MetaboList – April 2015

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Cancer Metabolism
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Metabolic Reprogramming of Cancer-Associated Fibroblasts by IDH3α Downregulation
Daoxiang Zhang, Yongbin Wang, Zhimin Shi, Jingyi Liu, Pan Sun, Xiaodan Hou, Jian Zhang, Shimin Zhao, Binhua P. Zhou, Jun Mi
http://www.cell.com/cell-reports/abstract/S2211-1247(15)00133-3

Mutant IDH is sufficient to initiate enchondromatosis in mice
Makoto Hirata, Masato Sasaki, Rob A. Cairns, Satoshi Inoue, Vijitha Puviindran, Wanda Y. Li, Bryan E. Snow, Lisa D. Jones, Qingxia Wei, Shingo Sato, Yuning J. Tang, Puviindran Nadesan, Jason Rockel, Heather Whetstone, Raymond Poon, Angela Weng, Stefan Gross, Kimberly Straley, Camelia Gliser, Yingxia Xu, Jay Wunder, Tak W. Mak, and Benjamin A. Alman
http://www.pnas.org/content/112/9/2829.abstract.html?etoc

Delivery-Corrected Imaging of Fluorescently-Labeled Glucose Reveals Distinct Metabolic Phenotypes in Murine Breast Cancer
Amy E. Frees, Narasimhan Rajaram, Samuel S. McCachren, Andrew N. Fontanella, Mark W. Dewhirst, Nimmi Ramanujam
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115529

Switching of Pyruvate Kinase Isoform L to M2 Promotes Metabolic Reprogramming in Hepatocarcinogenesis
Carmen Chak-Lui Wong, Sandy Leung-Kuen Au, Aki Pui-Wah Tse, Iris Ming-Jing Xu, Robin Kit-Ho Lai, David Kung-Chun Chiu, Larry Lai Wei, Dorothy Ngo-Yin Fan, Felice Ho-Ching Tsang, Regina Cheuk-Lam Lo, Chun-Ming Wong, Irene Oi-Lin Ng
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115036

Metabolic Phenotypes in Pancreatic Cancer
Min Yu, Quanbo Zhou, Yu Zhou, Zhiqiang Fu, Langping Tan, Xiao Ye, Bing Zeng, Wenchao Gao, Jiajia Zhou, Yimin Liu, Zhihua Li, Ye Lin, Qing Lin, Rufu Chen
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115153

Differential Expression of Lipid Metabolism-Related Proteins in Different Breast Cancer Subtypes
Sewha Kim, YuKyung Lee, Ja Seung Koo
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119473

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress
Shrivani Sriskanthadevan, Danny V. Jeyaraju, Timothy E. Chung, Swayam Prabha, Wei Xu, Marko Skrtic, Bozhena Jhas, Rose Hurren, Marcela Gronda, Xiaoming Wang, Yulia Jitkova, Mahadeo A. Sukhai, Feng-Hsu Lin, Neil Maclean, Rob Laister, Carolyn A. Goard, Peter J. Mullen, Stephanie Xie, Linda Z. Penn, Ian M. Rogers, John E. Dick, Mark D. Minden, and Aaron D. Schimmer
http://bloodjournal.org/content/125/13/2120.abstract?etoc

The anticancer gene ORCTL3 targets stearoyl-CoA desaturase-1 for tumour-specific apoptosis
G AbuAli, W Chaisaklert, E Stelloo, E Pazarentzos, M-S Hwang, D Qize, S V Harding, A Al-Rubaish, A J Alzahrani, A Al-Ali, T A B Sanders, E O Aboagye and S Grimm
http://www.nature.com/onc/journal/v34/n13/abs/onc201493a.html

Myc and Ras oncogenes engage different energy metabolism programs and evoke distinct patterns of oxidative and DNA replication stress.
Maya-Mendoza A, Ostrakova J, Kosar M, Hall A, Duskova P, Mistrik M, Merchut-Maya JM, Hodny Z, Bartkova J, Christensen C, Bartek J
http://www.moloncol.org/article/S1574-7891(14)00266-X/abstract

