MetaboList – July 2017

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Starvation
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Entosis Is Induced by Glucose Starvation
Jens C. Hamann, Alexandra Surcel, Ruoyao Chen, Carolyn Teragawa, John G. Albeck, Douglas N. Robinson, Michael Overholtzer
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30851-3

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions
Orianne Olivares, Jared R. Mayers, Victoire Gouirand, Margaret E. Torrence, Tristan Gicquel, Laurence Borge, Sophie Lac, Julie Roques, Marie-Noëlle Lavaut, Patrice Berthezène, Marion Rubis, Veronique Secq, Stéphane Garcia, Vincent Moutardier, Dominique Lombardo, Juan Lucio Iovanna, Richard Tomasini, Fabienne Guillaumond, Matthew G. Vander Heiden and Sophie Vasseur
https://www.nature.com/articles/ncomms16031

Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism
Douglas E. Biancur, Joao A. Paulo, Beata Małachowska, Maria Quiles Del Rey, Cristovão M. Sousa, Xiaoxu Wang, Albert S. W. Sohn, Gerald C. Chu, Steven P. Gygi, J. Wade Harper, Wojciech Fendler, Joseph D. Mancias and Alec C. Kimmelman
https://www.nature.com/articles/ncomms15965

DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy
Truc B. Nguyen, Sharon M. Louie, Joseph R. Daniele, Quan Tran, Andrew Dillin, Roberto Zoncu, Daniel K. Nomura, James A. Olzmann
http://www.cell.com/developmental-cell/fulltext/S1534-5807(17)30459-8

A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells
Jun-Kyu Byun, Yeon-Kyung Choi, Ji-Hyun Kim, Ji Yun Jeong, Hui-Jeon Jeon, Mi-Kyung Kim, Ilseon Hwang, Shin-Yup Lee, You Mie Lee, In-Kyu Lee, Keun-Gyu Park
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30897-5

Genome-wide RNAi Screen for Fat Regulatory Genes in C. elegans Identifies a Proteostasis-AMPK Axis Critical for Starvation Survival
Christopher M. Webster, Elizabeth C. Pino, Christopher E. Carr, Lianfeng Wu, Ben Zhou, Lucydalila Cedillo, Michael C. Kacergis, Sean P. Curran, Alexander A. Soukas
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30899-9

Autophagy is required for cell survival under L-asparaginase-induced metabolic stress in acute lymphoblastic leukemia cells
H Takahashi, J Inoue, K Sakaguchi, M Takagi, S Mizutani and J Inazawa
http://www.nature.com/onc/journal/v36/n30/abs/onc201759a.html

Phospho-Rasputin Stabilization by Sec16 Is Required for Stress Granule Formation upon Amino Acid Starvation
Angelica Aguilera-Gomez, Margarita Zacharogianni, Marinke M. van Oorschot, Heide Genau, Rianne Grond, Tineke Veenendaal, Kristina S. Sinsimer, Elisabeth A. Gavis, Christian Behrends, Catherine Rabouille
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30856-2

Autophagy fails to prevent glucose deprivation/glucose reintroduction-induced neuronal death due to calpain-mediated lysosomal dysfunction in cortical neurons
Cristian Gerónimo-Olvera, Teresa Montiel, Ruth Rincon-Heredia, Susana Castro-Obregón and Lourdes Massieu
http://www.nature.com/cddis/journal/v8/n6/full/cddis2017299a.html

Impaired autophagosome clearance contributes to neuronal death in a piglet model of neonatal hypoxic-ischemic encephalopathy
Derong Cui, Dawei Sun, Xintao Wang, Liye Yi, Ewa Kulikowicz, Michael Reyes, Junchao Zhu, Zeng-Jin Yang, Wei Jiang and Raymond C Koehler
http://www.nature.com/cddis/journal/v8/n7/abs/cddis2017318a.html

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Nutrient sensing
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Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK
Chen-Song Zhang ,Simon A. Hawley,Yue Zong,Mengqi Li,Zhichao Wang,Alexander Gray,Teng Ma,Jiwen Cui,Jin-Wei Feng,Mingjiang Zhu,Yu-Qing Wu,Terytty Yang Li,Zhiyun Ye,Shu-Yong Lin,Huiyong Yin, Hai-Long Piao, D. Grahame Hardie & Sheng-Cai Lin
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature23275.html

