Metabolist – September 2015

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Cancer Metabolism
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Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses
Ping-Chih Ho, Jessica Dauz Bihuniak, Andrew N. Macintyre, Matthew Staron, Xiaojing Liu, Robert Amezquita, Yao-Chen Tsui, Guoliang Cui, Goran Micevic, Jose C. Perales, Steven H. Kleinstein, E. Dale Abel, Karl L. Insogna, Stefan Feske, Jason W. Locasale, Marcus W. Bosenberg, Jeffrey C. Rathmell, Susan M. Kaech
http://www.cell.com/cell/abstract/S0092-8674(15)01025-9

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
Chih-Hao Chang, Jing Qiu, David O’Sullivan, Michael D. Buck, Takuro Noguchi, Jonathan D. Curtis, Qiongyu Chen, Mariel Gindin, Matthew M. Gubin, Gerritje J.W. van der Windt, Elena Tonc, Robert D. Schreiber, Edward J. Pearce, Erika L. Pearce
http://www.cell.com/cell/abstract/S0092-8674(15)01029-6

Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis
Simone Cardaci, Liang Zheng, Gillian MacKay, Niels J. F. van den Broek, Elaine D. MacKenzie, Colin Nixon, David Stevenson, Sergey Tumanov, Vinay Bulusu, Jurre J. Kamphorst, Alexei Vazquez, Stewart Fleming, Francesca Schiavi, Gabriela Kalna, Karen Blyth, Douglas Strathdee & Eyal Gottlieb
http://www.nature.com/ncb/journal/v17/n10/full/ncb3233.html

Lack of Evidence for PKM2 Protein Kinase Activity
Aaron M. Hosios, Brian P. Fiske, Dan Y. Gui, Matthew G. Vander Heiden
http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00571-7

TPD52 expression increases neutral lipid storage within cultured cells
Alvin Kamili, Nuruliza Roslan, Sarah Frost, Laurence C. Cantrill, Dongwei Wang, Austin Della-Franca, Robert K. Bright, Guy E. Groblewski, Beate K. Straub, Andrew J. Hoy, Yuyan Chen, and Jennifer A. Byrne
http://jcs.biologists.org/content/128/17/3223.abstract?etoc

O-GlcNAcylation of G6PD promotes the pentose phosphate pathway and tumor growth
Xiongjian Rao, Xiaotao Duan, Weimin Mao, Xuexia Li, Zhonghua Li, Qian Li, Zhiguo Zheng, Haimiao Xu, Min Chen, Peng G. Wang, Yingjie Wang, Binghui Shen and Wen Yi
http://www.nature.com/ncomms/2015/150924/ncomms9468/full/ncomms9468.html

2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling
Xudong Fu, Randall M. Chin, Laurent Vergnes, Heejun Hwang, Gang Deng, Yanpeng Xing, Melody Y. Pai, Sichen Li, Lisa Ta, Farbod Fazlollahi, Chuo Chen, Robert M. Prins, Michael A. Teitell, David A. Nathanson, Albert Lai, Kym F. Faull, Meisheng Jiang, Steven G. Clarke, Timothy F. Cloughesy, Thomas G. Graeber, Daniel Braas, Heather R. Christofk, Michael E. Jung, Karen Reue, Jing Huang
http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00276-4

p110α Hot Spot Mutations E545K and H1047R Exert Metabolic Reprogramming  Independently of p110α Kinase Activity
Aditi Chaudhari, Daniel Krumlinde, Annika Lundqvist, Levent M. Akyürek, Sashidhar Bandaru, Kristina Skålén, Marcus Ståhlman, Jan Borén, Yvonne Wettergren, Katarina Ejeskär, and Victoria Rotter Sopasakis
http://mcb.asm.org/content/35/19/3258.abstract?etoc

p63 supports aerobic respiration through hexokinase II
Guiditta Viticchiè, Massimiliano Agostini, Anna Maria Lena, Mara Mancini, Huiqing Zhou, Lello Zolla, David Dinsdale, Gaelle Saintigny, Gerry Melino, and Eleonora Candi
http://www.pnas.org/content/112/37/11577.abstract.html?etoc

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Anti-metabolic drugs
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Synthetic dosage lethality in the human metabolic network is highly predictive of tumor growth and cancer patient survival
Wout Megchelenbrink, Rotem Katzir, Xiaowen Lu, Eytan Ruppin, and Richard A. Notebaart
http://www.pnas.org/content/112/39/12217.abstract.html?etoc

The bifunctional autophagic flux by 2-deoxyglucose to control survival or growth of prostate cancer cells
Jeong Yong Jeon, Seung Won Kim, Ki Cheong Park and Mijin Yun
http://www.biomedcentral.com/1471-2407/15/623

Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress
Guy J. Leclerc, Joanna DeSalvo, Jianfeng Du1, Ningguo Gao, Gilles M. Leclerc, Mark A. Lehrman, Theodore J. Lampidis, Julio C. Barredo
http://www.lrjournal.com/article/S0145-2126(15)30360-X/abstract

Targeting glutaminolysis has antileukemic activity in acute myeloid  leukemia and synergizes with BCL-2 inhibition
Nathalie Jacque, Anne Marie Ronchetti, Clément Larrue, Godelieve Meunier,Rudy Birsen, Lise Willems, Estelle Saland, Justine Decroocq, Thiago Trovati Maciel, Mireille Lambert, Laury Poulain, Marie Anne Hospital, Pierre Sujobert, Laure Joseph, Nicolas Chapuis, Catherine Lacombe, Ivan Cruz Moura, Susan Demo, Jean Emmanuel Sarry, Christian Recher, Patrick  Mayeux, Jérôme Tamburini, and Didier Bouscary
http://bloodjournal.org/content/126/11/1346.abstract?etoc

Novel actions of 2-deoxy-D-glucose: protection against Shiga toxins and changes in cellular lipids
Simona Kavaliauskiene, Tore Skotland, Tuulia Sylvänne, Helena Simolin, Tove Irene Klokk, Maria Lyngaas Torgersen, Anne Berit Dyve Lingelem, Roger Simm, Kim Ekroos, Kirsten Sandvig
http://www.biochemj.org/content/470/1/23.long

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Starvation, mTOR
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Amino Acid Availability Modulates Vacuolar H+-ATPase Assembly
Laura A. Stransky and Michael Forgac
http://www.jbc.org/content/early/2015/09/16/jbc.M115.659128.abstract

Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A
Pui-Mun Wong, Yan Feng, Junru Wang, Rong Shi and Xuejun Jiang
http://www.nature.com/ncomms/2015/150827/ncomms9048/full/ncomms9048.html

DRAM-3 modulates autophagy and promotes cell survival in the absence of glucose
M Mrschtik, J O’Prey, L Y Lao, J S Long, F Beaumatin, D Strachan, M O’Prey, J Skommer and K M Ryan
http://www.nature.com/cdd/journal/v22/n10/abs/cdd201526a.html

Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1
Lawrence D. Schweitzer, William C. Comb, Liron Bar-Peled, David M. Sabatini
http://www.cell.com/cell-reports/abstract/S2211-1247(15)00830-X

Starvation-Dependent Regulation of Golgi Quality Control Links the TOR Signaling and Vacuolar Protein Sorting Pathways
Niv Dobzinski, Silvia G. Chuartzman, Rachel Kama, Maya Schuldiner, Jeffrey E. Gerst
http://www.cell.com/cell-reports/abstract/S2211-1247(15)00897-9

Endogenous Sterol Metabolites Regulate Growth of EGFR/KRAS-Dependent Tumors via LXR
Linara Gabitova, Diana Restifo, Andrey Gorin, Kunal Manocha, Elizabeth Handorf, Dong-Hua Yang, Kathy Q. Cai, Andres J. Klein-Szanto, David Cunningham, Lisa E. Kratz, Gail E. Herman, Erica A. Golemis, Igor Astsaturov
http://www.cell.com/cell-reports/abstract/S2211-1247(15)00894-3

SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme
C A Lewis, C Brault, B Peck, K Bensaad, B Griffiths, R Mitter, P Chakravarty, P East, B Dankworth, D Alibhai, A L Harris and A Schulze
http://www.nature.com/onc/journal/v34/n40/abs/onc2014439a.html

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Hypoxia
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Tumor-Promoting Effects of Myeloid-Derived Suppressor Cells Are Potentiated by Hypoxia-Induced Expression of miR-210
Muhammad Zaeem Noman, Bassam Janji, Shijun Hu, Joseph C. Wu, Fabio Martelli, Vincenzo Bronte, and Salem Chouaib
http://cancerres.aacrjournals.org/content/75/18/3771.abstract?etoc

Hypoxia Drives Breast Tumor Malignancy through a TET–TNFα–p38–MAPK Signaling Axis
Min-Zu Wu, Su-Feng Chen, Shin Nieh, Christopher Benner, Luo-Ping Ger, Chia-Ing Jan, Li Ma, Chien-Hung Chen, Tomoaki Hishida, Hong-Tai Chang, Yaoh-Shiang Lin, Nuria Montserrat, Pedro Gascon, Ignacio Sancho-Martinez,and Juan Carlos Izpisua Belmonte
http://cancerres.aacrjournals.org/content/75/18/3912.abstract?etoc

