MetaboList – December 2016

—————————–
Lipid metabolism
—————————–

Targeting metastasis-initiating cells through the fatty acid receptor CD36
Gloria Pascual, Alexandra Avgustinova, Stefania Mejetta, Mercè Martín, Andrés Castellanos, Camille Stephan-Otto Attolini,Antoni Berenguer, Neus Prats, Agustí Toll, Juan Antonio Hueto, Coro Bescós, Luciano Di Croce & Salvador Aznar Benitah
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature20791.html

The role of fatty acid β-oxidation in lymphangiogenesis
Brian W. Wong, Xingwu Wang, Annalisa Zecchin,  Bernard Thienpont,Ivo Cornelissen,Joanna Kalucka, Melissa García-Caballero, Rindert Missiaen, Hongling Huang, Ulrike Brüning, Silvia Blacher, Stefan Vinckier, Jermaine Goveia, Marlen Knobloch, Hui Zhao, Cathrin Dierkes, Chenyan Shi, René Hägerling, Veronica Moral-Dardé, Sabine Wyns, Martin Lippens, Sebastian Jessberger, Sarah-Maria Fendt, Aernout Luttun, Agnès Noel, Friedemann Kiefer, Bart Ghesquière, Lieve Moons, Luc Schoonjans, Mieke Dewerchin, Guy Eelen, Diether Lambrechts & Peter Carmeliet
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature21028.html

Weight control interventions improve therapeutic efficacy of dacarbazine in melanoma by reversing obesity-induced drug resistance
Malvi P, Chaube B, Singh S, Mohammad N, Pandey V, Vijayakumar M, Radhakrishnan R, Vanuopadath M, Nair S, Nair B, Bhat M
http://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-016-0162-8#Abs1

Destabilization of Fatty Acid Synthase by Acetylation Inhibits De Novo Lipogenesis and Tumor Cell Growth
Huai-Peng Lin, Zhou-Li Cheng, Ruo-Yu He, Lei Song, Meng-Xin Tian, Li-Sha Zhou, Beezly S. Groh, Wei-Ren Liu, Min-Biao Ji, Chen Ding, Ying-Hong Shi ,Kun-Liang Guan, Dan Ye, and Yue Xiong
http://cancerres.aacrjournals.org/content/76/23/6924.abstract?etoc

——————————–
Glucose metabolism
——————————–

Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy
Anna Rita Cantelmo, Lena-Christin Conradi, Aleksandra Brajic, Jermaine Goveia, Joanna Kalucka, Andreas Pircher, Pallavi Chaturvedi, Johanna Hol, Bernard Thienpont, Laure-Anne Teuwen, Sandra Schoors, Bram Boeckx, Joris Vriens, Anna Kuchnio, Koen Veys, Bert Cruys, Lise Finotto, Lucas Treps, Tor Espen Stav-Noraas, Francesco Bifari, Peter Stapor, Ilaria Decimo, Kim Kampen, Katrien De Bock, Guttorm Haraldsen, Luc Schoonjans, Ton Rabelink, Guy Eelen, Bart Ghesquière, Jalees Rehman, Diether Lambrechts, Asrar B. Malik, Mieke Dewerchin, Peter Carmeliet
http://www.cell.com/cancer-cell/fulltext/S1535-6108(16)30493-7

Glucose Metabolism Reprogrammed by Overexpression of IKKε Promotes Pancreatic Tumor Growth
Haseeb Zubair, Shafquat Azim, Sanjeev Kumar Srivastava, Aamir Ahmad, Arun
Bhardwaj, Mohammad Aslam Khan, Girijesh Kumar Patel, Sumit Arora, James
Elliot Carter, Seema Singh, and Ajay Pratap Singh
http://cancerres.aacrjournals.org/content/76/24/7254.abstract?etoc

eEF-2 kinase is a critical regulator of Warburg effect through controlling PP2A-A synthesis
Y Cheng, X Ren, Y Yuan, Y Shan, L Li, X Chen, L Zhang, Y Takahashi, J W Yang, B Han, J Liao, Y Li, H Harvey, A Ryazanov, G P Robertson, G Wan, D Liu, A F Chen, Y Tao and J-M Yang
http://www.nature.com/onc/journal/v35/n49/abs/onc2016166a.html

p53 coordinates DNA repair with nucleotide synthesis by suppressing PFKFB3 expression and promoting the pentose phosphate pathway
Derek A. Franklin, Yizhou He, Patrick L. Leslie, Andrey P. Tikunov, Nick Fenger, Jeffrey M. Macdonald & Yanping Zhang
http://www.nature.com/articles/srep38067

