MetaboList – December 2014

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Cancer Metabolism
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Acetate Dependence of Tumors
Sarah A. Comerford, Zhiguang Huang, Xinlin Du, Yun Wang, Ling Cai, Agnes K. Witkiewicz, Holly Walters, Mohammed N. Tantawy, Allie Fu, H. Charles Manning, Jay D. Horton, Robert E. Hammer, Steven L. McKnight, Benjamin P. Tu
http://www.cell.com/cell/abstract/S0092-8674(14)01451-2

Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases
Tomoyuki Mashimo, Kumar Pichumani, Vamsidhara Vemireddy, Kimmo J. Hatanpaa, Dinesh Kumar Singh, Shyam Sirasanagandla, Suraj Nannepaga, Sara G. Piccirillo, Zoltan Kovacs, Chan Foong, Zhiguang Huang, Samuel Barnett, Bruce E. Mickey, Ralph J. DeBerardinis, Benjamin P. Tu, Elizabeth A. Maher, Robert M. Bachoo
http://www.cell.com/cell/abstract/S0092-8674(14)01502-5

Targeting ABL1-Mediated Oxidative Stress Adaptation in Fumarate Hydratase-Deficient Cancer
Carole Sourbier, Christopher J. Ricketts, Shingo Matsumoto, Daniel R. Crooks, Pei-Jyun Liao, Philip Z. Mannes, Youfeng Yang, Ming-Hui Wei, Gaurav Srivastava, Sanchari Ghosh, Viola Chen, Cathy D. Vocke, Maria Merino, Ramaprasad Srinivasan, Murali C. Krishna, James B. Mitchell, Ann Marie Pendergast, Tracey A. Rouault, Len Neckers, W. Marston Linehan
http://www.cell.com/cancer-cell/abstract/S1535-6108(14)00409-7?elsca1=etoc&elsca2=email&elsca3=1535-6108_20141208_26_6_&elsca4=Cell%20Press

MCT4 Defines a Glycolytic Subtype of Pancreatic Cancer with Poor Prognosis and Unique Metabolic Dependencies
GuemHee Baek, Yan F. Tse, Zeping Hu, Derek Cox, Noah Buboltz
http://www.cell.com/cell-reports/abstract/S2211-1247(14)00991-7

Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate
Kamphorst  JJ, Chung  MK, Fan  J, Rabinowitz  JD
http://www.cancerandmetabolism.com/content/2/1/23/abstract

A long noncoding RNA connects c-Myc to tumor metabolism
Chiu-Lien Hung, Ling-Yu Wang, Yen-Ling Yu, Hong-Wu Chen, Shiv Srivastava, Gyorgy Petrovics, and Hsing-Jien Kung
http://www.pnas.org/content/111/52/18697.abstract.html?etoc

Alexey Antonov, Massimiliano Agostini, Maria Morello, Marilena Minieri, Gerry Melino, Ivano Amelio
Bioinformatics analysis of the serine and glycine pathway in cancer cells
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=2668

The Polyamine Catabolic Enzyme SAT1 Modulates Tumorigenesis and RadiationResponse in GBM
Adina Brett-Morris, Bradley M. Wright, Yuji Seo, Vinay Pasupuleti, JunranZhang, Jun Lu, Raffaella Spina, Eli E. Bar, Maneesh Gujrati, Rebecca Schur, Zheng-Rong Lu, and Scott M. Welford
http://cancerres.aacrjournals.org/content/74/23/6925.abstract?etoc

Loss of Abhd5 Promotes Colorectal Tumor Development and Progression by Inducing Aerobic Glycolysis and Epithelial-Mesenchymal Transition
Juanjuan Ou, Hongming Miao, Yinyan Ma, Feng Guo, Jia Deng, Xing Wei, Jie Zhou, Ganfeng Xie, Hang Shi, Bingzhong Xue, Houjie Liang, Liqing Yu
http://www.cell.com/cell-reports/abstract/S2211-1247(14)00970-X

