MetaboList – October 2016, part II

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Metabolism and metastasis
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Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis
Stefan Christen, Doriane Lorendeau, Roberta Schmieder, Dorien Broekaert, Kristine Metzger, Koen Veys, Ilaria Elia, Joerg Martin Buescher, Martin Franz Orth, Shawn Michael Davidson, Thomas Georg Philipp Grünewald, Katrien De Bock, Sarah-Maria Fendt
http://www.cell.com/cell-reports/fulltext/S2211-1247(16)31281-5

Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival
Edoardo Gaude and Christian Frezza
http://www.nature.com/articles/ncomms13041

Methionine deprivation suppresses triple-negative breast cancer metastasis in vitro and in vivo
Hyein Jeon, Jae Hwan Kim, Eunjung Lee, Young Jin Jang, Joe Eun Son, Jung Yeon Kwon, Tae-gyu Lim, Sunghoon Kim, Jung Han Yoon Park, Jong-Eun Kim,  and  Ki Won Lee
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=11615

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Metabolism, cancer and the immune system
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Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis
Mathias Wenes, Min Shang, Mario Di Matteo, Jermaine Goveia, Rosa Martín-Pérez, Jens Serneels, Hans Prenen, Bart Ghesquière, Peter Carmeliet, Massimiliano Mazzone
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30488-0

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity
Roger Geiger, Jan C. Rieckmann, Tobias Wolf, Camilla Basso, Yuehan Feng, Tobias Fuhrer, Maria Kogadeeva, Paola Picotti, Felix Meissner, Matthias Mann, Nicola Zamboni, Federica Sallusto, Antonio Lanzavecchia
http://www.cell.com/cell/abstract/S0092-8674(16)31313-7

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Glucose metabolism
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Hyaluronan production regulates metabolic and cancer stem-like properties of breast cancer cells via hexosamine biosynthetic pathway-coupled HIF-1 signaling
Theerawut Chanmee, Pawared Ontong, Tomomi Izumikawa, Miho Higashide, Nobutoshi Mochizuki, Chatchadawalai Chokchaitaweesuk, Manatsanan Khansai, Kazuki Nakajima, Ikuko Kakizaki, Prachya Kongtawelert, Naoyuki Taniguchi, and Naoki Itano
http://www.jbc.org/content/early/2016/10/06/jbc.M116.751263.abstract

Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis
Marie-Julie Nokin, Florence Durieux, Paul Peixoto, Barbara Chiavarina, Olivier Peulen, Arnaud Blomme, Andrei Turtoi, Brunella Costanza, Nicolas Smargiasso, Dominique Baiwir, Jean L Scheijen, Casper G Schalkwijk, Justine Leenders, Pascal De Tullio, Elettra Bianchi, Marc Thiry, Koji Uchida, David A Spiegel, James R Cochrane, Craig A Hutton, Edwin De Pauw, Philippe Delvenne, Dominique Belpomme, Vincent Castronovo and Akeila Bellahcène
https://elifesciences.org/content/5/e19375

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Amino acids
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Addiction to Coupling of the Warburg Effect with Glutamine Catabolism in Cancer Cells
Bradley Smith, Xenia L. Schafer, Aslihan Ambeskovic, Cody M. Spencer, Hartmut Land, Joshua Munger
http://www.cell.com/cell-reports/abstract/S2211-1247(16)31284-0

A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas
Gregory R Bean, Jeff C Kremer, Bethany C Prudner, Aaron D Schenone, Juo-Chin Yao, Matthew B Schultze, David Y Chen, Munir R Tanas, Douglas R Adkins, John Bomalaski, Brian P Rubin, Loren S Michel and Brian A Van Tine
http://www.nature.com/cddis/journal/v7/n10/abs/cddis2016232a.html

