MetaboList – January 2017

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Miscellaneous
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Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer
Prasenjit Dey, Joelle Baddour, Florian Muller, Chia Chin Wu, Huamin Wang, Wen-Ting Liao, Zangdao Lan, Alina Chen, Tony Gutschner,Yaan Kang, Jason Fleming, Nikunj Satani, Di Zhao, Abhinav Achreja, Lifeng Yang, Jiyoon Lee, Edward Chang, Giannicola Genovese, Andrea Viale, Haoqiang Ying, Giulio Draetta, Anirban Maitra, Y. Alan Wang, Deepak Nagrath & Ronald A. DePinho
http://www.nature.com/nature/journal/v542/n7639/full/nature21052.html

Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation
Vinay Bulusu, Sergey Tumanov, Evdokia Michalopoulou, Niels J. van den Broek, Gillian MacKay, Colin Nixon, Sandeep Dhayade, Zachary T. Schug, Johan Vande Voorde, Karen Blyth, Eyal Gottlieb, Alexei Vazquez, Jurre J. Kamphorst
http://www.cell.com/cell-reports/fulltext/S2211-1247(16)31762-4

The Anti-Warburg Effect Elicited by the cAMP-PGC1α Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes
Fan Xing, Yizhao Luan, Jing Cai, Sihan Wu, Jialuo Mai, Jiayu Gu, Haipeng Zhang, Kai Li, Yuan Lin, Xiao Xiao, Jiankai Liang, Yuan Li, Wenli Chen, Yaqian Tan, Longxiang Sheng, Bingzheng Lu, Wanjun Lu, Mingshi Gao, Pengxin Qiu, Xingwen Su, Wei Yin, Jun Hu, Zhongping Chen, Ke Sai, Jing Wang, Furong Chen, Yinsheng Chen, Shida Zhu, Dongbing Liu, Shiyuan Cheng, Zhi Xie, Wenbo Zhu, Guangmei Yan
http://www.cell.com/cell-reports/fulltext/S2211-1247(16)31742-9

Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype
Zahra Ashkavand, Ciara O’Flanagan, Mirko Hennig, Xiuxia Du, Stephen D. Hursting and Sergey A. Krupenko
http://mcr.aacrjournals.org/content/early/2017/01/20/1541-7786.MCR-16-0317

Nuclear Localization of Mitochondrial TCA Cycle Enzymes as a Critical Step in Mammalian Zygotic Genome Activation
Raghavendra Nagaraj, Mark S. Sharpley, Fangtao Chi, Daniel Braas, Yonggang Zhou, Rachel Kim, Amander T. Clark, Utpal Banerjee
http://www.cell.com/cell/fulltext/S0092-8674(16)31742-1

Kinetic Modeling and Analysis of the Akt/Mechanistic Target of Rapamycin Complex 1 (mTORC1) Signaling Axis Reveals Cooperative, Feedforward Regulation
Anisur Rahman and Jason M. Haugh
http://www.jbc.org/content/early/2017/01/09/jbc.M116.761205.abstract

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Microenvironment
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Gpr132 sensing of lactate mediates tumor–macrophage interplay to promote breast cancer metastasis
Peiwen Chen, Hao Zuo, Hu Xiong, Matthew J. Kolar, Qian Chu, Alan Saghatelian, Daniel J. Siegwart, and Yihong Wan
http://www.pnas.org/content/114/3/580.abstract.html?etoc

Microenvironmental autophagy promotes tumour growth
[Drosophila]
Nadja S. Katheder, Rojyar Khezri, Fergal O’Farrell, Sebastian W. Schultz, Ashish Jain, Mohammed M. Rahman, Kay O. Schink, Theodossis A. Theodossiou, Terje Johansen, Gábor Juhász, David Bilder, Andreas Brech, Harald Stenmark & Tor Erik Rusten
http://www.nature.com/nature/journal/v541/n7637/full/nature20815.html

Stromal cues regulate the pancreatic cancer epigenome and metabolome
Mara H. Sherman, Ruth T. Yu, Tiffany W. Tseng, Cristovao M. Sousa, Sihao Liu, Morgan L. Truitt, Nanhai He, Ning Ding, Christopher Liddle, Annette R. Atkins, Mathias Leblanc, Eric A. Collisson, John M. Asara, Alec C. Kimmelman, Michael Downes, and Ronald M. Evans
http://www.pnas.org/content/114/5/1129.abstract.html?etoc

