MetaboList – June 2015

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Cancer metabolism
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Regulation of nucleotide metabolism by mutant p53 contributes to its gain-of-function activities
Madhusudhan Kollareddy, Elizabeth Dimitrova, Krishna C. Vallabhaneni, Adriano Chan, Thuc Le, Krishna M. Chauhan, Zunamys I. Carrero, Gopalakrishnan Ramakrishnan, Kounosuke Watabe, Ygal Haupt, Sue Haupt, Radhika Pochampally, Gerard R. Boss, Damian G. Romero, Caius G. Radu and Luis A. Martinez
http://www.nature.com/ncomms/2015/150612/ncomms8389/full/ncomms8389.html

Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis
Yan Xiang, Zachary E. Stine, Jinsong Xia, Yunqi Lu, Roddy S. O’Connor, Brian J. Altman, Annie L. Hsieh, Arvin M. Gouw, Ajit G. Thomas, Ping Gao, Linchong Sun, Libing Song, Benedict Yan, Barbara S. Slusher, Jingli Zhuo, London L. Ooi, Caroline G.L. Lee, Anthony Mancuso, Andrew S. McCallion, Anne Le, Michael C. Milone, Stephen Rayport, Dean W. Felsher, Chi V. Dang
http://www.jci.org/articles/view/75836

Arginine deprivation using pegylated arginine deiminase has activity against primary acute myeloid leukemia cells in vivo
Farideh Miraki-Moud, Essam Ghazaly, Linda Ariza-McNaughton, Katharine A. Hodby, Andrew Clear, Fernando Anjos-Afonso, Konstantinos Liapis, Marianne Grantham, Fareeda Sohrabi, Jamie Cavenagh, John S. Bomalaski, John G. Gribben, Peter W. Szlosarek, Dominique Bonnet, and David C. Taussig
http://bloodjournal.org/content/125/26/4060.abstract?etoc

Extensive decoupling of metabolic genes in cancer.
Reznik E, Sander C.
http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004176

Metabolic plasticity maintains proliferation in pyruvate dehydrogenase deficient cells
Rajagopalan  K, Egnatchik  R, Calvaruso  M, Wasti  A, Padanad  M, Boroughs  L, Ko  B, Hensley  C, Acar  M, Hu  Z, Jiang  L, Pascual  J, Scaglioni  P, DeBerardinis  R
http://www.cancerandmetabolism.com/content/3/1/7/abstract

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AMPK/mTOR
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Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia
Pierre Sujobert, Laury Poulain, Etienne Paubelle, Florence Zylbersztejn, Adrien Grenier, Mireille Lambert, Elizabeth C. Townsend, Jean-Marie Brusq, Edwige Nicodeme, Justine Decrooqc, Ina Nepstad, Alexa S. Green, Johanna Mondesir, Marie-Anne Hospital, Nathalie Jacque, Alexandra Christodoulou, Tiffany A. Desouza, Olivier Hermine, Marc Foretz, Benoit Viollet, Catherine Lacombe, Patrick Mayeux, David M. Weinstock, Ivan C. Moura, Didier Bouscary, Jerome Tamburini
http://www.cell.com/cell-reports/abstract/S2211-1247(15)00495-7

Insulin resistance prevents AMPK-induced tau dephosphorylation through Akt-mediated increase in AMPKSer485 phosphorylation
Bhumsoo Kim, Claudia Figueroa-Romero, Crystal Pacut, Carey Backus, and Eva L. Feldman
http://www.jbc.org/content/early/2015/06/22/jbc.M115.636852.abstract

LKB1 Inactivation Elicits a Redox Imbalance to Modulate Non-small Cell Lung Cancer Plasticity and Therapeutic Response
Fuming Li, Xiangkun Han, Fei Li, Rui Wang, Hui Wang, Yijun Gao, Xujun Wang, Zhaoyuan Fang, Wenjing Zhang, Shun Yao, Xinyuan Tong, Yuetong Wang, Yan Feng, Yihua Sun, Yuan Li, Kwok-Kin Wong, Qiwei Zhai, Haiquan Chen, Hongbin Ji
http://www.sciencedirect.com/science/article/pii/S1535610815001348

