MetaboList – February 2016

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Nucleotide metabolism
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mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle
Issam Ben-Sahra, Gerta Hoxhaj, Stéphane J. H. Ricoult, John M. Asara, Brendan D. Manning
http://science.sciencemag.org/content/351/6274/728

Spatial colocalization and functional link of purinosomes with mitochondria
Jarrod B. French, Sara A. Jones, Huayun Deng, Anthony M. Pedley, Doory Kim, Chung Yu Chan, Haibei Hu, Raymond J. Pugh, Hong Zhao, Youxin Zhang, Tony Jun Huang, Ye Fang, Xiaowei Zhuang, Stephen J. Benkovic
http://science.sciencemag.org/content/351/6274/733

The PGC-1α/ERRα Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer
Étienne Audet-Walsh, David J. Papadopoli, Simon-Pierre Gravel, Tracey Yee, Gaëlle Bridon, Maxime Caron, Guillaume Bourque, Vincent Giguère, Julie St-Pierre
http://www.cell.com/cell-reports/abstract/S2211-1247(15)01542-9

The Interplay between Myc and CTP Synthase in Drosophila
Gabriel N. Aughey, Stuart J. Grice, Ji-Long Liu
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005867

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Cancer metabolism
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Metabolic Heterogeneity in Human Lung Tumors
Christopher T. Hensley, Brandon Faubert, Qing Yuan, Naama Lev-Cohain, Eunsook Jin, Jiyeon Kim, Lei Jiang, Bookyung Ko, Rachael Skelton, Laurin Loudat, Michelle Wodzak, Claire Klimko, Elizabeth McMillan, Yasmeen Butt, Min Ni, Dwight Oliver, Jose Torrealba, Craig R. Malloy, Kemp Kernstine, Robert E. Lenkinski, Ralph J. DeBerardinis
http://www.cell.com/cell/abstract/S0092-8674(15)01698-0

Tumour-specific proline vulnerability uncovered by differential ribosome codon reading
Fabricio Loayza-Puch, Koos Rooijers, Levi C. M. Buil, Jelle Zijlstra, Joachim F. Oude Vrielink, Rui Lopes, Alejandro Pineiro Ugalde, Pieter van Breugel, Ingrid Hofland, Jelle Wesseling, Olaf van Tellingen, Axel Bex & Reuven Agami
http://www.nature.com/nature/journal/v530/n7591/full/nature16982.html

Transketolase counteracts oxidative stress to drive cancer development
Iris Ming-Jing Xu, Robin Kit-Ho Lai, Shu-Hai Lin, Aki Pui-Wah Tse, David Kung-Chun Chiu, Hui-Yu Koh, Cheuk-Ting Law, Chun-Ming Wong, Zongwei Cai, Carmen Chak-Lui Wong, and Irene Oi-Lin Ng
http://www.pnas.org/content/113/6/E725.abstract.html?etoc

Lipid and metabolite profiles of human brain tumors by desorption electrospray ionization-MS
Alan K. Jarmusch, Valentina Pirro, Zane Baird, Eyas M. Hattab, Aaron A. Cohen-Gadol, and R. Graham Cooks
http://www.pnas.org/content/113/6/1486.abstract.html?etoc

Accumulated Metabolites of Hydroxybutyric Acid Serve as Diagnostic and Prognostic Biomarkers of Ovarian High-Grade Serous Carcinomas
Mika Hilvo, Ines de Santiago, Peddinti Gopalacharyulu, Wolfgang D. Schmitt, Jan Budczies, Marc Kuhberg, Manfred Dietel, Tero Aittokallio, Florian Markowetz, Carsten Denkert, Jalid Sehouli, Christian Frezza, Silvia Darb-Esfahani, and Elena Ioana Braicu
http://cancerres.aacrjournals.org/content/76/4/796.abstract?etoc

Diet-induced alteration of fatty acid synthase in prostate cancer progression
M Huang, A Koizumi, S Narita, T Inoue, N Tsuchiya, H Nakanishi, K Numakura, H Tsuruta, M Saito, S Satoh, H Nanjo, T Sasaki and T Habuchi
http://www.nature.com/oncsis/journal/v5/n2/abs/oncsis201542a.html

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Metabolic reprogramming
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Metabolic Reprogramming of Pancreatic Cancer Mediated by CDK4/6 Inhibition Elicits Unique Vulnerabilities
Jorge Franco, Uthra Balaji, Elizaveta Freinkman, Agnieszka K. Witkiewicz, Erik S. Knudsen
http://www.cell.com/cell-reports/abstract/S2211-1247(15)01550-8

Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2
Roxana S. Redis, Luz E. Vela, Weiqin Lu, Juliana Ferreira de Oliveira, Cristina Ivan, Cristian Rodriguez-Aguayo, Douglas Adamoski, Barbara Pasculli, Ayumu Taguchi, Yunyun Chen, Agustin F. Fernandez, Luis Valledor, Katrien Van Roosbroeck, Samuel Chang, Maitri Shah, Garrett Kinnebrew, Leng Han, Yaser Atlasi, Lawrence H. Cheung, Gilbert Y. Huang, Paloma Monroig, Marc S. Ramirez, Tina Catela Ivkovic, Long Van, Hui Ling, Roberta Gafà, Sanja Kapitanovic, Giovanni Lanza, James A. Bankson, Peng Huang, Stephen Y. Lai, Robert C. Bast, Michael G. Rosenblum, Milan Radovich, Mircea Ivan, Geoffrey Bartholomeusz, Han Liang, Mario F. Fraga, William R. Widger, Samir Hanash, Ioana Berindan-Neagoe, Gabriel Lopez-Berestein, Andre L.B. Ambrosio, Sandra M. Gomes Dias, George A. Calin
http://www.cell.com/molecular-cell/abstract/S1097-2765(16)00016-2

Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis
Cen Zhang, Juan Liu, Yuhan Zhao, Xuetian Yue, Yu Zhu, Xiaolong Wang, Hao Wu, Felix Blanco, Shaohua Li, Gyan Bhanot, Bruce G Haffty, Wenwei Hu and Zhaohui Feng
http://elifesciences.org/content/5/e10727v2/abstract2

Idh1 mutations contribute to the development of T-cell malignancies in genetically engineered mice
Zhenyue Hao, Rob A. Cairns, Satoshi Inoue, Wanda Y. Li, Yi Sheng, François Lemonnier, Andrew Wakeham, Bryan E. Snow, Carmen Dominguez-Brauer, Jing Ye, Dana M. Larsen, Kimberly S. Straley, Erica R. Tobin, Rohini Narayanaswamy, Philippe Gaulard, and Tak W. Mak
http://www.pnas.org/content/113/5/1387.abstract.html?etoc

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Nutrient sensing
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Deubiquitination and Activation of AMPK by USP10
Min Deng, Xu Yang, Bo Qin, Tongzheng Liu, Haoxing Zhang, Wei Guo, Seung Baek Lee, Jung Jin Kim, Jian Yuan, Huadong Pei, Liewei Wang, Zhenkun Lou
http://www.cell.com/molecular-cell/abstract/S1097-2765(16)00011-3

A CREB-Sirt1-Hes1 Circuitry Mediates Neural Stem Cell Response to Glucose Availability
Salvatore Fusco, Lucia Leone, Saviana Antonella Barbati, Daniela Samengo, Roberto Piacentini, Giuseppe Maulucci, Gabriele Toietta, Matteo Spinelli, Michael McBurney, Giovambattista Pani, Claudio Grassi
http://www.cell.com/cell-reports/abstract/S2211-1247(15)01548-X

Hexokinase 2 is an intracellular glucose sensor of yeast cells that maintains the structure and activity of Mig1 repressor complex
Montserrat Vega, Alberto Riera, Alejandra Fernandez-Cid, Pilar Herrero, and Fernando Moreno
http://www.jbc.org/content/early/2016/02/10/jbc.M115.711408.abstract

Lysosomal recruitment of TSC2 is a universal response to cellular stress
Constantinos Demetriades, Monika Plescher and Aurelio A. Teleman
http://www.nature.com/ncomms/2016/160212/ncomms10662/full/ncomms10662.html

C/EBPγ Is a Critical Regulator of Cellular Stress Response Networks through Heterodimerization with ATF4
Christopher J. Huggins, Manasi K. Mayekar, Nancy Martin, Karen L. Saylor,Mesfin Gonit, Parthav Jailwala, Manjula Kasoji, Diana C. Haines, Octavio A. Quiñones, and Peter F. Johnson
http://mcb.asm.org/content/36/5/693.abstract?etoc

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mTOR and cancer
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Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers
Susana Llanos, Juana M. García-Pedrero, Lucia Morgado-Palacin, Juan P. Rodrigo and Manuel Serrano
http://www.nature.com/ncomms/2016/160202/ncomms10438/full/ncomms10438.html