Resistance to glucose starvation as metabolic trait of platinum-resistant human epithelial ovarian cancer cells
Anna Pastò, Anna Pagotto, Giorgia Pilotto, Angela De Paoli, Gian Luca De Salvo, Alessandra Baldoni, Maria Ornella Nicoletto, Francesca Ricci, Giovanna Damia, Chiara Bellio, Stefano Indraccolo, Alberto Amadori
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B0%5D=14118&path%5B1%5D=45022#.WGYqUOrMJro.facebook

————————————–
Amino acid metabolism
————————————–

Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors
Shawn M Davidson, Oliver Jonas, Mark A Keibler, Han Wei Hou, Alba Luengo, Jared R Mayers, Jeffrey Wyckoff, Amanda M Del Rosario, Matthew Whitman, Christopher R Chin, Kendall J Condon, Alex Lammers, Katherine A Kellersberger, Brian K Stall, Gregory Stephanopoulos, Dafna Bar-Sagi, Jongyoon Han, Joshua D Rabinowitz, Michael J Cima, Robert Langer & Matthew G Vander Heiden
http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.4256.html

Stress Kinase GCN2 Controls the Proliferative Fitness and Trafficking of Cytotoxic T Cells Independent of Environmental Amino Acid Sensing
Lee-Ann Van de Velde, Xi-Zhi J. Guo, Lidija Barbaric, Amber M. Smith, Thomas H. Oguin III, Paul G. Thomas, Peter J. Murray
http://www.cell.com/cell-reports/fulltext/S2211-1247(16)31514-5

Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC
Jae-Seon Lee, Joon H Kang, Seon-Hyeong Lee, Dongwan Hong, Jaekyoung Son, Kyeong M Hong, Jaewhan Song and Soo-Youl Kim
http://www.nature.com/cddis/journal/v7/n12/abs/cddis2016404a.html?

————————–
AMPK and mTOR
————————–

Protein kinase C phosphorylates AMP-activated protein kinase α1 Ser487
Helen R. Heathcote, Sarah J. Mancini, Anastasiya Strembitska, Kunzah Jamal, James A. Reihill, Timothy M. Palmer, Gwyn W. Gould, and Ian P. Salt
http://www.biochemj.org/content/473/24/4681?etoc

PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation
Grace R. Anderson , Suzanne E. Wardell, Merve Cakir, Lorin Crawford, Jim C. Leeds, Daniel P. Nussbaum, Pallavi S. Shankar, Ryan S. Soderquist, Elizabeth M. Stein, Jennifer P. Tingley, Peter S. Winter, Elizabeth K. Zieser-Misenheimer, Holly M. Alley, Alexander Yllanes, Victoria Haney, Kimberly L. Blackwell, Shannon J. McCall, Donald P. McDonnell, Kris C. Wood
http://stm.sciencemag.org/content/8/369/369ra175

Acute stimulation of glucose influx upon mitoenergetic dysfunction requires LKB1, AMPK, Sirt2 and mTOR–RAPTOR
Dania C. Liemburg-Apers, Jori A. L. Wagenaars, Jan A. M. Smeitink, Peter H. G. M. Willems, and Werner J. H. Koopman
http://jcs.biologists.org/content/129/23/4411?etoc

———————–
Metformin
———————–

An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer
Lianfeng Wu, Ben Zhou, Noriko Oshiro-Rapley, Man Li, Joao A. Paulo, Christopher M. Webster, Fan Mou, Michael C. Kacergis, Michael E. Talkowski, Christopher E. Carr, Steven P. Gygi, Bin Zheng, Alexander A. Soukas
http://www.cell.com/cell/fulltext/S0092-8674(16)31667-1