Recurrent epimutation of SDHC in gastrointestinal stromal tumors
J. Keith Killian et al.
http://stm.sciencemag.org/content/6/268/268ra177.full?utm_source=eloqua

Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolism
Aspuria  PP, Lunt  SY, Väremo  L, Vergnes  L, Gozo  M, Beach  JA, Salumbides  B, Reue  K, Wiedemeyer  W, Nielsen  J, Karlan  BY, Orsulic  S
http://www.cancerandmetabolism.com/content/2/1/21/abstract

Modeling Alveolar Soft Part Sarcomagenesis in the Mouse: A Role for Lactate in the Tumor Microenvironment
Matthew L. Goodwin, Huifeng Jin, Krystal Straessler, Kyllie Smith-Fry, Ju-Fen Zhu, Michael J. Monument, Allie Grossmann, R. Lor Randall, Mario R. Capecchi, Kevin B. Jones
http://www.cell.com/cancer-cell/abstract/S1535-6108(14)00407-3?elsca1=etoc&elsca2=email&elsca3=1535-6108_20141208_26_6_&elsca4=Cell%20Press

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Anti-metabolic drugs
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Metformin Activates AMP-activated Protein Kinase by Promoting Formation of the αβγ Heterotrimeric Complex
Shumei Meng, Jia Cao, Qiyi He, Lishou Xiong, Evan Chang, Sally Radovick, Fredric E. Wondisford, and Ling He
http://www.jbc.org/content/early/2014/12/23/jbc.M114.604421.abstract

Serine Deprivation Enhances Antineoplastic Activity of Biguanides
Simon-Pierre Gravel, Laura Hulea, Nader Toban, Elena Birman, Marie-José Blouin, Mahvash Zakikhani, Yunhua Zhao, Ivan Topisirovic, Julie St-Pierre, and Michael Pollak
http://cancerres.aacrjournals.org/content/74/24/7521.abstract?etoc

Inhibition of Polo-like Kinase 1 (Plk1) Enhances the Anti-neoplastic Activity of Metformin in Prostate Cancer
Chen Shao, Nihal Ahmad, Kurt Hodges, Shihuan Kuang, Tim Ratliff, and Xiaoqi Liu
http://www.jbc.org/content/early/2014/12/10/jbc.M114.596817.abstract

Molecular Mechanisms of Fenofibrate-Induced Metabolic Catastrophe and Glioblastoma Cell Death
Anna Wilk, Dorota Wyczechowska, Adriana Zapata, Matthew Dean, Jennifer Mullinax, Luis Marrero, Christopher Parsons, Francesca Peruzzi, Frank Culicchia, Augusto Ochoa, Maja Grabacka, and Krzysztof Reiss
http://mcb.asm.org/content/35/1/182.abstract?etoc

Inhibition of mTORC1/2 Overcomes Resistance to MAPK Pathway Inhibitors Mediated by PGC1α and Oxidative Phosphorylation in Melanoma
Y.N. Vashisht Gopal, Helen Rizos, Guo Chen, Wanleng Deng, Dennie T. Frederick, Zachary A. Cooper, Richard A. Scolyer, Gulietta Pupo, Kakajan Komurov, Vasudha Sehgal, Jiexin Zhang, Lalit Patel, Cristiano G. Pereira,Bradley M. Broom, Gordon B. Mills, Prahlad Ram, Paul D. Smith, Jennifer A. Wargo, Georgina V. Long, and Michael A. Davies
http://cancerres.aacrjournals.org/content/74/23/7037.abstract?etoc

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Starvation
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O-GlcNAc-modification of ​SNAP-29 regulates autophagosome maturation
Bin Guo, Qianqian Liang, Lin Li, Zhe Hu, Fan Wu, Peipei Zhang, Yongfen Ma, Bin Zhao, Attila L. Kovács, Zhiyuan Zhang, Du Feng, She Chen & Hong Zhang
http://www.nature.com/ncb/journal/v16/n12/full/ncb3066.html?WT.ec_id=NCB-201412

