MetaboList – April 2015

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Cancer Metabolism
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SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance
Dohoon Kim, Brian P. Fiske, Kivanc Birsoy, Elizaveta Freinkman, Kenjiro Kami, Richard L. Possemato, Yakov Chudnovsky, Michael E. Pacold, Walter W. Chen, Jason R. Cantor, Laura M. Shelton, Dan Y. Gui, Manjae Kwon, Shakti H. Ramkissoon, Keith L. Ligon, Seong Woo Kang, Matija Snuderl, Matthew G. Vander Heiden & David M. Sabatini
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14363.html

Lysine Demethylase LSD1 Coordinates Glycolytic and Mitochondrial Metabolism in Hepatocellular Carcinoma Cells
Akihisa Sakamoto, Shinjiro Hino, Katsuya Nagaoka, Kotaro Anan, Ryuta Takase, Haruka Matsumori, Hidenori Ojima, Yae Kanai, Kazunori Arita, and Mitsuyoshi Nakao
http://cancerres.aacrjournals.org/content/75/7/1445.abstract?etoc

FOXOs support the metabolic requirements of normal and tumor cells by promoting IDH1 expression
Paraskevi Charitou, Maria Rodriguez‐Colman, Johan Gerrits, Miranda van Triest, Marian Groot Koerkamp, Marten Hornsveld, Frank Holstege, Nanda M Verhoeven‐Duif, and Boudewijn MT Burgering
http://EMBOr.embopress.org/content/16/4/456?etoc

Impact of Metabolic Heterogeneity on Tumor Growth, Invasion, and Treatment Outcomes
Mark Robertson-Tessi, Robert J. Gillies, Robert A. Gatenby, and Alexander R.A. Anderson
http://cancerres.aacrjournals.org/content/75/8/1567.abstract?etoc

SIRT3‐dependent GOT2 acetylation status affects the malate–aspartate NADH shuttle activity and pancreatic tumor growth
Hui Yang, Lisha Zhou, Qian Shi, Yuzheng Zhao, Huaipeng Lin, Mengli Zhang,Shimin Zhao, Yi Yang, Zhi‐Qiang Ling, Kun‐Liang Guan, Yue Xiong, and Dan Ye
http://EMBOJ.embopress.org/content/34/8/1110?etoc

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Anti-metabolic drugs
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The cytotoxicity of 3-bromopyruvate in breast cancer cells depends on extracellular pH
João Azevedo Silva, Odília Queirós, Ana Ribeiro, Fátima Baltazar, Ko H. Young, Peter L. Pedersen, Ana Preto and Margarida Casal
http://www.biochemj.org/bj/467/bj4670247.htm

Glycolysis inhibitor 2-deoxy-D-glucose suppresses carcinogen-induced rat hepatocarcinogenesis by restricting cancer cell metabolism
Zhaofa Wang Liming Zhang Dong Zhang Rongsheng Sun Qingyan Wang Xinyi Liu
http://www.spandidos-publications.com/mmr/11/3/1917

Inhibition of NADPH oxidase potentiates 2-DG induced suppression of glioblastoma cell migration and invasion. Role of AKT / HIF1α / HK-2 signaling axis.
Priyanka Gupta, Jagavelu kumaravelu and Durga Prasad Mishra.
http://online.liebertpub.com/doi/10.1089/ars.2014.5973

Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target
Francis Mussai, Sharon Egan, Joseph Higginbotham-Jones, Tracey Perry, Andrew Beggs, Elena Odintsova, Justin Loke, Guy Pratt, Kin Pong U, Anthony Lo, Margaret Ng, Pamela Kearns, Paul Cheng, and Carmela De Santo
http://bloodjournal.org/content/125/15/2386.abstract?etoc

In Silico Modeling-based Identification of GLUT4 Selective Inhibitors for Cancer Therapy
Rama K. Mishra, Changyong Wei, Richard C. Hresko, Richa Bajpai, Monique Heitmeier, Shannon M. Matulis, Ajay K. Nooka, Steven T. Rosen, Paul W. Hruz, Gary E. Schiltz, and Mala Shanmugam
J. Biol. Chem. published 6 April 2015 doi:10.1074/jbc.M114.628826
http://www.jbc.org/content/early/2015/04/06/jbc.M114.628826.abstract

