MetaboList – February 2015

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Cancer Metabolism
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Analysis of p53 Transactivation Domain Mutants Reveals Acad11 as a Metabolic Target Important for p53 Pro-Survival Function
Dadi Jiang, Edward L. LaGory, Daniela Kenzelmann Brož, Kathryn T. Bieging, Colleen A. Brady, Nichole Link, John M. Abrams, Amato J. Giaccia, Laura D. Attardi
http://www.cell.com/cell-reports/abstract/S2211-1247(15)00068-6

Deregulated Myc Requires MondoA/Mlx for Metabolic Reprogramming and Tumorigenesis
Patrick A. Carroll, Daniel Diolaiti, Lisa McFerrin, Haiwei Gu, Danijel Djukovic, Jianhai Du, Pei Feng Cheng, Sarah Anderson, Michelle Ulrich, James B. Hurley, Daniel Raftery, Donald E. Ayer, Robert N. Eisenman
http://www.cell.com/cancer-cell/abstract/S1535-6108(14)00475-9

Mitochondrial Division Is Requisite to RAS-Induced Transformation and Targeted by Oncogenic MAPK Pathway Inhibitors
Madhavika N. Serasinghe, Shira Y. Wieder, Thibaud T. Renault, Rana Elkholi, James J. Asciolla, Jonathon L. Yao, Omar Jabado, Kyle Hoehn, Yusuke Kageyama, Hiromi Sesaki, Jerry E. Chipuk
http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00004-0

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein
Jurre J. Kamphorst, Michel Nofal, Cosimo Commisso, Sean R. Hackett,  Wenyun Lu, Elda Grabocka, Matthew G. Vander Heiden, George Miller,  Jeffrey A. Drebin, Dafna Bar-Sagi, Craig B. Thompson, and Joshua D. Rabinowitz
http://cancerres.aacrjournals.org/content/75/3/544.abstract?etoc

Glutamate Dehydrogenase 1 Signals through Antioxidant Glutathione Peroxidase 1 to Regulate Redox Homeostasis and Tumor Growth
Lingtao Jin, Dan Li, Gina N. Alesi, Jun Fan, Hee-Bum Kang, Zhou Lu, Titus J. Boggon, Peng Jin, Hong Yi, Elizabeth R. Wright, Duc Duong, Nicholas T. Seyfried, Robert Egnatchik, Ralph J. DeBerardinis, Kelly R. Magliocca, Chuan He, Martha L. Arellano, Hanna J. Khoury, Dong M. Shin, Fadlo R. Khuri, Sumin Kang
http://www.cell.com/cancer-cell/abstract/S1535-6108(14)00515-7

Erk2 Phosphorylation of Drp1 Promotes Mitochondrial Fission and MAPK-Driven Tumor Growth
Jennifer A. Kashatus, Aldo Nascimento, Lindsey J. Myers, Annie Sher, Frances L. Byrne, Kyle L. Hoehn, Christopher M. Counter, David F. Kashatus
http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00003-9

Organization of Enzyme Concentration across the Metabolic Network in Cancer Cells
Neel S. Madhukar, Marc O. Warmoes, Jason W. Locasale
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0117131

Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia
Steven M Chan, Daniel Thomas,  M Ryan Corces-Zimmerman,  Seethu Xavy,  Suchita Rastogi,  Wan-Jen Hong,  Feifei Zhao,  Bruno C Medeiros,  David A Tyvoll  & Ravindra Majeti
http://www.nature.com/nm/journal/v21/n2/full/nm.3788.html?WT.ec_id=NM-201502

Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma
Fabienne Guillaumond, Ghislain Bidaut, Mehdi Ouaissi, Stéphane Servais, Victoire Gouirand, Orianne Olivares, Sophie Lac, Laurence Borge, Julie Roques, Odile Gayet, Michelle Pinault, Cyrille Guimaraes, Jérémy Nigri, Céline Loncle, Marie-Noëlle Lavaut, Stéphane Garcia, Anne Tailleux, Bart Staels, Ezequiel Calvo, Richard Tomasini, Juan Lucio Iovanna, and Sophie Vasseur
http://www.pnas.org/content/112/8/2473.abstract.html?etoc

