MetaboList – April 2016

——————————-
Cancer metabolism
——————————-

Reductive carboxylation supports redox homeostasis during anchorage-independent growth
Lei Jiang, Alexander A. Shestov, Pamela Swain, Chendong Yang, Seth J. Parker, Qiong A. Wang, Lance S. Terada, Nicholas D. Adams, Michael T. McCabe, Beth Pietrak, Stan Schmidt, Christian M. Metallo, Brian P. Dranka, Benjamin Schwartz & Ralph J. DeBerardinis
http://www.nature.com/nature/journal/v532/n7598/full/nature17393.html

Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer
Evan C. Lien, Costas A. Lyssiotis, Ashish Juvekar, Hai Hu, John M. Asara, Lewis C. Cantley, Alex Toker
http://www.nature.com/ncb/journal/v18/n5/full/ncb3341.html

Epithelial mesenchymal transition induces aberrant glycosylation through hexosamine biosynthetic pathway activation
Miguel C. Lucena, Patricia Carvalho-Cruz, Joana L. Donadio, Isadora A. Oliveira, Rafaela M. de Queiroz, Monica M. Marinho-Carvalho, Iron F. de Paula, Katia C. Gondim, Mark E. McComb, Catherine E. Costello, Stephen A. Whelan, Adriane R. Todeschini and Wagner B. Dias
http://www.jbc.org/content/early/2016/04/18/jbc.M116.729236.abstract

ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer
Sunghee Park, Ching-Yi Chang, Rachid Safi, Xiaojing Liu, Robert Baldi, Jeff S. Jasper, Grace R. Anderson, Tingyu Liu, Jeffrey C. Rathmell, Mark W. Dewhirst, Kris C. Wood, Jason W. Locasale, Donald P. McDonnell
http://www.cell.com/cell-reports/abstract/S2211-1247(16)30282-0

mTORC2 controls cancer cell survival by modulating gluconeogenesis
MW Khan, D Biswas, M Ghosh, S Mandloi, S Chakrabarti & P Chakrabarti
http://www.nature.com/articles/cddiscovery201516

A Balanced Tissue Composition Reveals New Metabolic and Gene Expression Markers in Prostate Cancer
May-Britt Tessem, Helena Bertilsson, Anders Angelsen, Tone F. Bathen, Finn Drabløs, Morten Beck Rye
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153727

MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis
Katya Marjon, Michael J. Cameron, Phong Quang, Michelle F. Clasquin, Everton Mandley, Kaiko Kunii, Michael McVay, Sung Choe, Andrew Kernytsky, Stefan Gross, Zenon Konteatis, Joshua Murtie, Michelle L. Blake, Jeremy Travins, Marion Dorsch, Scott A. Biller, Kevin M. Marks
http://www.cell.com/cell-reports/fulltext/S2211-1247(16)30299-6

Distinct Metabolic Signature of Human Bladder Cancer Cells Carrying an Impaired Fanconi Anemia Tumor-Suppressor Signaling Pathway
Jayabal Panneerselvam, Guoxiang Xie, Raymond Che, Mingming Su, Jun Zhang, Wei Jia, and Peiwen Fei
http://pubs.acs.org/doi/abs/10.1021/acs.jproteome.6b00076

PBRM1 Regulates the Expression of Genes Involved in Metabolism and Cell Adhesion in Renal Clear Cell Carcinoma
Basudev Chowdhury, Elizabeth G. Porter, Jane C. Stewart, Christina R. Ferreira, Matthew J. Schipma, Emily C. Dykhuizen
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153718

Isocitrate dehydrogenase 1 mutations prime the all-trans retinoic acid myeloid differentiation pathway in acute myeloid leukemia
Héléna Boutzen, Estelle Saland, Clément Larrue, Fabienne de Toni, Lara Gales, Florence A. Castelli, Mathilde Cathebas, Sonia Zaghdoudi, Lucille Stuani, Tony Kaoma, Romain Riscal, Guangli Yang, Pierre Hirsch, Marion David, Véronique De Mas-Mansat, Eric Delabesse, Laurent Vallar, François Delhommeau, Isabelle Jouanin, Ouathek Ouerfelli, Laurent Le Cam, Laetitia K. Linares, Christophe Junot, Jean-Charles Portais, François Vergez, Christian Récher, and Jean-Emmanuel Sarry
http://jem.rupress.org/content/213/4/483?etoc

