MetaboList – January 2016

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Cellular and cancer metabolism
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TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions
Inmaculada Martínez-Reyes, Lauren P. Diebold, Hyewon Kong, Michael Schieber, He Huang, Christopher T. Hensley, Manan M. Mehta, Tianyuan Wang, Janine H. Santos, Richard Woychik, Eric Dufour, Johannes N. Spelbrink, Samuel E. Weinberg, Yingming Zhao, Ralph J. DeBerardinis, Navdeep S. Chandel
http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00936-3

Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells
Oliver D.K. Maddocks, Christiaan F. Labuschagne, Peter D. Adams, Karen H. Vousden
http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00970-3

Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton
Hai Hu, Ashish Juvekar, Costas A. Lyssiotis, Evan C. Lien, John G. Albeck, Doogie Oh, Gopal Varma, Yin Pun Hung, Soumya Ullas, Josh Lauring, Pankaj Seth, Mark R. Lundquist, Dean R. Tolan, Aaron K. Grant, Daniel J. Needleman, John M. Asara, Lewis C. Cantley, Gerburg M. Wulf
http://www.cell.com/cell/abstract/S0092-8674(15)01706-7

NANOG Metabolically Reprograms Tumor-Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism
Chia-Lin Chen, Dinesh Babu Uthaya Kumar, Vasu Punj, Jun Xu, Linda Sher, Stanley M. Tahara, Sonja Hess, Keigo Machida
http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00619-1

An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma
A. Ari Hakimi, Ed Reznik, Chung-Han Lee, Chad J. Creighton, A. Rose Brannon, Augustin Luna, B. Arman Aksoy, Eric Minwei Liu, Ronglai Shen, William Lee, Yang Chen, Steve M. Stirdivant, Paul Russo, Ying-Bei Chen, Satish K. Tickoo, Victor E. Reuter, Emily H. Cheng, Chris Sander, James J. Hsieh
http://www.cell.com/cancer-cell/abstract/S1535-6108(15)00468-7

Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism
Harri M. Itkonen, Saurabh S. Gorad, Damien Y. Duveau, Sara E.S. Martin, Anna Barkovskaya, Tone F. Bathen, Siver A. Moestue and Ian G. Mills
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[0]=7039

Mitochondrial oncobioenergetic index: A potential biomarker to predict progression from indolent to aggressive prostate cancer
Praveen K. Vayalil, Aimee Landar
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=5487&pubmed-linkout=1

fMiRNA-192 and miRNA-204 Directly Suppress lncRNA HOTTIP and Interrupt GLS1-Mediated Glutaminolysis in Hepatocellular Carcinoma
Yunxia Ge, Xiaodan Yan, Yiguang Jin, Xinyu Yang, Xiang Yu, Liqing Zhou, Sichong Han, Qipeng Yuan, Ming Yang
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005726

Inhibitor of differentiation 1 transcription factor promotes metabolic reprogramming in hepatocellular carcinoma cells
Bal Krishan Sharma*, Ravindra Kolhe†, Stephen M. Black‡, Jonathan R. Keller§, Nahid F. Mivechi¶ and Ande Satyanarayana
http://www.fasebj.org/content/30/1/262.long

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Hypoxia
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MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B
Jing Hu, Tao Sun, Hui Wang, Zhengxin Chen, Shuai Wang, Lifeng Yuan, Tingyu Liu, Hai-Ri Li, Pingping Wang, Yukuan Feng, Qinhong Wang, Roger E. McLendon, Allan H. Friedman, Stephen T. Keir, Darell D. Bigner, Jeff Rathmell, Xiang-dong Fu, Qi-Jing Li, Huibo Wang, Xiao-Fan Wang
http://www.cell.com/cancer-cell/abstract/S1535-6108(15)00469-9

Catalytic activity of human carbonic anhydrase isoform IX is displayed both extra- and intracellularly
Michael Klier, Somayeh Jamali, Samantha Ames, Hans-Peter Schneider, Holger M. Becker and Joachim W. Deitmer
http://onlinelibrary.wiley.com/doi/10.1111/febs.13562/abstract