Integrated genomic and functional analyses reveal glyoxalase I as a novel metabolic oncogene in human gastric cancer
F Hosoda, Y Arai, N Okada, H Shimizu, M Miyamoto, N Kitagawa, H Katai, H Taniguchi, K Yanagihara, I Imoto, J Inazawa, M Ohki and T Shibata
http://www.nature.com/onc/journal/v34/n9/abs/onc201457a.html?WT.ec_id=ONC-201502

Rewired metabolism in drug-resistant leukemia cells: A metabolic switch hallmarked by reduced dependence on exogenous glutamine
Claudia Stäubert, Hasanuzzaman Bhuiyan, Anna Lindahl, Oliver Jay Broom, Yafeng Zhu, Saiful Islam, Sten Linnarsson, Janne Lehtiö, and Anders Nordström
http://www.jbc.org/content/early/2015/02/19/jbc.M114.618769.abstract

High-calorie diet exacerbates prostate neoplasia in mice with haploinsufficiency of Pten tumor suppressor gene
Jehnan Liu, Sadeesh K. Ramakrishnan, Saja S. Khuder, Meenakshi K. Kaw, Harrison T. Muturi, Sumona Ghosh Lester, Sang Jun Lee, Larisa V. Fedorova, Andrea J. Kim, Iman E. Mohamed, Cara Gatto-Weis, Kathryn M. Eisenmann, Philip B. Conran, Sonia M. Najjar
http://www.sciencedirect.com/science/article/pii/S2212877814002245

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Starvation
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HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth
Kurosh Ameri, Arman Jahangiri, Anthony M. Rajah, Kathryn V. Tormos, Ravi Nagarajan, Melike Pekmezci, Vien Nguyen, Matthew L. Wheeler, Michael P. Murphy, Timothy A. Sanders, Stefanie S. Jeffrey, Yerem Yeghiazarians, Paolo F. Rinaudo, Joseph F. Costello, Manish K. Aghi, Emin Maltepe
http://www.cell.com/cell-reports/abstract/S2211-1247(15)00033-9

PCK2 activation mediates an adaptive response to glucose depletion in lung cancer
K Leithner, A Hrzenjak, M Trötzmüller, T Moustafa, H C Köfeler, C Wohlkoenig, E Stacher, J Lindenmann, A L Harris, A Olschewski and H Olschewski
http://www.nature.com/onc/journal/v34/n8/abs/onc201447a.html

The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation
Yongjie Wei, Zhenyi An, Zhongju Zou, Rhea Sumpter Jr, Minfei Su, Xiao Zang, Sangita Sinha, Matthias Gaestel and Beth Levine
http://elifesciences.org/content/4/e05289

An mTORC1-Mdm2-Drosha Axis for miRNA Biogenesis in Response to Glucose- and Amino Acid-Deprivation
Peiying Ye, Yu Liu, Chong Chen, Fei Tang, Qi Wu, Xiang Wang, Chang-Gong Liu, Xiuping Liu, Runhua Liu, Yang Liu, Pan Zheng
http://www.sciencedirect.com/science/article/pii/S1097276514010120#

Deacetylation of Nuclear LC3 Drives Autophagy Initiation under Starvation
Rui Huang, Yinfeng Xu, Wei Wan, Xin Shou, Jiali Qian, Zhiyuan You, Bo Liu, Chunmei Chang, Tianhua Zhou, Jennifer Lippincott-Schwartz, Wei Liu
http://www.cell.com/molecular-cell/abstract/S1097-2765(14)00962-9

Vps15 is required for stress induced and developmentally triggered autophagy and salivary gland protein secretion in Drosophila
A L Anding and E H Baehrecke
http://www.nature.com/cdd/journal/v22/n3/abs/cdd2014174a.html?WT.ec_id=CDD-201503

Nitrogen Regulates AMPK to Control TORC1 Signaling
Elizabeth Davie, Gabriella M.A. Forte, Janni Petersen
http://www.cell.com/current-biology/abstract/S0960-9822(14)01637-6

Glucose Deprivation Triggers Protein Kinase C Dependent β-Catenin Proteasomal Degradation
Seung-Won Choi, Jun-kyu Song, Ye-Seal Yim, Ho-Geun Yun, and Kyung-Hee Chun
http://www.jbc.org/content/early/2015/02/17/jbc.M114.606756.abstract

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Drugs
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Antagonizing Bcl-2 Family Members Sensitizes Neuroblastoma and Ewing’s Sarcoma to an Inhibitor of Glutamine Metabolism
Rachelle R. Olsen, Michelle N. Mary-Sinclair, Zhirong Yin, Kevin W. Freeman
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116998

2-Deoxyglucose Impairs Saccharomyces cerevisiae Growth by Stimulating Snf1-Regulated and α-Arrestin-Mediated Trafficking of Hexose Transporters1 and 3
Allyson F. O’Donnell, Rhonda R. McCartney, Dakshayini G. Chandrashekarappa, Bob B. Zhang, Jeremy Thorner, and Martin C. Schmidt
http://mcb.asm.org/content/35/6/939.abstract?etoc

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AMPK / mTOR
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Degradation of AMPK by a Cancer-Specific Ubiquitin Ligase
Carlos T. Pineda, Saumya Ramanathan, Klementina Fon Tacer, Jenny L. Weon, Malia B. Potts, Yi-Hung Ou, Michael A. White, Patrick Ryan Potts
http://www.cell.com/cell/abstract/S0092-8674(15)00077-X

Suppression of the HSF1‐mediated proteotoxic stress response by the metabolic stress sensor AMPK
Siyuan Dai, Zijian Tang, Junyue Cao, Wei Zhou, Huawen Li, Stephen Sampson, and Chengkai Dai
http://EMBOJ.embopress.org/content/34/3/275?etoc

MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer
Peter C. Hart, Mao Mao, Andre Luelsdorf P. de Abreu, Kristine Ansenberger-Fricano, Dede N. Ekoue, Douglas Ganini, Andre Kajdacsy-Balla, Alan M. Diamond, Richard D. Minshall, Marcia E. L. Consolaro, Janine H. Santos and Marcelo G. Bonini
http://www.nature.com/ncomms/2015/150205/ncomms7053/full/ncomms7053.html

Inhibition of AMP kinase by the protein phosphatase 2A heterotrimer, PP2APpp2r2d
Biny K. Joseph, Hsing-Yin Liu, Jamie Francisco, Devanshi Pandya, Melissa Donigan, Christina Gallo-Ebert, Caroline Giordano, Adam Bata, and Joseph T. Nickels, Jr.
http://www.jbc.org/content/early/2015/02/18/jbc.M114.626259.abstract

Rheb Inhibits Protein Synthesis by Activating the PERK-eIF2α Signaling Cascade
Richa Tyagi, Neelam Shahani, Lindsay Gorgen, Max Ferretti, William Pryor, Po Yu Chen, Supriya Swarnkar, Paul F. Worley, Katrin Karbstein, Solomon H. Snyder, Srinivasa Subramaniam
http://www.cell.com/cell-reports/abstract/S2211-1247(15)00027-3

Renal tumours in a Tsc2+/− mouse model do not show feedback inhibition of Akt and are effectively prevented by rapamycin
J Yang, M Kalogerou, P A Samsel, Y Zhang, D F R Griffiths, J Gallacher, J R Sampson and M H Shen
http://www.nature.com/onc/journal/v34/n7/abs/onc201417a.html?WT.ec_id=ONC-201502

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Miscellaneous
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Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells
Bryce W. Carey, Lydia W. S. Finley, Justin R. Cross, C. David Allis & Craig B. Thompson
http://www.nature.com/nature/journal/v518/n7539/full/nature13981.html

PTPMT1 Inhibition Lowers Glucose through Succinate Dehydrogenase Phosphorylation
Anjali K. Nath, Justine H. Ryu, Youngnam N. Jin, Lee D. Roberts, Andre Dejam, Robert E. Gerszten, Randall T. Peterson
http://www.cell.com/cell-reports/abstract/S2211-1247(15)00023-6

Cellular memory of hypoxia elicits neuroblastoma metastasis and enables invasion by non-aggressive neighbouring cells
A Herrmann, M Rice, R Lévy, B L Pizer, P D Losty, D Moss and V Sée
http://www.nature.com/oncsis/journal/v4/n2/abs/oncsis201452a.html