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Miscellaneous
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Mitochondrial uncoupling links lipid catabolism to Akt inhibition and resistance to tumorigenesis
Sara M. Nowinski, Ashley Solmonson, Joyce E. Rundhaug, Okkyung Rho, Jiyoon Cho, Cory U. Lago, Christopher L. Riley, Sunhee Lee, Shohei Kohno, Christine K. Dao, Takeshi Nikawa, Shawn B. Bratton, Casey W. Wright, Susan M. Fischer, John DiGiovanni and Edward M. Mills
http://www.nature.com/ncomms/2015/150827/ncomms9137/full/ncomms9137.html

Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1
Shiwen Wang, Bowen Jiang, Tengfei Zhang, Lixia Liu, Yi Wang, Yiping Wang, Xiufei Chen, Huaipeng Lin, Lisha Zhou, Yukun Xia, Leilei Chen, Chen Yang, Yue Xiong, Dan Ye, Kun-Liang Guan
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002243

Lower glycolysis carries a higher flux than any biochemically possible alternative
Steven J. Court, Bartlomiej Waclaw and Rosalind J. Allen
http://www.nature.com/ncomms/2015/150929/ncomms9427/full/ncomms9427.html

Structure and mechanism of the mammalian fructose transporter GLUT5
Norimichi Nomura, Grégory Verdon, Hae Joo Kang, Tatsuro Shimamura, Yayoi Nomura, Yo Sonoda, Saba Abdul Hussien, Aziz Abdul Qureshi, Mathieu Coincon, Yumi Sato, Hitomi Abe, Yoshiko Nakada-Nakura, Tomoya Hino, Takatoshi Arakawa, Osamu Kusano-Arai, Hiroko Iwanari, Takeshi Murata, Takuya Kobayashi, Takao Hamakubo, Michihiro Kasahara, So Iwata & David Drew
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14909.html

PKA Phosphorylates the ATPase Inhibitory Factor 1 and Inactivates Its Capacity to Bind and Inhibit the Mitochondrial H+-ATP Synthase
Javier García-Bermúdez, María Sánchez-Aragó, Beatriz Soldevilla, Araceli del Arco, Cristina Nuevo-Tapioles, José M. Cuezva
http://www.cell.com/cell-reports/abstract/S2211-1247(15)00949-3

AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest
Elena Doménech, Carolina Maestre, Lorena Esteban-Martínez, David Partida, Rosa Pascual, Gonzalo Fernández-Miranda, Esther Seco,  Ramón Campos-Olivas, Manuel Pérez, Diego Megias, Katherine Allen, Miguel López, Asish K. Saha, Guillermo Velasco, Eduardo Rial, Raúl Méndez, Patricia Boya, María Salazar-Roa  & Marcos Malumbres
http://www.nature.com/ncb/journal/v17/n10/full/ncb3231.html

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Reviews
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The double trouble of metabolic diseases: the diabetes–cancer link
Slavica Tudzarova and Mahasin A. Osman
http://www.molbiolcell.org/content/26/18/3129.abstract?etoc

Tumors and Mitochondrial Respiration: A Neglected Connection
Andrea Viale, Denise Corti, and Giulio F. Draetta
http://cancerres.aacrjournals.org/content/75/18/3687.abstract?etoc

Metabolic Reprogramming of Immune Cells in Cancer Progression
Subhra K. Biswas
http://www.cell.com/immunity/abstract/S1074-7613(15)00361-1

Glucose addiction in cancer therapy: advances and drawbacks
Sara Granja, Celine Pinheiro, Rui Manuel Reis, Olga Martinho and Fatima Baltazar http://www.eurekaselect.com/131887/article#sthash.sj1HFftd.dpuf

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Comments
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Nutrient Competition: A New Axis of Tumor Immunosuppression
Madhusudhanan Sukumar, Rahul Roychoudhuri, Nicholas P. Restifo
http://www.cell.com/cell/abstract/S0092-8674(15)01116-2

Gluconeogenesis combats cancer: opening new doors in cancer biology
M W Khan and P Chakrabarti
http://www.nature.com/cddis/journal/v6/n9/full/cddis2015245a.html

How to Turn On an Ancient Metabolic Enzyme? Add Insulin and Deacetylate
Richard Robinson
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002244

Tumour immunology: An exhausting metabolic competition
http://www.nature.com/nrc/journal/v15/n10/full/nrc4014.html

Obesity: The supersized tumour microenvironment
http://www.nature.com/nrc/journal/v15/n10/full/nrc4024.html

New Compound Targets Warburg Effect
http://cancerdiscovery.aacrjournals.org/content/5/9/898.1.abstract?etoc

Dual Inhibition of ULK1 and mTOR Enhances Tumor Cell Apoptosis
http://cancerdiscovery.aacrjournals.org/content/5/9/OF5.abstract?etoc

mTORC1 Suppresses Consumption of Extracellular Proteins as Nutrients
http://cancerdiscovery.aacrjournals.org/content/5/9/OF10.abstract?etoc

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