MetaboList – July 2015

Cancer metabolism

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis
Kıvanç Birsoy, Tim Wang, Walter W. Chen, Elizaveta Freinkman, Monther Abu-Remaileh, David M. Sabatini

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells
Lucas B. Sullivan, Dan Y. Gui, Aaron M. Hosios, Lauren N. Bush, Elizaveta Freinkman, Matthew G. Vander Heiden

Reciprocal regulation of amino acid import and epigenetic state through Lat1 and EZH2
Stephen G Dann, Michael Ryskin, Anthony M Barsotti, Jonathon Golas, Celine Shi, Miriam Miranda, Christine Hosselet, Luanna Lemon, Judy Lucas,Maha Karnoub, Fang Wang, Jeremy S Myers, Scott J Garza, Maximillian T Follettie, Kenneth G Geles, Anke Klippel, Robert A Rollins, and Valeria R Fantin

Metabolic reprogramming during TGFβ1-induced epithelial-to-mesenchymal transition
L Jiang, L Xiao, H Sugiura, X Huang, A Ali, M Kuro-o, R J Deberardinis and D A Boothman

Genome-wide analysis links NFATC2 with asparaginase hypersensitivity
Christian A. Fernandez, Colton Smith, Wenjian Yang, Charles G. Mullighan,Chunxu Qu, Eric Larsen, W. Paul Bowman, Chengcheng Liu, Laura B. Ramsey, Tamara Chang, Seth E. Karol, Mignon L. Loh, Elizabeth A. Raetz, Naomi J. Winick, Stephen P. Hunger, William L. Carroll, Sima Jeha, Ching-Hon Pui, William E. Evans, Meenakshi Devidas, and Mary V. Relling

Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma
Edward L. LaGory, Colleen Wu, Cullen M. Taniguchi, Chien-Kuang Cornelia Ding, Jen-Tsan Chi, Rie von Eyben, David A. Scott, Adam D. Richardson, Amato J. Giaccia

Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma
Hideki Makinoshima, Masahiro Takita, Koichi Saruwatari, Shigeki Umemura, Yuuki Obata, Genichiro Ishii, Shingo Matsumoto, Eri Sugiyama, Atsushi Ochiai, Ryo Abe, Koichi Goto, Hiroyasu Esumi, and Katsuya Tsuchihara

Functional expression of sodium-glucose transporters in cancer
Claudio Scafoglio, Bruce A. Hirayama, Vladimir Kepe, Jie Liu, Chiara Ghezzi, Nagichettiar Satyamurthy, Neda A. Moatamed, Jiaoti Huang, Hermann Koepsell, Jorge R. Barrio, and Ernest M. Wright

UAP1 is overexpressed in prostate cancer and is protective against inhibitors of N-linked glycosylation
H M Itkonen, N Engedal, E Babaie, M Luhr, I J Guldvik, S Minner, J Hohloch, M C Tsourlakis, T Schlomm and I G Mills
[UDP-N-acetylglucosamine pyrophosphorylase 1]

Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism
Rushika M. Perera, Svetlana Stoykova, Brandon N. Nicolay, Kenneth N. Ross, Julien Fitamant, Myriam Boukhali, Justine Lengrand, Vikram Deshpande, Martin K. Selig, Cristina R. Ferrone, Jeff Settleman, Gregory Stephanopoulos, Nicholas J. Dyson, Roberto Zoncu, Sridhar Ramaswamy, Wilhelm Haas & Nabeel Bardeesy

TRIM35 Interacts with pyruvate kinase isoform M2 to suppress the Warburg effect and tumorigenicity in hepatocellular carcinoma
Z Chen, Z Wang, W Guo, Z Zhang, F Zhao, Y Zhao, D Jia, J Ding, H Wang, M Yao and X He

Loss of the tumor suppressor Hace1 leads to ROS-dependent glutamine addiction
N Cetinbas, M Daugaard, A R Mullen, S Hajee, B Rotblat, A Lopez, A Li, R J DeBerardinis and P H Sorensen

Chromosomal instability causes sensitivity to metabolic stress
Z Shaukat, D Liu, A Choo, R Hussain, L O’Keefe, R Richards, R Saint and S L Gregory


The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1
Wilhelm Palm, Youngkyu Park, Kevin Wright, Natalya N. Pavlova, David A. Tuveson, Craig B. Thompson

ATF4 mediates necrosis induced by glucose deprivation and apoptosis induced by 2-deoxyglucose in the same cells.
Clara L León-Annicchiarico, Silvia Ramírez-Peinado, Dídac Domínguez-Villanueva, Anika Gonsberg, Theodore J Lampidis, Cristina Muñoz-Pinedo

Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress
Stacey L. Lehman, George J. Cerniglia, Gregg J. Johannes, Jiangbin Ye, Sandra Ryeom, Constantinos Koumenis