MAPK14/p38α-dependent modulation of glucose metabolism affects ROS levels and autophagy during starvation
Enrico Desideri, Rolando Vegliante, Simone Cardaci, Ridvan Nepravishta, Maurizio Paci & Maria Rosa Ciriolo
http://www.tandfonline.com/doi/full/10.4161/auto.29456

A stress assembly that confers cell viability by preserving ERES components during amino-acid starvation
Margarita Zacharogianni, Angelica Aguilera Gomez, Tineke Veenendaal, Jan Smout and Catherine Rabouille
http://elifesciences.org/content/3/e04132

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Hypoxia / HIF
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Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia
Jiangbin Ye, Jing Fan, Sriram Venneti, Ying-Wooi Wan, Bruce R. Pawel, Ji Zhang, Lydia W.S. Finley, Chao Lu, Tullia Lindsten, Justin R. Cross, Guoliang Qing, Zhandong Liu, M. Celeste Simon, Joshua D. Rabinowitz, and Craig B. Thompson
http://cancerdiscovery.aacrjournals.org/content/4/12/1406.abstract?etoc

PHD3–SUMO conjugation represses HIF1 transcriptional activity independently of PHD3 catalytic activity
Analía Núñez-O’Mara, Almudena Gerpe-Pita, Sara Pozo, Onintza Carlevaris, Bakarne Urzelai, Fernando Lopitz-Otsoa, Manuel S. Rodríguez, and Edurne Berra
http://jcs.biologists.org/content/128/1/40.abstract?etoc

Cezanne (OTUD7B) regulates HIF‐1α homeostasis in a proteasome‐independent manner
Anja Bremm, Sonia Moniz, Julia Mader, Sonia Rocha, and David Komander
http://EMBOr.embopress.org/content/15/12/1268?etoc

The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy
Hao Wu, Danfeng Xue, Guo Chen, Zhe Han, Li Huang, Chongzhuo Zhu, Xiaohui Wang, Haijing Jin, Jun Wang, Yushan Zhu, Lei Liu & Quan Chen
http://www.tandfonline.com/doi/full/10.4161/auto.29568

Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1
Tomohiro Umezu, Hiroko Tadokoro, Kenko Azuma, Seiichiro Yoshizawa, KazumaOhyashiki, and Junko H. Ohyashiki
http://bloodjournal.org/content/124/25/3748.abstract?etoc

HIF-1α can act as a tumor suppressor gene in murine acute myeloid leukemia
Talia Velasco-Hernandez, Axel Hyrenius-Wittsten, Matilda Rehn, David Bryder, and Jörg Cammenga
http://bloodjournal.org/content/124/24/3597.abstract?etoc

Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells
Debangshu Samanta, Daniele M. Gilkes, Pallavi Chaturvedi, Lisha Xiang, and Gregg L. Semenza
http://www.pnas.org/content/111/50/E5429.abstract.html?etoc

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Miscellaneous
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Oncogene Pathway Activation in Mammary Tumors Dictates FDG-PET Uptake
James V. Alvarez, George K. Belka, Tien-Chi Pan, Chien-Chung Chen, Eric Blankemeyer, Abass Alavi, Joel S. Karp, and Lewis A. Chodosh
http://cancerres.aacrjournals.org/content/74/24/7583.abstract?etoc

Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner
Mohamed Elgendy, Marco Ciro, Amal Kamal Abdel-Aziz, Giuseppe Belmonte, Roberto Dal Zuffo, Ciro Mercurio, Clelia Miracco, Luisa Lanfrancone, Marco Foiani and Saverio Minucci
http://www.nature.com/ncomms/2014/141204/ncomms6637/full/ncomms6637.html?WT.ec_id=NCOMMS-20141210

