MetaboList – March 2016

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Metabolism of cancer and proliferating cells
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Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells
Aaron M. Hosios, Vivian C. Hecht, Laura V. Danai, Marc O. Johnson, Jeffrey C. Rathmell, Matthew L. Steinhauser, Scott R. Manalis, Matthew G. Vander Heiden
http://www.cell.com/developmental-cell/fulltext/S1534-5807(16)30036-3

Integration of tissue metabolomics, transcriptomics and immunohistochemistry reveals ERG- and gleason score-specific metabolomic alterations in prostate cancer
Sebastian Meller, Hellmuth-A Meyer, Bianca Bethan, Dimo Dietrich, Sandra González Maldonado, Michael Lein, Matteo Montani, Regina Reszka, Philipp Schatz, Erik Peter, Carsten Stephan, Klaus Jung, Beate Kamlage and Glen Kristiansen
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=6370

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer
Shawn M. Davidson, Thales Papagiannakopoulos, Benjamin A. Olenchock, Julia E. Heyman, Mark A. Keibler, Alba Luengo, Matthew R. Bauer, Abhishek K. Jha, James P. O’Brien, Kerry A. Pierce, Dan Y. Gui, Lucas B. Sullivan, Thomas M. Wasylenko, Lakshmipriya Subbaraj, Christopher R. Chin, Gregory Stephanopolous, Bryan T. Mott, Tyler Jacks, Clary B. Clish, Matthew G. Vander Heiden
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)00041-3

MicroRNA 211 Functions as a Metabolic Switch in Human Melanoma Cells
Joseph Mazar, Feng Qi, Bongyong Lee, John Marchica, Subramaniam Govindarajan, John Shelley, Jian-Liang Li, Animesh Ray, and Ranjan J. Perera
http://mcb.asm.org/content/36/7/1090.abstract?etoc

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Oncogenes and metabolism
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Mutant Kras copy number defines metabolic reprogramming and therapeutic susceptibilities
Emma M. Kerr, Edoardo Gaude, Frances K. Turrell, Christian Frezza & Carla P. Martins
http://www.nature.com/nature/journal/v531/n7592/full/nature16967.html

Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer
Jun Hyoung Park, Sajna Vithayathil, Santosh Kumar, Pi-Lin Sung, Lacey Elizabeth Dobrolecki, Vasanta Putluri, Vadiraja B. Bhat, Salil Kumar Bhowmik, Vineet Gupta, Kavisha Arora, Danli Wu, Efrosini Tsouko, Yiqun Zhang, Suman Maity, Taraka R. Donti, Brett H. Graham, Daniel E. Frigo, Cristian Coarfa, Patricia Yotnda, Nagireddy Putluri, Arun Sreekumar, Michael T. Lewis, Chad J. Creighton, Lee-Jun C. Wong, Benny Abraham Kaipparettu
http://www.cell.com/cell-reports/abstract/S2211-1247(16)30071-7

p54nrb/NONO regulates lipid metabolism and breast cancer growth through SREBP-1A
Z Zhu, X Zhao, L Zhao, H Yang, L Liu, J Li, J Wu, F Yang, G Huang and J Liu
http://www.nature.com/onc/journal/v35/n11/abs/onc2015197a.html

Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP
S J H Ricoult, J L Yecies, I Ben-Sahra and B D Manning
http://www.nature.com/onc/journal/v35/n10/abs/onc2015179a.html

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PRMT5
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Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5
Konstantinos J. Mavrakis et al.
http://science.sciencemag.org/content/351/6278/1208

MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells
Gregory V. Kryukov et al.
http://science.sciencemag.org/content/351/6278/1214

Arginine Methylation of SREBP1a via PRMT5 Promotes De Novo Lipogenesis and Tumor Growth
Liu Liu, Xiaoping Zhao, Li Zhao, Jiajin Li, Hao Yang, Zongping Zhu, Jianjun Liu, and Gang Huang
http://cancerres.aacrjournals.org/content/76/5/1260.abstract?etoc

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Glycolysis
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EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape
Seung-Oe Lim, Chia-Wei Li, Weiya Xia, Heng-Huan Lee, Shih-Shin Chang, JiaShen, Jennifer L. Hsu, Daniel Raftery, Danijel Djukovic, Haiwei Gu, Wei-Chao Chang, Hung-Ling Wang, Mong-Liang Chen, Longfei Huo, Chung-HsuanChen, Yun Wu, Aysegul Sahin, Samir M. Hanash, Gabriel N. Hortobagyi, and Mien-Chie Hung
http://cancerres.aacrjournals.org/content/76/5/1284.abstract?etoc