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Hypoxia and HIF-1
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A Lactate-Induced Response to Hypoxia
Dong Chul Lee, Hyun Ahm Sohn, Zee-Yong Park, Sangho Oh, Yun Kyung Kang, Kyoung-min Lee, Minho Kang, Ye Jin Jang, Suk-Jin Yang, Young Ki Hong, Hanmi Noh, Jung-Ae Kim, Dong Joon Kim, Kwang-Hee Bae, Dong Min Kim, Sang J. Chung, Hyang Sook Yoo, Dae-Yeul Yu, Kyung Chan Park, Young Il Yeom
http://www.cell.com/cell/abstract/S0092-8674(15)00264-0

Elongation Factor 2 Kinase Is Regulated by Proline Hydroxylation and Protects Cells during Hypoxia
Claire E. J. Moore, Halina Mikolajek, Sergio Regufe da Mota, Xuemin Wang,Justin W. Kenney, Jörn M. Werner, and Christopher G. Proud
http://mcb.asm.org/content/35/10/1788.abstract?etoc

Pyruvate sensitizes pancreatic tumors to hypoxia-activated prodrug TH-302
Wojtkowiak  JW, Cornnell  HC, Matsumoto  S, Saito  K, Takakusagi  Y, Dutta  P, Kim  M, Zhang  X, Leos  R, Bailey  KM, Martinez  G, Lloyd  MC, Weber  C, Mitchell  JB, Lynch  RM, Baker  AF, Gatenby  RA, Rejniak  KA, Hart  C, Krishna  MC, Gillies  RJ
http://www.cancerandmetabolism.com/content/3/1/2/abstract

Local Mitochondrial-Endolysosomal Microfusion Cleaves Voltage-Dependent Anion Channel 1 To Promote Survival in Hypoxia
M. Christiane Brahimi-Horn, Sandra Lacas-Gervais, Ricardo Adaixo, Karine Ilc, Matthieu Rouleau, Annick Notte, Marc Dieu, Carine Michiels, ThibaultVoeltzel, Véronique Maguer-Satta, Joffrey Pelletier, Marius Ilie, Paul Hofman, Bénédicte Manoury, Alexander Schmidt, Sebastian Hiller, Jacques Pouysségur, and Nathalie M. Mazure
http://mcb.asm.org/content/35/9/1491.abstract?etoc

Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization
L Wei, Y Zhou, C Qiao, T Ni, Z Li, Q You, Q Guo and N Lu
http://www.nature.com/cddis/journal/v6/n4/abs/cddis201586a.html?WT.ec_id=CDDIS-201504

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Metabolic stress / starvation
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Comprehensive Profiling of Amino Acid Response Uncovers Unique Methionine-Deprived Response Dependent on Intact Creatine Biosynthesis
Xiaohu Tang, Melissa M. Keenan, Jianli Wu, Chih-An Lin, Laura Dubois, J. Will Thompson, Stephen J. Freedland, Susan K. Murphy, Jen-Tsan Chi
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005158

Potential role for snoRNAs in PKR activation during metabolic stress
Osama A. Youssef, Sarah A. Safran, Takahisa Nakamura, David A. Nix, Gökhan S. Hotamisligil, and Brenda L. Bass
http://www.pnas.org/content/112/16/5023.abstract.html?etoc

The coordinated action of the MVB pathway and autophagy ensures cell survival during starvation [yeast]
Martin Müller, Oliver Schmidt, Mihaela Angelova, Klaus Faserl, Sabine Weys, Leopold Kremser, Thaddäus Pfaffenwimmer, Thomas Dalik, Claudine Kraft, Zlatko Trajanoski, Herbert Lindner and David Teis
http://elifesciences.org/content/early/2015/04/22/eLife.07736/article-data

In vivo imaging of the spatiotemporal activity of the eIF2α-ATF4 signaling pathway: Insights into stress and related disorders
Cédric Chaveroux, Valérie Carraro, Laurence Canaple, Julien Averous, Anne-Catherine Maurin, Céline Jousse, Yuki Muranishi, Laurent Parry, Florent Mesclon, Evelina Gatti, Jacques Mallet, Philippe Ravassard, Philippe Pierre, Pierre Fafournoux, and Alain Bruhat
http://stke.sciencemag.org/content/8/374/rs5.abstract

Protection of hypoglycemia-induced neuronal death by β-hydroxybutyrate involves the preservation of energy levels and decreased production of reactive oxygen species
Alberto Julio-Amilpas, Teresa Montiel, Eva Soto-Tinoco, Cristian Gerónimo-Olvera and Lourdes Massieu
http://www.nature.com/jcbfm/journal/v35/n5/abs/jcbfm20151a.html

