MetaboList – September 2016

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Cancer Metabolism
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Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
Marco Sciacovelli, Emanuel Gonçalves, Timothy Isaac Johnson, Vincent Roberto Zecchini, Ana Sofia Henriques da Costa, Edoardo Gaude, Alizee Vercauteren Drubbel, Sebastian Julian Theobald, Sandra Riekje Abbo, Maxine Gia Binh Tran, Vinothini Rajeeve, Simone Cardaci, Sarah Foster, Haiyang Yun, Pedro Cutillas, Anne Warren, Vincent Gnanapragasam, Eyal Gottlieb, Kristian Franze, Brian Huntly, Eamonn Richard Maher, Patrick Henry Maxwell, Julio Saez-Rodriguez, Christian Frezza
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature19353.html

Copy Number Alterations in Enzyme-Coding and Cancer-Causing Genes Reprogram Tumor Metabolism
Ashwini Kumar Sharma, Roland Eils, and Rainer König
http://cancerres.aacrjournals.org/content/76/14/4058.abstract?etoc

Metabolic requirements for cancer cell proliferation
Keibler M, Wasylenko T, Kelleher J, Iliopoulos O, Vander Heiden M, Stephanopoulos G
http://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-016-0156-6#Abs1

New insight into the role of metabolic reprogramming in melanoma cells harboring BRAF mutations
Anna Ferretta, Immacolata Maida, Stefania Guida, Amalia Azzariti, Letizia Porcelli, Stefania Tommasi, Paola Zanna, Tiziana Cocco, Michele Guida, Gabriella Guida
http://www.sciencedirect.com/science/article/pii/S0167488916302129

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Glycolysis and lactate
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Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer
Lucie Brisson, Piotr Bański, Martina Sboarina, Coralie Dethier, Pierre Danhier, Marie-Joséphine Fontenille, Vincent F. Van Hée, Thibaut Vazeille, Morgane Tardy, Jorge Falces, Caroline Bouzin, Paolo E. Porporato, Raphaël Frédérick, Carine Michiels, Tamara Copetti, Pierre Sonveaux
http://www.cell.com/cancer-cell/abstract/S1535-6108(16)30390-7

Upregulated Glucose Metabolism Correlates Inversely with CD8^+ T-cell Infiltration and Survival in Squamous Cell Carcinoma
Christian H. Ottensmeier, Kate L. Perry, Elena L. Harden, Jana Stasakova, Veronika Jenei, Jason Fleming, Oliver Wood, Jeongmin Woo, Christopher H. Woelk, Gareth J. Thomas, and Stephen M. Thirdborough
http://cancerres.aacrjournals.org/content/76/14/4136.abstract?etoc

Definition of a Novel Feed-Forward Mechanism for Glycolysis-HIF1α Signaling in Hypoxic Tumors Highlights Aldolase A as a Therapeutic Target
Geoffrey Grandjean, Petrus R. de Jong, Brian P. James, Mei Yee Koh, Robert Lemos, John Kingston, Alexander Aleshin, Laurie A. Bankston, Claudia P. Miller, Eun Jeong Cho, Ramakrishna Edupuganti, Ashwini Devkota, Gabriel Stancu, Robert C. Liddington, Kevin N. Dalby, and Garth Powis
http://cancerres.aacrjournals.org/content/76/14/4259.abstract?etoc

KDM4A Coactivates E2F1 to Regulate the PDK-Dependent Metabolic Switch between Mitochondrial Oxidation and Glycolysis
Ling-Yu Wang, Chiu-Lien Hung, Yun-Ru Chen, Joy C. Yang, Junjian Wang, Mel Campbell, Yoshihiro Izumiya, Hong-Wu Chen, Wen-Ching Wang, David K. Ann, Hsing-Jien Kung
http://www.cell.com/cell-reports/fulltext/S2211-1247(16)31064-6

Lactate/pyruvate transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancer
Sprowl-Tanio S, Habowski A, Pate K, McQuade M, Wang K, Edwards R, Grun F, Lyou Y, Waterman M
http://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-016-0159-3#Abs1

