MetaboList -November 2015

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Cancer metabolism
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Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis
Shiran Rabinovich, Lital Adler, Keren Yizhak, Alona Sarver, Alon Silberman, Shani Agron, Noa Stettner, Qin Sun, Alexander Brandis, Daniel Helbling, Stanley Korman, Shalev Itzkovitz, David Dimmock, Igor Ulitsky, Sandesh C. S. Nagamani, Eytan Ruppin & Ayelet Erez
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature15529.html

PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth
Emily D. Montal, Ruby Dewi, Kavita Bhalla, Lihui Ou, Bor Jang Hwang, Ashley E. Ropell, Chris Gordon, Wan-Ju Liu, Ralph J. DeBerardinis, Jessica Sudderth, William Twaddel, Laszlo G. Boros, Kenneth R. Shroyer, Sekhar Duraisamy, Ronny Drapkin, R. Scott Powers, Jason M. Rohde, Matthew B. Boxer, Kwok-Kin Wong, Geoffrey D. Girnun
http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00764-9

6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1–AMPK signalling
Ruiting Lin, Shannon Elf, Changliang Shan, Hee-Bum Kang, Quanjiang Ji, Lu Zhou, Taro Hitosugi, Liang Zhang, Shuai Zhang, Jae Ho Seo, Jianxin Xie, Meghan Tucker, Ting-Lei Gu, Jessica Sudderth, Lei Jiang, Matthew Mitsche, Ralph J. DeBerardinis, Shaoxiong Wu, Yuancheng Li, Hui Mao, Peng R. Chen, Dongsheng Wang,  Georgia Zhuo Chen, Selwyn J. Hurwitz, Sagar Lonial, Martha L. Arellano, Hanna J. Khoury, Fadlo R. Khuri, Benjamin H. Lee, Qunying Lei, Daniel J. Brat, Keqiang Ye, Titus J. Boggon, Chuan He, Sumin Kang, Jun Fan, & Jing Chen
http://www.nature.com/ncb/journal/v17/n11/full/ncb3255.html

Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth
Chunming Cheng, Peng Ru, Feng Geng, Junfeng Liu, Ji Young Yoo, Xiaoning Wu, Xiang Cheng, Vanessa Euthine, Peng Hu, Jeffrey Yunhua Guo, Etienne Lefai, Balveen Kaur, Axel Nohturfft, Jianjie Ma, Arnab Chakravarti, Deliang Guo
http://www.cell.com/cancer-cell/abstract/S1535-6108(15)00352-9

Nrf2 Activation Promotes Keratinocyte Survival during Early Skin Carcinogenesis via Metabolic Alterations
Frank Rolfs, Marcel Huber, Andreas Kuehne, Stefan Kramer, Eric Haertel, Sukalp Muzumdar, Johanna Wagner, Yasmine Tanner, Friederike Böhm, Sigrun  Smola, Nicola Zamboni, Mitchell P. Levesque, Reinhard Dummer, Hans-Dietmar Beer, Daniel Hohl, Sabine Werner, and Matthias Schäfer
http://cancerres.aacrjournals.org/content/75/22/4817.abstract?etoc

Src Inhibition Blocks c-Myc Translation and Glucose Metabolism to Prevent the Development of Breast Cancer
Shalini Jain, Xiao Wang, Chia-Chi Chang, Catherine Ibarra-Drendall, Hai Wang, Qingling Zhang, Samuel W. Brady, Ping Li, Hong Zhao, Jessica Dobbs,Matt Kyrish, Tomasz S. Tkaczyk, Adrian Ambrose, Christopher Sistrunk, Banu K. Arun, Rebecca Richards-Kortum, Wei Jia, Victoria L. Seewaldt, and Dihua Yu
http://cancerres.aacrjournals.org/content/75/22/4863.abstract?etoc

Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism
Charlotte Lussey-Lepoutre, Kate E. R. Hollinshead, Christian Ludwig, Mélanie Menara, Aurélie Morin, Luis-Jaime Castro-Vega, Seth J. Parker, Maxime Janin, Cosimo Martinelli, Chris Ottolenghi, Christian Metallo, Anne-Paule Gimenez-Roqueplo, Judith Favier and Daniel A. Tennant
http://www.nature.com/ncomms/2015/151102/ncomms9784/full/ncomms9784.html

