MetaboList – May 2017

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Nucleotides
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CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells
Jiyeon Kim, Zeping Hu, Ling Cai, Kailong Li, Eunhee Choi, Brandon Faubert, Divya Bezwada, Jaime Rodriguez-Canales, Pamela Villalobos, Yu-Fen Lin, Min Ni, Kenneth E. Huffman, Luc Girard, Lauren A. Byers, Keziban Unsal-Kacmaz, Christopher G. Peña, John V. Heymach, Els Wauters, Johan Vansteenkiste, Diego H. Castrillon, Benjamin P. C. Chen, Ignacio Wistuba, Diether Lambrechts, Jian Xu, John D. Minna & Ralph J. DeBerardinis
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature22359.html

Thymidine Catabolism as a Metabolic Strategy for Cancer Survival
Sho Tabata, Masatatsu Yamamoto, Hisatsugu Goto, Akiyoshi Hirayama, Maki Ohishi, Takuya Kuramoto, Atsushi Mitsuhashi, Ryuji Ikeda, Misako Haraguchi, Kohichi Kawahara, Yoshinari Shinsato, Kentaro Minami, Atsuro Saijo, Masaki Hanibuchi, Yasuhiko Nishioka, Saburo Sone, Hiroyasu Esumi, Masaru Tomita, Tomoyoshi Soga, Tatsuhiko Furukawa, Shin-ichi Akiyama
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30572-7

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Glucose metabolism
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Phosphoglycerate mutase 1 promotes cancer cell migration independent of its metabolic activity
D Zhang, N Jin, W Sun, X Li, B Liu, Z Xie, J Qu, J Xu, X Yang, Y Su, S Tang, H Han, D Chen, J Ding, M Tan, M Huang and M Geng
http://www.nature.com/onc/journal/v36/n20/abs/onc2016446a.html

Rewiring carbohydrate catabolism differentially affects survival of pancreatic cancer cell lines with diverse metabolic profiles
Tiziana Tataranni, Francesca Agriesti, Vitalba Ruggieri, Carmela Mazzoccoli, Vittorio Simeon, Ilaria Laurenzana, Rosella Scrima, Valerio Pazienza, Nazzareno Capitanio, Claudia Piccoli
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=17172&path%5B%5D=54977

PAK4 regulates G6PD activity by p53 degradation involving colon cancer cell growth
Xiumei Zhang, Xia Zhang, Yang Li, Yangguang Shao, Jianying Xiao, Ge Zhu and Feng Li
http://www.nature.com/cddis/journal/v8/n5/abs/cddis201785a.html

The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition
Justin Goodwin, Michael L. Neugent, Shin Yup Lee, Joshua H. Choe, Hyunsung Choi, Dana M. R. Jenkins, Robin J. Ruthenborg, Maddox W. Robinson, Ji Yun Jeong, Masaki Wake, Hajime Abe, Norihiko Takeda, Hiroko Endo, Masahiro Inoue, Zhenyu Xuan, Hyuntae Yoo, Min Chen, Jung-Mo Ahn, John D. Minna, Kristi L. Helke, Pankaj K. Singh, David B. Shackelford & Jung-whan Kim
https://www.nature.com/articles/ncomms15503

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Amino acids
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Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia
Ayuna Hattori, Makoto Tsunoda, Takaaki Konuma, Masayuki Kobayashi, Tamas Nagy, John Glushka, Fariba Tayyari, Daniel McSkimming, Natarajan Kannan, Arinobu Tojo, Arthur S. Edison & Takahiro Ito
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature22314.html

Essential amino acid mixtures drive cancer cells to apoptosis through proteasome inhibition and autophagy activation
Laura Bonfili, Valentina Cecarini, Massimiliano Cuccioloni, Mauro Angeletti, Vincenzo Flati, Giovanni Corsetti, Evasio Pasini, Francesco S. Dioguardi, Anna Maria Eleuteri
http://onlinelibrary.wiley.com/doi/10.1111/febs.14081/abstract

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Lipids
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STAT3 Regulation of Citrate Synthase Is Essential during the Initiation of Lymphocyte Cell Growth
Sarah MacPherson, Michael Horkoff, Cleo Gravel, Thomas Hoffmann, Johannes Zuber, Julian J. Lum
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30487-4

Acyl-CoA thioesterase 7 is involved in cell cycle progression via regulation of PKCζ–p53–p21 signaling pathway
Seung Hee Jung, Hyung Chul Lee, Hyun Jung Hwang, Hyun A Park, Young-Ah Moon, Bong Cho Kim, Hyeong Min Lee, Kwang Pyo Kim, Yong-Nyun Kim, Byung Lan Lee, Jae Cheol Lee, Young-Gyu Ko, Heon Joo Park and Jae-Seon Lee
http://www.nature.com/cddis/journal/v8/n5/abs/cddis2017202a.html

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Drugs
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Molecular docking studies of 3-bromopyruvate and its derivatives to metabolic regulatory enzymes: Implication in designing of novel anticancer therapeutic strategies
Saveg Yadav, Shrish Kumar Pandey, Vinay Kumar Singh, Yugal Goel, Ajay Kumar, Sukh Mahendra Singh
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0176403

Verapamil treatment induces cytoprotective autophagy by modulating cellular metabolism
lżbieta Kania, Beata Pająk, Jim O’Prey, Pablo Sierra Gonzalez, Anna Litwiniuk, Kaja Urbańska, Kevin M. Ryan, Arkadiusz Orzechowski
http://onlinelibrary.wiley.com/doi/10.1111/febs.14064/abstract

Evaluating a Dichloroacetate and Metformin Combination in a Mouse Model of Metastatic Cancer
Nathan Ward, Angela Poff, Ashley Van Putten, Thomas Seyfried and Dominic D’Agostino
http://www.fasebj.org/content/29/1_Supplement/725.10

Low dose of 2-deoxy-D-glucose kills acute lymphoblastic leukemia cells and reverses glucocorticoid resistance via N-linked glycosylation inhibition under normoxia
Gu, Ling; Yi, Zhihui; Zhang, Yanle; Ma, Zhigui; Zhu, Yiping; Gao, Ju
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=16046&pubmed-linkout=1

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Mitochondria
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Safety and tolerability of the first-in-class agent CPI-613 in combination with modified FOLFIRINOX in patients with metastatic pancreatic cancer: a single-centre, open-label, dose-escalation, phase 1 trial
Dr Angela Alistar, Bonny B Morris, Rodwige Desnoyer, Heidi D Klepin, Keyanoosh Hosseinzadeh, Clancy Clark, Amy Cameron, Prof John Leyendecker, Prof Ralph D’Agostino Jr, Umit Topaloglu, Lakmal W Boteju, Asela R Boteju, Rob Shorr, Zuzana Zachar, Paul M Bingham, Tamjeed Ahmed, Sandrine Crane, Riddhishkumar Shah, John J Migliano, Timothy S Pardee, Lance Miller, Gregory Hawkins, Guangxu Jin, Prof Wei Zhang, Prof Boris Pasche
http://thelancet.com/journals/lanonc/article/PIIS1470-2045(17)30314-5/abstract

Fumarate Mediates a Chronic Proliferative Signal in Fumarate Hydratase-Inactivated Cancer Cells by Increasing Transcription and Translation of Ferritin Genes
Michael John Kerins, Ajay Amar Vashisht, Benjamin Xi-Tong Liang, Spencer Jordan Duckworth, Brandon John Praslicka, James Akira Wohlschlegel, and Aikseng Ooi
http://mcb.asm.org/content/37/11/e00079-17.abstract?etoc

Overexpression of the ATPase Inhibitory Factor 1 Favors a Non-metastatic Phenotype in Breast Cancer
Lucía García-Ledo, Cristina Nuevo-Tapioles, Carmen Cuevas-Martín, Inmaculada Martínez-Reyes, Beatriz Soldevilla, Lucia González-Llorente, and Jose Cuezva
http://journal.frontiersin.org/article/10.3389/fonc.2017.00069/full

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Starvation / hypoxia
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Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function
Jun-ichi Sakamaki, Simon Wilkinson, Marcel Hahn, Nilgun Tasdemir, Jim O’Prey, William Clark, Ann Hedley, Colin Nixon, Jaclyn S. Long, Maria New, Tim Van Acker, Sharon A. Tooze, Scott W. Lowe, Ivan Dikic, Kevin M. Ryan
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30312-X

Single-cell time-lapse imaging of intracellular O2 in response to metabolic inhibition and mitochondrial cytochrome-c release
Heiko Düssmann, Sergio Perez-Alvarez, Ujval Anilkumar, Dmitri B Papkovsky and Jochen HM Prehn
https://www.nature.com/cddis/journal/v8/n6/full/cddis2017247a.html

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mTOR
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mTORC1 Balances Cellular Amino Acid Supply with Demand for Protein Synthesis through Post-transcriptional Control of ATF4
Yeonwoo Park, Andrea Reyna-Neyra, Lucas Philippe, Carson C. Thoreen
http://www.cell.com/cell-reports/abstract/S2211-1247(17)30536-3

mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate
Andrea L. Marat, Alexander Wallroth, Wen-Ting Lo, Rainer Müller, Giuseppe Danilo Norata, Marco Falasca, Carsten Schultz, Volker Haucke
http://science.sciencemag.org/content/356/6341/968

Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition
F Mateo, E J Arenas, H Aguilar, J Serra-Musach, G Ruiz de Garibay, J Boni, M Maicas, S Du, F Iorio, C Herranz-Ors, A Islam, X Prado, A Llorente, A Petit, A Vidal, I Català, T Soler, G Venturas, A Rojo-Sebastian, H Serra, D Cuadras, I Blanco, J Lozano, F Canals, A M Sieuwerts, V de Weerd, M P Look, S Puertas, N García, A S Perkins, N Bonifaci, M Skowron, L Gómez-Baldó, V Hernández, A Martínez-Aranda, M Martínez-Iniesta, X Serrat, J Cerón, J Brunet, M P Barretina, M Gil, C Falo, A Fernández, I Morilla, S Pernas, M J Plà, X Andreu, M A Seguí, R Ballester, E Castellà, M Nellist, S Morales, J Valls, A Velasco, X Matias-Guiu, A Figueras, J V Sánchez-Mut, M Sánchez-Céspedes, A Cordero, J Gómez-Miragaya, L Palomero, A Gómez, T F Gajewski, E E W Cohen, M Jesiotr, L Bodnar, M Quintela-Fandino, N López-Bigas, R Valdés-Mas, X S Puente, F Viñals, O Casanovas, M Graupera, J Hernández-Losa, S Ramón y Cajal, L García-Alonso, J Saez-Rodriguez, M Esteller, A Sierra, N Martín-Martín, A Matheu, A Carracedo, E González-Suárez, M Nanjundan, J Cortés, C Lázaro, M D Odero, J W M Martens, G Moreno-Bueno, M H Barcellos-Hoff, A Villanueva, R R Gomis and M A Pujana
http://www.nature.com/onc/journal/v36/n19/abs/onc2016427a.html

Oxidative stress downstream of mTORC1 but not AKT causes a proliferative defect in cancer cells resistant to PI3K inhibition
M Dermit, P Casado, V Rajeeve, E H Wilkes, D E Foxler, H Campbell, S Critchlow, T V Sharp, J G Gribben, R Unwin and P R Cutillas
http://www.nature.com/onc/journal/v36/n19/abs/onc2016435a.html

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IDH
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Mutant IDH1 regulates the tumor-associated immune system in gliomas
Nduka M. Amankulor, Youngmi Kim, Sonali Arora, Julia Kargl, Frank Szulzewsky, Mark Hanke, Daciana H. Margineantu, Aparna Rao, Hamid Bolouri, Jeff Delrow, David Hockenbery, A. McGarry Houghton, and Eric C. Holland
http://genesdev.cshlp.org/content/31/8/774.abstract?etoc

Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation
Andrea E. Calvert, Alexandra Chalastanis, Yongfei Wu, Lisa A. Hurley, Fotini M. Kouri, Yingtao Bi, Maureen Kachman, Jasmine L. May, Elizabeth Bartom, Youjia Hua, Rama K. Mishra, Gary E. Schiltz, Oleksii Dubrovskyi, Andrew P. Mazar, Marcus E. Peter, Hongwu Zheng, C. David James, Charles F. Burant, Navdeep S. Chandel, Ramana V. Davuluri, Craig Horbinski, Alexander H. Stegh
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30639-3

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Miscellaneous
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Inhibition of malic enzyme 1 disrupts cellular metabolism and leads to vulnerability in cancer cells in glucose-restricted conditions
S Murai, A Ando, S Ebara, M Hirayama, Y Satomi and T Hara
http://www.nature.com/oncsis/journal/v6/n5/abs/oncsis201734a.html

FGF-dependent metabolic control of vascular development
Pengchun Yu, Kerstin Wilhelm, Alexandre Dubrac, Joe K. Tung, Tiago C. Alves, Jennifer S. Fang, Yi Xie, Jie Zhu, Zehua Chen, Frederik De Smet, Jiasheng Zhang, Suk-Won Jin, Lele Sun, Hongye Sun, Richard G. Kibbey, Karen K. Hirschi, Nissim Hay, Peter Carmeliet, Thomas W. Chittenden, Anne Eichmann, Michael Potente & Michael Simons
http://www.nature.com/nature/journal/v545/n7653/full/nature22322.html

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Reviews
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Focus: Metabolism: Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine
Ji Zhang, Natalya N Pavlova, and Craig B Thompson
http://EMBOJ.embopress.org/content/36/10/1302?etoc

Non-metabolic functions of glycolytic enzymes in tumorigenesis
X Yu and S Li
http://www.nature.com/onc/journal/v36/n19/abs/onc2016410a.html

Cancer heterogeneity is not compatible with one unique cancer cell metabolic map
A Strickaert, M Saiselet, G Dom, X De Deken, J E Dumont, O Feron, P Sonveaux and C Maenhaut
http://www.nature.com/onc/journal/v36/n19/abs/onc2016411a.html

Cancer heterogeneity is not compatible with one unique cancer cell metabolic map
A Strickaert, M Saiselet, G Dom, X De Deken, J E Dumont, O Feron, P Sonveaux and C Maenhaut
http://www.nature.com/onc/journal/v36/n19/abs/onc2016411a.html

Metabolic Reprogramming and Oncogenesis: One Hallmark, Many Organelles
A.S.H. Costa, C. Frezza
http://www.sciencedirect.com/science/article/pii/S1937644817300011

Metabolic Instruction of Immunity
Michael D. Buck, Ryan T. Sowell, Susan M. Kaech, Erika L. Pearce
http://www.cell.com/cell/fulltext/S0092-8674(17)30416-6

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles
Lorenzo Galluzzi, José Manuel Bravo-San Pedro, Beth Levine, Douglas R. Green, Guido Kroemer
http://www.nature.com/nrd/journal/vaop/ncurrent/abs/nrd.2017.22.html

SnapShot:Macropinocytosis
Pedro E. Marques, Sergio Grinstein, Spencer A. Freeman
http://www.cell.com/cell/fulltext/S0092-8674(17)30485-3

Mitochondrial Deficiencies in the Predisposition to Paraganglioma
Charlotte Lussey-Lepoutre, Alexandre Buffet, Anne-Paule Gimenez-Roqueplo and Judith Favier
http://www.mdpi.com/2218-1989/7/2/17

Metabolic reprogramming in clear cell renal cell carcinoma
Hiromi I. Wettersten, Omran Abu Aboud, Primo N. Lara Jr & Robert H. Weiss
http://www.nature.com/nrneph/journal/vaop/ncurrent/full/nrneph.2017.59.html

Emerging Role of the Pentose Phosphate Pathway in Hepatocellular Carcinoma
Marta Kowalik, Amedeo Columbano, and Andrea Perra
http://journal.frontiersin.org/article/10.3389/fonc.2017.00087/full

Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy
Seema Gupta, Amrita Roy2 and Bilikere S. Dwarakanath
http://journal.frontiersin.org/article/10.3389/fonc.2017.00068/full

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Comments
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A mitochondrial drug to treat AML
Paolo Pinton
http://bloodjournal.org/content/129/19/2597?etoc

Therapeutic arginine starvation in ASS1-deficient cancers inhibits the Warburg effect
Jeff C. Kremer & Brian A. Van Tine
http://www.tandfonline.com/doi/full/10.1080/23723556.2017.1295131

ADI-PEG 20 Depletes Arginine to Induce Antitumor Activity [Mesothelioma + NSCLC]
http://cancerdiscovery.aacrjournals.org/content/7/6/549.2

Dietary Restriction of Serine and Glycine May Have Antitumor Effects
http://cancerdiscovery.aacrjournals.org/content/7/6/OF18

LACTB May Be a Tumor Suppressor Gene in Breast Cancer
http://cancerdiscovery.aacrjournals.org/content/7/6/OF23

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