MetaboList – November 2016

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Amino acid metabolism
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Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth
Lifeng Yang, Abhinav Achreja, Tsz-Lun Yeung, Lingegowda S. Mangala, Dahai Jiang, Cecil Han, Joelle Baddour, Juan C. Marini, Joseph Ni, Ryuichi Nakahara, Stephen Wahlig, Lisa Chiba, Sun Hye Kim, Joshua Morse, Sunila Pradeep, Archana Sidalaghatta Nagaraja, Monika Haemmerle, Noh Kyunghee, Mathew Derichsweiler, Thomas Plackemeier, Imelda Mercado-Uribe, Gabriel Lopez-Berestein, Tyler Moss, Prahlad T. Ram, Jinsong Liu, Xiongbin Lu, Samuel C. Mok, Anil K. Sood, Deepak Nagrath
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30542-3

LKB1 loss links serine metabolism to DNA methylation and tumorigenesis
Filippos Kottakis, Brandon N. Nicolay, Ahlima Roumane, Rahul Karnik, Hongcang Gu, Julia M. Nagle, Myriam Boukhali, Michele C. Hayward, Yvonne Y. Li, Ting Chen, Marc Liesa, Peter S. Hammerman, Kwok Kin Wong ,D. Neil Hayes, Orian S. Shirihai, Nicholas J. Dyson, Wilhelm Haas, Alexander Meissner & Nabeel Bardeesy
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature20132.html

Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer
Yi-Ping Wang, Wei Zhou, Jian Wang, Xian Huang, Yong Zuo, Tian-Shi Wang, Xue Gao, Ying-Ying Xu, Shao-Wu Zou, Ying-Bin Liu, Jin-Ke Cheng, Qun-Ying Lei
http://www.cell.com/molecular-cell/fulltext/S1097-2765(16)30577-9

Proline Starvation Induces Unresolved ER Stress and Hinders mTORC1-Dependent Tumorigenesis
Nisebita Sahu, Darlene Dela Cruz, Min Gao, Wendy Sandoval, Peter M. Haverty, Jinfeng Liu, Jean-Philippe Stephan, Benjamin Haley, Marie Classon, Georgia Hatzivassiliou, Jeff Settleman
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30424-7

Co-application of canavanine and irradiation uncouples anticancer potential of arginine deprivation from citrulline availability
Yuliya Kurlishchuk, Bozhena Vynnytska-Myronovska, Philipp Grosse-Gehling, Yaroslav Bobak, Friederike Manig, Oleg Chen, Sebastian R. Merker, Thomas Henle, Steffen Löck, Daniel E. Stange, Oleh Stasyk,  and  Leoni A. Kunz-Schughart
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=12320

Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes
Polina Matre, Juliana Velez, Rodrigo Jacamo, Yuan Qi, Xiaoping Su, Tianyu Cai, Steven M. Chan, Alessia Lodi, Shannon R. Sweeney, Helen Ma, Richard Eric Davis, Natalia Baran, Torsten Haferlach, Xiaohua Su, Elsa Renee Flores, Doriann Gonzalez, Sergej Konoplev, Ismael Samudio, Courtney DiNardo, Ravi Majeti, Aaron D. Schimmer, Weiqun Li, Taotao Wang, Stefano Tiziani,  and  Marina Konopleva
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=12944

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Cancer Immuno-metabolism
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Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis
Mathias Wenes, Min Shang, Mario Di Matteo, Jermaine Goveia, Rosa Martín-Pérez, Jens Serneels, Hans Prenen, Bart Ghesquière, Peter Carmeliet, Massimiliano Mazzone
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30488-0

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells
Almut Brand, Katrin Singer, Gudrun E. Koehl, Marlene Kolitzus, Gabriele Schoenhammer, Annette Thiel, Carina Matos, Christina Bruss, Sebastian Klobuch, Katrin Peter, Michael Kastenberger, Christian Bogdan, Ulrike Schleicher, Andreas Mackensen, Evelyn Ullrich, Stefan Fichtner-Feigl, Rebecca Kesselring, Matthias Mack, Uwe Ritter, Maximilian Schmid , Christian Blank , Katja Dettmer, Peter J. Oefner, Petra Hoffmann, Stefan Walenta , Edward K. Geissler, Jacques Pouyssegur, Andreas Villunger, André Steven, Barbara Seliger, Stephan Schreml, Sebastian Haferkamp, Elisabeth Kohl, Sigrid Karrer, Mark Berneburg, Wolfgang Herr , Wolfgang Mueller-Klieser, Kathrin Renner, Marina Kreutz
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30427-2