Activation of the Unfolded Protein Response by Lipid Bilayer Stress
Kristina Halbleib, Kristina Pesek, Roberto Covino, Harald F. Hofbauer, Dorith Wunnicke, Inga Hänelt, Gerhard Hummer, Robert Ernst
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30439-2

PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response
[yeast]
Elisa Ferrari, Christopher Bruhn, Marta Peretti, Corinne Cassani, Walter Vincenzo Carotenuto, Mohamed Elgendy, Ghadeer Shubassi, Chiara Lucca, Rodrigo Bermejo, Mario Varasi, Saverio Minucci, Maria Pia Longhese, Marco Foiani
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30367-2

Feedback Inhibition of the Rag GTPase GAP Complex Lst4-Lst7 Safeguards TORC1 from Hyperactivation by Amino Acid Signals
[yeast]
Marie-Pierre Péli-Gulli, Serena Raucci, Zehan Hu, Jörn Dengjel, Claudio De Virgilio
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30889-6

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Amino acid metabolism
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Extracellular vesicles are independent metabolic units with asparaginase activity
Nunzio Iraci, Edoardo Gaude, Tommaso Leonardi, Ana S H Costa, Chiara Cossetti, Luca Peruzzotti-Jametti, Joshua D Bernstock, Harpreet K Saini, Maurizio Gelati, Angelo Luigi Vescovi, Carlos Bastos, Nuno Faria, Luigi G Occhipinti, Anton J Enright, Christian Frezza & Stefano Pluchino
https://www.nature.com/nchembio/journal/vaop/ncurrent/full/nchembio.2422.html

mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT
Yuchao Gu, Claudio P. Albuquerque, Daniel Braas, Wei Zhang, Genaro R. Villa, Junfeng Bi, Shiro Ikegami, Kenta Masui, Beatrice Gini, Huijun Yang, Timothy C. Gahman, Andrew K. Shiau, Timothy F. Cloughesy, Heather R. Christofk, Huilin Zhou, Kun-Liang Guan, Paul S. Mischel
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30394-5

Cystine addiction of triple-negative breast cancer associated with EMT augmented death signaling
X Tang, C-K Ding, J Wu, J Sjol, S Wardell, I Spasojevic, D George, D P McDonnell, D S Hsu, J T Chang and J-T Chi
http://www.nature.com/onc/journal/v36/n30/abs/onc2016394a.html

Myc-induced glutaminolysis bypasses HIF-driven glycolysis in hypoxic small cell lung carcinoma cells
Matilda Munksgaard Thorén, Marica Vaapil, Johan Staaf, Maria Planck, Martin E. Johansson, Sofie Mohlin and Sven Påhlman
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=16904&path%5B%5D=54085

Epigenetic silencing of microRNA-137 enhances ASCT2 expression and tumor glutamine metabolism
J Dong, D Xiao, Z Zhao, P Ren, C Li, Y Hu, J Shi, H Su, L Wang, H Liu, B Li, P Gao and G Qing
http://www.nature.com/oncsis/journal/v6/n7/abs/oncsis201759a.html

ASCT2 regulates glutamine uptake and cell growth in endometrial carcinoma
A D Marshall, M van Geldermalsen, N J Otte, T Lum, M Vellozzi, A Thoeng, A Pang, R Nagarajah, B Zhang, Q Wang, L Anderson, J E J Rasko and J Holst
http://www.nature.com/oncsis/journal/v6/n7/abs/oncsis201770a.html

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Hexose metabolism
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MPI [mannose phosphate isomerase] depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect
Nataly Shtraizent, Charles DeRossi, Shikha Nayar, Ravi Sachidanandam, Liora S Katz, Adam Prince, Anna P Koh, Adam Vincek, Yoav Hadas, Yujin Hoshida, Donald K Scott, Efrat Eliyahu, Hudson H Freeze, Kirsten C Sadler
https://elifesciences.org/articles/22477

MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer
Surendra K. Shukla, Vinee Purohit, Kamiya Mehla, Venugopal Gunda, Nina V. Chaika, Enza Vernucci, Ryan J. King, Jaime Abrego, Gennifer D. Goode, Aneesha Dasgupta, Alysha L. Illies, Teklab Gebregiworgis, Bingbing Dai, Jithesh J. Augustine, Divya Murthy, Kuldeep S. Attri, Oksana Mashadova, Paul M. Grandgenett, Robert Powers, Quan P. Ly, Audrey J. Lazenby, Jean L. Grem, Fang Yu, José M. Matés, John M. Asara, Jung-whan Kim, Jordan H. Hankins, Colin Weekes, Michael A. Hollingsworth, Natalie J. Sarkova, Aaron R. Sasson, Jason B. Fleming, Jennifer M. Oliveto, Costas A. Lyssiotis, Lewis C. Cantley, Lyudmyla Berim, Pankaj K. Singh
http://www.cell.com/cancer-cell/fulltext/S1535-6108(17)30254-4

Autophagy-Dependent Shuttling of TBC1D5 Controls Plasma Membrane Translocation of GLUT1 and Glucose Uptake
Srirupa Roy, Andrew M. Leidal, Jordan Ye, Sabrina M. Ronen, Jayanta Debnath
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30360-X

Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis
L Jin, J Chun, C Pan, G N Alesi, D Li, K R Magliocca, Y Kang, Z G Chen, D M Shin, F R Khuri, J Fan and S Kang
http://www.nature.com/onc/journal/v36/n27/abs/onc20176a.html

Histone demethylase JMJD1A promotes urinary bladder cancer progression by enhancing glycolysis through coactivation of hypoxia inducible factor 1α
W Wan, K Peng, M Li, L Qin, Z Tong, J Yan, B Shen and C Yu
http://www.nature.com/onc/journal/v36/n27/abs/onc201713a.html

Cytosolic malate dehydrogenase activity helps support glycolysis in actively proliferating cells and cancer
E A Hanse, C Ruan, M Kachman, D Wang, X H Lowman and A Kelekar
http://www.nature.com/onc/journal/v36/n27/abs/onc201736a.html

HIF prolyl hydroxylase PHD3 regulates translational machinery and glucose metabolism in clear cell renal cell carcinoma
Petra Miikkulainen, Heidi Högel, Krista Rantanen, Tomi Suomi, Petri Kouvonen, Laura L. Elo and Panu M. Jaakkola
https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-017-0167-y

CHIP/Stub1 regulates the Warburg effect by promoting degradation of PKM2 in ovarian carcinoma
Y Shang, J He, Y Wang, Q Feng, Y Zhang, J Guo, J Li, S Li, Y Wang, G Yan, F Ren, Y Shi, J Xu, N Zeps, Y Zhai, D He and Z Chang
http://www.nature.com/onc/journal/v36/n29/abs/onc201731a.html

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Lipids
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mTORC1 activates SREBP-2 by suppressing cholesterol trafficking to lysosomes in mammalian cells
Walaa Eid, Kristin Dauner, Kevin C. Courtney, AnneMarie Gagnon, Robin J. Parks, Alexander Sorisky, and Xiaohui Zha
http://www.pnas.org/content/114/30/7999.abstract.html?etoc

Acetyl-CoA carboxylase inhibitors attenuate WNT and Hedgehog signaling and suppress pancreatic tumor growth
Elissaveta Petrova, Arne Scholz, Juliane Paul, Andrea Sturz, Katja Haike, Franziska Siegel, Dominik Mumberg and Ningshu Liu
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=12650&path%5B%5D=40079

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Mitochondria / Krebs
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Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism
Thomas Farge, Estelle Saland, Fabienne de Toni, Nesrine Aroua, Mohsen Hosseini, Robin Perry, Claudie Bosc, Mayumi Sugita, Lucille Stuani, Marine Fraisse, Sarah Scotland,Clément Larrue, Héléna Boutzen, Virginie Féliu, Marie-Laure Nicolau-Travers, Stéphanie Cassant-Sourdy, Nicolas Broin, Marion David, Nizar Serhan, Audrey Sarry,Suzanne Tavitian, Tony Kaoma, Laurent Vallar, Jason Iacovoni, Laetitia K. Linares, Camille Montersino, Rémy Castellano, Emmanuel Griessinger, Yves Collette, Olivier Duchamp, Yara Barreira, Pierre Hirsch, Tony Palama, Lara Gales, François Delhommeau, Barbara H. Garmy-Susini, Jean-Charles Portais, François Vergez, Mary Selak,Gwenn Danet-Desnoyers, Martin Carroll, Christian Récher and Jean-Emmanuel Sarry
http://cancerdiscovery.aacrjournals.org/content/7/7/716