Prolonged starvation drives reversible sequestration of lipid biosynthetic enzymes and organelle reorganization in Saccharomyces cerevisiae
Harsha Garadi Suresh, Aline Xavier da Silveira dos Santos, Wanda Kukulski, Jens Tyedmers, Howard Riezman, Bernd Bukau, and Axel Mogk
http://www.molbiolcell.org/content/26/9/1601.abstract?etoc

CAPER Is Vital for Energy and Redox Homeostasis by Integrating Glucose-Induced Mitochondrial Functions via ERR-α-Gabpa and Stress-Induced Adaptive Responses via NF-κB-cMYC
Yun Kyoung Kang, Nagireddy Putluri, Suman Maity, Anna Tsimelzon, Olga Ilkayeva, Qianxing Mo, David Lonard, George Michailidis, Arun Sreekumar, Christopher B. Newgard, Meng Wang, Sophia Y. Tsai, Ming-Jer Tsai, Bert W. O’Malley
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005116

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AMPK, mTOR
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Compartmentalized AMPK Signaling Illuminated by Genetically Encoded Molecular Sensors and Actuators
Takafumi Miyamoto, Elmer Rho, Vedangi Sample, Hiroki Akano, Masaki Magari, Tasuku Ueno, Kirill Gorshkov, Melinda Chen, Hiroshi Tokumitsu, Jin Zhang, Takanari Inoue
http://www.cell.com/cell-reports/abstract/S2211-1247(15)00348-4

A novel LKB1 isoform enhances AMPK metabolic activity and displays oncogenic properties
R Dahmani, P-A Just, A Delay, F Canal, L Finzi, C Prip-Buus, M Lambert, P Sujobert, K Buchet-Poyau, E Miller, C Cavard, S Marmier, B Terris, M Billaud and C Perret
http://www.nature.com/onc/journal/v34/n18/abs/onc2014182a.html

Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment
Kazuhiro Tanaka, Takashi Sasayama, Yasuhiro Irino, Kumi Takata, Hiroaki Nagashima, Naoko Satoh, Katsusuke Kyotani, Takashi Mizowaki, Taichiro Imahori, Yasuo Ejima, Kenta Masui, Beatrice Gini, Huijun Yang, Kohkichi Hosoda, Ryohei Sasaki, Paul S. Mischel, Eiji Kohmura
http://www.jci.org/articles/view/78239

Identification of a Non-Gatekeeper Hot Spot for Drug-Resistant Mutations in mTOR Kinase
Tzung-Ju Wu, Xiaowen Wang, Yanjie Zhang, Linghua Meng, John E. Kerrigan, Stephen K. Burley, X.F. Steven Zheng
http://www.cell.com/cell-reports/abstract/S2211-1247(15)00309-5

MCRS1 Binds and Couples Rheb to Amino Acid-Dependent mTORC1 Activation
Mohamad-Ali Fawal, Marta Brandt, Nabil Djouder
http://www.cell.com/developmental-cell/abstract/S1534-5807(15)00112-4

Pharmacological Inhibition of ULK1 Blocks mTOR-Dependent Autophagy
Katy J. Petherick, Owen J. L. Conway, Chido Mpamhanga, Simon A. Osborne, Ahmad Kamal, Barbara Saxty, and Ian G. Ganley
http://www.jbc.org/content/early/2015/04/01/jbc.C114.627778.abstract

mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3
K M Dodd, J Yang, M H Shen, J R Sampson and A R Tee
http://www.nature.com/onc/journal/v34/n17/abs/onc2014164a.html?WT.ec_id=ONC-201504

Dynamic phosphoproteomics reveals TORC1-dependent regulation of yeast nucleotide and amino acid biosynthesis
Ana Paula Oliveira, Christina Ludwig, Mattia Zampieri, Hendrik Weisser, Ruedi Aebersold, and Uwe Sauer
http://stke.sciencemag.org/content/8/374/rs4.abstract

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Miscellaneous
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Fatty acid carbon is essential for dNTP synthesis in endothelial cells
Sandra Schoors, Ulrike Bruning, Rindert Missiaen, Karla C. S. Queiroz, Gitte Borgers, Ilaria Elia, Annalisa Zecchin, Anna Rita Cantelmo, Stefan Christen, Jermaine Goveia, Ward Heggermont, Lucica Goddé, Stefan Vinckier, Paul P. Van Veldhoven, Guy Eelen, Luc Schoonjans, Holger Gerhardt, Mieke Dewerchin, Myriam Baes, Katrien De Bock, Bart Ghesquière, Sophia Y. Lunt, Sarah-Maria Fendt & Peter Carmeliet
http://www.nature.com/nature/journal/v520/n7546/full/nature14362.html