Evidence that does not support PKM2-catalyzed reaction as a rate-limiting step in cancer cell glycolysis
Jiansheng Xie, Chunyan Dai, and Xun Hu
http://www.jbc.org/content/early/2016/02/25/jbc.M115.704825.abstract

Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis
Xinjian Li, Yuhui Jiang, Jill Meisenhelder, Weiwei Yang, David H. Hawke, Yanhua Zheng, Yan Xia, Kenneth Aldape, Jie He, Tony Hunter, Liwei Wang, Zhimin Lu
http://www.cell.com/molecular-cell/fulltext/S1097-2765(16)00093-9

Parkin Regulates the Activity of Pyruvate Kinase M2
Kun Liu, Fangzhou Li, Haichao Han, Yue Chen, Zebin Mao, Jianyuan Luo, Yingming Zhao, Bin Zheng, Wei Gu, and Wenhui Zhao
http://www.jbc.org/content/early/2016/03/14/jbc.M115.703066.abstract

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Nutrient sensing
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The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
Lynne Chantranupong, Sonia M. Scaria, Robert A. Saxton, Melanie P. Gygi, Kuang Shen, Gregory A. Wyant, Tim Wang, J. Wade Harper, Steven P. Gygi, David M. Sabatini
http://www.cell.com/cell/fulltext/S0092-8674(16)30137-4

Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency
Kavya Reddy, Corey L. Cusack, Israel C. Nnah, Khoosheh Khayati, Chaitali Saqcena, Tuong B. Huynh, Scott A. Noggle, Andrea Ballabio, Radek Dobrowolski
http://www.cell.com/cell-reports/abstract/S2211-1247(16)30074-2

Metabolite Regulation of Nuclear Localization of Carbohydrate Response Element-binding Protein (ChREBP). Role of AMP as an Allosteric Inhibitor
Shogo Sato, Hunmin Jung, Tsutomu Nakagawa, Robert Pawlosky, Tomomi Takeshima, Wan-Ru Lee, Haruhiko Sakiyama, Sunil Laxman, R. Max Wynn, Benjamin Tu, John B. MacMillan, Jef K. De Brabander, Richard L. Veech, and Kosaku Uyeda
http://www.jbc.org/content/early/2016/03/16/jbc.M115.708982.abstract

The nutrient sensor OGT in PVN neurons regulates feeding
Olof Lagerlöf, Julia E. Slocomb, Ingie Hong, Yeka Aponte, Seth Blackshaw, Gerald W. Hart, Richard L. Huganir
http://science.sciencemag.org/content/351/6279/1293

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Starvation
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TFEB and TFE3 are novel components of the integrated stress response
José A Martina, Heba I Diab, Owen A Brady, and Rosa Puertollano
http://EMBOJ.embopress.org/content/35/5/479?etoc

PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L‐associated PI3K activity
Da‐Qian Xu, Zheng Wang, Chen‐Yao Wang, De‐Yi Zhang, Hui‐Da Wan, Zi‐Long Zhao, Jin Gu, Yong‐Xian Zhang, Zhi‐Gang Li, Kai‐Yang Man, Yi Pan, Zhi‐FeiWang, Zun‐Ji Ke, Zhi‐Xue Liu, Lu‐Jian Liao, and Yan Chen
http://EMBOJ.embopress.org/content/35/5/496?etoc

AMPK and PKA interaction in the regulation of survival of liver cancer cells subjected to glucose starvation
Anabela C. Ferretti, Facundo M. Tonucci, Florencia Hidalgo, Evangelina Almada, Maria C. Larocca, Cristián Favre
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=7404

Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death
Boxiao Ding, Anita Parmigiani, Ajit S. Divakaruni, Kellie Archer, Anne N. Murphy & Andrei V. Budanov
http://www.nature.com/articles/srep22538

A Repertoire of MicroRNAs Regulates Cancer Cell Starvation by Targeting Phospholipase D in a Feedback Loop That Operates Maximally in Cancer Cells
Kristen Fite, Lobna Elkhadragy, and Julian Gomez-Cambronero
http://mcb.asm.org/content/36/7/1078.abstract?etoc