Large-scale profiling of metabolic dysregulation in ovarian cancer.
Ke C, Hou Y, Zhang H, Fan L, Ge T, Guo B, Zhang F, Yang K, Wang J, Lou G, Li K
http://onlinelibrary.wiley.com/doi/10.1002/ijc.29010/abstract

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Crosstalk cell death / metabolism
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Effect of Polyunsaturated Fatty Acids and Their Metabolites on Bleomycin-Induced Cytotoxic Action on Human Neuroblastoma Cells In Vitro
Sailaja Polavarapu, Arul M. Mani, Naveen K. V. Gundala, Anasuya D. Hari, Siresha Bathina, Undurti N. Das
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0114766

Phospho-BAD BH3 Mimicry Protects β Cells and Restores Functional β Cell Mass in Diabetes
Sanda Ljubicic, Klaudia Polak, Accalia Fu, Jessica Wiwczar, Benjamin Szlyk, Yigang Chang, Juan C. Alvarez-Perez, Gregory H. Bird, Loren D. Walensky, Adolfo Garcia-Ocaña, Nika N. Danial
http://www.cell.com/cell-reports/abstract/S2211-1247(14)01123-1

Inhibition of Stat3 suppresses caspase-3 and the ubiquitin-proteasome system leading to preservation of muscle mass in cancer cachexia
Kleiton Augusto Santos Silva, Jiangling Dong, Yanjun Dong, Yanlan Dong, Nestor Schor, David J. Tweardy, Liping Zhang, and William E. Mitch
http://www.jbc.org/content/early/2015/03/18/jbc.M115.641514.abstract

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Starvation
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Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics
Angelika S. Rambold, Sarah Cohen, Jennifer Lippincott-Schwartz
http://www.cell.com/developmental-cell/abstract/S1534-5807(15)00072-6

Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation
Wuyang Wang, Qiong Gao, Meimei Yang, Xiaoli Zhang, Lu Yu, Maria Lawas, Xinran Li, Marthe Bryant-Genevier, Noel T. Southall, Juan Marugan, Marc Ferrer, and Haoxing Xu
http://www.pnas.org/content/112/11/E1373.abstract.html?etoc

Starvation Promotes REV1 SUMOylation and p53-Dependent Sensitization of Melanoma and Breast Cancer Cells
Hong Seok Shim, Min Wei, Sebastian Brandhorst, and Valter D. Longo
http://cancerres.aacrjournals.org/content/75/6/1056.abstract?etoc

Skp2-Dependent Ubiquitination and Activation of LKB1 Is Essential for Cancer Cell Survival under Energy Stress
Szu-Wei Lee, Chien-Feng Li, Guoxiang Jin, Zhen Cai, Fei Han, Chia-Hsin Chan, Wei-Lei Yang, Bin-Kui Li, Abdol Hossein Rezaeian, Hong-Yu Li, Hsuan-Ying Huang, Hui-Kuan Lin
http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00016-7

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AMPK / mTOR
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Dynamic Visualization of mTORC1 Activity in Living Cells
Xin Zhou, Terri L. Clister, Pamela R. Lowry, Marcus M. Seldin, G. William Wong, Jin Zhang
http://www.cell.com/cell-reports/abstract/S2211-1247(15)00177-1

AMPK modulates Hippo pathway activity to regulate energy homeostasis
Wenqi Wang, Zhen-Dong Xiao, Xu Li, Kathryn E. Aziz, Boyi Gan, Randy L. Johnson & Junjie Chen
http://www.nature.com/ncb/journal/v17/n4/full/ncb3113.html?WT.ec_id=NCB-201504

Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway
Jung-Soon Mo, Zhipeng Meng, Young Chul Kim, Hyun Woo Park, Carsten Gram Hansen, Soohyun Kim, Dae-Sik Lim & Kun-Liang Guan
http://www.nature.com/ncb/journal/v17/n4/full/ncb3111.html?WT.ec_id=NCB-201504

NFκB up-regulation of glucose transporter 3 is essential for hyperactive mammalian target of rapamycin-induced aerobic glycolysis and tumor growth
Xiaojun Zha,Zhongdong Hu,Shuang Ji1,Fuquan Jin,Keguo Jiang,Chunjia Li,Pan Zhao,Zhenzhen Tu,Xianguo Chen,
Lijun Di,Haisheng Zhou,Hongbing Zhang
http://www.cancerletters.info/article/S0304-3835%2815%2900017-8/abstract

Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer.
Barbier-Torres L1, Delgado TC1, García-Rodríguez JL1, Zubiete-Franco I1, Fernández-Ramos D1, Buqué X2, Cano A3, Gutiérrez-de Juan V1, Fernández-Domínguez I1, Lopitz-Otsoa F1, Fernández-Tussy P1, Boix L4,5, Bruix J4,5, Villa E6, Castro A3, Lu SC7, Aspichueta P2, Xirodimas D8, Varela-Rey M1, Mato JM1, Beraza N1, Martínez-Chantar ML1.
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=3191

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Anti-metabolic drugs
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Apoptotic Efficacy of Etomoxir in Human Acute Myeloid Leukemia Cells. Cooperation with Arsenic Trioxide and Glycolytic Inhibitors, and Regulation by Oxidative Stress and Protein Kinase Activities
María Cristina Estañ, Eva Calviño, Susana Calvo, Beatriz Guillén-Guío, María del Carmen Boyano-Adánez, Elena de Blas, Eduardo Rial, Patricio Aller
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115250

Glycolytic Switch in Response to Betulinic Acid in Non-Cancer Cells
Elke H. Heiss, Matthias P. Kramer, Atanas G. Atanasov, Hortenzia Beres, Daniel Schachner, Verena M. Dirsch
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115683

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Hypoxia
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Increased metabolites of 5-lipoxygenase from hypoxic ovarian cancer cells promote tumor-associated macrophage infiltration
Z Wen, H Liu, M Li, B Li, W Gao, Q Shao, B Fan, F Zhao, Q Wang, Q Xie, Y Yang, J Yu and X Qu
http://www.nature.com/onc/journal/v34/n10/abs/onc201485a.html

SIRT2 regulates tumour hypoxia response by promoting HIF-1α hydroxylation
K-S Seo, J-H Park, J-Y Heo, K Jing, J Han, K-N Min, C Kim, G Y Koh, K Lim, G-Y Kang, J Uee Lee, Y-H Yim, M Shong, T-H Kwak and G R Kweon
http://www.nature.com/onc/journal/v34/n11/abs/onc201476a.html?WT.ec_id=ONC-201503

c-Myc-mediated repression of miR-15-16 in hypoxia is induced by increased HIF-2α and promotes tumor angiogenesis and metastasis by upregulating FGF2
G Xue, H-L Yan, Y Zhang, L-Q Hao, X-T Zhu, Q Mei and S-H Sun
http://www.nature.com/onc/journal/v34/n11/abs/onc201482a.html?WT.ec_id=ONC-201503

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Miscellaneous
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Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research
Norman Moullan, Laurent Mouchiroud, Xu Wang, Dongryeol Ryu, Evan G. Williams, Adrienne Mottis, Virginija Jovaisaite, Michael V. Frochaux, Pedro M. Quiros, Bart Deplancke, Riekelt H. Houtkooper, Johan Auwerx
http://www.cell.com/cell-reports/abstract/S2211-1247(15)00180-1

