MetaboList – April 2017

Nucleotide synthesis / folate cycle

Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase
Jason R. Cantor, Monther Abu-Remaileh, Naama Kanarek, Elizaveta Freinkman, Xin Gao, Abner Louissaint Jr., Caroline A. Lewis, David M. Sabatini

Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma
Derek Lee, Iris Ming-Jing Xu, David Kung-Chun Chiu, Robin Kit-Ho Lai, Aki Pui-Wah Tse, Lynna Lan Li, Cheuk-Ting Law, Felice Ho-Ching Tsang, Larry Lai Wei, Cerise Yuen-Ki Chan, Chun-Ming Wong, Irene Oi-Lin Ng, and Carmen Chak-Lui Wong

Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers
Arimichi Okazaki, Paulo A. Gameiro, Danos Christodoulou, Laura Laviollette, Meike Schneider, Frances Chaves, Anat Stemmer-Rachamimov, Stephanie A. Yazinski, Richard Lee, Gregory Stephanopoulos, Lee Zou, and Othon Iliopoulos

Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication
Iosifina P. Foskolou, Christian Jorgensen, Katarzyna B. Leszczynska, Monica M. Olcina, Hanna Tarhonskaya, Bauke Haisma, Vincenzo D’Angiolella, William K. Myers, Carmen Domene, Emily Flashman, Ester M. Hammond

Glucose metabolism

PIK3CA mutant tumors depend on oxoglutarate dehydrogenase
Nina Ilic, Kıvanç Birsoy, Andrew J. Aguirre, Nora Kory, Michael E. Pacold, Shambhavi Singh, Susan E. Moody, Joseph D. DeAngelo, Nicole A. Spardy, Elizaveta Freinkman, Barbara A. Weir, Aviad Tsherniak, Glenn S. Cowley, David E. Root, John M. Asara, Francisca Vazquez, Hans R. Widlund, David M. Sabatini, and William C. Hahn

Identification of a Multienzyme Complex for Glucose Metabolism in Living Cells
Casey L. Kohnhorst, Minjoung Kyoung, Miji Jeon, Danielle L. Schmitt, Erin L. Kennedy, Julio Ramirez, Syrena M. Bracey, Bao Tran Luu, Sarah J. Russell, and Songon An

Glucose availability controls ATF4-mediated MITF suppression to drive melanoma cell growth
Jennifer Ferguson, Michael Smith, Isabel Zudaire, Claudia Wellbrock, Imanol Arozarena

MAGE-TRIM28 complex promotes the Warburg effect and hepatocellular carcinoma progression by targeting FBP1 for degradation
X Jin, Y Pan, L Wang, L Zhang, R Ravichandran, P R Potts, J Jiang, H Wu and H Huang

CUE domain‐containing protein 2 promotes the Warburg effect and tumorigenesis
Xiuying Zhong, Shengya Tian, Xiang Zhang, Xinwei Diao, Fangting Dong, JieYang, Zhaoyong Li, Linchong Sun, Lin Wang, Xiaoping He, Gongwei Wu, Xin Hu, Lihua Wang, Libing Song, Huafeng Zhang, Xin Pan, Ailing Li, and Ping Gao

Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c–SIRT2 axis
Young Cha,Min-Joon Han,Hyuk-Jin Cha,Janet Zoldan,Alison Burkart,Jin Hyuk Jung,Yongwoo Jang,Chun-Hyung Kim,Ho-Chang Jeong,Byung-Gyu Kim,Robert Langer,C. Ronald Kahn,Leonard Guarente & Kwang-Soo Kim

Amino acid metabolism / signaling

Modulating the therapeutic response of tumours to dietary serine and glycine starvation
Oliver D. K. Maddocks, Dimitris Athineos, Eric C. Cheung, Pearl Lee, Tong Zhang, Niels J. F. van den Broek, Gillian M. Mackay, Christiaan F. Labuschagne, David Gay, Flore Kruiswijk, Julianna Blagih, David F. Vincent, Kirsteen J. Campbell, Fatih Ceteci, Owen J. Sansom ,Karen Blyth & Karen H. Vousden