AICAR Enhances the Phagocytic Ability of Macrophages towards Apoptotic Cells through P38 Mitogen Activated Protein Kinase Activation Independent of AMP-Activated Protein Kinase
Hui Quan, Joung-Min Kim, Hyun-Jung Lee, Seong-Heon Lee, Jeong-Il Choi, Hong-Beom Bae
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127885

AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation
Albert Herms, Marta Bosch, Babu J.N. Reddy, Nicole L. Schieber, Alba Fajardo, Celia Rupérez, Andrea Fernández-Vidal, Charles Ferguson, Carles Rentero, Francesc Tebar, Carlos Enrich, Robert G. Parton, Steven P. Gross and Albert Pol
http://www.nature.com/ncomms/2015/150527/ncomms8176/full/ncomms8176.html

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mTOR
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Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP.
Ricoult SJ, Yecies JL, Ben-Sahra I, Manning BD.
http://www.nature.com/onc/journal/vaop/ncurrent/full/onc2015179a.html

Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9
Jennifer Jung, Heide Marika Genau, and Christian Behrends
http://mcb.asm.org/content/35/14/2479.abstract?etoc

Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1
Guoxiang Jin, Szu-Wei Lee, Xian Zhang, Zhen Cai, Yuan Gao, Ping-Chieh Chou, Abdol Hossein Rezaeian, Fei Han, Chi-Yun Wang, Juo-Chin Yao, Zhaohui Gong, Chia-Hsin Chan, Chih-Yang Huang, Fuu-Jen Tsai, Chang-Hai Tsai, Shih-Hsin Tu, Chih-Hsiung Wu, Dos D. Sarbassov, Yuan-Soon Ho, Hui-Kuan Lin
http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00346-9

The Ubiquitination of RagA GTPase by RNF152 Negatively Regulates mTORC1 Activation
Lu Deng, Cong Jiang, Lei Chen, Jiali Jin, Jie Wei, Linlin Zhao, Minghui Chen, Weijuan Pan, Yan Xu, Hongshang Chu, Xinbo Wang, Xin Ge, Dali Li, Lujian Liao, Mingyao Liu, Li Li, Ping Wang
http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00254-3

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Starvation, anti-metabolic drugs
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Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death
C-S Yang, K Matsuura, N-J Huang, A C Robeson, B Huang, L Zhang and S Kornbluth
http://www.nature.com/onc/journal/v34/n25/abs/onc2014271a.html

Metformin induces ER stress-dependent apoptosis through miR-708-5p/NNAT pathway in prostate cancer
J Yang, J Wei, Y Wu, Z Wang, Y Guo, P Lee and X Li
http://www.nature.com/oncsis/journal/v4/n6/abs/oncsis201518a.html

Reversible induction of translational isoforms of p53 in glucose deprivation
D Khan, A Katoch, A Das, A Sharathchandra, R Lal, P Roy, S Das, S Chattopadhyay and S Das
http://www.nature.com/cdd/journal/v22/n7/abs/cdd2014220a.html

Drug Redeployment to Kill Leukemia and Lymphoma Cells by Disrupting SCD1-Mediated Synthesis of Monounsaturated Fatty Acids
Andrew D. Southam, Farhat L. Khanim, Rachel E. Hayden, Julia K. Constantinou, Katarzyna M. Koczula, Robert H. Michell, Mark R. Viant, Mark T. Drayson, and Chris M. Bunce
http://cancerres.aacrjournals.org/content/75/12/2530.abstract?etoc

Molecular Pathways: Targeting Cellular Energy Metabolism in Cancer via Inhibition of SLC2A1 and LDHA.
Ooi AT, Gomperts BN.
http://clincancerres.aacrjournals.org/content/21/11/2440.abstract