Enantiomer-specific and paracrine leukemogenicity of mutant IDH metabolite 2-hydroxyglutarate
A Chaturved1, M M A Cruz1, N Jyotsana1, A Sharma1, R Goparaju1, A Schwarzer2, K Görlich1, R Schottmann1, E A Struys3, E E Jansen, C Rohde4, C Müller-Tidow4, R Geffers5, G Göhring6, A Ganser1, F Thol1 and M Heuser
http://www.nature.com/leu/journal/vaop/naam/abs/leu201671a.html

——————————————————-
Glycolysis and glycolytic enzymes
——————————————————-

mTORC1-Dependent Metabolic Reprogramming Underlies Escape from Glycolysis Addiction in Cancer Cells
Raju V. Pusapati, Anneleen Daemen, Catherine Wilson, Wendy Sandoval, Min Gao, Benjamin Haley, Andreas R. Baudy, Georgia Hatzivassiliou, Marie Evangelista, Jeff Settleman
http://www.cell.com/cancer-cell/abstract/S1535-6108(16)30052-6

Focal adhesion kinase-promoted tumor glucose metabolism is associated with a shift of mitochondrial respiration to glycolysis
J Zhang, Q Gao, Y Zhou, U Dier, N Hempel and S N Hochwald
http://www.nature.com/onc/journal/v35/n15/abs/onc2015256a.html

Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1α
Sangbin Lim, Hao Liu, Luciana Madeira da Silva, Ritu Arora, Zixing Liu, Joshua B. Phillips, David C. Schmitt, Tung Vu, Steven McClellan, Yifeng Lin, Wensheng Lin, Gary A. Piazza, Oystein Fodstad, and Ming Tan
http://cancerres.aacrjournals.org/content/76/8/2231.abstract?etoc

SH2 domain-containing phosphatase 1 regulates pyruvate kinase M2 in hepatocellular carcinoma
Wei-Tien Tai, Man-Hsin Hung, Pei-Yi Chu, Yao-Li Chen, Li-Ju Chen, Ming-Hsien Tsai, Min-Husan Chen, Chung-Wai Shiau, Yin-Pin Boo,  and Kuen- Feng Chen
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=7923

Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells
S Calabretta, P Bielli, I Passacantilli, E Pilozzi, V Fendrich, G Capurso, G Delle Fave and C Sette
http://www.nature.com/onc/journal/v35/n16/abs/onc2015270a.html

PARP Inhibition Suppresses Growth of EGFR-Mutant Cancers by Targeting Nuclear PKM2
Nan Li, Lin Feng, Hui Liu, Jiadong Wang, Moses Kasembeli, My Kim Tran, David J. Tweardy, Steven Hsesheng Lin, Junjie Chen
http://www.cell.com/cell-reports/abstract/S2211-1247(16)30359-X

Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides
Khyati Kapoor, Janet S. Finer-Moore, Bjørn P. Pedersen, Laura Caboni, Andrew Waight, Roman C. Hillig, Peter Bringmann, Iring Heisler, Thomas Müller, Holger Siebeneicher, and Robert M. Stroud
http://www.pnas.org/content/113/17/4711.abstract.html?etoc

GAPDH (glyceraldehyde-3-phosphate dehydrogenase) Protein-Protein Interaction Inhibitor Reveals a Non-Catalytic Role for GAPDH Oligomerization in Cell Death
Nir Qvit, Amit U. Joshi, Anna D. Cunningham, Julio C.B. Ferreira, and Daria Mochly-Rosen
http://www.jbc.org/content/early/2016/04/27/jbc.M115.711630.abstract

—————————————————-
Glutamine and other amino acids
—————————————————-

The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy
Michael J. Lukey, Kai Su Greene, Jon W. Erickson, Kristin F. Wilson and Richard A. Cerione
http://www.nature.com/ncomms/2016/160418/ncomms11321/full/ncomms11321.html

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor
AuthorsAbigail S. Krall, Shili Xu, Thomas G. Graeber, Daniel Braas, Heather R. Christofk
http://www.nature.com/ncomms/2016/160429/ncomms11457/full/ncomms11457.html