The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells.
Choe M, Brusgard JL, Chumsri S, Bhandary L, Zhao XF, Lu S, Goloubeva OG, Polster BM, Fiskum GM, Girnun GD, Kim MS, Passaniti A
http://onlinelibrary.wiley.com/doi/10.1002/jcb.25171/abstract

Saturated fatty acids regulate retinoic acid signalling and suppress tumorigenesis by targeting fatty acid-binding protein 5
Liraz Levi, Zeneng Wang, Mary Kathryn Doud, Stanley L. Hazen and Noa Noy
http://www.nature.com/ncomms/2015/151123/ncomms9794/full/ncomms9794.html

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Glutamine synthethase
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Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma
Saverio Tardito, Anaïs Oudin, Shafiq U. Ahmed, Fred Fack, Olivier Keunen, Liang Zheng, Hrvoje Miletic, Per Øystein Sakariassen, Adam Weinstock, Allon Wagner, Susan L. Lindsay, Andreas K. Hock, Susan C. Barnett, Eytan Ruppin, Svein Harald Mørkve, Morten Lund-Johansen, Anthony J. Chalmers, Rolf Bjerkvig, Simone P. Niclou, Eyal Gottlieb
http://www.nature.com/ncb/journal/v17/n12/full/ncb3272.html

Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation
Alex J. Bott, I-Chen Peng, Yongjun Fan, Brandon Faubert, Lu Zhao, Jinyu Li, Sarah Neidler, Yu Sun, Nadia Jaber, Dawid Krokowski, Wenyun Lu, Ji-An Pan, Scott Powers, Joshua Rabinowitz, Maria Hatzoglou, Daniel J. Murphy, Russell Jones, Song Wu, Geoffrey Girnun, Wei-Xing Zong
http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00482-9

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Anti-metabolic drugs
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Heightening Energetic Stress Selectively Targets LKB1-Deficient Non–Small Cell Lung Cancers
Milica Momcilovic, Robert McMickle, Evan Abt, Atsuko Seki, Sarah A. Simko, Clara Magyar, David B. Stout, Michael C. Fishbein, Tonya C. Walser, Steven M. Dubinett, and David B. Shackelford
http://cancerres.aacrjournals.org/content/75/22/4910.abstract?etoc

Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198
Remco J. Molenaar, Dennis Botman, Myrthe A. Smits, Vashendriya V. Hira, Sanne A. van Lith, Jan Stap, Peter Henneman, Mohammed Khurshed, Krissie Lenting, Adri N. Mul, Dionysia Dimitrakopoulou, Cornelis M. van Drunen, Ron A. Hoebe, Tomas Radivoyevitch, Johanna W. Wilmink, Jaroslaw P. Maciejewski, W. Peter Vandertop, William P. Leenders, Fonnet E. Bleeker, and Cornelis J. van Noorden
http://cancerres.aacrjournals.org/content/75/22/4790.abstract?etoc

JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification
Wenyi Sun, Zuoquan Xie, Yifu Liu, Dan Zhao, Zhixiang Wu, Dadong Zhang, Hao Lv, Shuai Tang, Nan Jin, Hualiang Jiang, Minjia Tan, Jian Ding, ChengLuo, Jian Li, Min Huang, and Meiyu Geng
http://cancerres.aacrjournals.org/content/75/22/4923.abstract?etoc

Inhibition of mitochondrial complex II by the anti-cancer agent lonidamine
Lili Guo, Alexander A. Shestov, Andrew J. Worth, Kavindra Nath, David S. Nelson, Dennis B. Leeper, Jerry D. Glickson, and Ian A. Blair
http://www.jbc.org/content/early/2015/10/31/jbc.M115.697516.abstract

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Hypoxia
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PI3K–mTORC2 but not PI3K–mTORC1 Regulates Transcription of HIF2A/EPAS1 and Vascularization in Neuroblastoma
Sofie Mohlin, Arash Hamidian, Kristoffer von Stedingk, Esther Bridges, Caroline Wigerup, Daniel Bexell, and Sven Påhlman
http://cancerres.aacrjournals.org/content/75/21/4617.abstract?etoc

