MetaboList – March 2017

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Amino acids and one-carbon/nucleotide metabolism
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PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition
Deepti Mathur, Elias Stratikopoulos, Sait Ozturk, Nicole Steinbach, Sarah Pegno, Sarah Schoenfeld, Raymund Yong, Vundavalli V. Murty, John M. Asara, Lewis C. Cantley and Ramon Parsons
http://cancerdiscovery.aacrjournals.org/content/7/4/380

Adaptive Reprogramming of De Novo Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer
Kristin K. Brown, Jessica B. Spinelli, John M. Asara and Alex Toker
http://cancerdiscovery.aacrjournals.org/content/7/4/391

Oncogene-Selective Sensitivity to Synchronous Cell Death following Modulation of the Amino Acid Nutrient Cystine
Ioannis Poursaitidis, Xiaomeng Wang, Thomas Crighton, Christiaan Labuschagne, David Mason, Shira L. Cramer, Kendra Triplett, Rajat Roy, Olivier E. Pardo, Michael J. Seckl, Scott W. Rowlinson, Everett Stone, Richard F. Lamb
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30252-8

TGFβ1‐induced leucine limitation uncovered by differential ribosome codon reading
Fabricio Loayza‐Puch, Koos Rooijers, Jelle Zijlstra, Behzad Moumbeini, Esther A Zaal, Joachim F Oude Vrielink, Rui Lopes, Alejandro P Ugalde, Celia R Berkers, and Reuven Agami
http://EMBOr.embopress.org/content/18/4/549?etoc

dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective
Ivana Celardo, Susann Lehmann, Ana C Costa, Samantha HY Loh and L Miguel Martins
http://www.nature.com/cdd/journal/v24/n4/abs/cdd2016158a.html?

Arsenic trioxide targets MTHFD1 and SUMO-dependent nuclear de novo thymidylate biosynthesis
Elena Kamynina, Erica R. Lachenauer, Aislyn C. DiRisio, Rebecca P. Liebenthal, Martha S. Field, and Patrick J. Stover
http://www.pnas.org/content/114/12/E2319.abstract.html?etoc

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Glucose metabolism
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Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures
Nicholas A Graham, Aspram Minasyan, Anastasia Lomova, Ashley Cass, Nikolas G Balanis, Michael Friedman, Shawna Chan, Sophie Zhao, Adrian Delgado, James Go, Lillie Beck, Christian Hurtz, Carina Ng, Rong Qiao, Johanna ten Hoeve, Nicolaos Palaskas, Hong Wu, Markus Müschen, Asha S Multani, Elisa Port, Steven M Larson, Nikolaus Schultz, Daniel Braas, Heather R Christofk, Ingo K Mellinghoff, Thomas G Graeber
http://msb.embopress.org/content/13/2/914

Cytosolic malate dehydrogenase activity helps support glycolysis in actively proliferating cells and cancer.
Hanse EA, Ruan C, Kachman M, Wang D, Lowman XH, Kelekar A.
http://www.nature.com/onc/journal/vaop/ncurrent/full/onc201736a.html

High mTORC1 activity drives glycolysis addiction and sensitivity to G6PD inhibition in acute myeloid leukemia cells
Laury Poulain, Pierre Sujobert, Florence Zylbersztejn, Lucille Stuani, Tony Palama, Catherine Lacombe,Patrick Mayeux, Thiago Trovati Maciel, Jean-Charles Portais, Jean-Emmanuel Sarry, Jerome Tamburini, Didier Bouscary, Nicolas Chapuis
http://www.nature.com/leu/journal/vaop/naam/abs/leu201781a.html

Hyperglycemia exacerbates colon cancer malignancy through hexosamine biosynthetic pathway
A Vasconcelos-dos-Santos, H F B R Loponte, N R Mantuano, I A Oliveira, I F de Paula, L K Teixeira, J C M de-Freitas-Junior, K C Gondim, N Heise, R Mohana-Borges, J A Morgado-Díaz, W B Dias and A R Todeschini
http://www.nature.com/oncsis/journal/v6/n3/abs/oncsis20172a.html

EGF induces epithelial-mesenchymal transition and cancer stem-like cell properties in human oral cancer cells via promoting Warburg effect
Qilin Xu, Qunzhou Zhang, Yasutaka Ishida, Souren Hajjar1, Xudong Tang1,3, Haoran Shi1, Chi V. Dang, Anh D. Le
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=13771

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Lipids
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LACTB is a tumour suppressor that modulates lipid metabolism and cell state
Zuzana Keckesova, Joana Liu Donaher, Jasmine De Cock,Elizaveta Freinkman, Susanne Lingrell,Daniel A. Bachovchin, Brian Bierie, Verena Tischler, Aurelia Noske, Marian C. Okondo, Ferenc Reinhardt, Prathapan Thiru,Todd R. Golub, Jean E. Vance & Robert A. Weinberg
http://www.nature.com/nature/journal/v543/n7647/full/nature21408.html

Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival
Marin E. Nelson, Sujoy Lahiri, Jenny D. Y. Chow, Frances L. Byrne, Stefan R. Hargett, David S. Breen, Ellen M. Olzomer, Lindsay E. Wu, Gregory J. Cooney, Nigel Turner, David E. James, Jill K. Slack-Davis, Carolin Lackner, Stephen H. Caldwell and Kyle L. Hoehn
http://www.nature.com/articles/ncomms14689

Lipid Desaturation Is a Metabolic Marker and Therapeutic Target of Ovarian Cancer Stem Cells
Junjie Li, Salvatore Condello, Jessica Thomes-Pepin, Xiaoxiao Ma, Yu Xia, Thomas D. Hurley, Daniela Matei, Ji-Xin Cheng
http://www.cell.com/cell-stem-cell/abstract/S1934-5909(16)30400-3

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Mitochondria
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The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species
Evan A. Bordt, Pascaline Clerc, Brian A. Roelofs, Andrew J. Saladino, László Tretter, Vera Adam-Vizi, Edward Cherok, Ahmed Khalil, Nagendra Yadava, Shealinna X. Ge, T. Chase Francis, Nolan W. Kennedy, Lora K. Picton, Tanya Kumar, Sruti Uppuluri, Alexandrea M. Miller, Kie Itoh, Mariusz Karbowski, Hiromi Sesaki, R. Blake Hill, Brian M. Polster
http://www.cell.com/developmental-cell/fulltext/S1534-5807(17)30116-8

SLC25A26 overexpression impairs cell function via mtDNA hypermethylation and rewiring of methyl metabolism
Alessio Menga, Erika M. Palmieri, Antonia Cianciulli, Vittoria Infantino, Massimiliano Mazzone, Antonio Scilimati, Ferdinando Palmieri, Alessandra Castegna and Vito Iacobazzi
http://onlinelibrary.wiley.com/doi/10.1111/febs.14028/abstract?campaign=woletoc

On the role of Mitofusin 2 in endoplasmic reticulum–mitochondria tethering
Riccardo Filadi, Elisa Greotti, Gabriele Turacchio, Alberto Luini, Tullio Pozzan, and Paola Pizzo
http://www.pnas.org/content/114/12/E2266.extract.html?etoc

Reply to Filadi et al.: Does Mitofusin 2 tether or separate endoplasmic reticulum and mitochondria?
Deborah Naon, Marta Zaninello, Marta Giacomello, Tatiana Varanita, Francesca Grespi, Sowmya Lakshminaranayan, Annalisa Serafini, Martina Semenzato, Stephanie Herkenne, Maria Isabel Hernández-Alvarez, Antonio Zorzano, Diego De Stefani, Gerald W. Dorn II, and Luca Scorrano
http://www.pnas.org/content/114/12/E2268.extract

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Hypoxia / angiogenesis
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GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis
Darya Zibrova, Franck Vandermoere, Olga Göransson, Mark Peggie, Karina V. Mariño, Anne Knierim, Katrin Spengler, Cora Weigert, Benoit Viollet, Nicholas A. Morrice, Kei Sakamoto, and Regine Heller
http://www.biochemj.org/content/474/6/983?etoc

Hypersensitive termination of the hypoxic response by a disordered protein switch
Rebecca B. Berlow,H. Jane Dyson& Peter E. Wright
http://www.nature.com/nature/journal/v543/n7645/full/nature21705.html

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Diet / diabetes
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Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy
Stefano Di Biase, Hong Seok Shim, Kyung Hwa Kim, Manlio Vinciguerra, Francesca Rappa, Min Wei, Sebastian Brandhorst, Francesco Cappello, Hamed Mirzaei, Changhan Lee, Valter D. Longo
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2001951

Impact of diabetes, insulin, and metformin use on the outcome of patients with human epidermal growth factor receptor 2–positive primary breast cancer: analysis from the ALTTO phase III randomized trial
Amir Sonnenblick, Dominique Agbor-Tarh, Ian Bradbury, Serena Di Cosimo, Hatem A. Azim, Debora Fumagalli, Severine Sarp, Antonio C. Wolff, Michael Andersson,Judith Kroep, Tanja Cufer, Sergio D. Simon, Pamela Salman, Masakazu Toi, Lyndsay Harris, Julie Gralow, Maccon Keane, Alvaro Moreno-Aspitia, Martine Piccart-Gebhart, and Evandro de Azambuja
http://ascopubs.org/doi/abs/10.1200/JCO.2016.69.7722

Metabolic effects of fasting on human and mouse blood in vivo
Federico Pietrocola, Yohann Demont, Francesca Castoldi, David Enot, Sylvère Durand, Michaela Semeraro, Elisa Elena Baracco, Jonathan Pol, Jose Manuel Bravo-San Pedro, Chloé Bordenave, Sarah Levesque, Juliette Humeau, Alexis Chery, Didier Métivier, Frank Madeo, M. Chiara Maiuri & Guido Kroemer
http://www.tandfonline.com/doi/full/10.1080/15548627.2016.1271513

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Glucose deprivation
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PHD2 Targeting Overcomes Breast Cancer Cell Death upon Glucose Starvation in a PP2A/B55α-Mediated Manner
Giusy Di Conza, Sarah Trusso Cafarello, Xingnan Zheng, Qing Zhang, Massimiliano Mazzone
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30301-7

BAP1 inhibits the ER stress gene regulatory network and modulates metabolic stress response
Fangyan Dai, Hyemin Lee, Yilei Zhang, Li Zhuang, Hui Yao, Yuanxin Xi, Zhen-Dong Xiao, M. James You, Wei Li, Xiaoping Su, and Boyi Gan
http://www.pnas.org/content/114/12/3192.abstract.html?etoc

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mTOR
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Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex
Brian M. Castellano , Ashley M. Thelen, Ofer Moldavski, McKenna Feltes, Reini E. N. van der Welle, Laurel Mydock-McGrane, Xuntian Jiang, Robert J van Eijkeren, Oliver B. Davis, Sharon M. Louie, Rushika M. Perera, Douglas F. Covey, Daniel K. Nomura, Daniel S. Ory, Roberto Zoncu
http://science.sciencemag.org/content/355/6331/1306

A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma
QiWen Fan, Ozlem Aksoy, Robyn A. Wong, Shirin Ilkhanizadeh, Chris J. Novotny, William C. Gustafson, Albert Yi-Que Truong, Geraldine Cayanan, Erin F. Simonds, Daphne Haas-Kogan, Joanna J. Phillips, Theodore Nicolaides, Masanori Okaniwa, Kevan M. Shokat, William A. Weiss
http://www.cell.com/cancer-cell/fulltext/S1535-6108(17)30014-4

Tor1 and CK2 kinases control a switch between alternative ribosome biogenesis pathways in a growth-dependent manner
Isabelle C. Kos-Braun, Ilona Jung, Martin Koš
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2000245