The Ephrin-A1/EPHA2 Signaling Axis Regulates Glutamine Metabolism in HER2-Positive Breast Cancer
Victoria M. Youngblood, Laura C. Kim, Deanna N. Edwards, Yoonha Hwang, Pranav R. Santapuram, Steven M. Stirdivant, Pengcheng Lu, Fei Ye, Dana M.Brantley-Sieders, and Jin Chen
http://cancerres.aacrjournals.org/content/76/7/1825.abstract?etoc

Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells
Angelika Bröer, Farid Rahimi, and Stefan Bröer
http://www.jbc.org/content/early/2016/04/26/jbc.M115.700534.abstract

RhoC is a Potent Regulator of Glutamine Metabolism and N-acetylaspartate Production in Inflammatory Breast Cancer Cells
Michelle L. Wynn, Joel A. Yates, Charles R. Evans, Lauren Van Wassenhove, Zhi Fen Wu, Sydney Bridges, Liwei Bao, Chelsea Fournier, Sepideh Ashrafzadeh, Matthew J. Merrins, Leslie S. Satin, Santiago Schnell, Charles F. Burant, and Sofia D. Merajver
http://www.jbc.org/content/early/2016/04/25/jbc.M115.703959.abstract

——————————-
Lipids and cancer
——————————-

Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer
Roman Camarda, Alicia Y Zhou, Rebecca A Kohnz, Sanjeev Balakrishnan, Celine Mahieu, Brittany Anderton, Henok Eyob, Shingo Kajimura, Aaron Tward, Gregor Krings, Daniel K Nomura & Andrei Goga
http://www.nature.com/nm/journal/v22/n4/full/nm.4055.html

Cyclin E Associates with the Lipogenic Enzyme ATP-Citrate Lyase to Enable Malignant Growth of Breast Cancer Cells
Kimberly S. Lucenay, Iman Doostan, Cansu Karakas, Tuyen Bui, Zhiyong Ding, Gordon B. Mills, Kelly K. Hunt, and Khandan Keyomarsi
http://cancerres.aacrjournals.org/content/76/8/2406.abstract?etoc

Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments
Peck B, Schug Z, Zhang Q, Dankworth B, Jones D, Smethurst E, Patel R, Mason S, Jiang M, Saunders  R, Howell M, Mitter R, Spencer-Dene B, Stamp G, McGarry L, James D, Shanks E, Aboagye E, Critchlow  S, Leung H, Harris A, Wakelam M, Gottlieb E, Schulze A
http://www.cancerandmetabolism.com/content/4/1/6/abstract

FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth
Felipe Slebe, Federico Rojo, Maria Vinaixa, Mar García-Rocha, Giorgia Testoni, Marc Guiu, Evarist Planet, Sara Samino, Enrique J. Arenas, Antoni Beltran, Ana Rovira, Ana Lluch, Xavier Salvatella, Oscar Yanes, Joan Albanell, Joan J. Guinovart and Roger R. Gomis
http://www.nature.com/ncomms/2016/160405/ncomms11199/full/ncomms11199.html

Tumor-Induced Hyperlipidemia Contributes to Tumor Growth
Jianfeng Huang, Lena Li, Jihong Lian, Silvia Schauer, Paul W. Vesely, Dagmar Kratky, Gerald Hoefler, Richard Lehner
http://www.cell.com/cell-reports/fulltext/S2211-1247(16)30261-3

—————————————–
Mitochondria, nucleotides
—————————————–

Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism
Joni Nikkanen, Saara Forsström, Liliya Euro, Ilse Paetau, Rebecca A. Kohnz, Liya Wang, Dmitri Chilov, Jenni Viinamäki, Anne Roivainen, Päivi Marjamäki, Heidi Liljenbäck, Sofia Ahola, Jana Buzkova, Mügen Terzioglu, Nahid A. Khan, Sini Pirnes-Karhu, Anders Paetau, Tuula Lönnqvist, Antti Sajantila, Pirjo Isohanni, Henna Tyynismaa, Daniel K. Nomura, Brendan J. Battersby, Vidya Velagapudi, Christopher J. Carroll, Anu Suomalainen
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30012-2