Inhibition of mTOR complex 2 induces GSK3/FBXW7-dependent degradation of sterol regulatory element-binding protein 1 (SREBP1) and suppresses lipogenesis in cancer cells
S Li, Y-T Oh, P Yue, F R Khuri and S-Y Sun
http://www.nature.com/onc/journal/v35/n5/abs/onc2015123a.html

Mesenchymal Tumorigenesis Driven by TSC2 Haploinsufficiency Requires HMGA2 and Is Independent of mTOR Pathway Activation
Jeanine D’Armiento, Takayuki Shiomi, Sarah Marks, Patrick Geraghty, Devipriya Sankarasharma, and Kiran Chada
http://cancerres.aacrjournals.org/content/76/4/844.abstract?etoc

Secreted IGFBP5 mediates mTORC1-dependent feedback inhibition of IGF-1 signalling
Ming Ding, Richard K. Bruick & Yonghao Yu
http://www.nature.com/ncb/journal/v18/n3/full/ncb3311.html

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Hypoxia / HIFs
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Systemic Reprogramming of Translation Efficiencies on Oxygen Stimulus
J.J. David Ho, Miling Wang, Timothy E. Audas, Deukwoo Kwon, Steven K. Carlsson, Sara Timpano, Sonia L. Evagelou, Shaun Brothers, Mark L. Gonzalgo, Jonathan R. Krieger, Steven Chen, James Uniacke, Stephen Lee
http://www.cell.com/cell-reports/abstract/S2211-1247(16)00057-7

Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth
Michael S. Nakazawa, T. S. Karin Eisinger-Mathason, Navid Sadri, Joshua D. Ochocki, Terence P. F. Gade, Ruchi K. Amin and M. Celeste Simon
http://www.nature.com/ncomms/2016/160203/ncomms10539/full/ncomms10539.html

Mutant versions of von Hippel-Lindau (VHL) can protect HIF1α from SART1-mediated degradation in clear-cell renal cell carcinoma
Á Ordóñez-Navadijo, E Fuertes-Yebra, B Acosta-Iborra, E Balsa, A Elorza, J Aragonés and M O Landazuri
http://www.nature.com/onc/journal/v35/n5/abs/onc2015113a.html

HIF-1α Promotes Glutamine-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics to Support Postimplantation Bone Cell Survival
Steve Stegen, Nick van Gastel, Guy Eelen, Bart Ghesquière, Flora D’Anna, Bernard Thienpont, Jermaine Goveia, Sophie Torrekens, Riet Van Looveren, Frank P. Luyten, Patrick H. Maxwell, Ben Wielockx, Diether Lambrechts, Sarah-Maria Fendt, Peter Carmeliet, Geert Carmeliet
http://www.cell.com/cell-metabolism/abstract/S1550-4131(16)00036-X

Hypoxia-Induced Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma Induces an Immunosuppressive Tumor Microenvironment to Promote Metastasis
Long-Yun Ye, Wei Chen, Xue-Li Bai, Xing-Yuan Xu, Qi Zhang, Xue-Feng Xia, Xu Sun, Guo-Gang Li, Qi-Da Hu, Qi-Han Fu, and Ting-Bo Liang
http://cancerres.aacrjournals.org/content/76/4/818.abstract?etoc

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Ischemia
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A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury
Edward T. Chouchani, Victoria R. Pell, Andrew M. James, Lorraine M. Work, Kourosh Saeb-Parsy, Christian Frezza, Thomas Krieg, Michael P. Murphy
http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00624-5

Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism
Annelies Quaegebeur, Inmaculada Segura, Roberta Schmieder, Dries Verdegem, Ilaria Decimo, Francesco Bifari, Tom Dresselaers, Guy Eelen, Debapriva Ghosh, Shawn M. Davidson, Sandra Schoors, Dorien Broekaert, Bert Cruys, Kristof Govaerts, Carla De Legher, Ann Bouché, Luc Schoonjans, Matt S. Ramer, Gene Hung, Goele Bossaert, Don W. Cleveland, Uwe Himmelreich, Thomas Voets, Robin Lemmens, C. Frank Bennett, Wim Robberecht, Katrien De Bock, Mieke Dewerchin, Bart Ghesquière, Sarah-Maria Fendt, Peter Carmeliet
http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00622-1

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress-induced myocardial necroptosis
Ting Zhang, Yan Zhang, Mingyao Cui, Li Jin, Yimei Wang
http://www.nature.com/nm/journal/v22/n2/full/nm.4017.html