Changes in Pyruvate Metabolism Detected by Magnetic Resonance Imaging Are Linked to DNA Damage and Serve as a Sensor of Temozolomide Response in Glioblastoma Cells
Ilwoo Park, Joydeep Mukherjee, Motokazu Ito, Myriam M. Chaumeil, Llewellyn E. Jalbert, Karin Gaensler, Sabrina M. Ronen, Sarah J. Nelson, and Russell O. Pieper
http://cancerres.aacrjournals.org/content/74/23/7115.abstract?etoc

Sirtuin 4 Is a Lipoamidase Regulating Pyruvate Dehydrogenase Complex Activity
Rommel A. Mathias, Todd M. Greco, Adam Oberstein,Hanna G. Budayeva, Rumela Chakrabarti, Elizabeth A. Rowland, Yibin Kang, Thomas Shenk, Ileana M. Cristea
http://www.cell.com/cell/abstract/S0092-8674(14)01523-2

AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting ​c-Myc dephosphorylation and degradation
Valentina Cianfanelli, Claudia Fuoco, Mar Lorente, Maria Salazar, Fabio Quondamatteo, Pier Federico Gherardini,
Daniela De Zio, Francesca Nazio, Manuela Antonioli, Melania D’Orazio, Tatjana Skobo, Matteo Bordi, Mikkel Rohde, Luisa Dalla Valle, Manuela Helmer-Citterich, Christine Gretzmeier, Joern Dengjel, Gian Maria Fimia, Mauro Piacentini, Sabrina Di Bartolomeo, Guillermo Velasco & Francesco Cecconi
http://www.nature.com/ncb/journal/v17/n1/full/ncb3072.html?WT.ec_id=NCB-201501

A Gnotobiotic Mouse Model Demonstrates That Dietary Fiber Protects against Colorectal Tumorigenesis in a Microbiota- and Butyrate-Dependent Manner
Dallas R. Donohoe, Darcy Holley, Leonard B. Collins, Stephanie A. Montgomery, Alan C. Whitmore, Andrew Hillhouse, Kaitlin P. Curry, Sarah W. Renner, Alicia Greenwalt, Elizabeth P. Ryan, Virginia Godfrey, Mark T. Heise, Deborah S. Threadgill, Anna Han, James A. Swenberg, David W. Threadgill, and Scott J. Bultman
http://cancerdiscovery.aacrjournals.org/content/4/12/1387.abstract?etoc

Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase
S Maniam, A S Coutts, M R Stratford, J McGouran, B Kessler and N B La Thangue
http://www.nature.com/cdd/journal/v22/n1/abs/cdd2014135a.html?WT.ec_id=CDD-201501

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Comments
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Acetate Fuels the Cancer Engine
Costas A. Lyssiotis, Lewis C. Cantley
http://www.cell.com/cell/abstract/S0092-8674(14)01579-7

Acetate metabolism in cancer cells
Hosios AM,Vander Heiden  MG
http://www.cancerandmetabolism.com/content/2/1/27/abstract

Hypoxic exosomes promote angiogenesis
Guo-Chang Fan
http://bloodjournal.org/content/124/25/3669?etoc

Targeting HIF function: the debate continues
Paresh Vyas
http://bloodjournal.org/content/124/24/3510?etoc

Mitochondrial One-Carbon Metabolism Maintains Redox Balance during Hypoxia
Inmaculada Martínez-Reyes and Navdeep S. Chandel
http://cancerdiscovery.aacrjournals.org/content/4/12/1371.abstract?etoc

Untangling the Fiber Yarn: Butyrate Feeds Warburg to Suppress Colorectal Cancer
Carlos Sebastián and Raul Mostoslavsky
http://cancerdiscovery.aacrjournals.org/content/4/12/1368.abstract?etoc

