MetaboList – August 2015

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Cancer metabolism
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Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling
Hee-Bum Kang, Jun Fan, Ruiting Lin, Shannon Elf, Quanjiang Ji, Liang Zhao, Lingtao Jin, Jae Ho Seo, Changliang Shan, Jack L. Arbiser, Cynthia Cohen, Daniel Brat, Henry M. Miziorko, Eunhee Kim, Omar Abdel-Wahab, Taha Merghoub, Stefan Fröhling, Claudia Scholl, Pablo Tamayo, David A. Barbie, Lu Zhou, Brian P. Pollack, Kevin Fisher, Ragini R. Kudchadkar, David H. Lawson, Gabriel Sica, Michael Rossi, Sagar Lonial, Hanna J. Khoury, Fadlo R. Khuri, Benjamin H. Lee, Titus J. Boggon, Chuan He, Sumin Kang, Jing Chen
http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00438-4

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors
Anneleen Daemen, David Peterson, Nisebita Sahu, Ron McCord, Xiangnan Du, Bonnie Liu, Katarzyna Kowanetz, Rebecca Hong, John Moffat, Min Gao, Aaron Boudreau, Rana Mroue, Laura Corson, Thomas O’Brien, Jing Qing, Deepak Sampath, Mark Merchant, Robert Yauch, Gerard Manning, Jeffrey Settleman, Georgia Hatzivassiliou, and Marie Evangelista
http://www.pnas.org/content/112/32/E4410.abstract.html?etoc

The Plasma Membrane Calcium Pump in Pancreatic Cancer Cells Exhibiting the Warburg Effect Relies on Glycolytic ATP
Andrew David James, Waseema Patel, Zohra Butt, Magretta Adiamah, Raga Dakhel, Ayse Latif, Carolina Uggenti, Eileithyia Swanton, Hiromi Imamura, Ajith Kumar Siriwardena, and Jason Irving Edward Bruce
http://www.jbc.org/content/early/2015/08/20/jbc.M115.668707.abstrac

IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism
Jose L. Izquierdo-Garcia, Pavithra Viswanath, Pia Eriksson, Larry Cai, Marina Radoul, Myriam M. Chaumeil, Michael Blough, H. Artee Luchman,  Samuel Weiss, J. Gregory Cairncross, Joanna J. Phillips, Russell O.  Pieper, and Sabrina M. Ronen
http://cancerres.aacrjournals.org/content/75/15/2999.abstract?etoc

PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation
Valeria Iansante, Pui Man Choy, Sze Wai Fung, Ying Liu, Jian-Guo Chai, Julian Dyson, Alberto Del Rio, Clive D’Santos, Roger Williams, Shilpa Chokshi, Robert A Anders, Concetta Bubici and Salvatore Papa
http://www.nature.com/ncomms/2015/150810/ncomms8882/full/ncomms8882.html

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Metabolic stress / antimetabolics
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ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate
Sejeong Shin, Gwen R. Buel, Laura Wolgamott, David R. Plas, John M. Asara, John Blenis, Sang-Oh Yoon
http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00492-X

Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy
Kevin Moreau, Ghita Ghislat, Warren Hochfeld, Maurizio Renna, Eszter Zavodszky, Gautam Runwal, Claudia Puri, Shirley Lee, Farah Siddiqi, Fiona M. Menzies, Brinda Ravikumar and David C. Rubinsztein
http://www.nature.com/ncomms/2015/150820/ncomms9045/full/ncomms9045.html

Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function
N.V. Rajeshkumar, Prasanta Dutta, Shinichi Yabuuchi, Roeland F. de Wilde,Gary V. Martinez, Anne Le, Jurre J. Kamphorst, Joshua D. Rabinowitz, Sanjay K. Jain, Manuel Hidalgo, Chi V. Dang, Robert J. Gillies, and Anirban Maitra
http://cancerres.aacrjournals.org/content/75/16/3355.abstract?etoc

The presence of wild type p53 in hematological cancers improves the efficacy of combinational therapy targeting metabolism
Nerea Allende-Vega, Ewelina Krzywinska, Stefania Orecchioni, Nuria Lopez-Royuela, Francesca Reggiani, Giovanna Talarico, Jean-François Rossi, Rodrigue Rossignol, Yosr Hicheri, Guillaume Cartro, Francesco Bertolini, Martin Villalba
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=4653