Glutaminolysis and Transferrin Regulate Ferroptosis
Minghui Gao, Prashant Monian, Nosirudeen Quadri, Ravichandran Ramasamy, Xuejun Jiang

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates
Daniel F. Egan, Matthew G.H. Chun, Mitchell Vamos, Haixia Zou, Juan Rong, Chad J. Miller, Hua Jane Lou, Dhanya Raveendra-Panickar, Chih-Cheng Yang, Douglas J. Shefflerm, Peter Teriete, John M. Asara, Benjamin E. Turk, Nicholas D.P. Cosford, Reuben J. Shaw

Metabolic stress induces a Wnt-dependent cancer stem cell-like state transition
E Lee, J Yang, M Ku, N H Kim, Y Park, C B Park, J-S Suh, E S Park, J I Yook, G B Mills, Y-M Huh and J-H Cheong

Anti-metabolites / diet

Chronic Dietary Administration of the Glycolytic Inhibitor 2-Deoxy-D-Glucose (2-DG) Inhibits the Growth of Implanted Ehrlich’s Ascites Tumor in Mice
Saurabh Singh, Sanjay Pandey, Anant Narayan Bhatt, Richa Chaudhary, Vikas Bhuria, Namita Kalra, Ravi Soni, Bal Gangadhar Roy, Daman Saluja, Bilikere S. Dwarakanath

Inhibition of Neuroblastoma Tumor Growth by Ketogenic Diet and/or Calorie Restriction in a CD1-Nu Mouse Model
Raphael Johannes Morscher , Sepideh Aminzadeh-Gohari, René Gunther Feichtinger, Johannes Adalbert Mayr, Roland Lang, Daniel Neureiter, Wolfgang Sperl, Barbara Kofler

Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis
Colin A. Flaveny, Kristine Griffett, Bahaa El-Dien M. El-Gendy, Melissa Kazantzis, Monideepa Sengupta, Antonio L. Amelio, Arindam Chatterjee, John Walker, Laura A. Solt, Theodore M. Kamenecka, Thomas P. Burris

Metformin Inhibits the Production of Reactive Oxygen Species from NADH:ubiquinone Oxidoreductase to Limit Induction of IL-1β, and Boosts IL-10 in LPS-activated Macrophages
Beth Kelly, Gillian M. Tannahill, Michael P. Murphy, and Luke A. J. O’Neill

2-Deoxy-d-Glucose Can Complement Doxorubicin and Sorafenib to Suppress the Growth of Papillary Thyroid Carcinoma Cells
Shuo-Yu Wang, Yau-Huei Wei, Dar-Bin Shieh, Li-Ling Lin, Shih-Ping Cheng, Pei-Wen Wang, Jiin-Haur Chuang

Hypoxia and HIFs

STIM1 Mediates Hypoxia-Driven Hepatocarcinogenesis via Interaction with HIF-1
Yongsheng Li, Bo Guo, Qichao Xie, Duyun Ye, Dongxin Zhang, Ying Zhu, Hongxiang Chen, Bo Zhu

High Glucose Upregulates ADAM17 through HIF-1α in Mesangial Cells
Renzhong Li, Lalita Uttarwar, Bo Gao, Martine Charbonneau, Yixuan Shi, John S.D. Chan, Claire M. Dubois, and Joan C. Krepinsky

Intracellular oxygen determined by respiration regulates localization of Ras and prenylated proteins
A Kim, R Davis and M Higuchi


Differential effects of AMPK agonists on cell growth and metabolism
E E Vincent, P P Coelho, J Blagih, T Griss, B Viollet and R G Jones

AMP-Activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcription Factor GLI1 in Medulloblastoma
Yen-Hsing Li, Jia Luo, Yung-Yi C. Mosley, Victoria E. Hedrick, Lake N. Paul, Julia Chang, GuangJun Zhang, Yu-Kuo Wang, Max R. Banko, Anne Brunet, Shihuan Kuang, Jen-Leih Wu, Chun-Ju Chang, Matthew P. Scott, Jer-Yen Yang

LKB1 reduces ROS-mediated cell damage via activation of p38
H-G Xu, Y-X Zhai, J Chen, Y Lu, J-W Wang, C-S Quan, R-X Zhao, X Xiao, Q He, K D Werle, H-G Kim, R Lopez, R Cui, J Liang, Y-L Li and Z-X Xu

Apoptotic cells activate AMPK and inhibit epithelial cell growth without change in intracellular energy stores
Vimal A. Patel, Donald Massenburg, Snezana Vujicic, Lanfei Feng, Meiyi Tang, Natalia Litbarg, Angelika Antoni, Joyce Rauch, Wilfred Lieberthal, and Jerrold S. Levine