ZRF1 is a novel S6 kinase substrate that drives the senescence programme
Manuela Barilari, Gregory Bonfils, Caroline Treins, Vonda Koka, Delphine De Villeneuve, Sylvie Fabrega, and Mario Pende
http://EMBOJ.embopress.org/content/36/6/736?etoc

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IDH
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Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles
Farshad Farshidfar, Siyuan Zheng, Marie-Claude Gingras, Yulia Newton, Juliann Shih, A. Gordon Robertson, Toshinori Hinoue, Katherine A. Hoadley, Ewan A. Gibb, Jason Roszik, Kyle R. Covington, Chia-Chin Wu, Eve Shinbrot, Nicolas Stransky, Apurva Hegde, Ju Dong Yang, Ed Reznik, Sara Sadeghi, Chandra Sekhar Pedamallu, Akinyemi I. Ojesina, Julian M. Hess, J. Todd Auman, Suhn K. Rhie, Reanne Bowlby, Mitesh J. Borad, Andrew X. Zhu, Josh M. Stuart, Chris Sander, Rehan Akbani, Andrew D. Cherniack, Vikram Deshpande, Taofic Mounajjed, Wai Chin Foo, Michael S. Torbenson, David E. Kleiner, Peter W. Laird, David A. Wheeler, Autumn J. McRee, Oliver F. Bathe, Jesper B. Andersen, Nabeel Bardeesy, Lewis R. Roberts, Lawrence N. Kwong
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30214-0

Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq
Andrew S. Venteicher , Itay Tirosh, Christine Hebert, Keren Yizhak, Cyril Neftel, Mariella G. Filbin, Volker Hovestadt, Leah E. Escalante, McKenzie L. Shaw, Christopher Rodman, Shawn M. Gillespie, Danielle Dionne, Christina C. Luo, Hiranmayi Ravichandran, Ravindra Mylvaganam, Christopher Mount, Maristela L. Onozato, Brian V. Nahed, Hiroaki Wakimoto, William T. Curry, A. John Iafrate, Miguel N. Rivera, Matthew P. Frosch, Todd R. Golub, Priscilla K. Brastianos, Gad Getz, Anoop P. Patel, Michelle Monje, Daniel P. Cahill, Orit Rozenblatt-Rosen, David N. Louis, Bradley E. Bernstein, Aviv Regev, Mario L. Suvà
http://science.sciencemag.org/content/355/6332/eaai8478

Oncometabolites D- and L-2-hydroxyglutarate Inhibit the AlkB Family DNA Repair Enzymes under Physiological Conditions
Fangyi Chen, Ke Bian, Qi Tang, Bogdan I Fedeles, Vipender Singh, Zachary T. Humulock, John M. Essigmann, and Deyu Li
http://pubs.acs.org/doi/abs/10.1021/acs.chemrestox.7b00009

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Diagnostics
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A plasma metabolomic signature discloses human breast cancer
Mariona Jové, Ricardo Collado, José Luís Quiles, Mari-Carmen Ramírez- Tortosa, Joaquim Sol, Maria Ruiz-Sanjuan, Mónica Fernandez, Capilla de la Torre Cabrera, Cesar Ramírez-Tortosa, Sergio Granados-Principal, Pedro Sánchez-Rovira, and Reinald Pamplona
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=14521

Diagnosis of prostate cancer by desorption electrospray ionization mass spectrometric imaging of small metabolites and lipids
Shibdas Banerjee, Richard N. Zare, Robert J. Tibshirani, Christian A. Kunder, Rosalie Nolley, Richard Fan, James D. Brooks, and Geoffrey A. Sonn
http://www.pnas.org/content/114/13/3334.abstract.html?etoc

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Stroma
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Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate
Chun-Kai Huang, Po-Hao Chang, Wen-Hung Kuo, Chi-Long Chen, Yung-Ming Jeng, King-Jen Chang, Jin-Yuh Shew, Chun-Mei Hu and Wen-Hwa Lee
http://www.nature.com/articles/ncomms14706

Metabolic reprogramming of the premalignant colonic mucosa is an early event in carcinogenesis
Mart Dela Cruz, Sarah Ledbetter, Sanjib Chowdhury, Ashish K. Tiwari, Navneet Momi, Ramesh K. Wali, Charles Bliss, Christopher Huang, David Lichtenstein, Swati Bhattacharya, Anisha Varma-Wilson, Vadim Backman, and Hemant K. Roy
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=16129

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Miscellaneous
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Metabolic origins of spatial organization in the tumor microenvironment
Carlos Carmona-Fontaine, Maxime Deforet, Leila Akkari, Craig B. Thompson, Johanna A. Joyce, and Joao B. Xavier
http://www.pnas.org/content/114/11/2934.abstract.html?etoc

Quantifying Intracellular Rates of Glycolytic and Oxidative ATP Production and Consumption Using Extracellular Flux Measurements
Shona A Mookerjee, Akos A Gerencser, David G Nicholls, and Martin D Brand
http://www.jbc.org/content/early/2017/03/07/jbc.M116.774471.abstract

Interplay between metabolic identities in the intestinal crypt supports stem cell function
Maria J. Rodríguez-Colman, Matthias Schewe, Maaike Meerlo, Edwin Stigter, Johan Gerrits, Mia Pras-Raves,Andrea Sacchetti, Marten Hornsveld, Koen C. Oost, Hugo J. Snippert, Nanda Verhoeven-Duif, Riccardo Fodde & Boudewijn M. T. Burgering
http://www.nature.com/nature/journal/v543/n7645/full/nature21673.html

Diabetic concentrations of metformin inhibit platelet-mediated ovarian cancer cell progression
Rafaela Erices, Sofía Cubillos, Raúl Aravena, Felice Santoro, Monica Marquez, Renan Orellana, Carolina Ramírez, Pamela González, Patricia Fuenzalida, María Loreto Bravo, Bárbara Oliva, Sumie Kato, Carolina Ibañez, Jorge Brañes, Erasmo Bravo, Catalina Alonso, Karen García, Clemente Arab, Vicente A. Torres, Alejandro S. Godoy, Jaime Pereira, Galdo Bustos, Julio Cesar Cardenas, Mauricio A. Cuello, and Gareth I. Owen
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=15348

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Reviews / comments
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Interplay between Immune Checkpoint Proteins and Cellular Metabolism
Sangbin Lim, Joshua B. Phillips, Luciana Madeira da Silva, Ming Zhou, Oystein Fodstad, Laurie B. Owen and Ming Tan
http://cancerres.aacrjournals.org/content/early/2017/02/27/0008-5472.CAN-16-1647

The Role of Autophagy in Cancer
Naiara Santana-Codina, Joseph D. Mancias, and Alec C. Kimmelman
http://www.annualreviews.org/doi/pdf/10.1146/annurev-cancerbio-041816-122338

Glutamine Metabolism in Cancer: Understanding the Heterogeneity
Ahmad A . Cluntun, Michael J . Lukey, Richard A . Cerione, Jason W . Locasale
http://www.cell.com/trends/cancer/fulltext/S2405-8033(17)30022-5

The metabolic programming of stem cells
Ng Shyh-Chang and Huck-Hui Ng
http://genesdev.cshlp.org/content/31/4/336.abstract?etoc

Adipocyte–Tumor Cell Metabolic Crosstalk in Breast Cancer
Andrew J. Hoy, Seher Balaban, Darren N. Saunders
http://www.sciencedirect.com/science/article/pii/S1471491417300291

Glutaminolysis: A Hallmark of Cancer Metabolism
Lifeng Yang, Sriram Venneti, and Deepak Nagrath
http://www.annualreviews.org/doi/10.1146/annurev-bioeng-071516-044546

Metabolomics: A Primer
Xiaojing Liu, Jason W. Locasale
http://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(17)30018-X

The sweet side of AMPK signaling: regulation of GFAT1
John W. Scott, Jonathan S. Oakhill
http://www.biochemj.org/content/474/7/1289?etoc

IDH-Mutant Tumors Vulnerable to PARP Inhibition
http://cancerdiscovery.aacrjournals.org/content/7/4/OF4

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