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AMPK / mTOR
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LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress
Xiaowen Liu, Zhen-Dong Xiao, Leng Han, Jiexin Zhang, Szu-Wei Lee, Wenqi Wang, Hyemin Lee, Li Zhuang, Junjie Chen, Hui-Kuan Lin, Jing Wang, Han Liang & Boyi Gan
http://www.nature.com/ncb/journal/v18/n4/full/ncb3328.html

AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes
Nathan P. Young, Anwesh Kamireddy, Jeanine L. Van Nostrand, Lillian J. Eichner, Maxim Nikolaievich Shokhirev, Yelena Dayn, and Reuben J. Shaw
http://genesdev.cshlp.org/content/30/5/535.abstract?etoc

mTOR complex-2 stimulates acetyl-CoA and de novo lipogenesis through ATP citrate lyase in HER2/PIK3CA-hyperactive breast cancer
Yaqing Chen, Jianchang Qian, Qun He, Hui Zhao, Lourdes Toral-Barza, Celine Shi, Xuesai Zhang, Jiang Wu and Ker Yu
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[0]=8279&path[1]=24507

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Hypoxia and HIFs
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Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia
Kyoung Eun Lee, Michelle Spata, Lauren J. Bayne, Elizabeth L. Buza, Amy C. Durham, David Allman, Robert H. Vonderheide, and M. Celeste Simon
http://cancerdiscovery.aacrjournals.org/content/6/3/256.abstract?etoc
Exosomes Derived from Hypoxic Oral Squamous Cell Carcinoma Cells Deliver miR-21 to Normoxic Cells to Elicit a Prometastatic Phenotype
Ling Li, Chao Li, Shaoxin Wang, Zhaohui Wang, Jian Jiang, Wei Wang, Xiaoxia Li, Jin Chen, Kun Liu, Chunhua Li, and Guiquan Zhu
http://cancerres.aacrjournals.org/content/76/7/1770.abstract?etoc

Formation of Renal Cysts and Tumors in Vhl/Trp53-Deficient Mice Requires HIF1α and HIF2α
Désirée Schönenberger, Sabine Harlander, Michal Rajski, Robert A. Jacobs,Anne-Kristine Lundby, Mojca Adlesic, Tomas Hejhal, Peter J. Wild, CarstenLundby, and Ian J. Frew
http://cancerres.aacrjournals.org/content/76/7/2025.abstract?etoc

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Amino acids
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Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon
T. Van Nguyen, J. Eugene Lee, Michael J. Sweredoski, Seung-Joo Yang, Seung-Je Jeon, Joseph S. Harrison, Jung-Hyuk Yim, Sang Ghil Lee, Hiroshi Handa, Brian Kuhlman, Ji-Seon Jeong, Justin M. Reitsma, Chul-Seung Park, Sonja Hess, Raymond J. Deshaies
http://www.cell.com/molecular-cell/fulltext/S1097-2765(16)00176-3

Amino Acid Transport Associated to Cluster of Differentiation 98 Heavy Chain (CD98hc) is at the Crossroad of Oxidative Stress and Amino Acid Availability.
Laura R. de la Ballina, Sara Cano-Crespo, Elena González-Muñoz, Susanna Bial, Soline Estrach, Laurence Cailleteau, Floriane Tissot, Hannelore Daniel, Antonio Zorzano, Mark H. Ginsberg, Manuel Palacin, and Chloé C. Féral
http://www.jbc.org/content/early/2016/03/05/jbc.M115.704254.abstract

Aspartate Rescues S-phase Arrest Caused by Suppression of Glutamine Utilization in KRas-driven Cancer Cells
Deven Patel, Deepak Menon, Elyssa Bernfeld, Victoria Mroz, Sampada Kalan, Diego Loayza, and David A. Foster
http://www.jbc.org/content/early/2016/02/26/jbc.M115.710145.abstract

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Nucleotides / mitochondria
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Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism
Joni Nikkanen, Saara Forsström, Liliya Euro, Ilse Paetau, Rebecca A. Kohnz, Liya Wang, Dmitri Chilov, Jenni Viinamäki, Anne Roivainen, Päivi Marjamäki, Heidi Liljenbäck, Sofia Ahola, Jana Buzkova, Mügen Terzioglu, Nahid A. Khan, Sini Pirnes-Karhu, Anders Paetau, Tuula Lönnqvist, Antti Sajantila, Pirjo Isohanni, Henna Tyynismaa, Daniel K. Nomura, Brendan J. Battersby, Vidya Velagapudi, Christopher J. Carroll, Anu Suomalainen
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30012-2

