Metabolist – November 2014

Cancer metabolism

A Role for the Mitochondrial Pyruvate Carrier as a Repressor of the Warburg Effect and Colon Cancer Cell Growth
John C. Schell, Kristofor A. Olson, Lei Jiang, Amy J. Hawkins, Jonathan G. Van Vranken, Jianxin Xie, Robert A. Egnatchik, Espen G. Earl, Ralph J. DeBerardinis, Jared Rutter

Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport
Chendong Yang, Bookyung Ko, Christopher T. Hensley, Lei Jiang, Ajla T. Wasti, Jiyeon Kim, Jessica Sudderth, Maria Antonietta Calvaruso, Lloyd Lumata, Matthew Mitsche, Jared Rutter, Matthew E. Merritt, Ralph J. DeBerardinis

Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier
Nathaniel M. Vacanti, Ajit S. Divakaruni, Courtney R. Green, Seth J. Parker, Robert R. Henry, Theodore P. Ciaraldi, Anne N. Murphy, Christian M. Metallo

Characterization of the Usage of the Serine Metabolic Network in Human Cancer
Mahya Mehrmohamadi, Xiaojing Liu, Alexander A. Shestov, Jason W. Locasale

IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo
Avinashnarayan Venkatanarayan, Payal Raulji, William Norton, Deepavali Chakravarti, Cristian Coarfa, Xiaohua Su, Santosh K. Sandur, Marc S. Ramirez, Jaehuk Lee, Charles V. Kingsley, Eliot F. Sananikone, Kimal Rajapakshe, Katherine Naff, Jan Parker-Thornburg, James A. Bankson, Kenneth Y. Tsai, Preethi H. Gunaratne & Elsa R. Flores

Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch
J B Tennakoon, Y Shi, J J Han, E Tsouko, M A White, A R Burns, A Zhang, X Xia, O R Ilkayeva, L Xin, M M Ittmann, F G Rick, A V Schally and D E Frigo

l-2-Hydroxyglutarate: An Epigenetic Modifier and Putative Oncometabolite in Renal Cancer
Eun-Hee Shim, Carolina B. Livi, Dinesh Rakheja, Jubilee Tan, Daniel Benson, Vishwas Parekh, Eun-Young Kho, Arindam P. Ghosh, Richard Kirkman,Sadanan Velu, Shilpa Dutta, Balachandra Chenna, Shane L. Rea, Robert J. Mishur, Qiuhua Li, Teresa L. Johnson-Pais, Lining Guo, Sejong Bae, Shi Wei, Karen Block, and Sunil Sudarshan

Metabolic and transcriptional profiling reveals pyruvate dehydrogenase kinase 4 as a mediator of epithelial-mesenchymal transition and drug resistance in tumor cells
Sun  Y, Daemen  A, Hatzivassiliou  G, Arnott  D, Wilson  C, Zhuang  G, Gao  M, Liu  P, Boudreau  A, Johnson  L, Settleman  J

Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer
Keren Yizhak, Edoardo Gaude, Sylvia Le Dévédec, Yedael Y Waldman, Gideon Y Stein, Bob van de Water, Christian Frezza and Eytan Ruppin

PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells
Yuhui Jiang, Yugang Wang, Ting Wang, David H. Hawke, Yanhua Zheng, Xinjian Li, Qin Zhou, Sadhan Majumder, Erfei Bi, David X. Liu, Suyun Huang and Zhimin Lu

Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis
T Liu, R J Kishton, A N Macintyre, V A Gerriets, H Xiang, X Liu, E D Abel, D Rizzieri, J W Locasale and J C Rathmell

β-alanine suppresses malignant breast epithelial cell aggressiveness through alterations in metabolism and cellular acidity in vitro.
Vaughan RA, Gannon NP, Garcia-Smith R, Licon-Munoz Y, Barberena MA, Bisoffi M, Trujillo KA

Selective Inhibition of Mutant Isocitrate Dehydrogenase 1 (IDH1) via Disruption of a Metal Binding Network by an Allosteric Small Molecule
Gejing Deng, Junqing Shen, Ming Yin, Jessica McManus, Magali Mathieu, Patricia Gee, Timothy He, Chaomei Shi, Olivier Bedel, Larry R. McLean, Frank Le-Strat, Ying Zhang, Jean-Pierre Marquette, Qiang Gao, Bailin Zhang, Alexey Rak, Dietmar Hoffmann, Eamonn Rooney, Aurelie Vassort, Walter Englaro, Yi Li, Vinod Patel, Francisco Adrian, Stefan Gross, Dmitri Wiederschain, Hong Cheng, and Stuart Licht


Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex
Anita Parmigiani, Aida Nourbakhsh, Boxiao Ding, Wei Wang, Young Chul Kim, Konstantin Akopiants, Kun-Liang Guan, Michael Karin, Andrei V. Budanov

PIP4kγ is a substrate for mTORC1 that maintains basal mTORC1 signaling during starvation
Ashley M. Mackey, Deborah A. Sarkes, Ian Bettencourt, John M. Asara, and Lucia E. Rameh

Transcriptional regulation of autophagy by an FXR–CREB axis
Sunmi Seok, Ting Fu, Sung-E Choi, Yang Li, Rong Zhu, Subodh Kumar, Xiaoxiao Sun, Gyesoon Yoon, Yup Kang, Wenxuan Zhong, Jian Ma, Byron Kemper & Jongsook Kim Kemper

Nutrient-sensing nuclear receptors coordinate autophagy
Jae Man Lee, Martin Wagner, Rui Xiao, Kang Ho Kim, Dan Feng, Mitchell A. Lazar & David D. Moore

Metabolic-Stress-Induced Rearrangement of the 14-3-3ζ Interactome Promotes Autophagy via a ULK1- and AMPK-Regulated 14-3-3ζ Interaction with Phosphorylated Atg9
Vajira K. Weerasekara, David J. Panek, David G. Broadbent, Jeffrey B. Mortenson, Andrew D. Mathis, Gideon N. Logan, John T. Prince, David M. Thomson, J. Will Thompson, and Joshua L. Andersen

The effect of glucose concentration and sodium phenylbutyrate treatment on mitochondrial bioenergetics and ER stress in 3T3-L1 adipocytes
Ross M. Tanis, Gerardo G. Piroli, Stani D. Day, Norma Frizzell

OPA1‐dependent cristae modulation is essential for cellular adaptation to metabolic demand
David A Patten, Jacob Wong, Mireille Khacho, Vincent Soubannier, Ryan J Mailloux, Karine Pilon‐Larose, Jason G MacLaurin, David S Park, Heidi M McBride, Laura Trinkle‐Mulcahy, Mary‐Ellen Harper, Marc Germain, and Ruth S Slack

p53-mediated Regulation of Phosphoglycerate Dehydrogenase (PHGDH) is crucial for the Apoptotic Response Upon Serine Starvation
Yang Ou, Shang-Jui Wang, Le Jiang, Bin Zheng, and Wei Gu


mTORC1-mediated translational elongation limits intestinal tumour initiation and growth
William J. Faller, Thomas J. Jackson, John R. P. Knight, Rachel A. Ridgway, Thomas Jamieson, Saadia A. Karim, Carolyn Jones, Sorina Radulescu, David J. Huels, Kevin B. Myant, Kate M. Dudek, Helen A. Casey, Alessandro Scopelliti, Julia B. Cordero, Marcos Vidal, Mario Pende, Alexey G. Ryazanov, Nahum Sonenberg, Oded Meyuhas, Michael N. Hall, Martin Bushell, Anne E. Willis & Owen J. Sansom

Rab1A Is an mTORC1 Activator and a Colorectal Oncogene
Janice D. Thomas, Yan-Jie Zhang, Yue-Hua Wei, Jun-Hung Cho, Laura E. Morris, Hui-Yun Wang, X.F. Steven Zheng

TORC2-dependent protein kinase Ypk1 phosphorylates ceramide synthase to stimulate synthesis of complex sphingolipids
Alexander Muir, Subramaniam Ramachandran, Françoise M Roelants, Garrett Timmons and Jeremy Thorner

AMPKα1 deficiency promotes cellular proliferation and DNA damage via p21 reduction in mouse embryonic fibroblasts
Hairong Xu, Yanhong Zhou, Kathleen A. Coughlan, Ye Ding, Shaobin Wang, Yue Wu, Ping Song, Ming-Hui Zou

Role of AMP-activated protein kinase in cross-talk between apoptosis and autophagy in human colon cancer
X Song, S-Y Kim, L Zhang, D Tang, D L Bartlett, Y T Kwon and Y J Lee

Pre-clinical study of drug combinations that reduce breast cancer burden due to aberrant mTOR and metabolism promoted by LKB1 loss
Rafaela Andrade-Vieira, Donna Goguen, Heidi A. Bentley, Chris V. Bowen and Paola A. Marignani[]=2818

Hypoxia / ischemia

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
Edward T. Chouchani, Victoria R. Pell, Edoardo Gaude, Dunja Aksentijević, Stephanie Y. Sundier, Ellen L. Robb, Angela Logan, Sergiy M. Nadtochiy, Emily N. J. Ord, Anthony C. Smith, Filmon Eyassu, Rachel Shirley, Chou-Hui Hu, Anna J. Dare, Andrew M. James, Sebastian Rogatti, Richard C. Hartley, Simon Eaton, Ana S. H. Costa, Paul S. Brookes, Sean M. Davidson, Michael R. Duchen, Kourosh Saeb-Parsy, Michael J. Shattock, Alan J. Robinson, Lorraine M. Work, Christian Frezza, Thomas Krieg & Michael P. Murphy

Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression
Rajesha Rupaimoole, Sherry Y. Wu, Sunila Pradeep, Cristina Ivan, Chad V. Pecot, Kshipra M. Gharpure, Archana S. Nagaraja, Guillermo N. Armaiz-Pena, Michael McGuire, Behrouz Zand, Heather J. Dalton, Justyna Filant, Justin Bottsford Miller, Chunhua Lu, Nouara C. Sadaoui, Lingegowda S. Mangala, Morgan Taylor, Twan van den Beucken, Elizabeth Koch, Cristian Rodriguez-Aguayo, Li Huang, Menashe Bar-Eli, Bradly G. Wouters, Milan Radovich, Mircea Ivan, George A. Calin, Wei Zhang, Gabriel Lopez-Berestein & Anil K. Sood

Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER
Twan van den Beucken, Elizabeth Koch, Kenneth Chu, Rajesha Rupaimoole, Peggy Prickaerts, Michiel Adriaens, Jan Willem Voncken, Adrian L. Harris, Francesca M. Buffa, Syed Haider, Maud H. W. Starmans, Cindy Q. Yao, Mircea Ivan, Cristina Ivan, Chad V. Pecot, Paul C. Boutros, Anil K. Sood, Marianne Koritzinsky and Bradly G. Wouters

Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR
Anne-Theres Henze, Boyan K. Garvalov, Sascha Seidel, Angel M. Cuesta, Mathias Ritter, Alina Filatova, Franziska Foss, Higinio Dopeso, Clara L. Essmann, Patrick H. Maxwell, Guido Reifenberger, Peter Carmeliet, Amparo Acker-Palmer and Till Acker

Hypoxia-inducible factor-2  (HIF-2 ), but not HIF-1 , is essential for hypoxic induction of class III β-tubulin expression in human glioblastoma cells
Karim Bordji, Alexandra Grandval, Leilane Cuhna-Alves, Emmanuèle Lechapt-Zalcman and Myriam Bernaudin

ALK-Dependent Control of Hypoxia-Inducible Factors Mediates Tumor Growth and Metastasis
Cinzia Martinengo, Teresa Poggio, Matteo Menotti, Maria Stella Scalzo, Cristina Mastini, Chiara Ambrogio, Elisa Pellegrino, Ludovica Riera, Roberto Piva, Domenico Ribatti, Fabio Pastorino, Patrizia Perri, Mirco Ponzoni, Qi Wang, Claudia Voena, and Roberto Chiarle

Hypoxia triggers endothelial endoplasmic reticulum stress and apoptosis via induction of VLDL receptor
Dan Yang, Lili Gao, Tingfeng Wang, Zhengdong Qiao, Yongjun Liang, Peng Zhang


AMPK—Sensing Energy while Talking to Other Signaling Pathways
D. Grahame Hardie

Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia
Rakesh K. Jain

Metformin: From Mechanisms of Action to Therapies
Marc Foretz, Bruno Guigas, Luc Bertrand, Michael Pollak, Benoit Viollet

Cholesterol and breast cancer pathophysiology
Erik R. Nelson, Ching-yi Chang, Donald P. McDonnell

SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis
Zhu  Y, Yan  Y, Principe  DR, Zou  X, Vassilopoulos  A, Gius  D

Targeting SREBP-1-driven lipid metabolism to treat cancer.
Guo D, Bell EH, Mischel P, Chakravarti A

Cancer Metabolism: Cross Talk Between Signaling and O-GlcNAcylation
Christina M. Ferrer,  Mauricio J. Reginato

PKM2: the thread linking energy metabolism reprogramming with epigenetics in cancer.
Chen L, Shi Y, Liu S, Cao Y, Wang X, Tao Y.

Previews / other

Rewiring Mitochondrial Pyruvate Metabolism: Switching Off the Light in Cancer Cells?
Peter W. Szlosarek, SukJun Lee, Patrick J. Pollard

Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy
Luengo A, Sullivan LB, Vander Heiden MG

mTORC1 gRABs the Golgi
Joan Sanchez-Gurmaches, David A. Guertin

Asparagine Protects Tumor Cells from Glutamine Depletion–Induced Cell Death

Metabolic Rewiring Is Required for Epithelial–Mesenchymal Transition

Tumor Hypoxia Is a Therapeutic Target in Soft-Tissue Sarcoma

Four key questions about metformin and cancer
Chandel N

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