Nutritional Stress Induced by Tryptophan-Degrading Enzymes Results in ATF4-Dependent Reprogramming of the Amino Acid Transporter Profile in Tumor Cells
Elina Timosenko, Hemza Ghadbane, Jonathan D. Silk, Dawn Shepherd, Uzi Gileadi, Lauren J. Howson, Robert Laynes, Qi Zhao, Robert L. Strausberg, Lars R. Olsen, Stephen Taylor, Francesca M. Buffa, Richard Boyd, and Vincenzo Cerundolo
http://cancerres.aacrjournals.org/content/76/21/6193.abstract?etoc

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Mitochondria
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The Assembly Pathway of Mitochondrial Respiratory Chain Complex I
Sergio Guerrero-Castillo, Fabian Baertling, Daniel Kownatzki, Hans J. Wessels, Susanne Arnold, Ulrich Brandt, Leo Nijtmans
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30480-6

Atomic structure of the entire mammalian mitochondrial complex I
Karol Fiedorczuk,James A. Letts,Gianluca Degliesposti,Karol Kaszuba,Mark Skehel&Leonid A. Sazanov
http://www.nature.com/nature/journal/v538/n7625/full/nature19794.html

Mechanism of super-assembly of respiratory complexes III and IV
Sara Cogliati, Enrique Calvo, Marta Loureiro, Adela M. Guaras, Rocio Nieto-Arellano, Carolina Garcia-Poyatos, Iakes Ezkurdia, Nadia Mercader, Jesús Vázquez & José Antonio Enriquez
http://www.nature.com/nature/journal/vaap/ncurrent/full/nature20157.html

A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation
Jason D. Arroyo, Alexis A. Jourdain, Sarah E. Calvo, Carmine A. Ballarano, John G. Doench, David E. Root, Vamsi K. Mootha
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30433-8

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Lipids and acetate
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ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch
Steven Zhao, AnnMarie Torres, Ryan A. Henry, Sophie Trefely, Martina Wallace, Joyce V. Lee, Alessandro Carrer, Arjun Sengupta, Sydney L. Campbell, Yin-Ming Kuo, Alexander J. Frey, Noah Meurs, John M. Viola, Ian A. Blair, Aalim M. Weljie, Christian M. Metallo, Nathaniel W. Snyder, Andrew J. Andrews, Kathryn E. Wellen
http://www.cell.com/cell-reports/abstract/S2211-1247(16)31325-0

Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth.
Ru P, Hu P, Geng F, Mo X, Cheng C, Yoo JY, Cheng X, Wu X, Guo JY, Nakano I, Lefai E, Kaur B, Chakravarti A, Guo D.
http://www.cell.com/cell-reports/abstract/S2211-1247(16)30903-2

Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis.
Geng F, Cheng X, Wu X, Yoo JY, Cheng C, Guo JY, Mo X, Ru P, Hurwitz B, Kim SH, Otero J, Puduvalli V, Lefai E, Ma J, Nakano I, Horbinski C, Kaur B, Chakravarti A, Guo D.
http://clincancerres.aacrjournals.org/content/22/21/5337.long

Endoplasmic Reticulum Stress Protein GRP78 Modulates Lipid Metabolism to Control Drug Sensitivity and Antitumor Immunity in Breast Cancer
Katherine L. Cook, David R. Soto-Pantoja, Pamela A.G. Clarke, M. IdaliaCruz, Alan Zwart, Anni Wärri, Leena Hilakivi-Clarke, David D. Roberts, and Robert Clarke
http://cancerres.aacrjournals.org/content/76/19/5657.abstract?etoc

Characterization of acetate transport in colorectal cancer cells and potential therapeutic implications
Suellen Ferro, João Azevedo-Silva, Margarida Casal, Manuela Côrte-Real, Fatima Baltazar, Ana Preto
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=12156

