MetaboList – July 2016

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Diet/obesity and Cancer
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Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity
Stefano Di Biase, Changhan Lee, Sebastian Brandhorst, Brianna Manes, Roberta Buono, Chia-Wei Cheng, Mafalda Cacciottolo, Alejandro Martin-Montalvo, Rafael de Cabo, Min Wei, Todd E. Morgan, Valter D. Longo
http://www.cell.com/cancer-cell/fulltext/S1535-6108(16)30265-3

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance
Federico Pietrocola, Jonathan Pol, Erika Vacchelli, Shuan Rao, David P. Enot, Elisa E. Baracco, Sarah Levesque, Francesca Castoldi, Nicolas Jacquelot, Takahiro Yamazaki, Laura Senovilla, Guillermo Marino, Fernando Aranda, Sylvère Durand, Valentina Sica, Alexis Chery, Sylvie Lachkar, Verena Sigl, Norma Bloy, Aitziber Buque, Simonetta Falzoni, Bernhard Ryffel, Lionel Apetoh, Francesco Di Virgilio, Frank Madeo, Maria Chiara Maiuri, Laurence Zitvogel, Beth Levine, Josef M. Penninger, Guido Kroemer
http://www.cell.com/cancer-cell/abstract/S1535-6108(16)30221-5

Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy
Joao Incio, Hao Liu, Priya Suboj, Shan M. Chin, Ivy X. Chen, Matthias Pinter, Mei R. Ng, Hadi T. Nia, Jelena Grahovac, Shannon Kao, Suboj Babykutty, Yuhui Huang, Keehoon Jung, Nuh N. Rahbari, Xiaoxing Han, Vikash P. Chauhan, John D. Martin, Julia Kahn, Peigen Huang, Vikram Desphande, James Michaelson, Theodoros P. Michelakos, Cristina R. Ferrone, Raquel Soares, Yves Boucher, Dai Fukumura, and Rakesh K. Jain
http://cancerdiscovery.aacrjournals.org/content/6/8/852.abstract?etoc

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Glycolytic enzymes
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Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan
Andrea J. Wolf, Christopher N. Reyes, Wenbin Liang, Courtney Becker, Kenichi Shimada, Matthew L. Wheeler, Hee Cheol Cho, Narcis I. Popescu, K. Mark Coggeshall, Moshe Arditi, David M. Underhill
http://www.cell.com/cell/fulltext/S0092-8674(16)30723-1

Regulation of HK2 expression through alterations in CpG methylation of the HK2 promoter during progression of hepatocellular carcinoma
Hyun Gyu Lee, Hyemi Kim, Taekwon Son, Youngtae Jeong, Seung Up Kim, Seung Myung Dong, Young Nyun Park, Jong Doo Lee, Jae Myun Lee, and Jeon Han Park
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=9723

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Lipid metabolism
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SREBP regulates the expression and metabolic functions of wild-type and oncogenic IDH1
Stéphane J.H. Ricoult, Christian C. Dibble, John M. Asara and Brendan D. Manning
http://mcb.asm.org/content/early/2016/06/21/MCB.00163-16.abstract

Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia
Xue Gao, Shu-Hai Lin, Feng Ren, Jin-Tao Li, Jia-Jia Chen, Chuan-Bo Yao, Hong-Bin Yang, Shu-Xia Jiang, Guo-Quan Yan, Di Wang, Yi Wang, Ying Liu, Zongwei Cai, Ying-Ying Xu, Jing Chen, Wenqiang Yu, Peng-Yuan Yang and Qun-Ying Lei
http://www.nature.com/ncomms/2016/160630/ncomms11960/full/ncomms11960.html

TAK1 regulates hepatic lipid homeostasis through SREBP
S Morioka, K Sai, E Omori, Y Ikeda, K Matsumoto and J Ninomiya-Tsuji
http://www.nature.com/onc/journal/v35/n29/abs/onc2015453a.html

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Glutamine metabolism
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Glutamine Metabolism Regulates the Pluripotency Transcription Factor OCT4
Glenn Marsboom, Guo-Fang Zhang, Nicole Pohl-Avila, Yanmin Zhang, Yang Yuan, Hojin Kang, Bo Hao, Henri Brunengraber, Asrar B. Malik, Jalees Rehman
http://www.cell.com/cell-reports/abstract/S2211-1247(16)30702-1

Targeting glutamine metabolism in multiple myeloma enhances BIM binding to BCL-2 eliciting synthetic lethality to venetoclax
R Bajpai, S M Matulis, C Wei, A K Nooka, H E Von Hollen, S Lonial, L H Boise and M Shanmugam
http://www.nature.com/onc/journal/v35/n30/abs/onc2015464a.html

Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target
Marina Bolzoni, Martina Chiu, Fabrizio Accardi, Rosanna Vescovini, Irma Airoldi, Paola Storti, Katia Todoerti, Luca Agnelli, Gabriele Missale, Roberta Andreoli, Massimiliano G. Bianchi, Manfredi Allegri, Amelia Barilli, Francesco Nicolini, Albertina Cavalli, Federica Costa, Valentina Marchica, Denise Toscani, Cristina Mancini, Eugenia Martella, Valeria Dall’Asta, Gaetano Donofrio, Franco Aversa, Ovidio Bussolati, and Nicola Giuliani
http://bloodjournal.org/content/128/5/667.abstract?etoc

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Nucleotides, mitochondrial metabolism
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Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion
Ashish Juvekar, Hai Hu, Sina Yadegarynia, Costas A. Lyssiotis, Soumya Ullas, Evan C. Lien, Gary Bellinger, Jaekyoung Son, Rosanna C. Hok, Pankaj Seth, Michele B. Daly, Baek Kim, Ralph Scully, John M. Asara, Lewis C. Cantley, and Gerburg M. Wulf
http://www.pnas.org/content/113/30/E4338.abstract.html?etoc

Structure of a Complete ATP Synthase Dimer Reveals the Molecular Basis of Inner Mitochondrial Membrane Morphology
Alexander Hahn, Kristian Parey, Maike Bublitz, Deryck J. Mills, Volker Zickermann, Janet Vonck, Werner Kühlbrandt, Thomas Meier
http://www.cell.com/molecular-cell/abstract/S1097-2765(16)30223-4

ATP/ADP Turnover and Import of Glycolytic ATP into Mitochondria in Cancer Cells is Independent of the Adenine Nucleotide Translocator
Eduardo N. Maldonado, David N. DeHart, Jyoti Patnaik, Sandra C. Klatt, Monika Beck Gooz, and John J. Lemasters
http://www.jbc.org/content/early/2016/07/25/jbc.M116.734814.abstract

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Hypoxia
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PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia
Robert S. Banh, Caterina Iorio, Richard Marcotte, Yang Xu, Dan Cojocari,Anas Abdel Rahman, Judy Pawling, Wei Zhang, Ankit Sinha, Christopher M. Rose, Marta Isasa, Shuang Zhang, Ronald Wu, Carl Virtanen, Toshiaki Hitomi, Toshiyuki Habu, Sachdev S. Sidhu, Akio Koizumi, Sarah E. Wilkins, Thomas Kislinger, Steven P. Gygi, Christopher J. Schofield, James W. Dennis, Bradly G. Wouters & Benjamin G. Neel
http://www.nature.com/ncb/journal/v18/n7/full/ncb3376.html

FUNDC1 regulates mitochondrial dynamics at the ER–mitochondrial contact site under hypoxic conditions
Wenxian Wu, Chunxia Lin, Keng Wu, Lei Jiang, Xiaojing Wang, Wen Li, Haixia Zhuang, Xingliang Zhang, Hao Chen, Shupeng Li, Yue Yang, Yue Lu, Jingjing Wang, Runzhi Zhu, Liangqing Zhang, Senfang Sui, Ning Tan, Bin Zhao, Jingjing Zhang, Longxuan Li, and Du Feng
http://EMBOJ.embopress.org/content/35/13/1368?etoc

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Starvation / nutrient sensing
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Mechanism of arginine sensing by CASTOR1 upstream of mTORC1
Robert A. Saxton, Lynne Chantranupong, Kevin E. Knockenhauer, Thomas U. Schwartz, David M. Sabatini
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature19079.html

The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis
Jae Ho Seo, Dayana B. Rivadeneira, M. Cecilia Caino, Young Chan Chae, David W. Speicher, Hsin-Yao Tang, Valentina Vaira, Silvano Bosari, Alessandro Palleschi, Paolo Rampini, Andrew V. Kossenkov, Lucia R. Languino, Dario C. Altieri
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002507

Changes in O-GlcNAc homeostasis activate the p53 pathway in ovarian cancer cells
Rafaela Muniz de Queiroz, Rashna Madan, Jeremy Chien, Wagner Barbosa Dias, and Chad Slawson
http://www.jbc.org/content/early/2016/07/11/jbc.M116.734533.abstract

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AMPK/mTOR
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AMP-activated protein kinase upregulates MAP kinase interacting serine/threonine kinase 1a-dependent phosphorylation of eukaryotic translation initiation factor 4E
Xiaoqing Zhu, Vivian Dahlmans, Ramon Thali, Christian Preisinger, Benoit Viollet, J. Willem Voncken, and Dietbert Neumann
http://www.jbc.org/content/early/2016/07/13/jbc.C116.740498.abstract

Structure of the Tuberous Sclerosis Complex 2 (TSC2) N-terminus Provides Insight into Complex Assembly and Tuberous Sclerosis Pathogenesis
Reinhard Zech, Stephan Kiontke, Uwe Mueller, Andrea Oeckinghaus, and Daniel Kümmel
http://www.jbc.org/content/early/2016/08/04/jbc.M116.732446.abstract

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Miscellaneous
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Glycolytic regulation of cell rearrangement in angiogenesis
Bert Cruys, Brian W. Wong, Anna Kuchnio, Dries Verdegem, Anna Rita Cantelmo, Lena-Christin Conradi, Saar Vandekeere, Ann Bouché, Ivo Cornelissen, Stefan Vinckier, Roeland M. H. Merks, Elisabetta Dejana, Holger Gerhardt, Mieke Dewerchin, Katie Bentley and Peter Carmeliet
http://www.nature.com/ncomms/2016/160720/ncomms12240/full/ncomms12240.html

Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche
Haobin Ye, Biniam Adane, Nabilah Khan, Timothy Sullivan, Mohammad Minhajuddin, Maura Gasparetto, Brett Stevens, Shanshan Pei, Marlene Balys, John M. Ashton, Dwight J. Klemm, Carolien M. Woolthuis, Alec W. Stranahan, Christopher Y. Park, Craig T. Jordan
http://www.cell.com/cell-stem-cell/fulltext/S1934-5909(16)30151-5

Deciphering the Duality of Clock and Growth Metabolism in a Cell Autonomous System Using NMR Profiling of the Secretome
Arjun Sengupta, Saikumari Y. Krishnaiah , Seth Rhoades , Jacqueline Growe , Barry Slaff , Anand Venkataraman, Anthony O. Olarerin-George , Chi Van Dang , John B. Hogenesch  and Aalim M. Weljie
http://www.mdpi.com/2218-1989/6/3/23

NHX-5, an endosomal Na+/H+ exchanger, is associated with metformin action
Jeongho Kim, Hye-Yeon Lee, Jheesoo Ahn, Moonjung Hyun, Inhwan Lee, Kyung-Jin Min, and Young-Jai You
http://www.jbc.org/content/early/2016/07/19/jbc.C116.744037.abstract

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Reviews
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Mitochondria and Cancer
Sejal Vyas, Elma Zaganjor, Marcia C. Haigis
http://www.cell.com/cell/abstract/S0092-8674(16)30908-4

Role of chaperone-mediated autophagy in metabolism
Inmaculada Tasset and Ana Maria Cuervo
http://onlinelibrary.wiley.com/doi/10.1111/febs.13677/abstract

Glutaminolysis as a target for cancer therapy
L Jin, G N Alesi and S Kang
http://www.nature.com/onc/journal/v35/n28/abs/onc2015447a.html

Revisiting autophagy addiction of tumor cells
Beat Nyfeler & Christina H. Eng
http://www.tandfonline.com/doi/full/10.1080/15548627.2016.1170265

How does metabolism affect cell death in cancer?
Elodie Villa, Jean‐Ehrland Ricci
http://onlinelibrary.wiley.com/doi/10.1111/febs.13570/abstract

Novel drugs that target the metabolic reprogramming in renal cell cancer
van der Mijn  J, Panka  D, Geissler  A, Verheul  H, Mier  J
http://www.cancerandmetabolism.com/content/4/1/14/abstract

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Comments
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Metabolism: A new layer of glycolysis
Maria V Liberti & Jason W Locasale
http://www.nature.com/nchembio/journal/v12/n8/full/nchembio.2133.html

A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase
Edouard Mullarky, Luke L. Lairson, Lewis C. Cantley & Costas A. Lyssiotis
http://www.tandfonline.com/doi/full/10.1080/23723556.2016.1164280

Co-activation of AMPK and mTORC1 as a new therapeutic option for acute myeloid leukemia
Pierre Sujobert & Jerome Tamburini
http://www.tandfonline.com/doi/full/10.1080/23723556.2015.1071303

Cell biology: The TORC1 pathway to protein destruction
Lynne Chantranupong& David M. Sabatini
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature18919.html

The interplay between lnRNAs, SNPs, and protein complexes – what does it mean for cancer metabolism?
Roxana S. Redis & George A. Calin
http://www.tandfonline.com/doi/full/10.1080/23723556.2016.1166308

InsP3R, the calcium whisperer: Maintaining mitochondrial function in cancer
Alenka Lovy, J. Kevin Foskett & César Cárdenas
http://www.tandfonline.com/doi/full/10.1080/23723556.2016.1185563

A link between TP53 polymorphisms and metabolism
Che-Pei Kung, Subhasree Basu & Maureen E. Murphy
http://www.tandfonline.com/doi/full/10.1080/23723556.2016.1173769

Releasing glutamate to stabilize HIF-1α
http://stke.sciencemag.org/content/9/436/ec158

Another mTOR complex?
http://stke.sciencemag.org/content/9/436/ec160

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