Snf1/AMP-activated protein kinase activates Arf3p to promote invasive yeast growth via a non-canonical GEF domain Jia-Wei Hsu, Kuan-Jung Chen and Fang-Jen S. Lee


Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance
Kenta Masui, Kazuhiro Tanaka, Shiro Ikegami, Genaro R. Villa, Huijun Yang, William H. Yong, Timothy F. Cloughesy, Kanato Yamagata, Nobutaka Arai, Webster K. Cavenee, and Paul S. Mischel

Hyperactivation of mTORC1 and mTORC2 by multiple oncogenic events causes addiction to eIF4E-dependent mRNA translation in T-cell leukemia
A Schwarzer, H Holtmann, M Brugman, J Meyer, C Schauerte, J Zuber, D Steinemann, B Schlegelberger, Z Li and C Baum

Lysosomal mTORC2/PHLPP1/Akt Regulate Chaperone-Mediated Autophagy
Esperanza Arias, Hiroshi Koga, Antonio Diaz, Enric Mocholi, Bindi Patel, Ana María Cuervo

S6K1 controls pancreatic β cell size independently of intrauterine growth restriction
Sung Hee Um, Melanie Sticker-Jantscheff, Gia Cac Chau, Kristina Vintersten, Matthias Mueller, Yann-Gael Gangloff, Ralf H. Adams, Jean-Francois Spetz, Lynda Elghazi, Paul T. Pfluger, Mario Pende, Ernesto Bernal-Mizrachi, Albert Tauler, Matthias H. Tschöp, George Thomas, Sara C. Kozma

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
Remi-Martin Laberge, Yu Sun, Arturo V. Orjalo, Christopher K. Patil, Adam Freund, Lili Zhou, Samuel C. Curran, Albert R. Davalos, Kathleen A. Wilson-Edell, Su Liu, Chandani Limbad, Marco Demaria, Patrick Li, Gene B. Hubbard, Yuji Ikeno, Martin Javors, Pierre-Yves Desprez, Christopher C. Benz, Pankaj Kapahi, Peter S. Nelson & Judith Campisi


Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways
Matthew A Mitsche, Jeffrey G McDonald, Helen H Hobbs and Jonathan C Cohen

A NAD‐dependent glutamate dehydrogenase coordinates metabolism with cell division in Caulobacter crescentus
François Beaufay, Jérôme Coppine, Aurélie Mayard, Géraldine Laloux, Xavier De Bolle, and Régis Hallez

PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion
M. Cecilia Caino, Jagadish C. Ghosh, Young Chan Chae, Valentina Vaira, Dayana B. Rivadeneira, Alice Faversani, Paolo Rampini, Andrew V. Kossenkov, Katherine M. Aird, Rugang Zhang, Marie R. Webster, Ashani T. Weeraratna, Silvano Bosari, Lucia R. Languino, and Dario C. Altieri

Molecular basis of ligand recognition and transport by glucose transporters
Dong Deng, Pengcheng Sun, Chuangye Yan, Meng Ke, Xin Jiang, Lei Xiong, Wenlin Ren, Kunio Hirata, Masaki Yamamoto, Shilong Fan & Nieng Yan

Arginylation regulates purine nucleotide biosynthesis by enhancing the activity of phosphoribosyl pyrophosphate synthase
Fangliang Zhang, Devang M. Patel, Kristen Colavita, Irina Rodionova, Brian Buckley, David A. Scott, Akhilesh Kumar, Svetlana A. Shabalina, Sougata Saha, Mikhail Chernov, Andrei L. Osterman and Anna Kashina


Oncometabolites: tailoring our genes
Stefan Nowicki and Eyal Gottlieb

Regulation of mTORC1 by PI3K signaling
Christian C. Dibble, Lewis C. Cantley

Evolution of Mitochondria as Signaling Organelles
Navdeep S. Chandel

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus
Carles Cantó, Keir J. Menzies, Johan Auwerx

How do glycolytic enzymes favour cancer cell proliferation by nonmetabolic functions?
H Lincet and P Icard

mTOR inhibition in T-cell lymphoma: a path(way) forward
Alison J. Moskowitz and Steven M. Horwitz

SnapShot: Immunometabolism
Peter J. Murray, Jeffrey Rathmell, Edward Pearce


Context-dependent utilization of serine in cancer
Mahya Mehrmohamadi & Jason W Locasale

You Down With ETC? Yeah, You Know D!
Jonathan G. Van Vranken, Jared Rutter

HIF-1 suppresses lipid catabolism to promote cancer progression
Huafeng Zhang

Boosting NAD+ for the prevention and treatment of liver cancer
Nabil Djouder

YAP enters the mTOR pathway to promote tuberous sclerosis complex
Ning Liang & Mario Pende

LKB1 Inactivation Promotes ROS-Induced Plasticity in NSCLC

Differentiating between nutrient sources

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