Metformin improves defective hematopoiesis and delays tumor formation in Fanconi anemia mice
Qing-Shuo Zhang, Weiliang Tang, Matthew Deater, Ngoc Phan, Andrea N. Marcogliese, Hui Li, Muhsen Al-Dhalimy, Angela Major, Susan Olson, Raymond J. Monnat Jr, and Markus Grompe
http://bloodjournal.org/content/128/24/2774.abstract?etoc

Syrosingopine sensitizes cancer cells to killing by metformin
Don Benjamin, Marco Colombi, Sravanth K. Hindupur, Charles Betz, Heidi A. Lane, Mahmoud Y. M. El-Shemerly, Min Lu, Luca Quagliata, Luigi Terracciano, Suzette Moes, Timothy Sharpe, Aleksandra Wodnar-Filipowicz, Christoph Moroni and Michael N. Hall
http://advances.sciencemag.org/content/2/12/e1601756

————————–
Hypoxia
————————–

Adenosine signaling mediates hypoxic responses in the chronic lymphocytic leukemia microenvironment
Sara Serra, Tiziana Vaisitti, Valentina Audrito, Cinzia Bologna, Roberta Buonincontri, Shih-Shih Chen, Francesca Arruga, Davide Brusa, Marta Coscia, Ozren Jaksic, Giorgio Inghirami, Davide Rossi, Richard R. Furman, Simon C. Robson, Gianluca Gaidano, Nicholas Chiorazzi, and Silvia Deaglio
http://www.bloodadvances.org/content/1/1/47.abstract?etoc=&sso-checked=true

In vivo functional dissection of a context-dependent role for Hif1α in pancreatic tumorigenesis
T Cheng, Z Jian, K Li, S Raulefs, I Regel, S Shen, X Zou, J Ruland, G O Ceyhan, H Friess, C W Michalski, J Kleeff and B Kong
http://www.nature.com/oncsis/journal/v5/n12/abs/oncsis201678a.html

Mechanisms through Which Hypoxia-Induced Caveolin-1 Drives Tumorigenesis and Metastasis in Hepatocellular Carcinoma
Xiaowen Mao, Sivia Yuen Sze Wong, Edith Yuk Ting Tse, Frankie Chi Fat Ko, Sze Keong Tey, Yin Shan Yeung, Kwan Man, Regina Cheuk-Lam Lo, Irene Oi-Lin Ng, and Judy Wai Ping Yam
http://cancerres.aacrjournals.org/content/76/24/7242.abstract?etoc

—————————
Miscellaneous
—————————

Integrative modelling of tumour DNA methylation quantifies the contribution of metabolism
Mahya Mehrmohamadi, Lucas K. Mentch, Andrew G. Clark & Jason W. Locasale
http://www.nature.com/articles/ncomms13666

The role of tumor metabolism as a driver of prostate cancer progression and lethal disease: results from a nested case-control study
Kelly  R, Sinnott  J, Rider  J, Ebot  E, Gerke  T, Bowden  M, Pettersson  A, Loda  M, Sesso  H, Kantoff  P, Martin  N, Giovannucci  E, Tyekucheva  S, Heiden  M, Mucci  L
http://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-016-0161-9#Abs1

IDH2 Mutations Define a Unique Subtype of Breast Cancer with Altered Nuclear Polarity
Sarah Chiang, Britta Weigelt, Huei-Chi Wen, Fresia Pareja, Ashwini Raghavendra, Luciano G. Martelotto, Kathleen A. Burke, Thais Basili, AnqiLi, Felipe C. Geyer, Salvatore Piscuoglio, Charlotte K.Y. Ng, Achim A. Jungbluth, Jörg Balss, Stefan Pusch, Gabrielle M. Baker, Kimberly S.  Cole, Andreas von Deimling, Julie M. Batten, Jonathan D. Marotti,  Hwei-Choo Soh, Benjamin L. McCalip, Jonathan Serrano, Raymond S. Lim, Kalliopi P. Siziopikou, Song Lu, Xiaolong Liu, Tarek Hammour, Edi Brogi, Matija Snuderl, A. John Iafrate, Jorge S. Reis-Filho, and Stuart J. Schnitt
http://cancerres.aacrjournals.org/content/76/24/7118.abstract?etoc