Tumor-Induced IL-6 Reprograms Host Metabolism to Suppress Anti-tumor Immunity
Thomas R. Flint, Tobias Janowitz, Claire M. Connell, Edward W. Roberts, Alice E. Denton, Anthony P. Coll, Duncan I. Jodrell, Douglas T. Fearon
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30541-1

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Metabolic reprogramming
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TIGAR Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer
Ying-Hui Ko, Marina Domingo-Vidal, Megan Roche, Zhao Lin, Diana Whitaker-Menezes, Erin Seifert, Claudia Capparelli, Madalina Tuluc, Ruth C. Birbe, Patrick Tassone, Joseph M Curry, Aurea Navarro-Sabate, Anna Manzano, Ramon Bartrons, Jaime Caro, and Ubaldo Martinez-Outschoorn
http://www.jbc.org/content/early/2016/11/01/jbc.M116.740209.abstract

Comparative metabolomics profiling of isogenic KRAS wild type and mutant NSCLC cells in vitro and in vivo
Laura Brunelli, Elisa Caiola, Mirko Marabese, Massimo Broggini & Roberta Pastorelli
http://www.nature.com/articles/srep28398

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Carbohydrates and glycolytic enzymes
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Enhanced Fructose Utilization Mediated by SLC2A5 Is a Unique Metabolic Feature of Acute Myeloid Leukemia with Therapeutic Potential
Wen-Lian Chen, Yue-Ying Wang, Aihua Zhao, Li Xia, Guoxiang Xie, Mingming Su, Linjing Zhao, Jiajian Liu, Chun Qu, Runmin Wei, Cynthia Rajani, Yan Ni, Zhen Cheng, Zhu Chen, Sai-Juan Chen, Wei Jia
http://www.cell.com/cancer-cell/fulltext/S1535-6108(16)30441-X

A novel role for pyruvate Kinase M2 as a corepressor for P53 during the DNA damage response in human tumor cells
Li Xia, Xin-Ran Wang, Xiao-Ling Wang, Su-Hui Liu, Xiao-Wei Ding, Guo-Qiang Chen, and Ying Lu
http://www.jbc.org/content/early/2016/11/03/jbc.M116.737056.abstract

Epithelial-mesenchymal transition induction is associated with augmented glucose uptake and lactate production in pancreatic ductal adenocarcinoma
Liu  M, Quek  L, Sultani  G, Turner  N
http://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-016-0160-x#Abs1

Proteomic identification of the lactate dehydrogenase A in a radioresistant prostate cancer xenograft mouse model for improving radiotherapy
Jingli Hao, Peter Graham, Lei Chang, Jie Ni, Valerie Wasinger, Julia Beretov, Junli Deng, Wei Duan, Joseph Bucci, David Malouf, David Gillatt,  and  Yong Li
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=12368

A causal link from ALK to hexokinase II overexpression and hyperactive glycolysis in EML4-ALK-positive lung cancer
Y Ma, C Yu, E M Mohamed, H Shao, L Wang, G Sundaresan, J Zweit, M Idowu and X Fang
http://www.nature.com/onc/journal/v35/n47/abs/onc2016150a.html

2-Deoxy glucose regulate MMP-9 in a SIRT-1 dependent and NFkB independent mechanism
Edatt, Lincy; Haritha, K.; Sruthi, T. V.; Aswini, P.; Kumar, V. B.
http://link.springer.com/article/10.1007%2Fs11010-016-2837-4

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Hypoxia and HIF-1
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Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition
Julianty Frost, Carles Galdeano, Pedro Soares, Morgan S. Gadd, Katarzyna M. Grzes, Lucy Ellis, Ola Epemolu, Satoko Shimamura, Marcus Bantscheff, Paola Grandi, Kevin D. Read, Doreen A. Cantrell, Sonia Rocha and Alessio Ciulli
http://www.nature.com/articles/ncomms13312

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions
Stephen P. Burr, Ana S.H. Costa, Guinevere L. Grice, Richard T. Timms, Ian T. Lobb, Peter Freisinger, Roger B. Dodd, Gordon Dougan, Paul J. Lehner, Christian Frezza, James A. Nathan
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30500-9