Diacylglycerol Metabolism and Signaling Is a Driving Force Underlying FASN Inhibitor Sensitivity in Cancer Cells
Daniel I. Benjamin, Daniel S. Li, Wallace Lowe, Timothy Heuer, George Kemble, and Daniel K. Nomura
http://pubs.acs.org/doi/abs/10.1021/acschembio.5b00240

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HIFs and hypoxia, oxidative stress
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Hypoxia Induces Production of L-2-Hydroxyglutarate
Andrew M. Intlekofer, Raymond G. Dematteo, Sriram Venneti, Lydia W.S. Finley, Chao Lu, Alexander R. Judkins, Ariën S. Rustenburg, Patrick B. Grinaway, John D. Chodera, Justin R. Cross, Craig B. Thompson
http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00290-9

Hypoxia-Mediated Increases in l-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress
William M. Oldham, Clary B. Clish, Yi Yang, Joseph Loscalzo
http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00288-0

Structural integration in hypoxia-inducible factors
Dalei Wu, Nalini Potluri, Jingping Lu, Youngchang Kim & Fraydoon Rastinejad
http://www.nature.com/nature/journal/v524/n7565/full/nature14883.html

Mitochondrial Proteostatic Collapse Leads to Hypoxic Injury
Daniel M. Kaufman, C. Michael Crowder
http://www.cell.com/current-biology/abstract/S0960-9822(15)00789-7

The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts
Anna Kuchnio, Stijn Moens, Ulrike Bruning, Karol Kuchnio, Bert Cruys, Bernard Thienpont, Michaël Broux, Andreea Alexandra Ungureanu, Rodrigo Leite de Oliveira, Françoise Bruyère, Henar Cuervo, Ann Manderveld, An Carton, Juan Ramon Hernandez-Fernaud, Sara Zanivan, Carmen Bartic, Jean-Michel Foidart, Agnes Noel, Stefan Vinckier, Diether Lambrechts, Mieke Dewerchin, Massimiliano Mazzone, Peter Carmeliet
http://www.cell.com/cell-reports/abstract/S2211-1247(15)00750-0

Acute Activation of Oxidative Pentose Phosphate Pathway as First-Line Response to Oxidative Stress in Human Skin Cells
Andreas Kuehne, Hila Emmert, Joern Soehle, Marc Winnefeld, Frank Fischer, Horst Wenck, Stefan Gallinat, Lara Terstegen, Ralph Lucius, Janosch Hildebrand, Nicola Zamboni
http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00456-6

Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival
H Choudhry, A Albukhari, M Morotti, S Haider, D Moralli, J Smythies, J Schödel, C M Green, C Camps, F Buffa, P Ratcliffe, J Ragoussis, A L Harris and D R Mole
http://www.nature.com/onc/journal/v34/n34/abs/onc2014378a.html

Knockout of Vdac1 activates hypoxia-inducible factor through reactive oxygen species generation and induces tumor growth by promoting metabolic reprogramming and inflammation
Brahimi-Horn  M, Giuliano  S, Saland  E, Lacas-Gervais  S, Sheiko  T, Pelletier  J, Bourget  I, Bost  F, Feral  C, Boulter  E, Tauc  M, Ivan  M, Garmy-Susini  B, Popa  A, Mari  B, Sarry  J, Craigen  W, Pouyssegur  J, Mazure  N
http://www.cancerandmetabolism.com/content/3/1/8/abstract

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AMPK
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A Critical SUMO1 Modification of LKB1 Regulates AMPK Activity during Energy Stress
Joan Ritho, Stefan T. Arold, Edward T.H. Yeh
http://www.cell.com/cell-reports/abstract/S2211-1247(15)00728-7

Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance
Jiyong Liang, Zhi-Xiang Xu, Zhiyong Ding, Yiling Lu, Qinghua Yu, Kaitlin D. Werle, Ge Zhou, Yun-Yong Park, Guang Peng, Michael J. Gambello and Gordon B. Mills
http://www.nature.com/ncomms/2015/150814/ncomms8926/full/ncomms8926.html

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mTOR
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Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade
Juan F. Linares, Angeles Duran, Miguel Reina-Campos, Pedro Aza-Blanc, Alex Campos, Jorge Moscat, Maria T. Diaz-Meco
http://www.cell.com/cell-reports/abstract/S2211-1247(15)00823-2