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Epigenetics
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Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation
Min Pan, Michael A. Reid, Xazmin H. Lowman, Rajan P. Kulkarni, Thai Q. Tran, Xiaojing Liu4, Ying Yang1, Jenny E. Hernandez-Davies1, Kimberly K. Rosales1, Haiqing Li5, Willy Hugo, Chunying Song, Xiangdong Xu, Dustin E. Schones, David K. Ann, Viviana Gradinaru, Roger S. Lo, Jason W. Locasale, Mei Kong
http://www.nature.com/ncb/journal/v18/n10/full/ncb3410.html

Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase
Xiaozhen He, Bin Yan, Shuang Liu, Jiantao Jia, Weiwei Lai, Xing Xin, Can-e Tang, Dixian Luo, Tan Tan, Yiqun Jiang, Ying Shi, Yating Liu, Desheng Xiao, Ling Chen, Shao Liu, Chao Mao, Gang Yin, Yan Cheng, Jia Fan, Ya Cao, Kathrin Muegge, and Yongguang Tao
http://cancerres.aacrjournals.org/content/76/19/5743.abstract?etoc

Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation
Eoin McDonnell, Scott B. Crown, Douglas B. Fox, Betül Kitir, Olga R. Ilkayeva, Christian A. Olsen, Paul A. Grimsrud, Matthew D. Hirschey
http://www.cell.com/cell-reports/fulltext/S2211-1247(16)31398-5

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Nutrient sensing / starvation
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Structural reverse genetics study of the PI5P4Kβ–nucleotide complexes reveals the presence of the GTP bioenergetic system in mammalian cells
Koh Takeuchi, Miki Senda, Yu-Hua Lo, Satoshi Kofuji, Yoshiki Ikeda, Atsuo T. Sasaki and Toshiya Senda
http://onlinelibrary.wiley.com/doi/10.1111/febs.13739/abstract

Dynamics of mTORC1 activation in response to amino acids
Maria Manifava, Matthew Smith, Sergio Rotondo, Simon Walker, Izabella Niewczas, Roberto Zoncu, Jonathan Clark and Nicholas T Ktistakis
https://elifesciences.org/content/5/e19960

Selective endosomal microautophagy is starvation-inducible in Drosophila
Anindita Mukherjee, Bindi Patel, Hiroshi Koga, Ana Maria Cuervo & Andreas Jenny
http://www.tandfonline.com/doi/full/10.1080/15548627.2016.1208887

Suppressed translation and ULK1 degradation as potential mechanisms of autophagy limitation under prolonged starvation
Giulia Allavena, Caroline Boyd, Kyaw Soe Oo, Emilia Maellaro, Boris Zhivotovsky & Vitaliy O. Kaminskyy
http://www.tandfonline.com/doi/full/10.1080/15548627.2016.1226733
[not sure what the stimuli are, in these two articles]

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mTOR / AMPK
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Cytotoxic Properties of a DEPTOR-mTOR Inhibitor in Multiple Myeloma Cells
Yijiang Shi, Tracy R. Daniels-Wells, Patrick Frost, Jihye Lee, Richard S.Finn, Carolyne Bardeleben, Manuel L. Penichet, Michael E. Jung, JosephGera, and Alan Lichtenstein
http://cancerres.aacrjournals.org/content/76/19/5822.abstract?etoc

Metformin Activates AMPK through the Lysosomal Pathway
Chen-Song Zhang, Mengqi Li, Teng Ma, Yue Zong, Jiwen Cui, Jin-Wei Feng, Yu-Qing Wu, Shu-Yong Lin, Sheng-Cai Lin
http://www.cell.com/cell-metabolism/abstract/S1550-4131(16)30481-8

AMPK promotes tolerance to Ras pathway inhibition by activating autophagy
S Sanduja, Y Feng, R A Mathis, E S Sokol, F Reinhardt, R Halaban and P B Gupta
http://www.nature.com/onc/journal/v35/n40/full/onc201670a.html

Nrf2 transcription factor can directly regulate mTOR; linking cytoprotective gene expression to a major metabolic regulator that generates redox activity
Gabriel Bendavit, Tahar Aboulkassim, Khalid Hilmi, Sujay Shah, and Gerald Batist
http://www.jbc.org/content/early/2016/10/26/jbc.M116.760249.abstract