PHD2 Is a Regulator for Glycolytic Reprogramming in Macrophages
Annemarie Guentsch, Angelika Beneke, Lija Swain, Katja Farhat, Shunmugam Nagarajan, Ben Wielockx, Kaamini Raithatha, Jan Dudek, Peter Rehling, Anke Zieseniss, Aline Jatho, Mei Chong, Celio X. C. Santos, Ajay M. Shah, and Dörthe M. Katschinski
http://mcb.asm.org/content/37/1/e00236-16.abstract?etoc

——————
Reviews
——————

Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions
Claudio Vernieri, Stefano Casola, Marco Foiani, Filippo Pietrantonio, Filippo de Braud, and Valter Longo
http://cancerdiscovery.aacrjournals.org/content/6/12/1315.abstract?etoc

Metabolic synthetic lethality in cancer therapy
Vincent Zecchini, Christian Frezza
http://www.sciencedirect.com/science/article/pii/S000527281630679X

Eradicating Quiescent Tumor Cells by Targeting Mitochondrial Bioenergetics
Xiaonan Zhang, Angelo De Milito, Asuman Demiroglu-Zergeroglu, Joachim Gullbo, Padraig D’Arcy, Stig Linder
http://www.cell.com/trends/cancer/fulltext/S2405-8033(16)30142-X

Nutrient Exploitation within the Tumor–Stroma Metabolic Crosstalk
Andrea Morandi, Elisa Giannoni, Paola Chiarugi
http://www.cell.com/trends/cancer/fulltext/S2405-8033(16)30164-9

Hypoxia-Inducible Factors: Master Regulators of Cancer Progression
Luana Schito, Gregg L. Semenza
http://www.tandfonline.com/doi/full/10.1080/23723556.2016.1160854

PKM2, cancer metabolism, and the road ahead
Talya L Dayton, Tyler Jacks, and Matthew G Vander Heiden
http://EMBOr.embopress.org/content/17/12/1721?etoc

Cancer Metabolism: Fueling More than Just Growth
Namgyu Lee, and Dohoon Kim
http://www.molcells.org/journal/view.html?uid=3646

Fumarates and Cancer
Gwenny M. Fuhler, Hester Eppinga, Maikel P. Peppelenbosch
http://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(16)30186-1

Tumor Metabolism, the Ketogenic Diet and β-Hydroxybutyrate: Novel Approaches to Adjuvant Brain Tumor Therapy
Eric C. Woolf, Nelofer Syed and Adrienne C. Scheck
http://journal.frontiersin.org/article/10.3389/fnmol.2016.00122/full

Enhanced Therapeutic Efficacy in Cancer Patients by Short-term Fasting: The Autophagy Connection
Gustav van Niekerk, Suzèl M. Hattingh, and Anna-Mart Engelbrecht
http://journal.frontiersin.org/article/10.3389/fonc.2016.00242/full

—————–
Comments
—————–

Serine Metabolism Links Tumor Suppression to the Epigenetic Landscape
Xia Gao, Jason W. Locasale
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30591-5

Fumarate drives EMT in renal cancer
Marco Sciacovelli and Christian Frezza
http://www.nature.com/cdd/journal/v24/n1/full/cdd2016137a.html

Metformin: Restraining Nucleocytoplasmic Shuttling to Fight Cancer and Aging
Jorge Iván Castillo-Quan, T. Keith Blackwell
http://www.cell.com/cell/fulltext/S0092-8674(16)31673-7

Nuclear reprogramming of cancer stem cells: Corrupting the epigenetic code of cell identity with oncometabolites
Javier A. Menendez & Tomás Alarcón
http://www.tandfonline.com/doi/full/10.1080/23723556.2016.1160854

Shedding Light on Fat Dependence in AML
http://cancerdiscovery.aacrjournals.org/content/6/12/OF8.abstract?etoc

AMPK and Sirt2 control compensatory glucose uptake
http://jcs.biologists.org/content/129/23/e2304?etoc

L-Arginine Regulates T-cell Metabolism to Promote Antitumor Activity
http://cancerdiscovery.aacrjournals.org/content/6/12/1302.1.abstract?etoc

Glioblastomas Exhibit a Targetable Dependency on Exogenous Cholesterol
http://cancerdiscovery.aacrjournals.org/content/6/12/1301.1.abstract?etoc

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: