MetaboList – August 2016

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Metabolism and the stroma
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Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion
Cristovão M. Sousa, Douglas E. Biancur, Xiaoxu Wang, Christopher J. Halbrook, Mara H. Sherman, Li Zhang, Daniel Kremer, Rosa F. Hwang, Agnes K. Witkiewicz, Haoqiang Ying, John M. Asara, Ronald M. Evans, Lewis C. Cantley, Costas A. Lyssiotis, Alec C. Kimmelman
http://www.nature.com/nature/journal/v536/n7617/full/nature19084.html

Salt-Inducible Kinase 2 Couples Ovarian Cancer Cell Metabolism with Survival at the Adipocyte-Rich Metastatic Niche
Fabrizio Miranda, David Mannion, Shujuan Liu, Yiyan Zheng, Lingegowda S. Mangala, Clara Redondo, Sandra Herrero-Gonzalez, Ruoyan Xu, Charlotte Taylor, Donatien Fotso Chedom, Mohammad Karaminejadranjbar, Ashwag Albukhari, Dahai Jiang, Sunila Pradeep, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Eidarus Salah, Kamal R. Abdul Azeez, Jonathan M. Elkins, Leticia Campo, Kevin A. Myers, Daniel Klotz, Serena Bivona, Sunanda Dhar, Robert C. Bast Jr., Hideyuki Saya, Hwan Geun Choi, Nathanael S. Gray, Roman Fischer, Benedikt M. Kessler, Christopher Yau, Anil K. Sood, Takeshi Motohara, Stefan Knapp, Ahmed Ashour Ahmed
http://www.cell.com/cancer-cell/fulltext/S1535-6108(16)30280-X

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Glycolysis and glycosylation
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Regulation of OGT by URI in Response to Glucose Confers c-MYC-Dependent Survival Mechanisms
Stefan Burén, Ana L. Gomes, Ana Teijeiro, Mohamad-Ali Fawal, Mahmut Yilmaz, Krishna S. Tummala, Manuel Perez, Manuel Rodriguez-Justo, Ramón Campos-Olivas, Diego Megías, Nabil Djouder
http://www.cell.com/cancer-cell/fulltext/S1535-6108(16)30283-5

PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis
Ji Liang, Ruixiu Cao, Yajuan Zhang, Yan Xia, Yanhua Zheng, Xinjian Li, Liwei Wang, Weiwei Yang and Zhimin Lu
http://www.nature.com/articles/ncomms12431

A key role for transketolase-like 1 in tumor metabolic reprogramming
Santiago Diaz-Moralli, Esther Aguilar, Silvia Marin, Johannes F. Coy, Mieke Dewerchin, Maciek R. Antoniewicz, Oscar Meca-Cortés, Leen Notebaert, Bart Ghesquière, Guy Eelen, Timothy M. Thomson, Peter Carmeliet,  and  Marta Cascante
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=10429

PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma
Sameer Agnihotri, Brian Golbourn, Xi Huang, Marc Remke, Susan Younger, Rob A. Cairns, Alan Chalil, Christian A. Smith, Stacey-Lynn Krumholtz, Danielle Mackenzie, Patricia Rakopoulos, Vijay Ramaswamy, Michael S. Taccone, Paul S. Mischel, Gregory N. Fuller, Cynthia Hawkins, William L. Stanford, Michael D. Taylor, Gelareh Zadeh, and James T. Rutka
http://cancerres.aacrjournals.org/content/76/16/4708.abstract?etoc

LncRNA‐MIF, a c‐Myc‐activated long non‐coding RNA, suppresses glycolysis by promoting Fbxw7‐mediated c‐Myc degradation
Pengfei Zhang, Limian Cao, Pingsheng Fan, Yide Mei, and Mian Wu
http://EMBOr.embopress.org/content/17/8/1204?etoc

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Amino acid transport and metabolism
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Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth
Yann Cormerais, Sandy Giuliano, Renaud LeFloch, Benoît Front, Jerome Durivault, Eric Tambutté, Pierre-André Massard, Laura Rodriguez de la Ballina, Hitoshi Endou, Michael F. Wempe, Manuel Palacin, Scott K. Parks,and Jacques Pouyssegur
http://cancerres.aacrjournals.org/content/76/15/4481.abstract?etoc

Characterization of Human and Yeast Mitochondrial Glycine Carriers with Implications for Heme Biosynthesis and Anemia
Paola Lunetti, Fabrizio Damiano, Giuseppe De Benedetto, Luisa Siculella, Antonio Pennetta, Luigina Muto, Eleonora Paradies, Carlo Marya Thomas Marobbio, Vincenza Dolce, and Loredana Capobianco
http://www.jbc.org/content/early/2016/07/30/jbc.M116.736876.abstract

Mechanistic Basis of Glutaminase Activation: A Key Enzyme that Promotes Glutamine Metabolism in Cancer Cells
Yunxing Li, Jon W. Erickson, Clint A. Stalnecker, William P. Katt, Qingqiu Huang, Richard A. Cerione, and Sekar Ramachandran
http://www.jbc.org/content/early/2016/08/19/jbc.M116.720268.abstract

Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1
Matthew Locke, Essam Ghazaly, Marta O. Freitas, Mikaella Mitsinga, Laura Lattanzio, Cristiana Lo Nigro, Ai Nagano, Jun Wang, Claude Chelala, Peter Szlosarek, Sarah A. Martin
http://www.cell.com/cell-reports/abstract/S2211-1247(16)30866-X

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Lipid metabolism
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Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis
Mahesh S. Padanad, Georgia Konstantinidou, Niranjan Venkateswaran, Margherita Melegari, Smita Rindhe, Matthew Mitsche, Chendong Yang, Kimberly Batten, Kenneth E. Huffman, Jingwen Liu, Ximing Tang, Jaime Rodriguez-Canales, Neda Kalhor, Jerry W. Shay, John D. Minna, Jeffrey McDonald, Ignacio I. Wistuba, Ralph J. DeBerardinis, Pier Paolo Scaglioni
http://www.cell.com/cell-reports/abstract/S2211-1247(16)30895-6

Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer
Zoe Hall, Zsuzsanna Ament, Catherine H. Wilson, Deborah L. Burkhart, Tom Ashmore, Albert Koulman, Trevor Littlewood, Gerard I. Evan, and Julian L. Griffin
http://cancerres.aacrjournals.org/content/76/16/4608.abstract?etoc

Oncoprotein HBXIP Modulates Abnormal Lipid Metabolism and Growth of Breast Cancer Cells by Activating the LXRs/SREBP-1c/FAS Signaling Cascade
Yu Zhao, Hang Li, Yingyi Zhang, Leilei Li, Runping Fang, Yinghui Li, Qian Liu, Weiying Zhang, Liyan Qiu, Fabao Liu, Xiaodong Zhang, and Lihong Ye
http://cancerres.aacrjournals.org/content/76/16/4696.abstract?etoc

Acidosis Drives the Reprogramming of Fatty Acid Metabolism in Cancer Cells through Changes in Mitochondrial and Histone Acetylation
Cyril Corbet, Adán Pinto, Ruben Martherus, João Pedro Santiago de Jesus, Florence Polet, Olivier Feron
http://www.cell.com/cell-metabolism/abstract/S1550-4131(16)30348-5

Cholesterol Metabolism and Prostate Cancer Lethality
Konrad H. Stopsack, Travis A. Gerke, Jennifer A. Sinnott, Kathryn L. Penney, Svitlana Tyekucheva, Howard D. Sesso, Swen-Olof Andersson, Ove Andrén, James R. Cerhan, Edward L. Giovannucci, Lorelei A. Mucci, and Jennifer R. Rider
http://cancerres.aacrjournals.org/content/76/16/4785.abstract?etoc

Torsins Are Essential Regulators of Cellular Lipid Metabolism
Micheline Grillet, Beatriz Dominguez Gonzalez, Adria Sicart, Maria Pöttler, Ana Cascalho, Karolien Billion, Sergio Hernandez Diaz, Jef Swerts, Teresa V. Naismith, Natalia V. Gounko, Patrik Verstreken, Phyllis I. Hanson, Rose E. Goodchild
http://www.cell.com/developmental-cell/fulltext/S1534-5807(16)30420-8

Glucose-independent acetate metabolism promotes melanoma cell survival and tumor growth
Alexander J. Lakhter, James Hamilton, Raymond L. Konger, Nickolay Brustovetsky, Hal E. Broxmeyer, and Samisubbu R. Naidu
http://www.jbc.org/content/early/2016/08/18/jbc.M115.712166.abstract

Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells
M A King, I G Ganley and V Flemington
http://www.nature.com/onc/journal/v35/n34/abs/onc2015511a.html

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Mitochondrial metabolism, nucleotides
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Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism
Walter W. Chen, Elizaveta Freinkman, Tim Wang, Kıvanç Birsoy, David M. Sabatini
http://www.cell.com/cell/fulltext/S0092-8674(16)30990-4

Structure of mammalian respiratory complex I
Jiapeng Zhu, Kutti R. Vinothkumar, Judy Hirst
http://www.nature.com/nature/journal/v536/n7616/full/nature19095.html

Therapeutic strategy for targeting aggressive malignant gliomas by disrupting their energy balance
Ahmed M. Hegazy, Daisuke Yamada, Masahiko Kobayashi, Susumu Kohno, Masaya Ueno, Mohamed A.E. Ali, Kumiko Ohta, Yuko Tadokoro, Yasushi Ino, Tomoki Todo, Tomoyoshi Soga, Chiaki Takahashi, and Atsushi Hirao
http://www.jbc.org/content/early/2016/08/11/jbc.M116.734756.abstract

Autophagy provides metabolic substrates to maintain energy charge and nucleotide  pools in Ras-driven lung cancer cells
Jessie Yanxiang Guo, Xin Teng, Saurabh V. Laddha, Sirui Ma, Stephen C. Van Nostrand, Yang Yang, Sinan Khor, Chang S. Chan, Joshua D. Rabinowitz, and Eileen White
http://genesdev.cshlp.org/content/30/15/1704.abstract?etoc

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Hypoxia
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Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche
David Clever, Rahul Roychoudhuri, Michael G. Constantinides, Michael H. Askenase, Madhusudhanan Sukumar, Christopher A. Klebanoff, Robert L. Eil, Heather D. Hickman, Zhiya Yu, Jenny H. Pan, Douglas C. Palmer, Anthony T. Phan, John Goulding, Luca Gattinoni, Ananda W. Goldrath, Yasmine Belkaid, Nicholas P. Restifo
http://www.cell.com/cell/abstract/S0092-8674(16)30982-5

Tumour hypoxia causes DNA hypermethylation by reducing TET activity
Bernard Thienpont, Jessica Steinbacher, Hui Zhao, Flora D’Anna, Anna Kuchnio, Athanasios Ploumakis, Bart Ghesquière, Laurien Van Dyck, Bram Boeckx, Luc Schoonjans, Els Hermans, Frederic Amant,  Vessela N. Kristensen, Kian Peng Koh8, Massimiliano Mazzone,  Mathew L. Coleman, Thomas Carell, Peter Carmeliet,  Diether Lambrechts
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature19081.html

pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
Jianping Guo,  Abhishek A. Chakraborty, Pengda Liu, Wenjian Gan, Xingnan Zheng, Hiroyuki Inuzuka, Bin Wang, Jinfang Zhang, Linli Zhang, Min Yuan, Jesse Novak, Jin Q. Cheng, Alex Toker, Sabina Signoretti, Qing Zhang, John M. Asara, William G. Kaelin Jr, Wenyi Wei
http://science.sciencemag.org/content/353/6302/929

Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming
Young Chan Chae, Valentina Vaira, M. Cecilia Caino, Hsin-Yao Tang, Jae Ho Seo, Andrew V. Kossenkov, Luisa Ottobrini, Cristina Martelli, Giovanni Lucignani, Irene Bertolini, Marco Locatelli, Kelly G. Bryant, Jagadish C. Ghosh, Sofia Lisanti, Bonsu Ku, Silvano Bosari, Lucia R. Languino, David W. Speicher, Dario C. Altieri
http://www.cell.com/cancer-cell/fulltext/S1535-6108(16)30335-X

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
Mun Chiang Chan, Nicholas E. Ilott, Johannes Schödel, David Sims, Anthony Tumber, Kerstin Lippl, David R. Mole, Christopher W. Pugh, Peter John Ratcliffe, Chris P. Ponting, and Christopher J. Schofield
http://www.jbc.org/content/early/2016/08/08/jbc.M116.749291.abstract

Metastasis Stimulation by Hypoxia and Acidosis-Induced Extracellular Lipid Uptake Is Mediated by Proteoglycan-Dependent Endocytosis
Julien A. Menard, Helena C. Christianson, Paulina Kucharzewska, Erika Bourseau-Guilmain, Katrin J. Svensson, Eva Lindqvist, Vineesh Indira Chandran, Lena Kjellén, Charlotte Welinder, Johan Bengzon, Maria C. Johansson, and Mattias Belting
http://cancerres.aacrjournals.org/content/76/16/4828.abstract?etoc

The Breast Cancer Tumor Suppressor TRIM29 is Expressed via ATM-Dependent Signaling in Response to Hypoxia
Muzaffer Dükel, W. Scott Streitfeld, Tsz Ching Chloe Tang, Lindsey R. F. Backman, Lingbao Ai, W. Stratford May, and Kevin D. Brown
http://www.jbc.org/content/early/2016/08/17/jbc.M116.730960.abstract

Hypoxia and Transforming Growth Factor Beta Cooperate to Induce Fibulin-5 Expression in Pancreatic Cancer
Mary Topalovski, Michelle Hagopian, Miao Wang, and Rolf A. Brekken
http://www.jbc.org/content/early/2016/08/16/jbc.M116.730945.abstract

Vascular Endothelial Cell Growth Factor A Acts via Platelet-Derived
Growth Factor Receptor α To Promote Viability of Cells Enduring Hypoxia
Steven Pennock, Leo A. Kim, and Andrius Kazlauskas
http://mcb.asm.org/content/36/18/2314.abstract?etoc

The Zinc Finger of Prolyl Hydroxylase Domain Protein 2 Is Essential for Efficient Hydroxylation of Hypoxia-Inducible Factor α
Patrick R. Arsenault, Daisheng Song, Yu Jin Chung, Tejvir S. Khurana, andFrank S. Lee
http://mcb.asm.org/content/36/18/2328.abstract?etoc

Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression
R Rupaimoole, C Ivan, D Yang, K M Gharpure, S Y Wu, C V Pecot, R A Previs, A S Nagaraja, G N Armaiz-Pena, M McGuire, S Pradeep, L S Mangala, C Rodriguez-Aguayo, L Huang, M Bar-Eli, W Zhang, G Lopez-Berestein, G A Calin and A K Sood
http://www.nature.com/onc/journal/v35/n33/abs/onc2015492a.html

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IDH and 2-HG
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Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2
Satoshi Inoue, Wanda Y. Li, Alan Tseng, Isabel Beerman, Andrew J. Elia, Sean C. Bendall, François Lemonnier, Ken J. Kron, David W. Cescon, Zhenyue Hao, Evan F. Lind, Naoya Takayama, Aline C. Planello, Shu Yi Shen, Alan H. Shih, Dana M. Larsen, Qinxi Li, Bryan E. Snow, Andrew Wakeham, Jillian Haight, Chiara Gorrini, Christian Bassi, Kelsie L. Thu, Kiichi Murakami, Alisha R. Elford, Takeshi Ueda, Kimberly Straley, Katharine E. Yen, Gerry Melino, Luisa Cimmino, Iannis Aifantis, Ross L. Levine, Daniel D. De Carvalho, Mathieu Lupien, Derrick J. Rossi, Garry P. Nolan, Rob A. Cairns, Tak W. Mak
http://www.cell.com/cancer-cell/fulltext/S1535-6108(16)30223-9

Acidic pH is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling
Sergiy M. Nadtochiy, Xenia Schafer, Dragony Fu, Keith Nehrke, Joshua Munger, and Paul S. Brookes
http://www.jbc.org/content/early/2016/08/10/jbc.M116.738799.abstract

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AMPK/LKB1/mTOR
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PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition
Pau Castel, Haley Ellis, Ruzica Bago, Eneda Toska, Pedram Razavi, F. Javier Carmona, Srinivasaraghavan Kannan, Chandra S. Verma, Maura Dickler, Sarat Chandarlapaty, Edi Brogi, Dario R. Alessi, José Baselga, Maurizio Scaltriti
http://www.cell.com/cancer-cell/fulltext/S1535-6108(16)30264-1

mTORC1-Driven Tumor Cells Are Highly Sensitive to Therapeutic Targeting  by Antagonists of Oxidative Stress
Jing Li, Sejeong Shin, Yang Sun, Sang-Oh Yoon, Chenggang Li, Erik Zhang, Jane Yu, Jianming Zhang, and John Blenis
http://cancerres.aacrjournals.org/content/76/16/4816.abstract?etoc

Leucyl-tRNA Synthetase Activates Vps34 in Amino Acid-Sensing mTORC1 Signaling
Mee-Sup Yoon, Kook Son, Edwin Arauz, Jung Min Han, Sunghoon Kim, Jie Chen
http://www.cell.com/cell-reports/abstract/S2211-1247(16)30894-4

VPS34 regulates TSC1/TSC2 heterodimer to mediate RheB and mTORC1/S6K1 activation and cellular transformation
Nishant Mohan, Yi Shen, Milos Dokmanovic, Yukinori Endo, Dianne S. Hirsch,  and  Wen Jin Wu
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=10469

The miR-17∼92 microRNA Cluster Is a Global Regulator of Tumor Metabolism
Said Izreig, Bozena Samborska, Radia M. Johnson, Alexey Sergushichev, Eric H. Ma, Carine Lussier, Ekaterina Loginicheva, Ariel O. Donayo, Maya C. Poffenberger, Selena M. Sagan, Emma E. Vincent, Maxim N. Artyomov, Thomas F. Duchaine, Russell G. Jones
http://www.cell.com/cell-reports/abstract/S2211-1247(16)30954-8

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Miscellaneous
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A Transcript-Specific eIF3 Complex Mediates Global Translational Control of Energy Metabolism
Meera Shah, Dan Su, Judith S. Scheliga, Tomáš Pluskal, Susanna Boronat, Khatereh Motamedchaboki, Alexandre Rosa Campos, Feng Qi, Elena Hidalgo, Mitsuhiro Yanagida, Dieter A. Wolf
http://www.cell.com/cell-reports/abstract/S2211-1247(16)30892-0

Metabolic reprogramming during neuronal differentiation
M Agostini, F Romeo, S Inoue, M V Niklison-Chirou, A J Elia, D Dinsdale, N Morone, R A Knight, T W Mak and G Melino
http://www.nature.com/cdd/journal/v23/n9/abs/cdd201636a.html

Transforming Growth Factor β Mediates Drug Resistance by Regulating the Expression of Pyruvate Dehydrogenase Kinase 4 in Colorectal Cancer
Yang Zhang, Yi Zhang, Liying Geng, Haowei Yi, Wei Huo, Geoffrey Talmon, Yeong C. Kim, San Ming Wang, and Jing Wang
http://www.jbc.org/content/291/33/17405.abstract.html

Distinct Metabolic States Can Support Self-Renewal and Lipogenesis in Human Pluripotent Stem Cells under Different Culture Conditions
Hui Zhang, Mehmet G. Badur, Ajit S. Divakaruni, Seth J. Parker, Christian Jäger, Karsten Hiller, Anne N. Murphy, Christian M. Metallo
http://www.cell.com/cell-reports/abstract/S2211-1247(16)30871-3

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Reviews
—————

Cycling hypoxia: A key feature of the tumor microenvironment
Carine Michiels, Céline Tellier, Olivier Feron
http://www.sciencedirect.com/science/article/pii/S0304419X16300440

Lipid desaturation – the next step in targeting lipogenesis in cancer?
Barrie Peck and Almut Schulze
http://onlinelibrary.wiley.com/doi/10.1111/febs.13681/abstract

AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours
Fiona A. Ross, Carol MacKintosh and D. Grahame Hardie
http://onlinelibrary.wiley.com/doi/10.1111/febs.13698/abstract

Special issue – Biochimica et Biophysica Acta (BBA) – Molecular Cell Research:
http://www.sciencedirect.com/science/journal/01674889/1863/10
Channels and transporters in cell metabolism
Pierre Sonveaux, Pierre Maechler, Jean-Claude Martinou
http://www.sciencedirect.com/science/article/pii/S0167488916301707

Including for instance:
– The mitochondrial pyruvate carrier in health and disease: To carry or not to carry?
Tom Bender, Jean-Claude Martinou
– Na+/H+ antiporter (NHE1) and lactate/H+ symporters (MCTs) in pH homeostasis and cancer metabolism
Laurent Counillon, Yann Bouret, Ibtissam Marchiq, Jacques Pouysségur
– Monocarboxylate transporters in the brain and in cancer
Jhudit Pérez-Escuredo, Vincent F. Van Hée, Martina Sboarina, Jorge Falces, Valéry L. Payen, Luc Pellerin, Pierre Sonveaux
– Glutamine transporters in mammalian cells and their functions in physiology and cancer
Yangzom D. Bhutia, Vadivel Ganapathy

Glycolysis inhibition as a cancers treatment and its role in an anti-tumour immune response
Kheshwant S. Gill, Philana Fernandes, Tracey R. O’Donovan, Sharon L. McKenna, Kishore K. Doddakula, Derek G. Power, Declan M. Soden, Patrick F. Forde
http://www.sciencedirect.com/science/article/pii/S0304419X16300452#cr0005

N-acetylgalactosaminyltransferases in cancer
Muhammad Ramzan Manwar Hussain, Daniel C. Hoessli and Min Fang
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=10042

Metabolic reprogramming: a hallmark of viral oncogenesis
P Lévy and B Bartosch
http://www.nature.com/onc/journal/v35/n32/abs/onc2015479a.html

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Comments / correspondence
———————————————–

Cancer metabolism: Friendly neighbours feed tumour cells
Jurre J. Kamphorst & Eyal Gottlieb
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature19420.html?WT.ec_id=NATURE-20160811&spMailingID=52032459&spUserID=MjA1NTQwMzgxNgS2&spJobID=981769299&spReportId=OTgxNzY5Mjk5S0

Measuring the Ability of Mice to Sense Dietary Essential Amino Acid Deficiency: The Importance of Amino Acid Status and Timing
Dorothy W. Gietzen, Tracy G. Anthony, Pierre Fafournoux, Anne-Catherine Maurin, Thomas J. Koehnle, Susan Hao
http://www.cell.com/cell-reports/fulltext/S2211-1247(16)31068-3?

Rapid Sensing of Dietary Amino Acid Deficiency Does Not Require GCN2
David E. Leib, Zachary A. Knight
http://www.cell.com/cell-reports/fulltext/S2211-1247(16)31067-1

The Whole (Cell) Is Less Than the Sum of Its Parts
Jonathan G. Van Vranken, Jared Rutter
http://www.cell.com/cell/abstract/S0092-8674(16)31060-1

Stromal–cancer cell crosstalk supports tumour metabolism
Iain Dickson
http://www.nature.com/nrgastro/journal/vaop/ncurrent/full/nrgastro.2016.137.html

Translation Factors Specify Cellular Metabolic State
Juan Mata
http://www.cell.com/cell-reports/abstract/S2211-1247(16)31011-7

Cancer: Suffocation of gene expression
Dan Ye, Yue Xiong
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature19426.html

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