Mitochondrial DNA plasticity is an essential inducer of tumorigenesis
W T Y Lee, J E Cain, A Cuddihy, J Johnson, A Dickinson, K-Y Yeung, B Kumar, T G Johns, D N Watkins, A Spencer & J C St John
http://www.nature.com/articles/cddiscovery201616

Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma
Justin L. Tan, Rachel D. Fogley, Ryan A. Flynn, Julien Ablain, Song Yang, Violaine Saint-André, Zi Peng Fan, Brian T. Do, Alvaro C. Laga, Koh Fujinaga, Cristina Santoriello, Celeste B. Greer, Yoon Jung Kim, John G. Clohessy, Anne Bothmer, Nicole Pandell, Serine Avagyan, John E. Brogie, Ellen van Rooijen, Elliott J. Hagedorn, Ng Shyh-Chang, Richard M. White, David H. Price, Pier Paolo Pandolfi, B. Matija Peterlin, Yi Zhou, Tae Hoon Kim, John M. Asara, Howard Y. Chang, Richard A. Young, Leonard I. Zon
http://www.cell.com/molecular-cell/fulltext/S1097-2765(16)00223-9

————
Drugs
————

BIRC5/Survivin as a target for glycolysis inhibition in high-stage neuroblastoma
J Hagenbuchner, U Kiechl-Kohlendorfer, P Obexer and M J Ausserlechner
http://www.nature.com/onc/journal/v35/n16/abs/onc2015264a.html

A novel agent exerts antitumor activity in breast cancer cells by targeting mitochondrial complex II
Liang Wang, Xiaojing Zhang, Guozhen Cui, Judy Yuet-Wa Chan, Li Wang, Chuwen Li, Luchen Shan, Changjiang Xu, Qingwen Zhang, Yuqiang Wang, Lijun Di, Simon Ming-Yuen Lee
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B0%5D=8410&path%5B1%5D=24966#.VxXTUq-Dkuo.facebook

Combined Treatment of MCF-7 Cells with AICAR and Methotrexate, Arrests Cell Cycle and Reverses Warburg Metabolism through AMP-Activated Protein Kinase (AMPK) and FOXO1
Tamás Fodor, Magdolna Szántó, Omar Abdul-Rahman, Lilla Nagy, Ádám Dér, Borbála Kiss, Peter Bai
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0150232

Metformin Decouples Phospholipid Metabolism in Breast Cancer Cells
Tim A. D. Smith, Su M. Phyu
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0151179

Metformin Pharmacokinetics in Mouse Tumors: Implications for Human Therapy
Ryan J.O. Dowling, Sonya Lam, Christian Bassi, Samar Mouaaz, Ahmed Aman, Taira Kiyota, Rima Al-awar, Pamela J. Goodwin, Vuk Stambolic
http://www.cell.com/cell-metabolism/abstract/S1550-4131(16)30109-7

Are Metformin Doses Used in Murine Cancer Models Clinically Relevant?
Navdeep S. Chandel, Dania Avizonis, Colleen R. Reczek, Samuel E. Weinberg, Stephan Menz, Roland Neuhaus, Sven Christian, Andrea Haegebarth, Carolyn Algire, Michael Pollak
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30113-9

——————–
Starvation
——————–

Protein Kinase A Activation Promotes Cancer Cell Resistance to Glucose Starvation and Anoikis
Roberta Palorini, Giuseppina Votta, Yuri Pirola, Humberto De Vitto, Sara De Palma, Cristina Airoldi, Michele Vasso, Francesca Ricciardiello, Pietro Paolo Lombardi, Claudia Cirulli, Raffaella Rizzi, Francesco Nicotra, Karsten Hiller, Cecilia Gelfi, Lilia Alberghina, Ferdinando Chiaradonna
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005931

Cystine Deprivation Triggers Programmed Necrosis in VHL-Deficient Renal Cell Carcinomas
Xiaohu Tang, Jianli Wu, Chien-Kuang Ding, Min Lu, Melissa M. Keenan, Chao-Chieh Lin, Chih-An Lin, Charles C. Wang, Daniel George, David S. Hsu, and Jen-Tsan Chi
http://cancerres.aacrjournals.org/content/76/7/1892.abstract?etoc

c-MYC responds to glucose deprivation in a cell-type-dependent manner
S Wu, X Yin, X Fang, J Zheng, L Li, X Liu & L Chu
http://www.nature.com/articles/cddiscovery201557

Regulation of Pyruvate Kinase M Switch towards PKM1 by LKB1-AMPK Axis Tolerates Hypoglycemic Stress in Cancer Cells
Prakasam Gopinath, Rajnish Kumar Singh, Mohammad Askandar Iqbal, Ashu Bhan Tiku, and Rameshwar N. K. Bamezai
http://www.jbc.org/content/early/2016/04/26/jbc.M116.729079.abstract

Lipid droplet–mediated ER homeostasis regulates autophagy and cell survival during starvation
Ariadna P. Velázquez, Takashi Tatsuta, Ruben Ghillebert, Ingmar Drescher, and Martin Graef
http://jcb.rupress.org/content/212/6/621.abstract

—————————
AMPK / mTOR
—————————

AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival
Rigel J. Kishton, Carson E. Barnes, Amanda G. Nichols, Sivan Cohen, Valerie A. Gerriets, Peter J. Siska, Andrew N. Macintyre, Pankuri Goraksha-Hicks, Aguirre A. de Cubas, Tingyu Liu, Marc O. Warmoes, E. Dale Abel, Allen Eng Juh Yeoh, Timothy R. Gershon, W. Kimryn Rathmell, Kristy L. Richards, Jason W. Locasale, Jeffrey C. Rathmell
http://www.cell.com/cell-metabolism/abstract/S1550-4131(16)30111-5

Rapamycin requires AMPK activity and p27 expression for promoting autophagy-dependent Tsc2-null cell survival
Tania Campos, Javiera Ziehe, Francisco Fuentes-Villalobos, Orlando Riquelme, Daniela Peña, Rodrigo Troncoso, Sergio Lavandero, Violeta Morin, Roxana Pincheira, Ariel F. Castro
http://www.sciencedirect.com/science/article/pii/S0167488916300623

The Prognostic Value of Decreased LKB1 in Solid Tumors: A Meta-Analysis
Jian Xiao, Yong Zou, Xi Chen, Ying Gao, Mingxuan Xie, Xiaoxiao Lu, Wei Li, Bixiu He, Shuya He, Shaojin You, Qiong Chen
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152674

Caspase-mediated cleavage of raptor participates in the inactivation of mTORC1 during cell death
R Martin, C Desponds, R O Eren, M Quadroni, M Thome & N Fasel
http://www.nature.com/articles/cddiscovery201624

—————–
Hypoxia
—————–

Hypoxia regulates global membrane protein endocytosis through caveolin-1 in cancer cells
E. Bourseau-Guilmain, J. A. Menard, E. Lindqvist, V. Indira Chandran, H. C. Christianson, M. Cerezo Magaña, J. Lidfeldt, G. Marko-Varga, C. Welinder, M. Belting
http://www.nature.com/ncomms/2016/160420/ncomms11371/full/ncomms11371.html

Glycerol-3-phosphate acyltransferase-1 upregulation by O-GlcNAcylation of Sp1 protects against hypoxia-induced mouse embryonic stem cell apoptosis via mTOR activation
H J Lee, J M Ryu, Y H Jung, K H Lee, D I Kim and H J Han
http://www.nature.com/cddis/journal/v7/n3/abs/cddis2015410a.html

HIF-1α regulates the interaction of chronic lymphocytic leukemia cells with the tumor microenvironment
Roberta Valsecchi, Nadia Coltella, Daniela Belloni, Manfredi Ponente, Elisa ten Hacken, Cristina Scielzo, Lydia Scarfò, Maria Teresa Sabrina Bertilaccio, Paola Brambilla, Elisa Lenti, Filippo Martinelli Boneschi, Andrea Brendolan, Elisabetta Ferrero, Marina Ferrarini, Paolo Ghia, Giovanni Tonon, Maurilio Ponzoni, Federico Caligaris-Cappio, and Rosa Bernardi
http://bloodjournal.org/content/127/16/1987.abstract?etoc

Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA
Chuanzhao Zhang, Debangshu Samanta, Haiquan Lu, John W. Bullen, Huimin Zhang, Ivan Chen, Xiaoshun He, and Gregg L. Semenza
http://www.pnas.org/content/113/14/E2047.abstract.html?etoc

Prolyl Hydroxylase 3 Attenuates MCL-1–Mediated ATP Production to Suppress the Metastatic Potential of Colorectal Cancer Cells
Praveenkumar Radhakrishnan, Nadine Ruh, Jonathan M. Harnoss, Judit Kiss, Martin Mollenhauer, Anna-Lena Scherr, Lisa K. Platzer, Thomas Schmidt, Klaus Podar, Joseph T. Opferman, Juergen Weitz, Henning Schulze-Bergkamen, Bruno C. Koehler, Alexis Ulrich, and Martin Schneider
http://cancerres.aacrjournals.org/content/76/8/2219.abstract?etoc

Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition
Lars Bräutigam, Linda Pudelko, Ann-Sofie Jemth, Helge Gad, Mohit Narwal, Robert Gustafsson, Stella Karsten, Jordi Carreras Puigvert, Evert Homan, Carsten Berndt, Ulrika Warpman Berglund, Pål Stenmark, and Thomas Helleday
http://cancerres.aacrjournals.org/content/76/8/2366.abstract?etoc

———————————————————-
Prognosis / diagnostics / methods
———————————————————-

Pre-diagnosis blood glucose and prognosis in women with breast cancer
Monzavi-Karbassi B, Gentry R, Kaur V, Siegel E, Jousheghany F, Medarametla S, Fuhrman B, Safar  A, Hutchins L, Kieber-Emmons T
http://www.cancerandmetabolism.com/content/4/1/7/abstract

Bridging the gap between non-targeted stable isotope labeling and metabolic flux analysis
Weindl  D, Cordes  T, Battello  N, Sapcariu  S, Dong  X, Wegner  A, Hiller  K
http://www.cancerandmetabolism.com/content/4/1/10/abstract

Determining Maximum Glycolytic Capacity Using Extracellular Flux Measurements
Shona A. Mookerjee, David G. Nicholls, Martin D. Brand
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152016

———————–
Miscellaneous
———————–

Metabolic maintenance of cell asymmetry following division in activated T lymphocytes
Katherine C. Verbist, Cliff S. Guy, Sandra Milasta, Swantje Liedmann, Marcin M. Kamiński, Ruoning Wang & Douglas R. Green
http://www.nature.com/nature/journal/v532/n7599/full/nature17442.html

The Mitochondrial Respiratory Chain Is Required for Organismal Adaptation to Hypoxia
Robert B. Hamanaka, Samuel E. Weinberg, Colleen R. Reczek, Navdeep S. Chandel
http://www.cell.com/cell-reports/fulltext/S2211-1247(16)30300-X

Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism inthe liver
Michael E. Fusakio, Jeffrey A. Willy, Yongping Wang, Emily T. Mirek, Rana J. T. Al Baghdadi, Christopher M. Adams, Tracy G. Anthony, and Ronald C. Wek
http://www.molbiolcell.org/content/27/9/1536.abstract?etoc

Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism
Yuefeng Tang, Martina Wallace, Joan Sanchez-Gurmaches, Wen-Yu Hsiao, Huawei Li, Peter L. Lee, Santiago Vernia, Christian M. Metallo & David A. Guertin
http://www.nature.com/ncomms/2016/160421/ncomms11365/full/ncomms11365.html

—————–
Reviews
—————–

Intermediates of Metabolism: From Bystanders to Signalling Molecules
Robert Haas, Danilo Cucchi, Joanne Smith, Valentina Pucino, Claire Elizabeth Macdougall, Claudio Mauro
http://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(16)00026-8

Changing perspective on oncometabolites: from metabolic signature of cancer to tumorigenic and immunosuppressive agents
Mauro Corrado, Luca Scorrano and Silvia Campello
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[0]=8727&path[1]=26258

The Role of Cholesterol in Cancer
Omer F. Kuzu, Mohammad A. Noory, and Gavin P. Robertson
http://cancerres.aacrjournals.org/content/76/8/2063.abstract?etoc

Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot
Deborah C.I. Goberdhan, Clive Wilson, Adrian L. Harris
http://www.cell.com/cell-metabolism/abstract/S1550-4131(16)30116-4

A lysosome-centered view of nutrient homeostasis
Vinod K. Mony, Shawna Benjamin & Eyleen J. O’Rourke
http://www.tandfonline.com/doi/full/10.1080/15548627.2016.1147671

Chronic Myeloid Leukemia and Hepatoblastoma: Two Cancer Models to Link Metabolism to Stem Cells
Maria Grazia Cipolleschi, Ilaria Marzi, Elisabetta Rovida and Persio Dello Sbarba
http://journal.frontiersin.org/article/10.3389/fonc.2016.00095/full

Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumor-associated miRNAs in breast and pancreatic cancers
Bin Bao, Asfar S. Azmi, Shadan Ali, Feras Zaiem, Fazlul H. Sarkar
http://atm.amegroups.com/article/view/3965/4955

—————–
Comments
—————–

Glycoholics Anonymous: Cancer Sobers Up with mTORC1
Vivian Fu, Toshiro Moroishi, Kun-Liang Guan
http://www.cell.com/cancer-cell/fulltext/S1535-6108(16)30099-X

mTORC1 signaling activates NRF1 to increase cellular proteasome levels.
Zhang Y, Manning BD.
http://www.tandfonline.com/doi/abs/10.1080/15384101.2015.1044188?journalCode=kccy20

Mutant KRAS Copy-Number Gain Drives Metabolic Reprogramming
http://cancerdiscovery.aacrjournals.org/content/6/4/342.1.abstract?etoc

Differential Ribosome Codon Reading Reveals Limiting Amino Acids
http://cancerdiscovery.aacrjournals.org/content/6/4/340.2.abstract?etoc

MTAP Deletion Promotes Cancer-Cell Dependence on PRMT5
http://cancerdiscovery.aacrjournals.org/content/6/4/OF11.abstract?etoc

An arginine sensor for mTORC1
http://stke.sciencemag.org/content/9/422/ec79.abstract

Metabolic reprogramming of pyruvate dehydrogenase is essential for the proliferation of glioma cells expressing mutant IDH1
Pavithra Viswanath & Sabrina M. Ronen
http://www.tandfonline.com/doi/full/10.1080/23723556.2015.1077922

Mitochondrial respiratory defects promote the Warburg effect and cancer progression
Satish Srinivasan, Manti Guha & Narayan G. Avadhani
http://www.tandfonline.com/doi/full/10.1080/23723556.2015.1085120

Vascular endothelial growth factor blockade elicits a stable metabolic shift in tumor cells: therapeutic implications
Stefano Indraccolo
http://www.tandfonline.com/doi/full/10.1080/23723556.2015.1008307

Autophagy degrades hypoxia inducible factors
Adela DePavia, Eric Jonasch & Xian-De Liu
http://www.tandfonline.com/doi/full/10.1080/23723556.2015.1104428

More challenges ahead—metabolic heterogeneity of pancreatic cancer stem cells
Christopher Heeschen & Patricia Sancho
http://www.tandfonline.com/doi/full/10.1080/23723556.2015.1105353

Chewing the fat for Akt1 inhibition and oncosuppression
Sara M. Nowinski, Ashley Solmonson & Edward M. Mills
http://www.tandfonline.com/doi/full/10.1080/23723556.2015.1102795

SCAP links glucose to lipid metabolism in cancer cells
Deliang Guo
http://www.tandfonline.com/doi/full/10.1080/23723556.2015.1132120

A metabolic link between the urea cycle and cancer cell proliferation
Sandesh C.S. Nagamani & Ayelet Erez
http://www.tandfonline.com/doi/full/10.1080/23723556.2015.1127314

—————–
Webinars
—————–

Metabolomics: Redefining the Role of Fuels in Tumorigenesis
http://view6.workcast.net/register?cpak=7286280958007358&referrer=etoc

Webinar | Metabolic regulation of immunity: Exploring programs that drive immune development and function
Jeffrey Rathmell , Russell Jones, Christoph Hess
http://science.sciencemag.org/content/352/6284/478.2

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: