew M. James, Sebastian Rogatti, Richard C. Hartley, Simon Eaton, Ana S. H. Costa, Paul S. Brookes, Sean M. Davidson, Michael R. Duchen, Kourosh Saeb-Parsy, Michael J. Shattock, Alan J. Robinson, Lorraine M. Work, Christian Frezza, Thomas Krieg & Michael P. Murphy
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13909.html

Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression
Rajesha Rupaimoole, Sherry Y. Wu, Sunila Pradeep, Cristina Ivan, Chad V. Pecot, Kshipra M. Gharpure, Archana S. Nagaraja, Guillermo N. Armaiz-Pena, Michael McGuire, Behrouz Zand, Heather J. Dalton, Justyna Filant, Justin Bottsford Miller, Chunhua Lu, Nouara C. Sadaoui, Lingegowda S. Mangala, Morgan Taylor, Twan van den Beucken, Elizabeth Koch, Cristian Rodriguez-Aguayo, Li Huang, Menashe Bar-Eli, Bradly G. Wouters, Milan Radovich, Mircea Ivan, George A. Calin, Wei Zhang, Gabriel Lopez-Berestein & Anil K. Sood
http://www.nature.com/ncomms/2014/141029/ncomms6202/full/ncomms6202.html?WT.ec_id=NCOMMS-20141105

Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER
Twan van den Beucken, Elizabeth Koch, Kenneth Chu, Rajesha Rupaimoole, Peggy Prickaerts, Michiel Adriaens, Jan Willem Voncken, Adrian L. Harris, Francesca M. Buffa, Syed Haider, Maud H. W. Starmans, Cindy Q. Yao, Mircea Ivan, Cristina Ivan, Chad V. Pecot, Paul C. Boutros, Anil K. Sood, Marianne Koritzinsky and Bradly G. Wouters
http://www.nature.com/ncomms/2014/141029/ncomms6203/full/ncomms6203.html?WT.ec_id=NCOMMS-20141105

Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR
Anne-Theres Henze, Boyan K. Garvalov, Sascha Seidel, Angel M. Cuesta, Mathias Ritter, Alina Filatova, Franziska Foss, Higinio Dopeso, Clara L. Essmann, Patrick H. Maxwell, Guido Reifenberger, Peter Carmeliet, Amparo Acker-Palmer and Till Acker
http://www.nature.com/ncomms/2014/141125/ncomms6582/full/ncomms6582.html?WT.ec_id=NCOMMS-20141126

Hypoxia-inducible factor-2  (HIF-2 ), but not HIF-1 , is essential for hypoxic induction of class III β-tubulin expression in human glioblastoma cells
Karim Bordji, Alexandra Grandval, Leilane Cuhna-Alves, Emmanuèle Lechapt-Zalcman and Myriam Bernaudin
http://onlinelibrary.wiley.com/doi/10.1111/febs.13062/abstract?campaign=woletoc

ALK-Dependent Control of Hypoxia-Inducible Factors Mediates Tumor Growth and Metastasis
Cinzia Martinengo, Teresa Poggio, Matteo Menotti, Maria Stella Scalzo, Cristina Mastini, Chiara Ambrogio, Elisa Pellegrino, Ludovica Riera, Roberto Piva, Domenico Ribatti, Fabio Pastorino, Patrizia Perri, Mirco Ponzoni, Qi Wang, Claudia Voena, and Roberto Chiarle
http://cancerres.aacrjournals.org/content/74/21/6094.abstract?etoc

Hypoxia triggers endothelial endoplasmic reticulum stress and apoptosis via induction of VLDL receptor
Dan Yang, Lili Gao, Tingfeng Wang, Zhengdong Qiao, Yongjun Liang, Peng Zhang
http://www.sciencedirect.com/science/article/pii/S0014579314007601

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Reviews
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AMPK—Sensing Energy while Talking to Other Signaling Pathways
D. Grahame Hardie
http://www.cell.com/cell-metabolism/abstract/S1550-4131(14)00410-0

Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia
Rakesh K. Jain
http://www.sciencedirect.com/science/article/pii/S1535610814004103

Metformin: From Mechanisms of Action to Therapies
Marc Foretz, Bruno Guigas, Luc Bertrand, Michael Pollak, Benoit Viollet
http://www.cell.com/cell-metabolism/abstract/S1550-4131(14)00441-0

Cholesterol and breast cancer pathophysiology
Erik R. Nelson, Ching-yi Chang, Donald P. McDonnell
http://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760(14)00173-8

SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis
Zhu  Y, Yan  Y, Principe  DR, Zou  X, Vassilopoulos  A, Gius  D
http://www.cancerandmetabolism.com/content/2/1/15/abstract

Targeting SREBP-1-driven lipid metabolism to treat cancer.
Guo D, Bell EH, Mischel P, Chakravarti A
http://www.eurekaselect.com/112234/article

Cancer Metabolism: Cross Talk Between Signaling and O-GlcNAcylation
Christina M. Ferrer,  Mauricio J. Reginato
http://link.springer.com/protocol/10.1007%2F978-1-4939-0992-6_7

PKM2: the thread linking energy metabolism reprogramming with epigenetics in cancer.
Chen L, Shi Y, Liu S, Cao Y, Wang X, Tao Y.
http://www.mdpi.com/1422-0067/15/7/11435

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Previews / other
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Rewiring Mitochondrial Pyruvate Metabolism: Switching Off the Light in Cancer Cells?
Peter W. Szlosarek, SukJun Lee, Patrick J. Pollard
http://www.sciencedirect.com/science/article/pii/S1097276514008284

Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy
Luengo A, Sullivan LB, Vander Heiden MG
http://www.biomedcentral.com/1741-7007/12/82

mTORC1 gRABs the Golgi
Joan Sanchez-Gurmaches, David A. Guertin
http://www.cell.com/cancer-cell/abstract/S1535-6108(14)00415-2

Asparagine Protects Tumor Cells from Glutamine Depletion–Induced Cell Death
http://cancerdiscovery.aacrjournals.org/content/4/11/OF19.abstract?etoc

Metabolic Rewiring Is Required for Epithelial–Mesenchymal Transition
http://cancerdiscovery.aacrjournals.org/content/4/11/OF20.abstract?etoc

Tumor Hypoxia Is a Therapeutic Target in Soft-Tissue Sarcoma
http://cancerdiscovery.aacrjournals.org/content/4/11/OF21.abstract?etoc

Four key questions about metformin and cancer
Chandel N
http://www.biomedcentral.com/1741-7007/12/85

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