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Obesity / diet
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Obesity-associated NLRC4 inflammasome activation drives breast cancer progression
Ryan Kolb, Liem Phan, Nicholas Borcherding, Yinghong Liu, Fang Yuan, Ann M. Janowski, Qing Xie, Kathleen R. Markan, Wei Li, Matthew J. Potthoff, Enrique Fuentes-Mattei, Lesley G. Ellies, C. Michael Knudson, Mong-Hong Lee, Sai-Ching J. Yeung, Suzanne L. Cassel, Fayyaz S. Sutterwala and Weizhou Zhang
http://www.nature.com/articles/ncomms13007

Dietary energy restriction reduces high-fat diet-enhanced metastasis of Lewis lung carcinoma in mice
Sneha Sundaram,  and  Lin Yan
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=11598

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Miscellaneous
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Systemic Analysis of Atg5-Null Mice Rescued from Neonatal Lethality by Transgenic ATG5 Expression in Neurons
Saori R. Yoshii, Akiko Kuma, Takumi Akashi, Taichi Hara, Atsushi Yamamoto, Yoshitaka Kurikawa, Eisuke Itakura, Satoshi Tsukamoto, Hiroshi Shitara, Yoshinobu Eishi, Noboru Mizushima
http://www.cell.com/developmental-cell/fulltext/S1534-5807(16)30597-4

Coordinated Activities of Multiple Myc-Dependent and Myc-Independent Biosynthetic Pathways in Hepatoblastoma
Huabo Wang, Jie Lu, Lia R. Edmeunds, Sucheta Kulkarni, James Dolezal, Junyan Tao, Sarangarajan Ranganathan, Laura Jackson, Marc Fromherz, Donna Beer Stolz, Radha Uppala, Sivakama Bharathi, Satdarshan P. Monga, Eric S. Goetzman, and Edward V. Prochownik
http://www.jbc.org/content/early/2016/10/13/jbc.M116.754218.abstract

An AMP-activated protein kinase–stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice
Maria Rohm, Michaela Schäfer, Victor Laurent, Bilgen Ekim Üstünel, Katharina Niopek, Carolyn Algire, Oksana Hautzinger, Tjeerd P Sijmonsma, Annika Zota, Dasa Medrikova, Natalia S Pellegata, Mikael Ryden, Agné Kulyte, Ingrid Dahlman,Peter Arner, Natasa Petrovic, Barbara Cannon, Ez-Zoubir Amri, Bruce E Kemp, Gregory R Steinberg, Petra Janovska, Jan Kopecky, Christian Wolfrum, Matthias Blüher, Mauricio Berriel Diaz & Stephan Herzig
http://www.nature.com/nm/journal/v22/n10/full/nm.4171.html

Activation of AMP-Activated Protein Kinase by Metformin Induces Protein Acetylation in Prostate and Ovarian Cancer Cells
Luciano Galdieri, Himavanth Gatla, Ivana Vancurova, and Ales Vancura
http://www.jbc.org/content/early/2016/10/12/jbc.M116.742247.abstract

Expression of Idh1R132H in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis
Chiara Bardella, Osama Al-Dalahmah, Daniel Krell, Pijus Brazauskas, Khalid Al-Qahtani, Marketa Tomkova, Julie Adam, Sébastien Serres, Helen Lockstone, Luke Freeman-Mills, Inga Pfeffer, Nicola Sibson, Robert Goldin, Benjamin Schuster-Böeckler, Patrick J. Pollard, Tomoyoshi Soga, James S. McCullagh, Christopher J. Schofield, Paul Mulholland, Olaf Ansorge, Skirmantas Kriaucionis, Peter J. Ratcliffe, Francis G. Szele, Ian Tomlinson
http://www.cell.com/cancer-cell/abstract/S1535-6108(16)30402-0