A Mitochondria-Specific Isoform of FASTK Is Present In Mitochondrial RNA Granules and Regulates Gene Expression and Function
Alexis A. Jourdain, Mirko Koppen, Christopher D. Rodley, Kinsey Maundrell, Naïg Gueguen, Pascal Reynier, Adela M. Guaras, José A. Enriquez, Paul Anderson, Maria Simarro, Jean-Claude Martinou
http://www.cell.com/cell-reports/abstract/S2211-1247(15)00105-9

miR‐290/371‐Mbd2‐Myc circuit regulates glycolytic metabolism to promote pluripotency
Yang Cao, Wen‐Ting Guo, Shengya Tian, Xiaoping He, Xi‐Wen Wang, Xiaomeng Liu, Kai‐Li Gu, Xiaoyu Ma, De Huang, Lan Hu, Yongping Cai, Huafeng Zhang, Yangming Wang, and Ping Gao
http://EMBOJ.embopress.org/content/34/5/609?etoc

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Methods
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Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo
Sriram Venneti, Mark P. Dunphy, Hanwen Zhang, Kenneth L. Pitter, Patrick Zanzonico, Carl Campos, Sean D. Carlin, Gaspare La Rocca, Serge Lyashchenko, Karl Ploessl, Daniel Rohle, Antonio M. Omuro, Justin R. Cross, Cameron W. Brennan, Wolfgang A. Weber, Eric C. Holland, Ingo K. Mellinghoff, Hank F. Kung, Jason S. Lewis, and Craig B. Thompson
http://stm.sciencemag.org/content/7/274/274ra17.full?utm_campaign=email-stm-toc&utm_src=email

Non-Invasive, Simultaneous Quantification of Vascular Oxygenation and Glucose Uptake in Tissue
Narasimhan Rajaram, Andrew F. Reesor, Christine S. Mulvey, Amy E. Frees, Nirmala Ramanujam
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0117132

Limitations of detection of anaplerosis and pyruvate cycling from metabolism of [1-13C] acetate
Shawn C Burgess, Mathew E Merritt, John G Jones, Jeffrey D Browning, A Dean Sherry & Craig R Malloy
http://www.nature.com/nm/journal/v21/n2/full/nm.3789.html?WT.ec_id=NM-201502

Response to Burgess
Douglas E Befroy, Richard G Kibbey, Rachel J Perry, Kitt Falk Petersen, Douglas L Rothman  & Gerald I Shulman
http://www.nature.com/nm/journal/v21/n2/full/nm.3790.html?WT.ec_id=NM-201502

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Reviews
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Famine versus feast: understanding the metabolism of tumors in vivo
Jared R. Mayers, Matthew G. Vander Heiden
http://www.cell.com/trends/biochemical-sciences/abstract/S0968-0004(15)00005-5

A roadmap for interpreting 13C metabolite labeling patterns from cells
Joerg M Buescher, Maciek R Antoniewicz, Laszlo G Boros, Shawn C Burgess, Henri Brunengraber, Clary B Clish, Ralph J DeBerardinis, Olivier Feron, Christian Frezza, Bart Ghesquiere, Eyal Gottlieb, Karsten Hiller, Russell G Jones, Jurre J Kamphorst, Richard G Kibbey, Alec C Kimmelman, Jason W Locasale, Sophia Y Lunt, Oliver DK Maddocks, Craig Malloy, Christian M Metallo, Emmanuelle J Meuillet, Joshua Munger, Katharina Nöh, Joshua D Rabinowitz, Markus Ralser, Uwe Sauer, Gregory Stephanopoulos, Julie St-Pierre, Daniel A Tennant, Christoph Wittmann, Matthew G Vander Heiden, Alexei Vazquez, Karen Vousden, Jamey D Young, Nicola Zamboni, Sarah-Maria Fendt
http://www.sciencedirect.com/science/article/pii/S0958166915000221#

Oxidative stress and autophagy: the clash between damage and metabolic needs
G Filomeni, D De Zio and F Cecconi
http://www.nature.com/cdd/journal/v22/n3/abs/cdd2014150a.html?WT.ec_id=CDD-201503