In vivo genetic dissection of tumor growth and the warburg effect
Cheng-Wei Wang, Arunima Purkayastha, Kevin T Jones, Shivani K Thaker and Utpal Banerjee
https://elifesciences.org/content/5/e18126

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Amino acid depletion
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Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers
Jared R. Mayers , Margaret E. Torrence, Laura V. Danai, Thales Papagiannakopoulos, Shawn M. Davidson, Matthew R. Bauer, Allison N. Lau, Brian W. Ji, Purushottam D. Dixit, Aaron M. Hosios, Alexander Muir, Christopher R. Chin, Elizaveta Freinkman, Tyler Jacks, Brian M. Wolpin, Dennis Vitkup, Matthew G. Vander Heiden
http://science.sciencemag.org/content/353/6304/1161

Proline Starvation Induces Unresolved ER Stress and Hinders mTORC1-Dependent Tumorigenesis
Nisebita Sahu, Darlene Dela Cruz, Min Gao, Wendy Sandoval, Peter M. Haverty, Jinfeng Liu, Jean-Philippe Stephan, Benjamin Haley, Marie Classon, Georgia Hatzivassiliou, Jeff Settleman
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30424-7

IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3
Michael A. Reid, Xazmin H. Lowman, Min Pan, Thai Q. Tran, Marc O. Warmoes, Mari B. Ishak Gabra, Ying Yang, Jason W. Locasale, and Mei Kong
http://genesdev.cshlp.org/content/30/16/1837.abstract?etoc

Leucine deprivation inhibits proliferation and induces apoptosis of human breast cancer cells via fatty acid synthase
Fei Xiao, Chunxia Wang, Hongkun Yin, Junjie Yu, Shanghai Chen, Jing Fang,  and  Feifan Guo
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=11626

Glucose-dependent anaplerosis in cancer cells is required for cellular redox balance in the absence of glutamine
Naniye Mallı Cetinbas, Jessica Sudderth, Robert C. Harris, Aysun Cebeci, Gian L. Negri, Ömer H. Yılmaz, Ralph J. DeBerardinis & Poul H. Sorensen
http://www.nature.com/articles/srep32606

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Fatty acid metabolism
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PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2
Natalie J. German, Haejin Yoon, Rushdia Z. Yusuf, J. Patrick Murphy, Lydia W.S. Finley, Gaëlle Laurent, Wilhelm Haas, F. Kyle Satterstrom, Jlenia Guarnerio, Elma Zaganjor, Daniel Santos, Pier Paolo Pandolfi, Andrew H. Beck, Steven P. Gygi, David T. Scadden, William G. Kaelin Jr., Marcia C. Haigis
http://www.cell.com/molecular-cell/abstract/S1097-2765(16)30428-2

Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response
Hyun-Eui Kim, Ana Rodrigues Grant, Milos S. Simic, Rebecca A. Kohnz, Daniel K. Nomura, Jenni Durieux, Celine E. Riera, Melissa Sanchez, Erik Kapernick, Suzanne Wolff, Andrew Dillin
http://www.cell.com/cell/fulltext/S0092-8674(16)31078-9

Adipocyte Exosomes Promote Melanoma Aggressiveness through Fatty Acid Oxidation: A Novel Mechanism Linking Obesity and Cancer
Ikrame Lazar, Emily Clement, Stéphanie Dauvillier, Delphine Milhas, Manuelle Ducoux-Petit, Sophie LeGonidec, Cédric Moro, Vanessa Soldan, Stéphane Dalle, Stéphanie Balor, Muriel Golzio, Odile Burlet-Schiltz, Philippe Valet, Catherine Muller, and Laurence Nieto
http://cancerres.aacrjournals.org/content/76/14/4051.abstract?etoc

Cullin3–KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression
Cen Zhang, Juan Liu, Grace Huang, Yuhan Zhao, Xuetian Yue, Hao Wu, Jun Li, Junlan Zhu, Zhiyuan Shen, Bruce G. Haffty, Wenwei Hu, and Zhaohui Feng
http://genesdev.cshlp.org/content/30/17/1956.abstract?etoc

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Hypoxia/Ischemia
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Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
Rasheduzzaman Chowdhury, Ivanhoe K. H. Leung, Ya-Min Tian, Martine I. Abboud, Wei Ge, Carmen Domene, François-Xavier Cantrelle, Isabelle Landrieu, Adam P. Hardy, Christopher W. Pugh, Peter J. Ratcliffe, Timothy D. W. Claridge and Christopher J. Schofield
http://www.nature.com/ncomms/2016/160826/ncomms12673/full/ncomms12673.html

Tissue Stiffness and Hypoxia Modulate the Integrin-Linked Kinase ILK to Control Breast Cancer Stem-like Cells
Mei-Fong Pang, Michael J. Siedlik, Siyang Han, Melody Stallings-Mann, Derek C. Radisky, and Celeste M. Nelson
http://cancerres.aacrjournals.org/content/76/18/5277.abstract?etoc

Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism
Yunlong Yang, Yin Zhang, Hideki Iwamoto, Kayoko Hosaka, Takahiro Seki, Patrik Andersson, Sharon Lim, Carina Fischer, Masaki Nakamura, Mitsuhiko Abe, Renhai Cao, Peter Vilhelm Skov, Fang Chen, Xiaoyun Chen, Yongtian Lu, Guohui Nie and Yihai Cao
http://www.nature.com/ncomms/2016/160901/ncomms12680/full/ncomms12680.html

On-Target Efficacy of a HIF2α Antagonist in Preclinical Kidney Cancer Models
Hyejin Cho, Xinlin Du, James P. Rizzi, Ella Liberzon, Abhishek A. Chakraborty, Wenhua Gao, Ingrid Carvo, Sabina Signoretti, Richard Bruick, John A. Josey, Eli M. Wallace, William G. Kaelin Jr
http://www.nature.com/nature/journal/vaap/ncurrent/full/nature19795.html

Targeting Renal Cell Carcinoma with a HIF-2 antagonist
Wenfang Chen, Haley Hill, Alana Christie, Min Soo Kim, Eboni Holloman, Andrea Pavia-Jimenez, Farrah Homayoun, Yuanqing Ma, Nirav Patel1, 2, Paul Yell, Guiyang Hao, Qurratulain Yousuf, Allison Joyce, Ivan Pedrosa, Heather Geiger, He Zhang, Jenny Chang1, Kevin H. Gardner, Richard K. Bruick1, 9, Catherine Reeves, Tae Hyun Hwang, Kevin Courtney, Eugene Frenkel, Xiankai Sun, Naseem Zojwalla, Tai Wong, James P. Rizzi, Eli M. Wallace, John A. Josey10, Yang Xie, Xian-Jin Xie, Payal Kapur, Renée M. McKay, James Brugarolas
http://www.nature.com/nature/journal/vaap/ncurrent/full/nature19796.html

Differential regulation of LncRNA-SARCC suppresses VHL-mutant RCC cell proliferation yet promotes VHL-normal RCC cell proliferation via modulating androgen receptor/HIF-2α/C-MYC axis under hypoxia
W Zhai, Y Sun, M Jiang, M Wang, T A Gasiewicz, J Zheng and C Chang
http://www.nature.com/onc/journal/v35/n37/abs/onc201619a.html

SUMO Signaling by Hypoxic Inactivation of SUMO-Specific Isopeptidases
Kathrin Kunz, Kristina Wagner, Luca Mendler, Soraya Hölper, Nathalie Dehne, Stefan Müller
http://www.cell.com/cell-reports/fulltext/S2211-1247(16)31095-6

Hypoxia and MITF regulate KIT oncogenic properties in melanocytes
F Laugier, J Delyon, J André, A Bensussan and N Dumaz
http://www.nature.com/onc/journal/v35/n38/abs/onc201639a.html

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Nutrient sensing/metabolic stress
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PIKfyve Regulates Vacuole Maturation and Nutrient Recovery following Engulfment
Shefali Krishna, Wilhelm Palm, Yongchan Lee, Wendy Yang, Urmi Bandyopadhyay, Haoxing Xu, Oliver Florey, Craig B. Thompson, Michael Overholtzer
http://www.cell.com/developmental-cell/fulltext/S1534-5807(16)30552-4

Amino Acids Regulate mTORC1 by an Obligate Two-Step Mechanism
Julia Dyachok, Svetlana Earnest, Erica N. Iturraran, Melanie H. Cobb, and Elliott M. Ross
http://www.jbc.org/content/early/2016/09/01/jbc.M116.732511.abstract

Metabolic Stress-Induced Phosphorylation of KAP1 Ser473 Blocks Mitochondrial Fusion in Breast Cancer Cells
Chun-Ting Cheng, Ching-Ying Kuo, Ching Ouyang, Chien-Feng Li, Yiyin Chung, David C. Chan, Hsing-Jien Kung and David K. Ann
http://cancerres.aacrjournals.org/content/76/17/5006.abstract?etoc

Positive Allosteric Modulation of the Calcium-sensing Receptor by Physiological Concentrations of Glucose
Johan Medina, Yuko Nakagawa, Masahiro Nagasawa, Anny Fernandez, Kazushige Sakaguchi, Tesuya Kitaguchi, and Itaru Kojima
http://www.jbc.org/content/early/2016/09/09/jbc.M116.729863.abstract

AMPK regulates autophagy by phosphorylating BECN1 at threonine 388
Deyi Zhang, Wei Wang, Xiujie Sun, Daqian Xu, Chenyao Wang, Qian Zhang, Huafei Wang, Wenwen Luo, Yan Chen, Huaiyong Chen & Zhixue Liu
http://www.tandfonline.com/doi/full/10.1080/15548627.2016.1185576

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mTOR
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The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway
Mélissa Carbonneau, Laurence M. Gagné, Marie-Eve Lalonde, Marie-Anne Germain, Alena Motorina, Marie-Christine Guiot, Blandine Secco, Emma E. Vincent, Anthony Tumber, Laura Hulea, Jonathan Bergeman, Udo Oppermann, Russell G. Jones, Mathieu Laplante, Ivan Topisirovic, Kevin Petrecca, Marc-Étienne Huot and Frédérick A. Mallette
http://www.nature.com/articles/ncomms12700

The hVps34‐SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth
Ruzica Bago, Eeva Sommer, Pau Castel, Claire Crafter, Fiona P Bailey, Natalia Shpiro, José Baselga, Darren Cross, Patrick A Eyers, and Dario R Alessi
http://EMBOJ.embopress.org/content/35/17/1902?etoc

Rapalogs Efficacy Relies on the Modulation of Antitumor T-cell Immunity
Laurent Beziaud, Laura Mansi, Patrice Ravel, Elodie Lauret Marie-Joseph, Caroline Laheurte, Laurie Rangan, Francis Bonnefoy, Jean-René Pallandre, Laura Boullerot, Clémentine Gamonet, Sindy Vrecko, Lise Queiroz, Tristan Maurina, Guillaume Mouillet, Thierry Nguyen Tan Hon, Elsa Curtit, BernardRoyer, Béatrice Gaugler, Jagadeesh Bayry, Eric Tartour, Antoine Thiery-Vuillemin, Xavier Pivot, Christophe Borg, Yann Godet, and Olivier Adotévi
http://cancerres.aacrjournals.org/content/76/14/4100.abstract?etoc

mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1
Joseph G. Moloughney, Peter K. Kim, Nicole M. Vega-Cotto, Chang-Chih Wu, Sisi Zhang, Matthew Adlam, Thomas Lynch, Po-Chien Chou, Joshua D. Rabinowitz, Guy Werlen, Estela Jacinto
http://www.cell.com/molecular-cell/fulltext/S1097-2765(16)30368-9

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Drugs
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Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer
Amira Elgogary, Qingguo Xu, Brad Poore, Jesse Alt, Sarah C. Zimmermann, Liang Zhao, Jie Fu, Baiwei Chen, Shiyu Xia, Yanfei Liu, Marc Neisser, Christopher Nguyen, Ramon Lee, Joshua K. Park, Juvenal Reyes, Thomas Hartung, Camilo Rojas, Rana Rais, Takashi Tsukamoto, Gregg L. Semenza, Justin Hanes, Barbara S. Slusher, and Anne Le
http://www.pnas.org/content/113/36/E5328.abstract.html?etoc

Synergistic Anticancer Action of Lysosomal Membrane Permeabilization and Glycolysis Inhibition
Milica Kosic, Katarina Arsikin-Csordas, Verica Paunovic, Raymond A. Firestone, Biljana Ristic, Aleksandar Mircic, Sasa Petricevic, Mihajlo Bosnjak, Nevena Zogovic, Milos Mandic, Vladimir Bumbasirevic, Vladimir Trajkovic, and Ljubica Harhaji-Trajkovic
http://www.jbc.org/content/early/2016/09/01/jbc.M116.752113.abstract

Identification of Small Molecule Inhibitors of Human Cytochrome c Oxidase that Target Chemoresistant Glioma Cells
Claudia R. Oliva, Tahireh Markert, Larry J. Ross, E. Lucile White, Lynn Rasmussen, Wei Zhang, Maaike Everts, Douglas R. Moellering, Shannon M. Bailey, Mark J. Suto, and Corinne E. Griguer
http://www.jbc.org/content/early/2016/09/27/jbc.M116.749978.abstract

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Miscellaneous
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The architecture of the mammalian respirasome
Jinke Gu,Meng Wu,Runyu Guo,Kaige Yan,Jianlin Lei,Ning Gao & Maojun Yang
http://www.nature.com/nature/journal/v537/n7622/full/nature19359.html

The architecture of respiratory supercomplexes
James A. Letts, Karol Fiedorczuk, Leonid A. Sazanov
http://www.nature.com/nature/journal/v537/n7622/full/nature19774.html

A PGC1α-mediated transcriptional axis suppresses melanoma metastasis
Chi Luo, Ji-Hong Lim, Yoonjin Lee, Scott R. Granter, Ajith Thomas, Francisca Vazquez, Hans R. Widlund, Pere Puigserver,
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature19347.html

mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation
Hu Zeng, Sivan Cohen, Cliff Guy, Sharad Shrestha, Geoffrey Neale, Scott A. Brown, Caryn Cloer, Rigel J. Kishton, Xia Gao, Ben Youngblood, Mytrang Do, Ming O. Li, Jason W. Locasale, Jeffrey C. Rathmell, Hongbo Chi
http://www.cell.com/immunity/abstract/S1074-7613(16)30341-7

A rapid method for quantifying free and bound acetate based on alkylation and GC-MS analysis
Tumanov S, Bulusu V, Gottlieb E, Kamphorst J
http://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-016-0157-5#Abs1

Starving cancer from the outside and inside: separate and combined effects of calorie restriction and autophagy inhibition on Ras-driven tumors
Lashinger L, O’Flanagan C, Dunlap  S, Rasmussen  A, Sweeney  S, Guo  J, Lodi  A, Tiziani S, White E, Hursting S
http://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-016-0158-4#Abs1

The Pentose Phosphate Pathway Regulates the Circadian Clock
Guillaume Rey, Utham K. Valekunja, Kevin A. Feeney, Lisa Wulund, Nikolay B. Milev, Alessandra Stangherlin, Laura Ansel-Bollepalli, Vidya Velagapudi, John S. O’Neill, Akhilesh B. Reddy
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30375-8

E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity
Matthieu Lacroix, Geneviève Rodier, Olivier Kirsh, Thibault Houles, Hélène Delpech, Berfin Seyran, Laurie Gayte, Francois Casas, Laurence Pessemesse, Maud Heuillet, Floriant Bellvert, Jean-Charles Portais, Charlene Berthet, Florence Bernex, Michele Brivet, Audrey Boutron, Laurent Le Cam, and Claude Sardet
http://www.pnas.org/content/113/39/10998.abstract.html?etoc