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Comments
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Blocking fatty acid synthesis reduces lung tumor growth in mice
Jiyeon Kim and Ralph J DeBerardinis
http://www.nature.com/nm/journal/v22/n10/full/nm.4195.html

Targeting HIF2α in Clear-Cell Renal Cell Carcinoma
Christopher J. Ricketts, Daniel R. Crooks, W. Marston Linehan
http://www.cell.com/cancer-cell/fulltext/S1535-6108(16)30451-2

Warburg meets epigenetics
Chirag H. Patel, Jonathan D. Powell
http://science.sciencemag.org/content/354/6311/419

Targeting mutant p53 through the mevalonate pathway
William Freed-Pastor and Carol Prives
http://www.nature.com/ncb/journal/v18/n11/full/ncb3435.html

Oncometabolite Accumulation and Epithelial-to-Mesenchymal Transition: The Turn of Fumarate
Maxime Janin, Manel Esteller
http://www.cell.com/cell-metabolism/abstract/S1550-4131(16)30505-8

Antiangiogenic resistance via metabolic symbiosis
Gabriela Jiménez-Valerio & Oriol Casanovas
http://www.tandfonline.com/doi/full/10.1080/23723556.2016.1211979

Normoxic or hypoxic adaptation in response to antiangiogenic therapy: Clinical implications
M. Quintela-Fandino
http://www.tandfonline.com/doi/full/10.1080/23723556.2016.1217368

Regional tumour glutamine supply affects chromatin and cell identity
Jonas W. Højfeldt and Kristian Helin
http://www.nature.com/ncb/journal/v18/n10/full/ncb3414.html

A Guardian Angel Phosphatase for Mainline Carbon Metabolism
Guillaume A. Beaudoin, Andrew D. Hanson
http://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(16)30105-0

Fumarate Promotes EMT by Downregulating Antimetastatic miRNAs
http://cancerdiscovery.aacrjournals.org/content/6/10/1081.2.abstract?etoc

Tumor Hypoxia Suppresses TET Activity to Enhance DNA Methylation
http://cancerdiscovery.aacrjournals.org/content/6/10/OF7.abstract?etoc

Arginine Activates mTORC1 through Allosteric Control of CASTOR1
http://cancerdiscovery.aacrjournals.org/content/6/10/OF10.abstract?etoc

Tumour metabolism: The sugar-free, full-fat diet
http://www.nature.com/nrc/journal/v16/n10/full/nrc.2016.99.html

Tumour metabolism: Feeding your friends
http://www.nature.com/nrc/journal/v16/n10/full/nrc.2016.96.html

Tumour metabolism: Adapting to harsh conditions [PDK1]
http://www.nature.com/nrc/journal/v16/n10/full/nrc.2016.98.html

Tumour metabolism: Metabolic flexibility
http://www.nature.com/nrc/journal/v16/n10/full/nrc.2016.101.html

Tumour metabolism: Functions of fumarate
http://www.nature.com/nrc/journal/v16/n10/full/nrc.2016.102.html

Tumour metabolism: Reflecting their origins
http://www.nature.com/nrc/journal/v16/n11/full/nrc.2016.106.html

Tumour metabolism: Translating the undruggable target [HIF2a]
http://www.nature.com/nrc/journal/v16/n11/full/nrc.2016.109.html

Tumour metabolism: Lactic acid: not just a waste product?
http://www.nature.com/nrc/journal/v16/n11/full/nrc.2016.107.html

Tumour metabolism: Building up and breaking down fatty acids
http://www.nature.com/nrc/journal/v16/n11/full/nrc.2016.111.html

Tumour metabolism: Location matters [glutamine]
http://www.nature.com/nrc/journal/v16/n11/full/nrc.2016.117.html

Tumour metabolism: Targeting proline metabolism?
http://www.nature.com/nrc/journal/v16/n11/full/nrc.2016.119.html

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