Regulation of mitochondrial pyruvate uptake by alternative pyruvate carrier complexes
Tom Bender, Gabrielle Pena, and Jean‐Claude Martinou
http://EMBOJ.embopress.org/content/34/7/911?etoc

Treatment of glioma patients with ketogenic diets: report of two cases treated with an IRB-approved energy-restricted ketogenic diet protocol and review of the literature
Schwartz  K, Chang  HT, Nikolai  M, Pernicone  J, Rhee  S, Olson  K, Kurniali  PC, Hord  NG, Noel  M
http://www.cancerandmetabolism.com/content/3/1/3/abstract

Malignant Drosophila Tumors Interrupt Insulin Signaling to Induce Cachexia-like Wasting
Alejandra Figueroa-Clarevega, David Bilder
http://www.cell.com/developmental-cell/abstract/S1534-5807(15)00143-4

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation
Nikolaos Patsoukis, Kankana Bardhan, Pranam Chatterjee, Duygu Sari, Bianling Liu, Lauren N. Bell, Edward D. Karoly, Gordon J. Freeman, Victoria Petkova, Pankaj Seth, Lequn Li and Vassiliki A. Boussiotis
http://www.nature.com/ncomms/2015/150326/ncomms7692/full/ncomms7692.html

A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity
Shuxi Qiao,     Michael Dennis, Xiufeng Song, Douangsone D. Vadysirisack, Devika Salunke, Zachary Nash, Zhifen Yang, Marc Liesa, Jun Yoshioka, Shu-Ichi Matsuzawa, Orian S. Shirihai, Richard T. Lee, John C. Reed & Leif W. Ellisen
http://www.nature.com/ncomms/2015/150428/ncomms8014/full/ncomms8014.html

An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation
Mattaini  KR, Brignole  EJ, Kini  M, Davidson  SM, Fiske  BP, Drennan  CL, Vander Heiden  MG
http://www.cancerandmetabolism.com/content/3/1/5/abstract

Beyond Glycolysis: GAPDHs Are Multi-functional Enzymes Involved in Regulation of ROS, Autophagy, and Plant Immune Responses
Elizabeth Henry, Nicholas Fung, Jun Liu, Georgia Drakakaki, Gitta Coaker
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005199

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Reviews
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Mitochondria as biosynthetic factories for cancer proliferation
Ahn  CS, Metallo  CM
http://www.cancerandmetabolism.com/content/3/1/1/abstract

Novel therapeutic targets of tumor metabolism.
Kishton RJ, Rathmell JC.
http://journals.lww.com/journalppo/pages/articleviewer.aspx?year=2015&issue=03000&article=00004&type=abstract

Mitophagy and cancer
Chourasia  AH, Boland  ML, Macleod  KF
http://www.cancerandmetabolism.com/content/3/1/4/abstract

Autophagy in malignant transformation and cancer progression
Lorenzo Galluzzi, Federico Pietrocola, José Manuel Bravo‐San Pedro, Ravi K Amaravadi, Eric H Baehrecke, Francesco Cecconi, Patrice Codogno, Jayanta Debnath, David A Gewirtz, Vassiliki Karantza, Alec Kimmelman, Sharad Kumar, Beth Levine, Maria Chiara Maiuri, Seamus J Martin, Josef Penninger, Mauro Piacentini, David C Rubinsztein, Hans‐Uwe Simon, Anne Simonsen, Andrew M Thorburn, Guillermo Velasco, Kevin M Ryan, and Guido Kroemer
http://EMBOJ.embopress.org/content/34/7/856?etoc

Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies
Y Aye, M Li, M J C Long and R S Weiss
http://www.nature.com/onc/journal/v34/n16/abs/onc2014155a.html?WT.ec_id=ONC-201504

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Comments
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Metabolism: Growth in the fat lane
Robert A. Egnatchik, Ralph J. DeBerardinis
http://www.nature.com/nature/journal/v520/n7546/full/nature14375.html

Targeting hexokinase 2 in castration resistant prostate cancer
Yibin Deng & Junxuan Lu
http://www.tandfonline.com/doi/abs/10.4161/23723556.2014.974465?ai=1jft2&ui=79l0u&af=T

Mitochondrial genome transfer to tumour cells breaks the rules and establishes a new precedent in cancer biology
Michael V. Berridge, Carole Crasso & Jiri Neuzil
http://www.tandfonline.com/doi/abs/10.1080/23723556.2015.1023929?ai=1jft2&ui=79l0u&af=T

 

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