Disruption of cytochrome c oxidase function induces the Warburg effect and metabolic reprogramming
S Srinivasan, M Guha, D W Dong, K A Whelan, G Ruthel, Y Uchikado, S Natsugoe, H Nakagawa and N G Avadhani
http://www.nature.com/onc/journal/v35/n12/abs/onc2015227a.html

The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration
Georg Gdynia, Sven W. Sauer, Jürgen Kopitz, Dominik Fuchs, Katarina Duglova, Thorsten Ruppert, Matthias Miller, Jens Pahl, Adelheid Cerwenka, Markus Enders, Heimo Mairbäurl, Marcin M. Kamiński, Roland Penzel, Christine Zhang, Jonathan C. Fuller, Rebecca C. Wade, Axel Benner, Jenny Chang-Claude, Hermann Brenner, Michael Hoffmeister, Hanswalter Zentgraf, Peter Schirmacher, Wilfried Roth
http://www.nature.com/ncomms/2016/160307/ncomms10764/full/ncomms10764.html

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Drugs
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Reversal of the glycolytic phenotype of primary effusion lymphoma cells by combined targeting of cellular metabolism and PI3K/Akt/mTOR signaling
Mediani, L; Gibellini, F; Bertacchini, J; Frasson, C; Bosco, R; Accordi, B; Basso, G; Bonora, M; Calabro, ML; Mattiolo, A; Sgarbi, G; Baracca, A; Pinton, P; Riva, G; Rampazzo, E; Petrizza, L; Prodi, L; Milani, D; Luppi, M; Potenza, L; De Pol, A; Cocco, L; Capitani, S; Marmiroli, S
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=6315

Structural analysis of dihydrofolate reductases enables rationalization of antifolate binding affinities and suggests repurposing possibilities
Amrisha Bhosle and Nagasuma Chandra
http://onlinelibrary.wiley.com/doi/10.1111/febs.13662/abstract

Gas6/Axl is the sensor of arginine-auxotrophic response in targeted chemotherapy with arginine-depleting agents
W-B Tsai, Y Long, J-R Park, J T Chang, H Liu, J Rodriguez-Canales, N Savaraj, L G Feun, M A Davies, I I Wistuba and M T Kuo
http://www.nature.com/onc/journal/v35/n13/abs/onc2015237a.html

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Techniques
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Positron Emission Tomography Imaging of Tumor Cell Metabolism and Application to Therapy Response Monitoring
Amarnath Challapalli and Eric O. Aboagye
http://journal.frontiersin.org/article/10.3389/fonc.2016.00044/full

Potential Clinical Roles for Metabolic Imaging with Hyperpolarized [1-13C]Pyruvate
Eva M. Serrao and Kevin M. Brindle
http://journal.frontiersin.org/article/10.3389/fonc.2016.00059/full

Molecular Imaging of Metabolic Reprograming in Mutant IDH Cells
Pavithra Viswanath, Myriam M. Chaumeil, and Sabrina M. Ronen
http://journal.frontiersin.org/article/10.3389/fonc.2016.00060/full

Quantitative Imaging of D-2-Hydroxyglutarate in Selected Histological Tissue Areas by a Novel Bioluminescence Technique
Nadine F. Voelxen, Stefan Walenta, Martin Proescholdt, Katja Dettmer, Stefan Pusch, and Wolfgang Mueller-Klieser
http://journal.frontiersin.org/article/10.3389/fonc.2016.00046/full

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Miscellaneous
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Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism
Hongyun Zhao, Lifeng Yang, Joelle Baddour, Abhinav Achreja, Vincent Bernard, Tyler Moss, Juan Marini, Thavisha Tudawe, Elena G Seviour, F Anthony San Lucas, Hector Alvarez, Sonal Gupta, Sourindra N Maiti, Laurence Cooper, Donna Peehl, Prahlad T Ram, Anirban Maitra and Deepak Nagrath
http://elifesciences.org/content/5/e10250v1

Registered report: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
Oliver Fiehn Megan Reed Showalter Christine E Schaner-Tooley Reproducibility Project: Cancer Biology
http://elifesciences.org/content/5/e12626v1/article-info