Brain Expressed X-Linked 2 Is Pivotal for Hyperactive mTOR-Mediated Tumorigenesis
Zhongdong Hu, Ying Wang, Fuqiang Huang, Rongrong Chen, Chunjia Li, Fang Wang, June Goto, David J. Kwiatkowski, Joanna Wdzieczak-Bakala, Pengfei Tu, Jianmiao Liu, Xiaojun Zha and Hongbing Zhang
http://m.jbc.org/content/early/2015/08/20/jbc.M115.665208.abstract?papetoc

Diacylglycerol kinase-ζ regulates mTORC1 and lipogenic metabolism in cancer cells through SREBP-1
P Torres-Ayuso, M Tello-Lafoz, I Mérida and A Ávila-Flores
http://www.nature.com/oncsis/journal/v4/n8/abs/oncsis201522a.html

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Miscellaneous
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Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions
Robert Haas, Joanne Smith, Vidalba Rocher-Ros, Suchita Nadkarni, Trinidad Montero-Melendez, Fulvio D’Acquisto, Elliot J. Bland, Michele Bombardieri, Costantino Pitzalis, Mauro Perretti, Federica M. Marelli-Berg, Claudio Mauro
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002202

PTEN mediates Notch-dependent stalk cell arrest in angiogénesis
Helena Serra, Iñigo Chivite, Ana Angulo-Urarte, Adriana Soler, James D. Sutherland, Amaia Arruabarrena-Aristorena, Anan Ragab, Radiance Lim, Marcos Malumbres, Marcus Fruttiger, Michael Potente, Manuel Serrano, Àngels Fabra, Francesc Viñals, Oriol Casanovas, Pier Paolo Pandolfi, Anna Bigas, Arkaitz Carracedo, Holger Gerhardt and Mariona Graupera
http://www.nature.com/ncomms/2015/150731/ncomms8935/full/ncomms8935.html

Manganese superoxide dismutase deficiency triggers mitochondrial uncoupling and the Warburg effect
Y Xu, S Miriyala, F Fang, V Bakthavatchalu, T Noel, D M Schell, C Wang, W H St Clair and D K St Clair
http://www.nature.com/onc/journal/v34/n32/abs/onc2014355a.html

Monitoring Mitochondrial Pyruvate Carrier Activity in Real Time Using a BRET-Based Biosensor: Investigation of the Warburg Effect
Vincent Compan, Sandra Pierredon, Benoît Vanderperre, Petra Krznar, Ibtissam Marchiq, Nicola Zamboni, Jacques Pouyssegur, Jean-Claude Martinou
http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00529-8

The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity
Buvana Ravishankar, Haiyun Liu, Rahul Shinde, Kapil Chaudhary, Wei Xiao, Jillian Bradley, Marianne Koritzinsky, Michael P. Madaio, and Tracy L. McGaha
http://www.pnas.org/content/112/34/10774.abstract.html?etoc

Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation
Yuhui Jiang, Xu Qian, Jianfeng Shen, Yugang Wang, Xinjian Li, Rui Liu, Yan Xia, Qianming Chen, Guang Peng, Shiaw-Yih Lin & Zhimin Lu
http://www.nature.com/ncb/journal/v17/n9/full/ncb3209.html

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Reviews / Comments
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Glutaminolysis and autophagy in cancer
Victor H Villar, Faten Merhi, Mojgan Djavaheri-Mergny & Raúl V Durán
http://www.tandfonline.com/doi/abs/10.1080/15548627.2015.1053680#.Vd7vP3HtlBc

Autophagy at the crossroads of catabolism and anabolism
Jasvinder Kaur & Jayanta Debnath
http://www.nature.com/nrm/journal/v16/n8/full/nrm4024.html

Structural biology: Hypoxia response becomes crystal clear
Ronen Marmorstein, M. Celeste Simon
http://www.nature.com/nature/journal/v524/n7565/full/nature14641.html

A New Hydroxy Metabolite of 2-Oxoglutarate Regulates Metabolism in Hypoxia
Adrian L. Harris
http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00345-9

Addicted to AA (Acetoacetate): A Point of Convergence between Metabolism and BRAF Signaling
Sebastian Trousil, Bin Zheng
http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00582-1

Balancing mitochondrial biogenesis and mitophagy to maintain energy metabolism homeostasis
K Palikaras, E Lionaki and N Tavernarakis
http://www.nature.com/cdd/journal/v22/n9/full/cdd201586a.html

Quantitative FDG-PET: a new biomarker in PMBCL
Michel Meignan
http://bloodjournal.org/content/126/8/924?etoc

Fumarate in DNA repair
Susan P. Lees-Miller
http://www.nature.com/ncb/journal/v17/n9/full/ncb3232.html

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