Suppression of miR‐199a maturation by HuR is crucial for hypoxia‐induced glycolytic switch in hepatocellular carcinoma
Ling‐Fei Zhang, Jia‐Tao Lou, Ming‐Hua Lu, Chunfang Gao, Shuang Zhao, BiaoLi, Sheng Liang, Yong Li, Dangsheng Li, and Mo‐Fang Liu
http://EMBOJ.embopress.org/content/34/21/2671?etoc

HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
Huimin Zhang, Haiquan Lu, Lisha Xiang, John W. Bullen, Chuanzhao Zhang, Debangshu Samanta, Daniele M. Gilkes, Jianjun He, and Gregg L. Semenza
http://www.pnas.org/content/112/45/E6215.abstract.html?etoc

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Nutrient sensing / mTOR
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GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2
Jiangbin Ye, Wilhelm Palm, Min Peng, Bryan King, Tullia Lindsten,Ming O. Li, Constantinos Koumenis and Craig B. Thompson
http://genesdev.cshlp.org/content/29/22/2331.abstract

Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism
Samantha J. Mentch, Mahya Mehrmohamadi, Lei Huang, Xiaojing Liu, Diwakar Gupta, Dwight Mattocks, Paola Gómez Padilla, Gene Ables, Marcas M. Bamman, Anna E. Thalacker-Mercer, Sailendra N. Nichenametla, Jason W. Locasale
http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00457-X

Mild Glucose Starvation Induces KDM2A-Mediated H3K36me2 Demethylation through AMPK To Reduce rRNA Transcription and Cell Proliferation
Yuji Tanaka, Hirohisa Yano, Sachiko Ogasawara, Sho-ichi Yoshioka, Hiromi Imamura, Kengo Okamoto, and Makoto Tsuneoka
http://mcb.asm.org/content/35/24/4170.abstract?etoc

Serine and SAM Responsive Complex SESAME Regulates Histone Modification Crosstalk by Sensing Cellular Metabolism
Shanshan Li, Selene K. Swanson, Madelaine Gogol, Laurence Florens, Michael P. Washburn, Jerry L. Workman, Tamaki Suganuma
http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00763-7

Re-examination of Dietary Amino Acid Sensing Reveals a GCN2-Independent Mechanism
David E. Leib, Zachary A. Knight
http://www.cell.com/cell-reports/abstract/S2211-1247(15)01080-3

p53-regulated autophagy is controlled by glycolysis and determines cell fate
Lei Duan, Ricardo E. Perez, Batzaya Davaadelger, Elena N. Dedkova, Lothar A. Blatter and Carl G. Maki
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=5218

Cell type–specific abundance of 4EBP1 primes prostate cancer sensitivity or resistance to PI3K pathway inhibitors
Andrew C. Hsieh, Hao G. Nguyen,  Lexiaochuan Wen, Merritt P. Edlind, Peter R. Carroll, Won Kim, and Davide Ruggero
http://stke.sciencemag.org/content/8/403/ra116.abstract

mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation
K He, X Zheng, M Li, L Zhang and J Yu
http://www.nature.com/onc/journal/vaop/ncurrent/full/onc201579a.html

NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition
Hai-Xin Yuan, Zhen Wang, Fa-Xing Yu, Fulong Li, Ryan C. Russell,Jenna L. Jewell, and Kun-Liang Guan
http://genesdev.cshlp.org/content/29/22/2362.abstract

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AMPK
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Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction
Bethany E. Schaffer, Rebecca S. Levin, Nicholas T. Hertz, Travis J. Maures, Michael L. Schoof, Pablo E. Hollstein, Bérénice A. Benayoun, Max R. Banko, Reuben J. Shaw, Kevan M. Shokat, Anne Brunet
http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00466-0

LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment
Christopher G. Peña, Yuji Nakada, Hatice D. Saatcioglu, Gina M. Aloisio, Ileana Cuevas, Song Zhang, David S. Miller, Jayanthi S. Lea, Kwok-Kin Wong, Ralph J. DeBerardinis, Antonio L. Amelio, Rolf A. Brekken, Diego H. Castrillon
http://www.jci.org/articles/view/82152