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Starvation / fasting
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Starved epithelial cells uptake extracellular matrix for survival
Taru Muranen, Marcin P. Iwanicki, Natasha L. Curry, Julie Hwang, Cory D. DuBois, Jonathan L. Coloff, Daniel S. Hitchcock, Clary B. Clish, Joan S. Brugge & Nada Y. Kalaany
http://www.nature.com/articles/ncomms13989

mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation
Victor H. Villar, Tra Ly Nguyen, Vanessa Delcroix, Silvia Terés, Marion Bouchecareilh, Bénédicte Salin, Clément Bodineau, Pierre Vacher, Muriel Priault, Pierre Soubeyran and Raúl V. Durán
http://www.nature.com/articles/ncomms14124

General Control Nonderepressible 2 (GCN2) Kinase Inhibits Target of Rapamycin Complex 1 in Response to Amino Acid Starvation in Saccharomyces cerevisiae
Wenjie Yuan, Shuguang Guo, Jiaoqi Gao, Mingming Zhong, Gonghong Yan, Wangmeng Wu, Yapeng Chao, and Yu Jiang
http://www.jbc.org/content/early/2017/01/05/jbc.M116.772194.abstract

Regulation of Serine-Threonine Kinase Akt Activation by NAD+-Dependent Deacetylase SIRT7
Jia Yu, Bo Qin, Fengying Wu, Sisi Qin, Somaira Nowsheen, Shan Shan, Jacqueline Zayas, Huadong Pei, Zhenkun Lou, Liewei Wang
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30027-X

Fasting selectively blocks development of acute lymphoblastic leukemia via leptin-receptor upregulation
Zhigang Lu, Jingjing Xie, Guojin Wu, Jinhui Shen, Robert Collins, Weina Chen, Xunlei Kang, Min Luo, Yizhou Zou, Lily Jun-Shen Huang, ames F Amatruda, Tamra Slone, Naomi Winick, Philipp E Scherer, Cheng Cheng Zhang
http://www.nature.com/nm/journal/v23/n1/full/nm.4252.html

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Glycolysis, gluconeogenesis, PPP
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Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23
Yao Wei, Dong Wang, Fangfang Jin, Zhen Bian, Limin Li, Hongwei Liang, Mingzhen Li, Lei Shi, Chaoyun Pan, Dihan Zhu, Xi Chen, Gang Hu, Yuan Liu, Chen-Yu Zhang and Ke Zen
http://www.nature.com/articles/ncomms14041

c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis
Jia Zhang, Suili Wang, Bin Jiang, Lihong Huang, Zhiliang Ji, Xiaotong Li, Huamin Zhou, Aidong Han, Ai Chen, Yanan Wu, Huanhuan Ma, Wentao Zhao, Qingwen Zhao, Changchuan Xie, Xiaoyan Sun, Yanming Zhou, Huiying Huang, Muhammad Suleman, Furong Lin, Lin Zhou, Fang Tian, Meijun Jin, Yana Cai, Nan Zhang & Qinxi Li
http://www.nature.com/articles/ncomms13732

An N-end rule pathway that recognizes proline and destroys gluconeogenic enzymes
Shun-Jia Chen , Xia Wu, Brandon Wadas, Jang-Hyun Oh, Alexander Varshavsky
http://science.sciencemag.org/content/355/6323/eaal3655?

Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin
S Elf, R Lin, S Xia, Y Pan, C Shan, S Wu, S Lonial, M Gaddh, M L Arellano, H J Khoury, F R Khuri, B H Lee, T J Boggon, J Fan and J Chen
http://www.nature.com/onc/journal/v36/n2/abs/onc2016196a.html

Pyruvate kinase M2 (PKM2) expression correlates with prognosis in solid cancers: a meta-analysis
Haiyan Zhu, Hui Luo, Xuejie Zhu, Xiaoli Hu, Lihong Zheng,  and  Xueqiong Zhu
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=13703

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Glycosylation
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O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway
C M Ferrer, T Y Lu, Z A Bacigalupa, C D Katsetos, D A Sinclair and M J Reginato
http://www.nature.com/onc/journal/v36/n4/abs/onc2016228a.html

Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation
Lindsey Araujo, Phillip Khim, Haik Mkhikian, Christie-Lynn Mortales and Michael Demetriou
https://elifesciences.org/content/6/e21330

Mitochondrial O-GlcNAc transferase (mOGT) regulates mitochondrial structure, function and survival in HeLa cells
Juliana L. Sacoman, Raul Y. Dagda, Amanda R. Burnham-Marusich, Ruben K. Dagda, and Patricia M. Berninsone
http://www.jbc.org/content/early/2017/01/18/jbc.M116.726752.abstract?papetoc

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Lipids
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Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration
Balaban  S, Shearer  R, Lee  L, van Geldermalsen  M, Schreuder  M, Shtein  H, Cairns  R, Thomas  K, Fazakerley  D, Grewal  T, Holst  J, Saunders  D, Hoy  A
http://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-016-0163-7#Abs1

Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells
Jessica E. C. Jones, William P. Esler, Rushi Patel, Adhiraj Lanba, Nicholas B. Vera, Jeffrey A. Pfefferkorn, Cecile Vernochet
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0169566

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Amino Acids
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Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers
Jeff Charles Kremer, Bethany Cheree Prudner, Sara Elaine Stubbs Lange, Gregory Richard Bean, Matthew Bailey Schultze, Caitlyn Brook Brashears, Megan DeAnna Radyk, Nathan Redlich, Shin-Cheng Tzeng, Kenjiro Kami, Laura Shelton, Aixiao Li, Zack Morgan, John Stephen Bomalaski, Takashi Tsukamoto, Jon McConathy, Loren Scott Michel, Jason Matthew Held, Brian Andrew Van Tine
http://www.cell.com/cell-reports/fulltext/S2211-1247(16)31799-5

Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer
Milica Momcilovic, Sean T. Bailey, Jason T. Lee, Michael C. Fishbein, Clara Magyar, Daniel Braas, Thomas Graeber, Nicholas J. Jackson, Johannes Czernin, Ethan Emberley, Matthew Gross, Julie Janes, Andy Mackinnon, Alison Pan, Mirna Rodriguez, Melissa Works, Winter Zhang, Francesco Parlati, Susan Demo, Edward Garon, Kostyantyn Krysan, Tonya C. Walser, Steven M. Dubinett, Saman Sadeghi, Heather R. Christofk, David B. Shackelford
http://www.cell.com/cell-reports/fulltext/S2211-1247(16)31768-5

GLUT1 and ASCT2 as Predictors for Prognosis of Hepatocellular Carcinoma
Hong-Wei Sun, Xing-Juan Yu, Wen-Chao Wu, Jing Chen, Ming Shi, Limin Zheng, Jing Xu
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0168907

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Mitochondria
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Differential contribution of the mitochondrial translation pathway to the survival of diffuse large B-cell lymphoma subsets
Erik Norberg, Ana Lako, Pei-Hsuan Chen, Illana A Stanley, Feng Zhou, Scott B Ficarro, Bjoern Chapuy, Linfeng Chen, Scott Rodig, Donghyuk Shin, Dong Wook Choi, Sangho Lee, Margaret A Shipp, Jarrod A Marto and Nika N Danial
http://www.nature.com/cdd/journal/v24/n2/abs/cdd2016116a.html

Mitochondrial respiratory gene expression is suppressed in many cancers
Ed Reznik, Qingguo Wang, Konnor La, Nikolaus Schultz and Chris Sander
https://elifesciences.org/content/6/e21592

Depletion of mitochondria in mammalian cells through enforced mitophagy
[method]
Clara Correia-Melo, Gabriel Ichim, Stephen W G Tait & João F Passos
http://www.nature.com/nprot/journal/v12/n1/full/nprot.2016.159.html

The Assembly Pathway of Mitochondrial Respiratory Chain Complex I
Sergio Guerrero-Castillo, Fabian Baertling, Daniel Kownatzki, Hans J. Wessels, Susanne Arnold, Ulrich Brandt, Leo Nijtmans
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30480-6

AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1
Traci L. Marin , Brendan Gongol, Fan Zhang, Marcy Martin, David A. Johnson, Han Xiao, Yinsheng Wang, Shankar Subramaniam, Shu Chien, John Y.-J. Shyy
http://stke.sciencemag.org/content/10/464/eaaf7478

Mitochondrial mutations and metabolic adaptation in pancreatic cancer
Hardie  R, van Dam  E, Cowley  M, Han  T, Balaban  S, Pajic  M, Pinese  M, Iconomou  M, Shearer  R, McKenna  J, Miller  D, Waddell  N, Pearson  J, Grimmond  S,   Australian Pancreatic Cancer Genome Initiative, Sazanov  L, Biankin  A, Villas-Boas  S, Hoy  A, Turner  N, Saunders  D
http://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-017-0164-1#Abs1

Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors
Doriane Lorendeau, Gianmarco Rinaldi, Ruben Boon, Pieter Spincemaille, Kristine Metzger , Christian Jäger, Stefan Christen, Xiangyi Dong, Sabine Kuenen, Karin Voordeckers, Patrik Verstreken, David Cassiman, Pieter Vermeersch, Catherine Verfaillie, Karsten Hiller, Sarah-Maria Fendt
http://www.sciencedirect.com/science/article/pii/S1096717616302178

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Hypoxia
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Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments
Georg Fluegen, Alvaro Avivar-Valderas,Yarong Wang,Michael R. Padgen, James K. Williams, Ana Rita Nobre, Veronica Calvo,J ulie F. Cheung, Jose Javier Bravo-Cordero, David Entenberg, James Castracane, Vladislav Verkhusha, Patricia J. Keely, John Condeelis & Julio A. Aguirre-Ghiso
http://www.nature.com/ncb/journal/v19/n2/full/ncb3465.html

Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL−/− clear cell renal carcinoma
Wenhua Gao, Wei Li, Tengfei Xiao, Xiaole Shirley Liu, and William G. Kaelin Jr.
http://www.pnas.org/content/114/5/1027.abstract.html?etoc

Mortalin-mediated and ERK-controlled targeting of HIF-1α to mitochondria confers resistance to apoptosis under hypoxia
Ilias Mylonis, Maria Kourti, Martina Samiotaki, George Panayotou, and George Simos
http://jcs.biologists.org/content/130/2/466?etoc

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Drugs
————

Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex.
Jessica J. Howell, Kristina Hellberg, Marc Turner, George Talbott, Matthew J. Kolar, Debbie S. Ross, Gerta Hoxhaj, Alan Saghatelian, Reuben J. Shaw, Brendan D. Manning
http://www.sciencedirect.com/science/article/pii/S1550413116306428

Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity
Qian Wang, Maria V. Liberti, Pei Liu, Xiaobing Deng, Ying Liu, Jason W. Locasale, Luhua Lai
http://www.sciencedirect.com/science/article/pii/S2451945616304366

Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin
Chaojun Xue, Changyuan Wang, Yaoting Sun, Qiang Meng, Zhihao Liu, Xiaokui Huo, Pengyuan Sun, Huijun Sun, Xiaodong Ma, Xiaochi Ma, Jinyong Peng, Kexin Liu
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[0]=14373

Therapeutic potential of the metabolic modulator phenformin in targeting the stem cell compartment in melanoma
Tiziana Petrachi, Alessandra Romagnani, Adriana Albini, Caterina Longo, Giuseppe Argenziano, Giulia Grisendi, Massimo Dominici, Alessia Ciarrocchi,  and  Katiuscia Dallaglio
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=14321

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Reviews
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Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer
Christopher J. Halbrook, Costas A. Lyssiotis
http://www.cell.com/cancer-cell/fulltext/S1535-6108(16)30601-8

Angiogenesis and Metabolism: Entwined for Therapy Resistance
Gabriela Jiménez-Valerio, Oriol Casanovas
http://www.cell.com/trends/cancer/fulltext/S2405-8033(16)30185-6

Metabolic Reprogramming in Brain Tumors
Sriram Venneti, Craig Thompson
http://www.annualreviews.org/doi/10.1146/annurev-pathol-012615-044329

Potential role of the N-MYC downstream-regulated gene family in reprogramming cancer metabolism under hypoxia
Ga Young Lee1, Yang-Sook Chun1,3, Hyun-Woo Shin1,2,3 and Jong-Wan Park
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B0%5D=10684

Mitochondrial dynamics as regulators of cancer biology
Andrew Paul Trotta, Jerry Edward Chipuk
https://link.springer.com/article/10.1007/s00018-016-2451-3

A New View into the Regulation of Purine Metabolism: The Purinosome
Anthony M. Pedley, Stephen J. Benkovic
http://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(16)30172-4

Integrins and Cell Metabolism: An Intimate Relationship Impacting Cancer
Rehman Ata and Costin N. Antonescu
http://www.mdpi.com/1422-0067/18/1/189

Metabolic rewiring in melanoma
B I Ratnikov, D A Scott, A L Osterman, J W Smith and Z A Ronai
http://www.nature.com/onc/journal/v36/n2/abs/onc2016198a.html

Metabolic regulation of gene expression through histone acylations
Benjamin R. Sabari, Di Zhang, C. David Allis & Yingming Zhao
http://www.nature.com/nrm/journal/v18/n2/abs/nrm.2016.140.html

Caloric restriction – A promising anti-cancer approach: From molecular mechanisms to clinical trials
Gelina S. Kopeina, Vyacheslav V. Senichkin, Boris Zhivotovsky
https://www.sciencedirect.com/science/article/pii/S0304419X16301019

Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer
S Chouaib, M Z Noman, K Kosmatopoulos and M A Curran
http://www.nature.com/onc/journal/v36/n4/abs/onc2016225a.html

The Tumor Microenvironment Modulates Choline and Lipid Metabolism
Noriko Mori, Flonné Wildes, Tomoyo Takagi, Kristine Glunde, and Zaver M. Bhujwalla
http://journal.frontiersin.org/article/10.3389/fonc.2016.00262

Targeting Phospholipid Metabolism in Cancer
Menglin Cheng, Zaver M. Bhujwalla, and Kristine Glunde
http://journal.frontiersin.org/article/10.3389/fonc.2016.00266

Time and Circumstances: Cancer Cell Metabolism at Various Stages of Disease Progression
Georg F. Weber
http://journal.frontiersin.org/article/10.3389/fonc.2016.00257

VDAC3 As a Potential Marker of Mitochondrial Status Is Involved in Cancer and Pathology
Simona Reina, Francesca Guarino, Andrea Magrì, and Vito De Pinto
http://journal.frontiersin.org/article/10.3389/fonc.2016.00264

SnapShot: Non-coding RNAs and Metabolism
Roxana Simona Redis, George Adrian Calin
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30645-3

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Comments
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Endothelial Cells Get β-ox-ed In to Support Lymphangiogenesis
Aaron M. Hosios, Matthew G. Vander Heiden
http://www.cell.com/developmental-cell/fulltext/S1534-5807(17)30004-7

Starving leukemia to induce differentiation
Chia-Wei Cheng and Omer H Yilmaz
http://www.nature.com/nm/journal/v23/n1/full/nm.4259.html

Building a Beautiful Beast: Mammalian Respiratory Complex I
Adela M. Guaras, José Antonio Enríquez
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30652-0

Stem cells: Valine starvation leads to a hungry niche
R. Grant Rowe, George Q. Daley
http://www.nature.com/nature/journal/v541/n7636/full/nature21106.html

One carbon, many roads
Eyal Gottlieb and Karen H Vousden
http://www.nature.com/cdd/journal/v24/n2/full/cdd2016160a.html

Cancer: Double trouble for tumours
Giulia Biffi& David A. Tuveson
http://www.nature.com/nature/journal/v542/n7639/full/nature21117.html

Development: Metabolism regulates lymphangiogenesis
http://www.nature.com/nrm/journal/v18/n2/full/nrm.2017.5.html

Metastasis: The fat controller
http://www.nature.com/nrc/journal/v17/n2/full/nrc.2017.3.html

Tumour metabolism: Packed full of protein!
http://www.nature.com/nrc/journal/v17/n2/full/nrc.2017.2.html

Placing the nuclear pore in the metformin mechanism of action
http://stke.sciencemag.org/content/10/460/eaam6836

Arginine Methylation of MDH1 Disrupts PDAC Metabolism and Growth
http://cancerdiscovery.aacrjournals.org/content/7/1/OF15.abstract?etoc

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