Hypoxia-induced oxidative stress promotes MUC4 degradation via autophagy to enhance pancreatic cancer cells survival
S Joshi, S Kumar, M P Ponnusamy and S K Batra
http://www.nature.com/onc/journal/v35/n45/abs/onc2016119a.html

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Lipids
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An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers
Genaro R. Villa, Jonathan J. Hulce, Ciro Zanca, Junfeng Bi, Shiro Ikegami, Gabrielle L. Cahill, Yuchao Gu, Kenneth M. Lum, Kenta Masui, Huijun Yang, Xin Rong, Cynthia Hong, Kristen M. Turner, Feng Liu, Gary C. Hon, David Jenkins, Michael Martini, Aaron M. Armando, Oswald Quehenberger, Timothy F. Cloughesy, Frank B. Furnari, Webster K. Cavenee, Peter Tontonoz, Timothy C. Gahman, Andrew K. Shiau, Benjamin F. Cravatt, Paul S. Mischel
http://www.cell.com/cancer-cell/fulltext/S1535-6108(16)30443-3

FASN regulates cellular response to genotoxic treatments by increasing PARP-1 expression and DNA repair activity via NF-κB and SP1
Xi Wu, Zizheng Dong, Chao J. Wang, Lincoln James Barlow, Valerie Fako, Moises A. Serrano, Yue Zou, Jing-Yuan Liu, and Jian-Ting Zhang
http://www.pnas.org/content/113/45/E6965.abstract.html?etoc

Phospholipase D1-regulated autophagy supplies free fatty acids to counter nutrient stress in cancer cells
Ming Cai, Jingquan He, Jian Xiong, Li Wei Rachel Tay, Ziqing Wang, Colin Rog, Jingshu Wang, Yizhao Xie, Guobin Wang, Yoshiko Banno, Feng Li, Michael Zhu and Guangwei Du
http://www.nature.com/cddis/journal/v7/n11/abs/cddis2016355a.html

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Mitochondria
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Structure of Mammalian Respiratory Supercomplex I1III2IV1
Meng Wu, Jinke Gu, Runyu Guo, Yushen Huang, Maojun Yang
http://www.cell.com/cell/fulltext/S0092-8674(16)31533-1

Cellular Allometry of Mitochondrial Functionality Establishes the Optimal Cell Size
Teemu P. Miettinen, Mikael Björklund
http://www.cell.com/developmental-cell/fulltext/S1534-5807(16)30626-8

Establishment of mitochondrial pyruvate carrier 1 (MPC1) gene knockout mice with preliminary gene function analyses
Xiaoli Li, Yaqing Li, Gaoyang Han, Xiaoran Li, Yasai Ji, Zhirui Fan, Yali Zhong, Jing Cao, Jing Zhao, Goscinski Mariusz, Mingzhi Zhang, Jianguo Wen, Jahn M. Nesland,  and  Zhenhe Suo
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=13210

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Nutrient sensing / AMPK / mTOR
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Autophagy requires poly(adp-ribosyl)ation-dependent AMPK nuclear export
José M Rodríguez-Vargas, María I Rodríguez, Jara Majuelos-Melguizo, Ángel García-Diaz, Ariannys González-Flores, Abelardo López-Rivas, László Virág, Giuditta Illuzzi, Valerie Schreiber, Françoise Dantzer and F Javier Oliver
http://www.nature.com/cdd/journal/v23/n12/abs/cdd201680a.html

A systems study reveals concurrent activation of AMPK and mTOR by amino acids
Piero Dalle Pezze, Stefanie Ruf, Annika G. Sonntag, Miriam Langelaar-Makkinje, Philip Hall, Alexander M. Heberle, Patricia Razquin Navas, Karen van Eunen, Regine C. Tölle, Jennifer J. Schwarz, Heike Wiese, Bettina Warscheid, Jana Deitersen, Björn Stork, Erik Fäßler, Sascha Schäuble, Udo Hahn, Peter Horvatovich, Daryl P. Shanley and Kathrin Thedieck
http://www.nature.com/articles/ncomms13254

Proliferating helper T cells require Rictor/mTORC2 to integrate signals from limiting environmental amino acids
Lee-Ann Van de Velde and Peter J Murray
http://www.jbc.org/content/early/2016/10/31/jbc.C116.763623.abstract

Autophagy is required for PDAC glutamine metabolism
Ju-Won Seo, Jungwon Choi, So-Yeon Lee, Suhyun Sung, Hyun Ju Yoo, Min-Ji Kang, Heesun Cheong & Jaekyoung Son
http://www.nature.com/articles/srep37594

Fyn phosphorylates AMPK to inhibit AMPK activity and AMP-dependent activation of autophagy
Eijiro Yamada, Shuichi Okada, Claire C. Bastie, Manu Vatish, Yasuyo Nakajima, Ryo Shibusawa, Atsushi Ozawa, Jeffrey E. Pessin,  and  Masanobu Yamada
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=11916

Prognostic significance of AMPK in human malignancies: A meta-analysis
Xiaoming Shuai, Jinbo Gao, Ming Cai, Guobin Wang,  and  Kaixiong Tao
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=12405

Activation of AMP-activated Protein Kinase by Metformin Induces Protein Acetylation in Prostate and Ovarian Cancer Cells
Luciano Galdieri, Himavanth Gatla, Ivana Vancurova, and Ales Vancura
http://www.jbc.org/content/291/48/25154.abstract.html

AMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin
Nicolas Aznar, Arjun Patel, Cristina C Rohena, Ying Dunkel, Linda P Joosen, Vanessa Taupin, Irina Kufareva, Marilyn G Farquhar and Pradipta Ghosh
https://elifesciences.org/content/5/e20795

In vivo vizualisation of mono-ADP-ribosylation by dPARP16 upon amino-acid starvation
Angelica Aguilera-Gomez, Marinke M van Oorschot, Tineke Veenendaal and Catherine Rabouille
https://elifesciences.org/content/5/e21475

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Metformin and other drugs
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Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin
Dan Y. Gui, Lucas B. Sullivan, Alba Luengo, Aaron M. Hosios, Lauren N. Bush, Nadege Gitego, Shawn M. Davidson, Elizaveta Freinkman, Craig J. Thomas, Matthew G. Vander Heiden
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30484-3

Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers
Xiaojing Liu, Iris L. Romero, Lacey M. Litchfield, Ernst Lengyel, Jason W. Locasale
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30483-1

Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways
Seong M. Kim, Saurabh G. Roy, Bin Chen, Tiffany M. Nguyen, Ryan J. McMonigle, Alison N. McCracken, Yanling Zhang, Satoshi Kofuji, Jue Hou, Elizabeth Selwan, Brendan T. Finicle, Tricia T. Nguyen, Archna Ravi, Manuel U. Ramirez, Tim Wiher, Garret G. Guenther, Mari Kono, Atsuo T. Sasaki, Lois S. Weisman, Eric O. Potma, Bruce J. Tromberg, Robert A. Edwards, Stephen Hanessian, Aimee L. Edinger
http://www.jci.org/articles/view/87148

Fatal Liver and Bone Marrow Toxicity by Combination Treatment of Dichloroacetate and Artesunate in a Glioblastoma Multiforme Patient: Case Report and Review of the Literature
Martin Uhl, Stefan Schwab, and Thomas Efferth
http://journal.frontiersin.org/article/10.3389/fonc.2016.00204/full

Cellular effects of fluorodeoxyglucose: Global changes in the lipidome and alteration in intracellular transport
Simona Kavaliauskiene, Maria Lyngaas Torgersen, Anne Berit Dyve Lingelem, Tove Irene Klokk, Tuulia Lintonen, Helena Simolin, Kim Ekroos, Tore Skotland,  and  Kirsten Sandvig
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=13089

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Miscellaneous
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Low carbohydrate diet prevents Mcl-1-mediated resistance to BH3-mimetics
Camila Rubio-Patiño, Jozef P. Bossowski, Elodie Villa, Laura Mondragón, Barbara Zunino, Emma Proïcs, Johanna Chiche, Frédéric Bost, Els Verhoeyen,  and  Jean-Ehrland Ricci
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=12309

Epigenomic Deconvolution of Breast Tumors Reveals Metabolic Coupling between Constituent Cell Types
Vitor Onuchic, Ryan J. Hartmaier, David N. Boone, Michael L. Samuels, Ronak Y. Patel, Wendy M. White, Vesna D. Garovic, Steffi Oesterreich, Matt E. Roth, Adrian V. Lee, Aleksandar Milosavljevic
http://www.cell.com/cell-reports/fulltext/S2211-1247(16)31477-2

Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses
Yang Ou, Shang-Jui Wang, Dawei Li, Bo Chu, and Wei Gu
http://www.pnas.org/content/113/44/E6806.abstract.html?etoc

In Vivo Imaging of Tumor Metabolism and Acidosis by Combining PET and MRI-CEST pH Imaging
Dario L. Longo, Antonietta Bartoli, Lorena Consolino, Paola Bardini, Francesca Arena, Markus Schwaiger, and Silvio Aime
http://cancerres.aacrjournals.org/content/76/22/6463.abstract?etoc

Mutant IDH1 Expression Drives TERT Promoter Reactivation as Part of the Cellular Transformation Process
Shigeo Ohba, Joydeep Mukherjee, Tor-Christian Johannessen, Andrew Mancini, Tracy T. Chow, Matthew Wood, Lindsey Jones, Tali Mazor, Roxanne E. Marshall, Pavithra Viswanath, Kyle M. Walsh, Arie Perry, Robert J.A. Bell, Joanna J. Phillips, Joseph F. Costello, Sabrina M. Ronen, and Russell O. Pieper
http://cancerres.aacrjournals.org/content/76/22/6680.abstract?etoc

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Reviews
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Serine Synthesis Helps Hypoxic Cancer Stem Cells Regulate Redox
Debangshu Samanta and Gregg L. Semenza
http://cancerres.aacrjournals.org/content/76/22/6458.abstract?etoc

Undercover: gene control by metabolites and metabolic enzymes
Jan A. van der Knaap and C. Peter Verrijzer
http://genesdev.cshlp.org/content/30/21/2345.abstract?etoc

Drugging the addict: non‐oncogene addiction as a target for cancer therapy
Remco Nagel, Ekaterina A Semenova, Anton Berns
http://embor.embopress.org/content/early/2016/10/04/embr.201643030

Metabolic Imaging in Prostate Cancer: Where We Are
Claudia Testa1, Cristian Pultrone, David Neil Manners, Riccardo Schiavina and Raffaele Lodi
http://journal.frontiersin.org/article/10.3389/fonc.2016.00225/full

Functional characterization of AMP-activated protein kinase signaling in tumorigenesis
Ji Cheng, Tao Zhang, Hongbin Ji, Kaixiong Tao, Jianping Guo, Wenyi Wei
http://www.sciencedirect.com/science/article/pii/S0304419X16300683

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Previews / other
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An Alternative Sugar Fuels AML
Rob A. Cairns, Tak W. Mak
http://www.cell.com/cancer-cell/fulltext/S1535-6108(16)30502-5

A conversation with Gregg Semenza
Ushma S. Neill
http://www.jci.org/articles/view/90960

Cancer Metabolism: A Conversation with Dr. Jason Locasale
https://www.cancer.gov/research/key-initiatives/ras/ras-central/blog/2016/cancer-metabolism-locasale

Fumarate drives EMT in renal cancer
Marco Sciacovelli and Christian Frezza
http://www.nature.com/cdd/journal/vaop/ncurrent/full/cdd2016137a.html

Cancer metabolism pipeline breaks new ground
Asher Mullard
http://www.nature.com/nrd/journal/v15/n11/full/nrd.2016.223.html

Cholesterol: An Achilles’ Heel for Glioblastoma?
Zhenyi An, William A. Weiss
http://www.cell.com/cancer-cell/fulltext/S1535-6108(16)30498-6

Inner Secrets of the Respirasome
Andrew Melber, Dennis R. Winge
http://www.cell.com/cell/fulltext/S0092-8674(16)31597-5

An apple a day may not keep the doctor away, if you have AML
http://stm.sciencemag.org/content/8/363/363ec174

PGC1α Represses Melanoma Cell Invasion and Metastasis
http://cancerdiscovery.aacrjournals.org/content/6/11/1208.2.abstract?etoc

Metabolism Differs in PDAC and NSCLC with the Same Genetic Background
http://cancerdiscovery.aacrjournals.org/content/6/11/OF11.abstract?etoc

Tumour metabolism: RED(D1) or dead
http://www.nature.com/nrc/journal/v16/n12/full/nrc.2016.132.html

Tumour metabolism: When metabolic and epigenetic states converge
http://www.nature.com/nrc/journal/v16/n12/full/nrc.2016.134.html

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