Sustained O-GlcNAcylation reprograms mitochondrial function to regulate energy metabolism
Ee Phie Tan, Steven R. McGreal, Stefan Graw, Robert Tessman, Scott J. Koppel, Pramod Dhakal, Zhen Zhang, Miranda Machacek, Natasha E. Zachara, Devin C. Koestler, Kenneth R. Peterson, John P. Thyfault, Russell H. Swerdlow, Partha Krishnamurthy, Luciano DiTacchio, Udayan Apte, and Chad Slawson
http://www.jbc.org/content/early/2017/07/24/jbc.M117.797944.abstract

Short-term starvation is a strategy to unravel the cellular capacity of oxidizing specific exogenous/endogenous substrates in mitochondria
Julianna Dias Zeidler, Lorena O. Fernandes-Siqueira, Ana S. Carvalho, Eduardo Cararo-Lopes, Matheus H.S. Dias, Luisa A. Ketzer, Antonio Galina, and Andrea T. Da Poian
http://www.jbc.org/content/early/2017/06/29/jbc.M117.786582.abstract

Sorafenib Targets the Mitochondrial Electron Transport Chain Complexes and ATP Synthase to Activate the PINK1-Parkin Pathway and Modulate Cellular Drug Response
Conggang Zhang, Zeyu Liu, Eric Bunker, Adrian Ramirez, Schuyler Lee, Yinghua Peng, Aik Choon Tan, S Gail Eckhardt, Douglas A Chapnick, and Xuedong Liu
http://www.jbc.org/content/early/2017/07/03/jbc.M117.783175.abstract

Targeted exome sequencing of Krebs cycle genes reveals candidate cancer predisposing mutations in pheochromocytomas and paragangliomas.
Laura Remacha, Iñaki Comino-Méndez, Susan Richter, Laura Contreras, María Currás-Freixes, Guillermo Pita, Rocío Letón, Antonio Galarreta, Rafael Torres-Pérez, Emiliano Honrado, Scherezade Jiménez, Lorena Maestre, Sebastian Moran, Manel Esteller, Jorgina Satrústegui, Graeme Eisenhofer, Mercedes Robledo and Alberto Cascón
http://clincancerres.aacrjournals.org/content/early/2017/07/18/1078-0432.CCR-16-2250

Analysis of SDHAF3 in familial and sporadic pheochromocytoma and paraganglioma
Trisha Dwight, Un Na, Edward Kim, Ying Zhu, Anne Louise Richardson, Bruce G. Robinson, Katherine M. Tucker, Anthony J. Gill, Diana E. Benn, Roderick J. Clifton-Bligh and Dennis R. Winge
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-017-3486-z

MITOCHONDRIAL PYRUVATE CARRIER FUNCTION DETERMINES CELL STEMNESS AND METABOLIC REPROGRAMMING IN CANCER CELLS
Xiaoli Li, Gaoyang Han, Xiaoran Li, Quancheng Kan, Zhirui Fan, Yaqing Li, Yasai Ji, Jing Zhao, Mingzhi Zhang,Mantas Grigalavicius, Viktor Berge, Mariusz Adam Goscinski, Jahn M. Nesland, and Zhenhe Suo
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=18199&path%5B%5D=58346

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Hypoxia, HIFs
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Glycolytic Enzymes Coalesce in G Bodies under Hypoxic Stress
Meiyan Jin, Gregory G. Fuller, Ting Han, Yao Yao, Amelia F. Alessi, Mallory A. Freeberg, Nathan P. Roach, James J. Moresco, Alla Karnovsky, Misuzu Baba, John R. Yates III, Aaron D. Gitler, Ken Inoki, Daniel J. Klionsky, John K. Kim
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30930-0

HIF activation causes synthetic lethality between the VHL tumor suppressor and the EZH1histone methyltransferase
Abhishek A. Chakraborty , Eijiro Nakamura, Jun Qi, Amanda Creech, Jacob D. Jaffe, Joshiawa Paulk, Jesse S. Novak, Kshithija Nagulapalli, Samuel K. McBrayer, Glenn S. Cowley, Javier Pineda, Jiaxi Song, Yaoyu E. Wang, Steven A. Carr, David E. Root, Sabina Signoretti, James E. Bradner, William G. Kaelin, Jr
http://stm.sciencemag.org/content/9/398/eaal5272