DisABLing Kidney Cancers Caused by Fumarate Hydratase Mutations
William G. Kaelin
http://www.cell.com/cancer-cell/abstract/S1535-6108(14)00473-5?elsca1=etoc&elsca2=email&elsca3=1535-6108

Mutant p53 exerts oncogenic functions by modulating cancer cell metabolism
Ge Zhou & Jeffrey N Myers
http://www.tandfonline.com/doi/abs/10.4161/23723548.2014.963441?ai=1gumh&ui=79l0u&af=T

Metabolic vulnerability of KRAS-driven cancer cells
David A Foster
http://www.tandfonline.com/doi/abs/10.4161/23723548.2014.963445?ai=1gumh&ui=79l0u&af=T


Meeting report
The 2014 Beatson International Cancer Conference: Powering the Cancer Machine
Kamphorst  JJ, Murphy  DJ
http://www.cancerandmetabolism.com/content/2/1/25/abstract

Size does matter
Liron Bar-Peled
http://www.sciencemag.org/content/346/6214/1191.full

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Reviews
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Mitochondrial reactive oxygen species and cancer
Sullivan  LB, Chandel  NS
http://www.cancerandmetabolism.com/content/2/1/17/abstract

Is Reliance on Mitochondrial Respiration a “Chink in the Armor” of Therapy-Resistant Cancer?
Dieter A. Wolf
http://www.cell.com/cancer-cell/abstract/S1535-6108(14)00391-2?elsca1=etoc&elsca2=email&elsca3=1535-6108

Metabolic Control of Autophagy
Lorenzo Galluzzi, Federico Pietrocola, Beth Levine, Guido Kroemer
http://www.cell.com/cell/abstract/S0092-8674(14)01437-8?elsca1=etoc&elsca2=email&elsca3=0092-8674

Metabolic Inflexibility: When Mitochondrial Indecision Leads to Metabolic Gridlock
Deborah M. Muoio
http://www.cell.com/cell/abstract/S0092-8674(14)01511-6?elsca1=etoc&elsca2=email&elsca3=0092-8674

Metabolic alterations accompanying oncogene-induced senescence
Katherine M Aird & Rugang Zhang
http://www.tandfonline.com/doi/abs/10.4161/23723548.2014.963481?ai=1gumh&ui=79l0u&af=T

VEGF signaling, mTOR complexes, and the endoplasmic reticulum: Towards a role of metabolic sensing in the regulation of angiogenesis
Evdoxia Karali, Sofia Bellou, Dimitris Stellas, Apostolos Klinakis, Carol Murphy & Theodore Fotsis   http://www.tandfonline.com/doi/abs/10.4161/23723548.2014.964024?ai=1gumh&ui=79l0u&af=T

Impact of acetylation on tumor metabolism
Di Zhao, Fu-Long Li, Zhou-Li Cheng & Qun-Ying Lei
http://www.tandfonline.com/doi/abs/10.4161/23723548.2014.963452?ai=1gumh&ui=79l0u&af=T

Caloric restriction mimetics: natural/physiological pharmacological autophagy inducers
Guillermo Mariño, Federico Pietrocola, Frank Madeo & Guido Kroemer
http://www.tandfonline.com/doi/abs/10.4161/auto.36413

The multifaceted regulation and functions of PKM2 in tumor progression
Zongwei Li, Peng Yang, Zhuoyu Li
http://www.sciencedirect.com/science/article/pii/S0304419X14000614

The driver and passenger effects of isocitrate dehydrogenase 1 and 2 mutations in oncogenesis and survival prolongation
Remco J. Molenaar, Tomas Radivoyevitch, Jaroslaw P. Maciejewski, Cornelis J.F. van Noorden, Fonnet E. Bleeker
http://www.sciencedirect.com/science/article/pii/S0304419X14000493

Mechanisms of Hypoxia-Mediated Immune Escape in Cancer
Ivraym B. Barsoum, Madhuri Koti, D. Robert Siemens, and Charles H. Graham
http://cancerres.aacrjournals.org/content/74/24/7185.abstract?etoc