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Drugs and mechanisms
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MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4
Candice Sun Hong, Nicholas A. Graham, Wen Gu, Carolina Espindola Camacho, Vei Mah, Erin L. Maresh, Mohammed Alavi, Lora Bagryanova, Pascal A.L. Krotee, Brian K. Gardner, Iman Saramipoor Behbahan, Steve Horvath, David Chia, Ingo K. Mellinghoff, Sara A. Hurvitz, Steven M. Dubinett, Susan E. Critchlow, Siavash K. Kurdistani, Lee Goodglick, Daniel Braas, Thomas G. Graeber, Heather R. Christofk
http://www.cell.com/cell-reports/abstract/S2211-1247(16)30035-3

Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers
Edouard Mullarky, Natasha C. Lucki, Reza Beheshti Zavareh, Justin L. Anglin, Ana P. Gomes, Brandon N. Nicolay, Jenny C. Y. Wong, Stefan Christen, Hidenori Takahashi, Pradeep K. Singh, John Blenis, J. David Warren, Sarah-Maria Fendt, John M. Asara, Gina M. DeNicola, Costas A. Lyssiotis, Luke L. Lairson, and Lewis C. Cantley
http://www.pnas.org/content/113/7/1778.abstract.html?etoc

Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase
Panayotis C Theodoropoulos, Stephen S Gonzales, Sarah E Winterton, Carlos Rodriguez-Navas, John S McKnight, Lorraine K Morlock, Jordan M Hanson, Bethany Cross, Amy E Owen, Yingli Duan, Jose R Moreno, Andrew Lemoff, Hamid Mirzaei, Bruce A Posner, Noelle S Williams, Joseph M Ready & Deepak Nijhawan
http://www.nature.com/nchembio/journal/vaop/ncurrent/full/nchembio.2016.html

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Methods
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Oxygen-Enhanced MRI Accurately Identifies, Quantifies, and Maps Tumor Hypoxia in Preclinical Cancer Models
James P.B. O’Connor, Jessica K.R. Boult, Yann Jamin, Muhammad Babur, Katherine G. Finegan, Kaye J. Williams, Ross A. Little, Alan Jackson, Geoff J.M. Parker, Andrew R. Reynolds, John C. Waterton, and Simon P. Robinson
http://cancerres.aacrjournals.org/content/76/4/787.abstract?etoc

A Method for Multiplexed Measurement of Mitochondrial Pyruvate Carrier Activity
Lawrence R. Gray, Adam J. Rauckhorst, and Eric B. Taylor
http://www.jbc.org/content/early/2016/01/28/jbc.M115.711663.abstract

Impact of Freezing Delay Time on Tissue Samples for Metabolomic Studies
Tonje H. Haukaas, Siver A. Moestue, Riyas Vettukattil, Beathe Sitter, Santosh Lamichhane, Remedios Segura, Guro F. Giskeødegård, and Tone F. Bathen
http://journal.frontiersin.org/article/10.3389/fonc.2016.00017/full

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Miscellaneous
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Proinflammatory signal suppresses proliferation and shifts macrophage metabolism from Myc-dependent to HIF1α-dependent
Lingling Liu, Yun Lu, Jennifer Martinez, Yujing Bi, Gaojian Lian, Tingting Wang, Sandra Milasta, Jian Wang, Mao Yang, Guangwei Liu, Douglas R. Green, and Ruoning Wang
http://www.pnas.org/content/113/6/1564.abstract.html?etoc

Regulation of glucose metabolism by p62/SQSTM1 through HIF1α
Ke Chen, Jin Zeng, Haibing Xiao, Chunhua Huang, Junhui Hu, Weimin Yao, Gan Yu, Wei Xiao, Hua Xu, and Zhangqun Ye
http://jcs.biologists.org/content/129/4/817.abstract?etoc

Expression of Concern: Sirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria. Nataly Shulga, Robin Wilson-Smith, John G. Pastorino. J Cell Sci doi: 10.1242/jcs.061846
Michael Way
http://jcs.biologists.org/content/129/4/868?etoc

Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis
Brian J. DeBosch, Monique R. Heitmeier, Allyson L. Mayer, Cassandra B. Higgins, Jan R. Crowley, Thomas E. Kraft, Maggie Chi, Elizabeth P. Newberry, Zhouji Chen, Brian N. Finck, Nicholas O. Davidson, Kevin E. Yarasheski, Paul W. Hruz, and Kelle H. Moley
http://stke.sciencemag.org/content/9/416/ra21.abstract

SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions
Abhishek Bhardwaj and Sanjeev Das
http://www.pnas.org/content/113/5/E538.abstract.html?etoc

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Reviews
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AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs
D. Grahame Hardie, Bethany E. Schaffer, Anne Brunet
http://www.cell.com/trends/cell-biology/abstract/S0962-8924(15)00215-9

Mitochondrial Dynamics and Metabolic Regulation
Timothy Wai, Thomas Langer
http://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760(15)00236-2

Energy disruptors: rising stars in anticancer therapy?
F Bost, A-G Decoux-Poullot, J F Tanti and S Clavel
http://www.nature.com/oncsis/journal/v5/n1/full/oncsis201546a.html

T Cells and Cancer: How Metabolism Shapes Immunity
Barbara Molon, Bianca Calì and Antonella Viola
http://journal.frontiersin.org/article/10.3389/fimmu.2016.00020/full

Integration of omics: more than the sum of its parts
Buescher  J, Driggers  EM
http://www.cancerandmetabolism.com/content/4/1/4/abstract

Fat, Calories, and Cancer
Yves A. DeClerck
http://cancerres.aacrjournals.org/content/76/3/509?etoc

A Retrospective: On Clinical Studies with 5-Fluorouracil
V. Craig Jordan
http://cancerres.aacrjournals.org/content/76/4/767?etoc

Oxygen-Enhanced MRI Is a Major Advance in Tumor Hypoxia Imaging
Mark W. Dewhirst and Samuel R. Birer
http://cancerres.aacrjournals.org/content/76/4/769?etoc

Potential of Induced Metabolic Bioluminescence Imaging to Uncover Metabolic Effects of Antiangiogenic Therapy in Tumors
Stefano Indraccolo and Wolfgang Mueller-Klieser
http://journal.frontiersin.org/article/10.3389/fonc.2016.00015/full

Understanding cachexia as a cancer metabolism syndrome
P E Porporato
http://www.nature.com/oncsis/journal/v5/n2/abs/oncsis20163a.html

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Comments
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(TORC)ing up purine biosynthesis
Eric H. Ma and Russell G. Jones
http://science.sciencemag.org/content/351/6274/670

Bringing IDH into the Fold
Gelareh Zadeh, Kenneth Aldape
http://www.cell.com/cancer-cell/abstract/S1535-6108(16)30004-6?

An expanded role for mTORC1 in autophagy
Young-Mi Kim, Ji-Man Park, Douglas Grunwald & Do-Hyung Kim
http://www.tandfonline.com/doi/full/10.1080/23723556.2015.1010958

Influence of metabolic stress on translation of p53 isoforms
Debjit Khan, Samit Chattopadhyay & Saumitra Das
http://www.tandfonline.com/doi/full/10.1080/23723556.2015.1039689

Metabolic rewiring in cancer-associated fibroblasts provides a niche for oncogenesis and metastatic dissemination
Jingyi Liu, Jun Mi & Binhua P. Zhou
http://www.tandfonline.com/doi/full/10.1080/23723556.2015.1056331

AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA
Susmita Kaushik & Ana Maria Cuervo
http://www.tandfonline.com/doi/full/10.1080/15548627.2015.1124226

Cell biology: Form follows function for mitochondria
Chunxin Wang & Richard Youle
http://www.nature.com/nature/journal/v530/n7590/full/530288a.html

Mystery solved: Trehalose kickstarts autophagy by blocking glucose transport
Pablo Mardones, David C. Rubinsztein, and Claudio Hetz
http://stke.sciencemag.org/content/9/416/fs2.abstract

p62 regulates glucose metabolism through HIF1α
http://jcs.biologists.org/content/129/4/e0403?etoc

Cancer biology: Metabolism varies within tumours
http://www.nature.com/nature/journal/v530/n7590/full/530257c.html

Releasing aldolase from the cytoskeleton
http://stke.sciencemag.org/content/9/413/ec21.abstract

IDH1-Mutant Cancers Are Susceptible to NAD^+ Depletion
http://cancerdiscovery.aacrjournals.org/content/6/2/117.1.abstract?etoc

Hypoxia Promotes Cancer Stem Cells via ID2-Dependent VHL Inactivation
http://cancerdiscovery.aacrjournals.org/content/6/2/120.1.abstract?etoc

 

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