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Nutrient sensing / starvation / mTOR / AMPK
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The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Kazutaka Sumita, Yu-Hua Lo, Koh Takeuchi, Miki Senda, Satoshi Kofuji, Yoshiki Ikeda, Jumpei Terakawa, Mika Sasaki, Hirofumi Yoshino, Nazanin Majd, Yuxiang Zheng, Emily Rose Kahoud, Takehiro Yokota, Brooke M. Emerling, John M. Asara, Tetsuo Ishida, Jason W. Locasale, Takiko Daikoku, Dimitrios Anastasiou, Toshiya Senda, Atsuo T. Sasaki
http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00945-4

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress
Erin Quan Toyama, Sébastien Herzig, Julien Courchet, Tommy L. Lewis Jr., Oliver C. Losón, Kristina Hellberg, Nathan P. Young, Hsiuchen Chen, Franck Polleux, David C. Chan, Reuben J. Shaw
http://science.sciencemag.org/content/351/6270/275

Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity
Bernadette Carroll, Dorothea Maetzel, Oliver DK Maddocks, Gisela Otten, Matthew Ratcliff, Graham R Smith, Elaine A Dunlop, João F Passos, Owen R Davies, Rudolf Jaenisch, Andrew R Tee, Sovan Sarkar and Viktor I Korolchuk
http://elifesciences.org/content/early/2016/01/07/eLife.11058

KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism
Erhu Zhao, Jane Ding, Yingfeng Xia, Mengling Liu, Bingwei Ye, Jeong-Hyeon Choi, Chunhong Yan, Zheng Dong, Shuang Huang, Yunhong Zha, Liqun Yang, Hongjuan Cui, Han-Fei Ding
http://www.cell.com/cell-reports/abstract/S2211-1247(15)01494-1

Autophagy exacerbates caspase-dependent apoptotic cell death after short times of starvation
Paolo Mattiolo, Victor J. Yuste, Jacint Boix, Judit Ribas
http://www.sciencedirect.com/science/article/pii/S0006295215006310

Ral GTPase and the exocyst regulate autophagy in a tissue‐specific manner
Kirsten Tracy, Panagiotis D Velentzas, and Eric H Baehrecke
http://EMBOr.embopress.org/content/17/1/110?etoc

WAC Regulates mTOR Activity by Acting as an Adaptor for the TTT and Pontin/Reptin Complexes
Gabriela David-Morrison, Zhen Xu, Yan-Ning Rui, Wu-Lin Charng, Manish Jaiswal, Shinya Yamamoto, Bo Xiong, Ke Zhang, Hector Sandoval, Lita Duraine, Zhongyuan Zuo, Sheng Zhang, Hugo J. Bellen
http://www.cell.com/developmental-cell/abstract/S1534-5807(15)00828-X

Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma
Jessica Okosun, Rachel L Wolfson, Jun Wang, Shamzah Araf, Lucy Wilkins, Brian M Castellano, Leire Escudero-Ibarz, Ahad Fahad Al Seraihi, Julia Richter, Stephan H Bernhart, Alejo Efeyan, Sameena Iqbal, Janet Matthews, Andrew Clear, José Afonso Guerra-Assunção, Csaba Bödör, Hilmar Quentmeier, Christopher Mansbridge, Peter Johnson, Andrew Davies, Jonathan C Strefford, Graham Packham, Sharon Barrans, Andrew Jack, Ming-Qing Du, Maria Calaminici, T Andrew Lister, Rebecca Auer, Silvia Montoto, John G Gribben, Reiner Siebert, Claude Chelala, Roberto Zoncu, David M Sabatini & Jude Fitzgibbon
http://www.nature.com/ng/journal/v48/n2/full/ng.3473.html

Nutrient-Regulated Phosphorylation of ATG13 Inhibits Starvation-Induced Autophagy
Cindy Puente, Ronald C. Hendrickson, and Xuejun Jiang
http://www.jbc.org/content/early/2016/01/22/jbc.M115.689646.abstract

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Miscellaneous
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Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis
Takla Griss, Emma E. Vincent, Robert Egnatchik, Jocelyn Chen, Eric H. Ma, Brandon Faubert, Benoit Viollet, Ralph J. DeBerardinis, Russell G. Jones
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002309

Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis
Cen Zhang, Juan Liu, Yuhan Zhao, Xuetian Yue, Yu Zhu, Xiaolong Wang, Hao Wu, Felix Blanco, Shaohua Li, Gyan Bhanot, Bruce G Haffty, Wenwei Hu and Zhaohui Feng
http://elifesciences.org/content/early/2016/01/11/eLife.10727