Regulation of Glutamine Carrier Proteins by RNF5 Determines Breast Cancer Response to ER Stress-Inducing Chemotherapies
Young Joo Jeon, Sihem Khelifa, Boris Ratnikov, David A. Scott, Yongmei Feng, Fabio Parisi, Chelsea Ruller, Eric Lau, Hyungsoo Kim, Laurence M. Brill, Tingting Jiang, David L. Rimm, Robert D. Cardiff, Gordon B. Mills, Jeffrey W. Smith, Andrei L. Osterman, Yuval Kluger, Ze’ev A. Ronai
http://www.cell.com/cancer-cell/abstract/S1535-6108(15)00056-2

Brief Report: Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism
Xia Liu, Hong Zheng, Wen-Mei Yu, Todd M. Cooper, Kevin D. Bunting, and Cheng-Kui Qu
http://bloodjournal.org/content/125/10/1562.abstract?etoc

Metabolomics Evaluation of Serum Markers for Cachexia and Their Intra-Day Variation in Patients with Advanced Pancreatic Cancer
Yutaka Fujiwara, Takashi Kobayashi, Naoko Chayahara, Yoshinori Imamura, Masanori Toyoda, Naomi Kiyota, Toru Mukohara, Shin Nishiumi, Takeshi Azuma, Masaru Yoshida, Hironobu Minami
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113259

Role of 2-[18F] Fluoro-2-Deoxy-D-Glucose-Positron Emission Tomography/Computed Tomography in the Post-Therapy Surveillance of Breast Cancer
Hong-Tai Chang, Chin Hu, Yu-Li Chiu, Nan-Jing Peng, Ren-Shyan Liu
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115127

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Reviews
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Metabolic pathways promoting cancer cell survival and growth
Lindsey K. Boroughs and Ralph J. DeBerardinis
http://www.nature.com/ncb/journal/v17/n4/full/ncb3124.html

Nutrient-Sensing Mechanisms across Evolution
Lynne Chantranupong, Rachel L. Wolfson, David M. Sabatini
http://www.cell.com/cell/abstract/S0092-8674(15)00242-1

Regulation of mitochondrial nutrient and energy metabolism by BCL-2 family proteins
Alfredo Giménez-Cassina, Nika N. Danial
http://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760(15)00027-2

Molecular drivers of cellular metabolic reprogramming in melanoma
Cecilie Abildgaard, Per Guldberg
http://www.cell.com/trends/molecular-medicine/abstract/S1471-4914(14)00224-X

T cell metabolic fitness in antitumor immunity.
Siska PJ, Rathmell JC.
http://www.cell.com/trends/immunology/abstract/S1471-4906(15)00038-1

PI3K at the crossroads of tumor angiogenesis signaling pathways
Adriana Soler, Ana Angulo-Urarte & Mariona Graupera
http://www.tandfonline.com/doi/abs/10.4161/23723556.2014.975624?ai=1gumh&ui=79l0u&af=T

Molecular mechanisms of mTOR regulation by stress
Alexander Martin Heberle, Mirja Tamara Prentzell, Karen van Eunen, Barbara Marleen Bakker, Sushma Nagaraja Grellscheid & Kathrin Thedieck
http://www.tandfonline.com/doi/abs/10.4161/23723548.2014.970489?ai=1gumh&ui=79l0u&af=T

Current Opinion in Cell Biology special issue
http://www.sciencedirect.com/science/journal/09550674/33/supp/C
Editorial overview: Cell regulation: Cell biology, fueling a renaissance in metabolism
Jodi Nunnari, Johan Auwerx