Metabolic Signatures of Human Breast Cancer
Prachi Mishra & Stefan Ambs
http://www.tandfonline.com/doi/abs/10.4161/23723556.2014.992217?ai=1jft2&ui=79l0u&af=T

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Comments
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Web of the Extended Myc Network Captures Metabolism for Tumorigenesis
Chi V. Dang
http://www.cell.com/cancer-cell/abstract/S1535-6108(15)00019-7

A synthetic lethal approach targeting mutant isocitrate dehydrogenase in acute myeloid leukemia
Amit Verma and Ulrich Steidl
http://www.nature.com/nm/journal/v21/n2/full/nm.3796.html?WT.ec_id=NM-201502

Vascular endothelial growth factor blockade elicits a stable metabolic shift in tumor cells: therapeutic implications
Stefano Indraccolo
http://www.tandfonline.com/doi/full/10.1080/23723556.2015.1008307#abstract

Context-dependent utilization of serine in cancer
Mahya Mehrmohamadi & Jason W Locasale
http://www.tandfonline.com/doi/abs/10.1080/23723556.2014.996418?ai=1jft2&ui=79l0u&af=T

Cellular stress response cross talk maintains protein and energy homeostasis
Cynthia L Swan and Lea Sistonen
http://emboj.embopress.org/content/34/3/267?etoc

Harnessing the Nuclear Receptor PPARγ to Inhibit the Growth of Lung Adenocarcinoma by Rewiring Metabolic Circuitries
Paul Yenerall & Ralf Kittler
http://www.tandfonline.com/doi/abs/10.4161/23723556.2014.980660?ai=1jft2&ui=79l0u&af=T

An expanded role for mTORC1 in autophagy
Young-Mi Kim, Ji-Man Park, Douglas Grunwald & Do-Hyung Kim
http://www.tandfonline.com/doi/abs/10.1080/23723556.2015.1010958?ai=1jft2&ui=79l0u&af=T

The cancer cell ‘energy grid’: TGF-β1 signaling coordinates metabolism for migration
Lei Jiang, Ralph Deberardinis & David A. Boothman
http://www.tandfonline.com/doi/abs/10.4161/23723556.2014.981994?ai=1jft2&ui=79l0u&af=T

Metabolic stressors disrupt proteome homeostasis to suppress malignancy
Chengkai Dai
http://www.tandfonline.com/doi/abs/10.1080/23723556.2014.1002718?ai=1jft2&ui=79l0u&af=T

Untargeted metabolomics for profiling oncogene-specific metabolic signatures of prostate cancer
Carmen Priolo & Massimo Loda
http://www.tandfonline.com/doi/abs/10.1080/23723556.2014.1001197?ai=1jft2&ui=79l0u&af=T

Glutathione peroxidase 4 (Gpx4) and ferroptosis: what is so special about it?
Marcus Conrad & Jose Pedro Friedmann Angeli
http://www.tandfonline.com/doi/abs/10.4161/23723556.2014.995047?ai=1jft2&ui=79l0u&af=T

Sweet connections: O-GlcNAcylation links cancer cell metabolism and survival
Christina M Ferrer & Mauricio J Reginato
http://www.tandfonline.com/doi/abs/10.4161/23723548.2014.961809?ai=1gumh&ui=79l0u&af=T

UCP2 induces metabolic reprogramming to inhibit proliferation of cancer cells
Pauline Esteves, Claire Pecqueur & Marie-Clotilde Alves-Guerra
http://www.tandfonline.com/doi/abs/10.4161/23723556.2014.975024?ai=1gumh&ui=79l0u&af=T

Metastasis: Feeding the beast
http://www.nature.com/nrc/journal/v15/n3/full/nrc3913.html?WT.ec_id=NRC-201503

Nitrogen stress activates AMPK
http://stke.sciencemag.org/content/8/365/ec41.abstract?utm_campaign=email-sig-toc&utm_src=email

FH-Deficient Cancers Depend on ABL1-Mediated Metabolic Adaptation
http://cancerdiscovery.aacrjournals.org/content/5/2/OF9.abstract?etoc

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