WNT Signaling: an Emerging Mediator of Cancer Cell Metabolism?
Victoria Sherwood
http://mcb.asm.org/content/35/1/2.abstract?etoc


Cancer Letters special issue: Cancer Metabolism
Edited by Shree Ram Singh, Ming Tan, Pranela Rameshwar
http://www.cancerletters.info/issue/S0304-3835(14)X0026-1

Including:

Cancer Metabolism: Targeting metabolic pathways in cancer therapy
Shree Ram Singh, Ming Tan, Pranela Rameshwar

The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism
Jianrong Lu, Ming Tan, Qingsong Cai

The AMP-activated protein kinase (AMPK) and cancer: Many faces of a metabolic regulator
Brandon Faubert, Emma E. Vincent, Maya C. Poffenberger, Russell G. Jones

Metabolic adaptation to cancer growth: From the cell to the organism
Xavier Escoté, Lluís Fajas

Cancer metabolism and mass spectrometry-based proteomics
Weidong Zhou, Lance A. Liotta, Emanuel F. Petricoin

PKM2 contributes to cancer metabolism
Nicholas Wong, Diane Ojo, Judy Yan, Damu Tang

Mevalonate metabolism in cancer
Georg Gruenbacher, Martin Thurnher

Tumor suppressor p53 and its mutants in cancer metabolism
Juan Liu, Cen Zhang, Wenwei Hu, Zhaohui Feng

Nucleotide metabolism, oncogene-induced senescence and cancer
Katherine M. Aird, Rugang Zhang

Acetate/acetyl-CoA metabolism associated with cancer fatty acid synthesis: Overview and application
Yukie Yoshii, Takako Furukawa, Tsuneo Saga, Yasuhisa Fujibayashi

Mitochondrial dysfunctions in cancer: Genetic defects and oncogenic signaling impinging on TCA cycle activity
Enrico Desideri, Rolando Vegliante, Maria Rosa Ciriolo

How folate metabolism affects colorectal cancer development and treatment; a story of heterogeneity and pleiotropy
Barbara Anne Jennings, Gavin Willis

Estrogen metabolism and breast cancer
Hamed Samavat, Mindy S. Kurzer

O-GlcNAc signaling in cancer metabolism and epigenetics
Jay Prakash Singh, Kaisi Zhang, Jing Wu, Xiaoyong Yang

Antagonistic role of natural compounds in mTOR-mediated metabolic reprogramming
Claudia Cerella, Anthoula Gaigneaux, Mario Dicato, Marc Diederich

Hypoxia and hypoxia inducible factors in tumor metabolism
Wen Zeng, Peiyi Liu, Weimin Pan, Shree Ram Singh, Yiyong Wei

Adaptations of energy metabolism during cerebellar neurogenesis are co-opted in medulloblastoma
Katherine Tech, Mohanish Deshmukh, Timothy R. Gershon

Cellular metabolism in colorectal carcinogenesis: Influence of lifestyle, gut microbiome and metabolic pathways
Hanne R. Hagland, Kjetil Søreide

Epidemiological-molecular evidence of metabolic reprogramming on proliferation, autophagy and cell signaling in pancreas cancer
Kjetil Søreide, Malin Sund

Metabolic therapy: A new paradigm for managing malignant brain cancer
Thomas N. Seyfried, Roberto Flores, Angela M. Poff, Dominic P. D’Agostino, Purna Mukherjee

The emerging roles of microRNAs in cancer metabolism
Brian Chan, Jacob Manley, Jae Lee, Shree Ram Singh

Epigenetics and cancer metabolism
Christelle Johnson, Marc O. Warmoes, Xiling Shen, Jason W. Locasale

Cancer cell metabolism and developmental homeodomain/POU domain transcription factors: A connecting link
Biswa Pratim Das Purkayastha, Jagat Kumar Roy

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