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Reviews
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Mitochondria and Cancer
Wei-Xing Zong, Joshua D. Rabinowitz, Eileen White
http://www.cell.com/molecular-cell/fulltext/S1097-2765(16)00095-2

Mitochondria and the hallmarks of cancer
Evangelos Giampazolias and Stephen W.G. Tait
http://onlinelibrary.wiley.com/doi/10.1111/febs.13603/abstract

Pyruvate and Metabolic Flexibility: Illuminating a Path Toward Selective Cancer Therapies
Kristofor A. Olson, John C. Schell, Jared Rutter
http://www.cell.com/trends/biochemical-sciences/abstract/S0968-0004(16)00003-7

The ever-expanding role of HIF in tumour and stromal biology
Edward L. LaGory and Amato J. Giaccia
http://www.nature.com/ncb/journal/v18/n4/full/ncb3330.html

HIF3α: the little we know
Linda Ravenna, Luisa Salvatori and Matteo A. Russo
http://onlinelibrary.wiley.com/doi/10.1111/febs.13572/abstract

DUBs, New Members in the Hypoxia Signaling clUb
Amelie S. Schober and Edurne Berra
http://journal.frontiersin.org/article/10.3389/fonc.2016.00053/full

Hypoxia and Hypoxia-Inducible Factors in Leukemias
Margaux Deynoux, Nicola Sunter, Olivier Hérault, and Frédéric Mazurier
http://journal.frontiersin.org/article/10.3389/fonc.2016.00041/full

Mechanisms of metabolic dysfunction in cancer-associated cachexia
Michele Petruzzelli and Erwin F. Wagner
http://genesdev.cshlp.org/content/30/5/489.abstract?etoc

Metabolism and the UPRmt
Yi-Fan Lin, Cole M. Haynes
http://www.cell.com/molecular-cell/fulltext/S1097-2765(16)00088-5

Mitofusins, from Mitochondria to Metabolism
Emilie Schrepfer, Luca Scorrano
http://www.cell.com/molecular-cell/fulltext/S1097-2765(16)00133-7

Dietary and pharmacological modification of the insulin/IGF-1 system: exploiting the full repertoire against cancer
R J Klement and M K Fink
http://www.nature.com/oncsis/journal/v5/n2/abs/oncsis20162a.html

Profiling cancer metabolism at the ‘omic’; level: a last resort or the next frontier?
Gelman  S, Patti  G
http://www.cancerandmetabolism.com/content/4/1/2/abstract

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Comments
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The Nurture of Tumors Can Drive Their Metabolic Phenotype
Zachary T. Schug, Johan Vande Voorde, Eyal Gottlieb
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30065-1

CASTORing New Light on Amino Acid Sensing
James E. Hughes Hallett, Brendan D. Manning
http://www.cell.com/cell/fulltext/S0092-8674(16)30258-6

Toward a Molecular Definition of Leucine-Dependent mTORC1 Activation
Robert T. Abraham
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30061-4

You Are What You Eat… or Are You?
Jason M. Tanner, Jared Rutter
http://www.cell.com/developmental-cell/fulltext/S1534-5807(16)30076-4

AMPK Promotes Autophagy by Facilitating Mitochondrial Fission
Chen-Song Zhang, Sheng-Cai Lin
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30066-3

A satiating signal
Gary J. Schwartz
http://science.sciencemag.org/content/351/6279/1268

Warburg effect(s)-a biographical sketch of Otto Warburg and his impacts on tumor metabolism
Angela M. Otto
http://www.cancerandmetabolism.com/content/4/1/5/abstract

PI3K Promotes Glycolysis through Release of Cytoskeletal Aldolase
http://cancerdiscovery.aacrjournals.org/content/6/3/229.1.abstract?etoc

PI5P4Kβ Is a Lipid Kinase GTP Sensor That Promotes Tumorigenesis
http://cancerdiscovery.aacrjournals.org/content/6/3/225.2.abstract?etoc

Controlling glutamine metabolism by acetylation
http://stke.sciencemag.org/content/9/421/ec73.abstract

Tumour metabolism: Feeding the TCA cycle in vivo
http://www.nature.com/nrc/journal/v16/n4/full/nrc.2016.29.html

Kras rewires metabolic networks
http://stke.sciencemag.org/content/9/418/ec56.abstract

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