Phosphorylation of the exchange factor DENND3 by ULK in response to starvation activates Rab12 and induces autophagy
Jie Xu, Maryam Fotouhi, and Peter S McPherson
http://EMBOr.embopress.org/content/16/6/709?etoc

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Hypoxia / HIF / ischemia
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Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis
Amal M. El-Naggar, Chansey J. Veinotte, Hongwei Cheng, Thomas G.P. Grunewald, Gian Luca Negri, Syam Prakash Somasekharan, Dale P. Corkery, Franck Tirode, Joan Mathers, Debjit Khan, Alastair H. Kyle, Jennifer H. Baker, Nancy E. LePard, Steven McKinney, Shamil Hajee, Momir Bosiljcic, Gabriel Leprivier, Cristina E. Tognon, Andrew I. Minchinton, Kevin L. Bennewith, Olivier Delattre, Yuzhuo Wang, Graham Dellaire, Jason N. Berman, Poul H. Sorensen
http://www.sciencedirect.com/science/article/pii/S1535610815001361

Tip110 Regulates the Cross Talk between p53 and Hypoxia-Inducible Factor 1α under Hypoxia and Promotes Survival of Cancer Cells
Khalid Amine Timani, Ying Liu, Yan Fan, Khalid S. Mohammad, and Johnny J.He
http://mcb.asm.org/content/35/13/2254.abstract?etoc

Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-Inducible Factor (FIH) as an Oxygen Sensor
Hanna Tarhonskaya, Adam P. Hardy, Emily A. Howe, Nikita D. Loik, Holger B. Kramer, James S. O. McCullagh, Christopher J. Schofield, and Emily Flashman
http://www.jbc.org/content/early/2015/06/25/jbc.M115.653014.abstract

The Opa1-Dependent Mitochondrial Cristae Remodeling Pathway Controls Atrophic, Apoptotic, and Ischemic Tissue Damage
Tatiana Varanita, Maria Eugenia Soriano, Vanina Romanello, Tania Zaglia, Rubén Quintana-Cabrera, Martina Semenzato, Roberta Menabò, Veronica Costa, Gabriele Civiletto, Paola Pesce, Carlo Viscomi, Massimo Zeviani, Fabio Di Lisa, Marco Mongillo, Marco Sandri, Luca Scorrano
http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00219-3

HIF1α Represses Cell Stress Pathways to Allow Proliferation of Hypoxic Fetal Cardiomyocytes
Nuno Guimarães-Camboa, Jennifer Stowe, Ivy Aneas, Noboru Sakabe, Paola Cattaneo, Lindsay Henderson, Michael S. Kilberg, Randall S. Johnson, Ju Chen, Andrew D. McCulloch, Marcelo A. Nobrega, Sylvia M. Evans, Alexander C. Zambon
http://www.sciencedirect.com/science/article/pii/S1534580715002853

HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma
Bo Qiu, Daniel Ackerman, Danielle J. Sanchez, Bo Li, Joshua D. Ochocki, Alison Grazioli, Ekaterina Bobrovnikova-Marjon, J. Alan Diehl, Brian Keith, and M. Celeste Simon
http://cancerdiscovery.aacrjournals.org/content/5/6/652.abstract?etoc

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Miscellaneous
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A Protein Kinase C Phosphorylation Motif in GLUT1 Affects Glucose Transport and is Mutated in GLUT1 Deficiency Syndrome
Eunice E. Lee, Jing Ma, Anastasia Sacharidou, Wentao Mi, Valerie K. Salato, Nam Nguyen, Youxing Jiang, Juan M. Pascual, Paula E. North, Philip W. Shaul, Marcel Mettlen, Richard C. Wang
http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00271-3

A novel autoregulatory loop between the Gcn2-Atf4 pathway and L-Proline metabolism controls stem cell identity
C D’Aniello, A Fico, L Casalino, O Guardiola, G Di Napoli, F Cermola, D De Cesare, R Tatè, G Cobellis, E J Patriarca and G Minchiotti
http://www.nature.com/cdd/journal/v22/n7/abs/cdd201524a.html

Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions
Li Qiang, Ning Kon, Wenhui Zhao, Le Jiang, Colette M. Knight, Carrie Welch, Utpal Pajvani, Wei Gu, Domenico Accili
http://www.cell.com/cell-reports/abstract/S2211-1247(15)00551-3

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Reviews
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The p53 family and the hypoxia-inducible factors (HIFs): determinants of cancer progression
Ivano Amelio, Gerry Melino
http://www.cell.com/trends/biochemical-sciences/abstract/S0968-0004(15)00086-9

Impact of MYC in regulation of tumor cell metabolism
Wahlström T, Arsenian Henriksson M.
http://www.sciencedirect.com/science/article/pii/S1874939914001928

p53 in survival, death and metabolic health: a lifeguard with a licence to kill
Flore Kruiswijk, Christiaan F. Labuschagne & Karen H. Vousden
http://www.nature.com/nrm/journal/v16/n7/abs/nrm4007.html?lang=en

Metabolic dysregulation in monogenic disorders and cancer — finding method in madness
Ayelet Erez & Ralph J. DeBerardinis
http://www.nature.com/nrc/journal/v15/n7/abs/nrc3949.html?lang=en

Organ-Specific Cancer Metabolism and Its Potential for Therapy
Ilaria Elia, Roberta Schmieder, Stefan Christen, Sarah-Maria Fendt
http://link.springer.com/chapter/10.1007%2F164_2015_10

Acetyl Coenzyme A: A Central Metabolite and Second Messenger
Federico Pietrocola, Lorenzo Galluzzi, José Manuel Bravo-San Pedro, Frank Madeo, Guido Kroemer
http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00226-0

Metabolic control of signalling pathways and metabolic auto-regulation
Doriane Lorendeau, Stefan Christen, Gianmarco Rinaldi and Sarah-Maria Fendt
http://onlinelibrary.wiley.com/doi/10.1111/boc.201500015/abstract

Sirtuins and the Metabolic Hurdles in Cancer
Natalie J. German and Marcia C. Haigis
http://www.cell.com/current-biology/fulltext/S0960-9822(15)00556-4

Fructose consumption and cancer: is there a connection?
Port AM1, Ruth MR, Istfan NW.
http://www.ncbi.nlm.nih.gov/pubmed/22922366

Application of Metabolomics in Drug Resistant Breast Cancer Research
Ayesha N. Shajahan-Haq , Mehar S. Cheema and Robert Clarke
http://www.mdpi.com/2218-1989/5/1/100

SEA you later alli-GATOR – a dynamic regulator of the TORC1 stress response pathway
Svetlana Dokudovskaya and Michael P. Rout
http://jcs.biologists.org/content/128/12/2219.abstract?etoc

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Comments / other
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PKCs Sweeten Cell Metabolism by Phosphorylation of Glut1
Peter J. Siska, Jeffrey C. Rathmell
http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00392-5

HK2/hexokinase-II integrates glycolysis and autophagy to confer cellular protection
Valerie P Tan & Shigeki Miyamoto
http://www.tandfonline.com/doi/abs/10.1080/15548627.2015.1042195

Arginine addiction in AML
William Plunkett
http://bloodjournal.org/content/125/26/3971?etoc

Science Webinar Series – Part 3: Targeting Cancer Pathways: Tumor Metabolism and Proliferation
M. Celeste Simon and Nissim Hay
http://webinar.sciencemag.org/webinar/archive/part-3-targeting-cancer-pathways

Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling
Diane C. Fingar
http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00396-2

SHMT2 Drives Ischemic Glioma Cell Survival and Sensitivity to Excess Glycine
http://cancerdiscovery.aacrjournals.org/content/5/6/574.1.abstract?etoc

Beyond Energy Homeostasis: the Expanding Role of AMP-Activated Protein Kinase in Regulating Metabolism
David Carling, Benoit Viollet
Meeting report
http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00217-X

A conversation with Craig Thompson
http://www.jci.org/articles/view/82626

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