Including:
– AMPK: positive and negative regulation, and its role in whole-body energy homeostasis
D Grahame Hardie
– ROS-dependent signal transduction
Colleen R Reczek, Navdeep S Chandel
– Hexosamine pathway and (ER) protein quality control
Martin S Denzel, Adam Antebi
– Cell cycle regulation of mitochondrial function
Isabel C Lopez-Mejia, Lluis Fajas
– Molecular basis for the regulation of the nuclear receptor LRH-1
Sokrates Stein, Kristina Schoonjans
– Mitochondrial pyruvate import and its effects on homeostasis
Benoit Vanderperre, Tom Bender, Edmund RS Kunji, Jean-Claude Martinou
– Metabolic control via the mitochondrial protein import machinery
Magdalena Opalinska, Chris Meisinger
– PPARs and ERRs: molecular mediators of mitochondrial metabolism
Weiwei Fan, Ronald Evans
– mTOR signaling in cellular and organismal energetics
Verena Albert, Michael N Hall
– Lipid-dependent regulation of the unfolded protein response
Romain Volmer, David Ron
– The mitochondrial unfolded protein response — synchronizing genomes
Virginija Jovaisaite, Johan Auwerx
– Membrane contact sites, gateways for lipid homeostasis
Sujoy Lahiri, Alexandre Toulmay, William A Prinz
– Epigenetic modulation of metabolic decisions
Anita Ost, John Andrew Pospisilik
– PINK1/Parkin-mediated mitophagy in mammalian cells
Akinori Eiyama, Koji Okamoto
– Endocrine aspects of organelle stress — cell non-autonomous signaling of mitochondria and the ER
Robert Schinzel, Andrew Dillin
– Mitochondrial division and fusion in metabolism
Madhuparna Roy, P Hemachandra Reddy, Miho Iijima, Hiromi Sesaki
– The life cycle of lipid droplets
Hayaa F Hashemi, Joel M Goodman
– Acetyl-CoA and the regulation of metabolism: mechanisms and consequences
Lei Shi, Benjamin P Tu

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Comments
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Eat this, not that! How selective autophagy helps cancer cells survive
Robin Mathew & Eileen White
http://www.tandfonline.com/doi/abs/10.4161/23723556.2014.975638?ai=1gumh&ui=79l0u&af=T

The GLU that Holds Cancer Together: Targeting GLUtamine Transporters in Breast Cancer
Michael A. Moses, Len Neckers
http://www.cell.com/cancer-cell/abstract/S1535-6108(15)00060-4

IDH1/2 Mutations and BCL-2 Dependence: An Unexpected Chink in AML’s Armour
Elodie Pronier, Ross L. Levine
http://www.cell.com/cancer-cell/abstract/S1535-6108(15)00063-X

Autophagy: Starvation Relieves Transcriptional Repression of ATG Genes
Rodney J. Devenish, Mark Prescott
http://www.cell.com/current-biology/abstract/S0960-9822(15)00077-9

WWOX loss activates aerobic glycolysis
Muhannad Abu-Remaileh, Victoria L Seewaldt & Rami I Aqeilane965640
http://www.tandfonline.com/doi/abs/10.4161/23723548.2014.965640

Harnessing the nuclear receptor PPARγ to inhibit the growth of lung adenocarcinoma by rewiring metabolic circuitries
Paul Yenerall & Ralf Kittler
http://www.tandfonline.com/doi/abs/10.4161/23723556.2014.980660?ai=1gumh&ui=79l0u&af=T

Energy stress tames the Hippo pathway
Iswar K. Hariharan
http://www.nature.com/ncb/journal/v17/n4/full/ncb3141.html?WT.ec_id=NCB-201504

Lipid metabolism: Fatty acids on the move
http://www.nature.com/nrm/journal/v16/n4/full/nrm3972.html

BCL2 Is Synthetic Lethal to IDH1/2 Mutations in AML
http://cancerdiscovery.aacrjournals.org/content/5/3/223.1.abstract?etoc

MONDOA Is Required for MYC-Driven Metabolic Changes
http://cancerdiscovery.aacrjournals.org/content/5/3/226.2.abstract?etoc

Acetyl-CoA Synthetase 2 Confers a Growth Advantage under Metabolic Stress
http://cancerdiscovery.aacrjournals.org/content/5/3/OF10.abstract?etoc

Extracellular Metabolism Drives Tumor Cell Survival at Metastatic Sites
http://cancerdiscovery.aacrjournals.org/content/5/3/OF11.abstract?etoc

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