Nucleus accumbens-associated protein-1 promotes glycolysis and survival of hypoxic tumor cells via the HDAC4-HIF-1α axis
Y Zhang, Y-J Ren, L-C Guo, C Ji, J Hu, H-H Zhang, Q-H Xu, W-D Zhu, Z-J Ming, Y-S Yuan, X Ren, J Song and J-M Yang
http://www.nature.com/onc/journal/v36/n29/abs/onc201751a.html

GATA3 interacts with and stabilizes HIF-1α to enhance cancer cell invasiveness
M-C Lin, J-J Lin, C-L Hsu, H-F Juan, P-J Lou and M-C Huang
http://www.nature.com/onc/journal/v36/n30/abs/onc20178a.html

Myc-induced glutaminolysis bypasses HIF-driven glycolysis in hypoxic small cell lung carcinoma cells
Matilda Munksgaard Thorén, Marica Vaapil, Johan Staaf, Maria Planck, Martin E. Johansson, Sofie Mohlin and Sven Påhlman
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=16904&path%5B%5D=54085

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Metformin
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Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug
Hao Wu, Eduardo Esteve, Valentina Tremaroli, Muhammad Tanweer Khan,R obert Caesar, Louise Mannerås-Holm, Marcus Ståhlman, Lisa M Olsson, Matteo Serino, Mercè Planas-Fèlix, Gemma Xifra, Josep M Mercader, David Torrents, Rémy Burcelin, Wifredo Ricart, Rosie Perkins, José Manuel Fernàndez-Real & Fredrik Bäckhed
http://www.nature.com/nm/journal/v23/n7/full/nm.4345.html

The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells
Camille Loubiere, Stephan Clavel, Jerome Gilleron, Rania Harisseh, Jeremy Fauconnier, Issam Ben-Sahra, Lisa Kaminski, Kathiane Laurent, Stephanie Herkenne, Sandra Lacas-Gervais, Damien Ambrosetti, Damien Alcor, Stephane Rocchi, Mireille Cormont, Jean-François Michiels, Bernard Mari, Nathalie M. Mazure, Luca Scorrano, Alain Lacampagne, Abdallah Gharib, Jean-François Tanti & Frederic Bost
https://www.nature.com/articles/s41598-017-05052-2

Targeting Oxygen-Sensing Prolyl Hydroxylase for Metformin-Associated Lactic Acidosis Treatment
Tomoko Oyaizu-Toramaru, Tomohiro Suhara, Noriyo Hayakawa, Takashi Nakamura, Akiko Kubo, Shizuka Minamishima, Kyoji Yamaguchi, Takako Hishiki, Hiroshi Morisaki, Makoto Suematsu, and Yoji Andrew Minamishima
http://mcb.asm.org/content/37/16/e00248-17.abstract?etoc

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Miscellaneous
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Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation
Ho-Joon Lee, Mark P. Jedrychowski, Arunachalam Vinayagam, Ning Wu, Ng Shyh-Chang, Yanhui Hu, Chua Min-Wen, Jodene K. Moore, John M. Asara, Costas A. Lyssiotis, Norbert Perrimon, Steven P. Gygi, Lewis C. Cantley, Marc W. Kirschner
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30905-1

EWS/FLI is a Master Regulator of Metabolic Reprogramming in Ewing Sarcoma
Jason M Tanner, Claire Bensard, Peng Wei, Nathan M Krah, John C Schell, Jamie D Gardiner, Joshua D. Schiffman, Stephen L Lessnick and Jared Rutter
http://mcr.aacrjournals.org/content/early/2017/07/18/1541-7786.MCR-17-0182

Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination
Sharanya Sivanand, Seth Rhoades, Qinqin Jiang, Joyce V. Lee, Joseph Benci, Jingwen Zhang, Salina Yuan, Isabella Viney, Steven Zhao, Alessandro Carrer, Michael J. Bennett, Andy J. Minn, Aalim M. Weljie, Roger A. Greenberg, Kathryn E. Wellen
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30435-5

Brief Report: Low expression of hexokinase-2 is associated with false-negative FDG–positron emission tomography in multiple myeloma
Leo Rasche, Edgardo Angtuaco, James E. McDonald, Amy Buros, Caleb Stein, Charlotte Pawlyn, Sharmilan Thanendrarajan, Carolina Schinke, Rohan Samant, Shmuel Yaccoby, Brian A. Walker, Joshua Epstein, Maurizio Zangari, Frits van Rhee, Tobias Meissner, Hartmut Goldschmidt, Kari Hemminki, Richard Houlston, Bart Barlogie, Faith E. Davies, Gareth J. Morgan, and Niels Weinhold
http://bloodjournal.org/content/130/1/30.abstract?etoc