The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility
Chun-Shik Shin, Prashant Mishra, Jeramie D. Watrous, Valerio Carelli, Marilena D’Aurelio, Mohit Jain and David C. Chan

Glutamine activates STAT3 to control cancer cell proliferation independently of glutamine metabolism
A Cacace, M Sboarina, T Vazeille and P Sonveaux

SNAT7 is the primary lysosomal glutamine exporter required for extracellular protein-dependent growth of cancer cells
Quentin Verdon, Marielle Boonen, Christopher Ribes, Michel Jadot, Bruno Gasnier, and Corinne Sagné

Tumor-associated mutant p53 promotes cancer cell survival upon glutamine deprivation through p21 induction
T Q Tran, X H Lowman, M A Reid, C Mendez-Dorantes, M Pan, Y Yang and M Kong

Head and Neck Squamous Cell Carcinoma Metabolism Draws on Glutaminolysis, and Stemness Is Specifically Regulated by Glutaminolysis via Aldehyde Dehydrogenase
Pachiyappan Kamarajan, Thekkelnaycke M. Rajendiran, Jason Kinchen∥, Mercedes Bermúdez, Theodora Danciu, and Yvonne L. Kapila


A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC)
Imelda T Sandoval, Richard Glenn C Delacruz, Braden N Miller, Shauna Hill, Kristofor A Olson, Ana E Gabriel, Kevin Boyd, Christeena Satterfield, Holly Van Remmen, Jared Rutter and David A Jones

Succinate dehydrogenase B-deficient cancer cells are highly sensitive to bromodomain and extra-terminal inhibitors
Satoshi Kitazawa, Shunsuke Ebara, Ayumi Ando, Yuji Baba, Yoshinori Satomi, Tomoyoshi Soga, and Takahito Hara


Myoferlin regulates cellular lipid metabolism and promotes metastases in triple-negative breast cancer
A Blomme, B Costanza, P de Tullio, M Thiry, G Van Simaeys, S Boutry, G Doumont, E Di Valentin, T Hirano, T Yokobori, S Gofflot, O Peulen, A Bellahcène, F Sherer, C Le Goff, E Cavalier, A Mouithys-Mickalad, F Jouret, P G Cusumano, E Lifrange, R N Muller, S Goldman, P Delvenne, E De Pauw, M Nishiyama, V Castronovo and A Turtoi

Oncogene KRAS activates fatty acid synthase, resulting in specific ERK and lipid signatures associated with lung adenocarcinoma
Arvin M. Gouw, Livia S. Eberlin, Katherine Margulis, Delaney K. Sullivan, Georgia G. Toal, Ling Tong, Richard N. Zare, and Dean W. Felsher

Hypoxia and HIFs

Mitochondrial complex I deactivation is related to superoxide production in acute hypoxia
Pablo Hernansanz-Agustín, Elena Ramos,Elisa Navarro, Esther Parada, Nuria Sánchez-López, Laura Peláez-Aguado,
J. Daniel Cabrera-García, Daniel Tello, Izaskun Buendia, Anabel Marina, Javier Egea, Manuela G. López, Anna Bogdanova, Antonio Martínez-Ruiz

Regulation of hypoxia responses by flavin adenine dinucleotide‐dependent modulation of HIF‐1α protein stability
Suk‐Jin Yang, Young Soo Park, Jung Hee Cho, Byul Moon, Hyun‐Jung An, Ju Yeon Lee, Zhi Xie, Yuli Wang, David Pocalyko, Dong Chul Lee, Hyun Ahm Sohn, Minho Kang, Jin Young Kim, Eunhee Kim, Kyung Chan Park, Jung‐Ae Kim, and Young Il Yeom

Monomethyltransferase SETD8 regulates breast cancer metabolism via stabilizing hypoxia-inducible factor 1 alpha
Huang, Run; Yu, Yang; Zong, Xiangyun; Li, Xiaolin; Ma, Lisi; Zheng, Qi

Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat
Thomas J. Park , Jane Reznick, Bethany L. Peterson, Gregory Blass, Damir Omerba??i??, Nigel C. Bennett, P. Henning J. L. Kuich, Christin Zasada, Brigitte M. Browe, Wiebke Hamann, Daniel T. Applegate, Michael H. Radke, Tetiana Kosten, Heike Lutermann, Victoria Gavaghan, Ole Eigenbrod, Valérie Bégay, Vince G. Amoroso, Vidya Govind, Richard D. Minshall, Ewan St. J. Smith, John Larson, Michael Gotthardt, Stefan Kempa, Gary R. Lewin

Starvation, mTOR

Amino acid–insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells
Demetrios Kalaitzidis, Dongjun Lee, Alejo Efeyan, Youmna Kfoury, Naema Nayyar, David B. Sykes, Francois E. Mercier, Ani Papazian, Ninib Baryawno, Gabriel D. Victora, Donna Neuberg, David M. Sabatini, David T. Scadden

Decreased ATF4 expression as a mechanism of acquired resistance to long-term amino acid limitation in cancer cells
Florent Mesclon, Sarah Lambert-Langlais, Valérie Carraro, Laurent Parry, Isabelle Hainault, Céline Jousse, Anne-Catherine Maurin, Alain Bruhat, Pierre Fafournoux, and Julien Averous

Formation of a Snf1-Mec1-Atg1 Module on Mitochondria Governs Energy Deprivation-Induced Autophagy by Regulating Mitochondrial Respiration
Cong Yi, Jingjing Tong, Puzhong Lu, Yizheng Wang, Jinxie Zhang, Chen Sun, Kangning Yuan, Renyu Xue, Bing Zou, Nianzhong Li, Shuhua Xiao, Chong Dai, Yuwei Huang, Liling Xu, Lin Li, She Chen, Di Miao, Haiteng Deng, Hongliang Li, Li Yu

AKT activation was not essential for hepatocellular carcinoma cell survival under glucose deprivation
Zhou, Jing; Tang, Yue; Xie, Ze-Jun; Lu, Jing-Ning; Deng, Jing-Huan; Huang, Xiao-Wei; Chuan Hooi, Shing; He, Min; Lu, Guo-Dong


AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations
Katharine Yen, Jeremy Travins, Fang Wang, et al and Shin-San Michael Su

Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas
Gary Kohanbash, Diego A. Carrera, Shruti Shrivastav, Brian J. Ahn, Naznin Jahan, Tali Mazor, Zinal S. Chheda, Kira M. Downey, Payal B. Watchmaker, Casey Beppler, Rolf Warta, Nduka A. Amankulor, Christel Herold-Mende, Joseph F. Costello, Hideho Okada

Oncometabolite D-2-Hydroxyglutarate enhances gene silencing through inhibition of specific H3K36 histone demethylases
Ryan Janke, Anthony T Iavarone and Jasper Rine

IDH1 Mutation Promotes Tumorigenesis by Inhibiting JNK Activation and Apoptosis Induced by Serum Starvation
Bin Jiang, Jia Zhang, Jinmei Xia, Wentao Zhao, Yanan Wu, Minggang Shi, Lianzhong Luo, Huamin Zhou, Ai Chen, Huanhuan Ma, Qingwen Zhao, Muhammad Suleman, Furong Lin, Lin Zhou, Jinyang Wang, Yan Zhang, Ying He, Xiaotong Li, Li-Man Hung, Tak Wah Mak, Qinxi Li


Metformin alters DNA methylation genome-wide via the H19/SAHH axis
T Zhong, Y Men, L Lu, T Geng, J Zhou, A Mitsuhashi, M Shozu, N J Maihle, G G Carmichael, H S Taylor and Y Huang

Metformin Directly Binds the Alarmin HMGB1 and Inhibits its Proinflammatory Activity
Takahiro Horiuchi, Natsumi Sakata, Yoshihiro Narumi, Tomohiro Kimura, Takashi Hayashi, Keisuke Nagano, Keyue Liu, Masahiro Nishibori, Sohei Tsukita, Tetsuya Yamada, Hideki Katagiri, Ryutaro Shirakawa, and Hisanori Horiuchi

2-Deoxy-D-glucose suppresses the migration and reverses the drug resistance of colon cancer cells through ADAM expression regulation
Park, Ga B.; Chung, Yoon H.; Kim, Daejin


A Metabolic Function for Phospholipid and Histone Methylation
Cunqi Ye, Benjamin M. Sutter, Yun Wang, Zheng Kuang, Benjamin P. Tu

An analytic approximation of the feasible space of metabolic networks
Alfredo Braunstein, Anna Paola Muntoni and Andrea Pagnani

Glutathione Primes T Cell Metabolism for Inflammation
Tak W. Mak, Melanie Grusdat, Gordon S. Duncan, Catherine Dostert, Yannic Nonnenmacher, Maureen Cox, Carole Binsfeld, Zhenyue Hao, Anne Brüstle, Momoe Itsumi, Christian Jäger, Ying Chen, Olaf Pinkenburg, Bärbel Camara, Markus Ollert, Carsten Bindslev-Jensen, Vasilis Vasiliou, Chiara Gorrini, Philipp A. Lang, Michael Lohoff, Isaac S. Harris, Karsten Hiller, Dirk Brenner

Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes
Shunsuke Kon,Kojiro Ishibashi, … et al & Yasuyuki Fujita


mTORC1 signaling and the metabolic control of cell growth
Issam Ben-Sahra, Brendan D Manning

Mitochondrial metabolites: undercover signalling molecules
Christian Frezza

Autophagy and Tumor Metabolism
Alec C. Kimmelman, Eileen White

Metabolic Mechanisms of Epigenetic Regulation
Jordan L. Meier

Mammalian SWI/SNF Enzymes and the Epigenetics of Tumor Cell Metabolic Reprogramming
Jeffrey A. Nickerson, Qiong Wu and Anthony N. Imbalzano

The lysosome: a crucial hub for AMPK and mTORC1 signalling
Bernadette Carroll and Elaine A. Dunlop

AMPK signalling in health and disease
David Carling

mTORC1 and mTORC2 in cancer and the tumor microenvironment
L C Kim, R S Cook and J Chen

In vivo Reprogramming of Cancer Metabolism by MYC
Roman Camarda, Jeremy Williams and Andrei Goga

The Enigma of the Respiratory Chain Supercomplex
Dusanka Milenkovic, James N. Blaza, Nils-Göran Larsson, Judy Hirst

Macrophage Metabolism As Therapeutic Target for Cancer, Atherosclerosis, and Obesity.
Geeraerts X, Bolli E, Fendt SM, Van Ginderachter JA.

Metabolic Hallmarks of Tumor and Immune Cells in the Tumor Microenvironment
Kathrin Renner, Katrin Singer1, Gudrun E. Koehl3, Edward K. Geissler3, Katrin Peter1, Peter J. Siska and Marina Kreutz

AKT/PKB Signaling: Navigating the Network
Brendan D. Manning, Alex Toker

Multifaceted Effects of Antimetabolite and Anticancer Drug, 2-Deoxyglucose on Eukaryotic Cancer Models Budding and Fission Yeast
Vishwanatha, A; D’Souza, CJM

Racial disparity in metabolic regulation of cancer
Kuldeep S. Attri1, Divya Murthy1, Pankaj K. Singh

Sensing the Environment Through Sestrins: Implications for Cellular Metabolism
A. Parmigiani, A.V. Budanov

One-carbon metabolism and nucleotide biosynthesis as attractive targets for anticancer therapy
Oleg Shuvalov, Alexey Petukhov, Alexandra Daks, Olga Fedorova, Elena Vasileva, Nickolai A. Barlev

Comments / other

When cancer needs what’s non-essential
Mark R. Sullivan and Matthew G. Vander Heiden

Quiescence-like Metabolism to Push Cancer Out of the Race
Verónica Torrano, Arkaitz Carracedo

Neurons eat glutamate to stay alive
Sarah-Maria Fendt, Patrik Verstreken

Optimizing Next-Generation AML Therapy: Activity of Mutant IDH2 Inhibitor AG-221 in Preclinical Models
Daniel Thomas and Ravindra Majeti

SIRT2 and glycolytic enzyme acetylation in pluripotent stem cells
Tong Ming Liu& Ng Shyh-Chang

Metabolic changes promote rejection of oncogenic cells
Jonathan L. Coloff and Joan S. Brugge

MCB cover: Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death Receptors (Iurlaro and Muñoz-Pinedo)

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