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Reviews
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Recent insights into the function of autophagy in cancer
Ravi Amaravadi, Alec C. Kimmelman, and Eileen White
http://genesdev.cshlp.org/content/30/17/1913.abstract?etoc

Molecular or Metabolic Reprograming: What Triggers Tumor Subtypes?
Katherine Eason and Anguraj Sadanandam
http://cancerres.aacrjournals.org/content/76/18/5195.abstract?etoc

Metabolic Plasticity as a Determinant of Tumor Growth and Metastasis
Camille Lehuédé, Fanny Dupuy, Rebecca Rabinovitch, Russell G. Jones, and Peter M. Siegel
http://cancerres.aacrjournals.org/content/76/18/5201.abstract?etoc

News about VDAC1 in Hypoxia
N. M. Mazure
http://journal.frontiersin.org/article/10.3389/fonc.2016.00193/full

Oncogenic regulation of tumor metabolic reprogramming
Míriam Tarrado-Castellarnau, Pedro de Atauri,  and  Marta Cascante
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=10911

Targeting polyamine metabolism for cancer therapy and prevention
Tracy R. Murray-Stewart, Patrick M. Woster, and Robert A. Casero, Jr
http://www.biochemj.org/content/473/19/2937?etoc

O-GlcNAcylation in Cancer Biology: Linking Metabolism and Signaling
Christina M. Ferrer, Valerie L. Sodi, Mauricio J. Reginato
http://www.sciencedirect.com/science/article/pii/S0022283616302078

Arginine dependence of tumor cells: targeting a chink in cancer’s armor
M D Patil, J Bhaumik, S Babykutty, U C Banerjee and D Fukumura
http://www.nature.com/onc/journal/v35/n38/abs/onc201637a.html

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Comments / other
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Cancer metabolism at a glance
Alexei Vazquez, Jurre J. Kamphorst, Elke K. Markert, Zachary T. Schug, Saverio Tardito, and Eyal Gottlieb
http://jcs.biologists.org/content/129/18/3367?etoc

Into Thin Air: How We Sense and Respond to Hypoxia
Craig B. Thompson
http://www.cell.com/cell/fulltext/S0092-8674(16)31133-3

Making Sense of the Unexpected
The 2016 Albert Lasker Basic Medical Research Award is being awarded to Greg Semenza, William Kaelin, and Peter Ratcliffe
http://www.cell.com/cell/fulltext/S0092-8674(16)31145-X

mTORC2 Puts Its Shoulder to Krebs’ Wheel
Sebastian I. Arriola Apelo, Dudley W. Lamming
http://www.cell.com/molecular-cell/fulltext/S1097-2765(16)30430-0

Glycolysis Inhibitors for Anticancer Therapy: A Review of Recent Patents.
Sheng H, Tang W.
http://www.eurekaselect.com/141320/article

One way fumarate can promote metastasis
http://stke.sciencemag.org/content/9/447/ec221

Cancer anabolic metabolism inhibitors move into clinic
http://www.nature.com/nbt/journal/v34/n8/full/nbt0816-794.html

Hypoxia Prevents AKT Hydroxylation and Promotes AKT Hyperactivation
http://cancerdiscovery.aacrjournals.org/content/6/10/1078.1.abstract?etoc

IDH1 Mutations Can Drive AML through TET2-Independent Mechanisms
http://cancerdiscovery.aacrjournals.org/content/6/9/941.2.abstract?etoc

Autophagic Pancreatic Stellate Cells Promote Pancreatic Tumor Growth
http://cancerdiscovery.aacrjournals.org/content/6/10/OF9.abstract?etoc

Webinar | Key signaling pathways in cancer: Emerging trends in immunometabolism
Erika L. Pearce , Luke O’Neill
http://webinar.sciencemag.org/webinar/archive/key-signaling-pathways-cancer-0?_ga=1.228586653.1836067324.1457647586

Book: Navigating Metabolism
Navdeep Chandel
http://www.cshlpress.com/default.tpl?action=full&–eqskudatarq=1037

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