SR4 Uncouples Mitochondrial Oxidative Phosphorylation, Modulates AMPK-mTOR Signaling, and Inhibits Proliferation of HepG2 Hepatocarcinoma Cells
James L. Figarola, Jyotsana Singhal, Joshua D. Tompkins, George W. Rogers, Charles Warden, David Horne, Arthur D. Riggs, Sanjay Awasthi, and Sharad S. Singhal
http://www.jbc.org/content/early/2015/11/03/jbc.M115.686352.abstract

RACK1 Promotes Autophagy by Enhancing the Atg14L-Beclin 1-Vps34-Vps15 Complex Formation upon Phosphorylation by AMPK
Yawei Zhao, Qingyang Wang, Guihua Qiu, Silei Zhou, Zhaofei Jing, Jingyang Wang, Wendie Wang, Junxia Cao, Kun Han, Qianqian Cheng, Beifen Shen, Yingyu Chen, Weiping J. Zhang, Yuanfang Ma, Jiyan Zhang
http://www.cell.com/cell-reports/abstract/S2211-1247(15)01165-1

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Miscellaneous
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MYC-induced reprogramming of glutamine catabolism supports optimal virus replication
Minh Thai, Shivani K. Thaker, Jun Feng, Yushen Du, Hailiang Hu, Ting Ting Wu, Thomas G. Graeber, Daniel Braas and Heather R. Christofk
http://www.nature.com/ncomms/2015/151112/ncomms9873/full/ncomms9873.html

Oxidative phosphorylation-dependent regulation of cancer cell apoptosis in response to anticancer agents
N Yadav, S Kumar, T Marlowe, A K Chaudhary, R Kumar, J Wang, J O’Malley, P M Boland, S Jayanthi, T K S Kumar, N Yadava and D Chandra
http://www.nature.com/cddis/journal/v6/n11/abs/cddis2015305a.html

Mitofusins deficiency elicits mitochondrial metabolic reprogramming to pluripotency
M J Son, Y Kwon, M-Y Son, B Seol, H-S Choi, S-W Ryu, C Choi and Y S Cho
http://www.nature.com/cdd/journal/v22/n12/abs/cdd201543a.html

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Reviews
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Cancer’s Fuel Choice: New Flavors for a Picky Eater
Gina M. DeNicola, Lewis C. Cantley
http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00809-6

Autophagy, Metabolism, and Cancer.
White E, Mehnert JM, Chan CS.
http://clincancerres.aacrjournals.org/content/21/22/5037.long

Metabolic Enzymes Enjoying New Partnerships as RNA-Binding Proteins
Alfredo Castello, Matthias W. Hentze, Thomas Preiss
http://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760(15)00195-2

Protein Breakdown in Cancer Cachexia
Marco Sandri
http://www.sciencedirect.com/science/article/pii/S1084952115002487

Metabolism and Epigenetics
Ryan Janke, Anne E. Dodson, and Jasper Rine
http://www.annualreviews.org/doi/abs/10.1146/annurev-cellbio-100814-125544

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Previews
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Rethinking glutamine addiction
Abigail S. Krall and Heather R. Christofk
http://www.nature.com/ncb/journal/v17/n12/full/ncb3278.html

Metabolic Mechanisms of Drug Resistance in Leukemia
Birgit Knoechel, Jon C. Aster
http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00521-5

Cancer Cells Hijack Gluconeogenic Enzymes to Fuel Cell Growth
Eduardo Balsa-Martinez, Pere Puigserver
http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00865-5

Cell signalling: How mTORC1 senses leucine
http://www.nature.com/nrm/journal/v16/n12/full/nrm4088.html

Tumor Glucose Consumption Inhibits T-cell Function
http://cancerdiscovery.aacrjournals.org/content/5/11/1121.1.abstract?etoc

Pyruvate Carboxylase Drives Tumorigenesis of SDH-Deficient Cells
http://cancerdiscovery.aacrjournals.org/content/5/11/OF13.abstract?etoc

SnapShot: Hypoxia-Inducible Factors
Kyoung Eun Lee, M. Celeste Simon
http://www.cell.com/cell/abstract/S0092-8674(15)01491-9

2 Responses to MetaboList -November 2015

  1. dlucamed says:

    Hi, I’m searching for recentemente articles related new functionts of IGF1R and peaditric oncology applications. Do you have any material on this?

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