Noninvasive Quantification of 2-Hydroxyglutarate in Human Gliomas with IDH1 and IDH2 Mutations
Uzay E. Emir, Sarah J. Larkin, Nick de Pennington, Natalie Voets, Puneet Plaha, Richard Stacey, Khalid Al-Qahtani, James Mccullagh, Christopher J.Schofield, Stuart Clare, Peter Jezzard, Tom Cadoux-Hudson, and Olaf Ansorge
http://cancerres.aacrjournals.org/content/76/1/43.abstract?etoc

Synergic chemoprevention with dietary carbohydrate restriction and supplementation of AMPK-activating phytochemicals: the role of SIRT1.
Lee JD1, Choi MA, Ro SW, Yang WI, Cho AE, Ju HL, Baek S, Chung SI, Kang WJ, Yun M, Park JH.
http://www.ncbi.nlm.nih.gov/pubmed/?term=25747515

ccmGDB: a database for cancer cell metabolism genes
Pora Kim, Feixiong Cheng, Junfei Zhao and Zhongming Zhao
http://nar.oxfordjournals.org/content/44/D1/D959.long

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Reviews
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The Warburg Effect: How Does it Benefit Cancer Cells?
Maria V. Liberti, Jason W. Locasale
http://www.cell.com/trends/biochemical-sciences/abstract/S0968-0004(15)00241-8

The Emerging Hallmarks of Cancer Metabolism
Natalya N. Pavlova, Craig B. Thompson
http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00621-X

Obesity and Cancer: The Oil that Feeds the Flame
Joan Font-Burgada, Beicheng Sun, Michael Karin
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(15)00630-0

Lipid metabolic reprogramming in cancer cells
S Beloribi-Djefaflia, S Vasseur and F Guillaumond
http://www.nature.com/oncsis/journal/v5/n1/abs/oncsis201549a.html

Control of YAP/TAZ Activity by Metabolic and Nutrient-Sensing Pathways
Giulia Santinon, Arianna Pocaterra, Sirio Dupont
http://www.cell.com/trends/cell-biology/abstract/S0962-8924(15)00235-4

Mitochondrial Dynamics and Metabolic Regulation
Timothy Wai, Thomas Langer
http://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760(15)00236-2

Mathematical models of cancer metabolism
Markert E, Vazquez A
http://www.cancerandmetabolism.com/content/3/1/14/abstract

Hypoxia and metabolic adaptation of cancer cells
K L Eales, K E R Hollinshead and D A Tennant
http://www.nature.com/oncsis/journal/v5/n1/abs/oncsis201550a.html

Energy disruptors: rising stars in anticancer therapy?
F Bost, A-G Decoux-Poullot, J F Tanti and S Clavel
http://www.nature.com/oncsis/journal/v5/n1/abs/oncsis201546a.html

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Comments
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Chasing One-Carbon Units to Understand the Role of Serine in Epigenetics
Seth J. Parker, Christian M. Metallo
http://www.cell.com/molecular-cell/abstract/S1097-2765(16)00007-1

AMPK, a key regulator of metabolic/energy homeostasis and mitochondrial biogenesis in cancer cells
B Chaube and M K Bhat
http://www.nature.com/cddis/journal/v7/n1/full/cddis2015404a.html

Vitamin C Targets GAPDH to Kill KRAS- and BRAF-Mutant Cancer Cells
http://cancerdiscovery.aacrjournals.org/content/6/1/13.1.abstract?etoc

IDH Mutations Drive Tumorigenesis via Mitochondrial Hypersuccinylation
http://cancerdiscovery.aacrjournals.org/content/6/1/OF16.abstract?etoc

Glucose Activates SREBPs and Tumor Growth through N-Glycosylation of SCAP
http://cancerdiscovery.aacrjournals.org/content/6/1/12.1.abstract?etoc

The Urea Cycle Enzyme ASS1 Regulates Pyrimidine Synthesis in Tumors
http://cancerdiscovery.aacrjournals.org/content/6/1/OF17.abstract?etoc

GTP sensor is a lipid kinase
http://stke.sciencemag.org/content/9/412/ec15.abstract

Metabolism: Totally addicted to NAD+
http://www.nature.com/nrc/journal/v16/n2/full/nrc.2015.19.html

Hypoxia micromanages glioma
http://stke.sciencemag.org/content/9/411/ec11.abstract

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