——————–
Reviews
——————–

Metabolic Interactions in the Tumor Microenvironment
Costas A. Lyssiotis, Alec C. Kimmelman
http://www.cell.com/trends/cell-biology/fulltext/S0962-8924(17)30102-2

Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors
Gabriela Andrejeva, Jeffrey C. Rathmell
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30346-7

Mitochondrial Dynamics in Regulating the Unique Phenotypes of Cancer and Stem Cells
Hsiuchen Chen, David C. Chan
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30340-6

Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy
Rigel J. Kishton, Madhusudhanan Sukumar, Nicholas P. Restifo
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30358-3

Ancillary Activity: Beyond Core Metabolism in Immune Cells
Daniel J. Puleston, Matteo Villa, Erika L. Pearce
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30362-5

The Mitochondrial Complex(I)ty of Cancer
Felix Urra, Felipe Muñoz, Alenka Lovy, and Cesar Cardenas
http://journal.frontiersin.org/article/10.3389/fonc.2017.00118/full

Exploring cancer metabolism using stable isotope-resolved metabolomics (SIRM)
Ronald C. Bruntz, Andrew N. Lane, Richard M. Higashi, and Teresa W.-M. Fan
http://m.jbc.org/content/292/28/11601.abstract.html

Nutrition, inflammation and cancer
Laurence Zitvogel, Federico Pietrocola and Guido Kroemer
http://www.nature.com/ni/journal/v18/n8/full/ni.3754.html

Targeting Hypoxia-Inducible Factors for Antiangiogenic Cancer Therapy
Sergio Rey, Luana Schito, Bradly G. Wouters, Scott Eliasof, Robert S. Kerbel
http://www.cell.com/trends/cancer/fulltext/S2405-8033(17)30088-2

Succinate dehydrogenase (SDH) deficiency, Carney triad and the epigenome.
Settas N, Faucz FR, Stratakis CA.
https://linkinghub.elsevier.com/retrieve/pii/S0303-7207(17)30392-1

Mitochondria on the move: emerging paradigms of organelle trafficking in tumour plasticity and metastasis
Dario C Altieri
http://www.nature.com/bjc/journal/v117/n3/full/bjc2017201a.html

Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF
Daniela F. Quail, Oakley C. Olson, Priya Bhardwaj, Logan A. Walsh, Leila Akkari et al.
http://www.nature.com/ncb/journal/v19/n8/full/ncb3578.html

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Comments
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Metabolism: Energy sensing through a sugar diphosphate
Bruce E. Kemp & Jonathan S. Oakhill
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature23099.html

MUC-king with HIF May Rewire Pyrimidine Biosynthesis and Curb Gemcitabine Resistance in Pancreatic Cancer
Chi V. Dang
http://www.cell.com/cancer-cell/fulltext/S1535-6108(17)30257-X

Adding Polyamine Metabolism to the mTORC1 Toolkit in Cell Growth and Cancer
Ana P. Gomes, Tanya Schild, John Blenis
http://www.cell.com/developmental-cell/fulltext/S1534-5807(17)30546-4

Novel Mitochondrial Mechanisms of Cytarabine Resistance in Primary AML Cells
Aaron D. Schimmer
http://cancerdiscovery.aacrjournals.org/content/7/7/670

Exploiting tumour addiction with a serine and glycine-free diet
Ivano Amelio, Gerry Melino and Christian Frezza
http://www.nature.com/cdd/journal/v24/n8/full/cdd201783a.html

Lipid Droplets Guard Mitochondria during Autophagy
Till Klecker, Ralf J. Braun, Benedikt Westermann
http://www.cell.com/developmental-cell/fulltext/S1534-5807(17)30506-3

A novel role for a glycolytic pathway kinase in regulating autophagy has implications in cancer therapy
Aileen R. Ariosa & Daniel J. Klionsky
http://www.tandfonline.com/doi/full/10.1080/15548627.2017.1321723

The skinny on obesity and cancer
Jaclyn Sceneay and Sandra S. McAllister
http://www.nature.com/ncb/journal/v19/n8/full/ncb3583.html

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