MetaboList – September 2017

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Glucose metabolism
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A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product
Maria V. Liberti, Ziwei Dai, Suzanne E. Wardell, Joshua A. Baccile, Xiaojing Liu, Xia Gao, Robert Baldi, Mahya Mehrmohamadi, Marc O. Johnson, Neel S. Madhukar, Alexander A. Shestov, Iok I. Christine Chio, Olivier Elemento, Jeffrey C. Rathmell, Frank C. Schroeder, Donald P. McDonnell, Jason W. Locasale
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30502-8

LncRNA wires up Hippo and Hedgehog signaling to reprogramme glucose metabolism
Xin Zheng, Han Han, Guang‐Ping Liu, Yan‐Xiu Ma, Ruo‐Lang Pan, Ling‐Jie Sang, Rui‐Hua Li, Luo‐Jia Yang, Jeffrey R Marks, Wenqi Wang, Aifu Lin
http://emboj.embopress.org/content/early/2017/09/28/embj.201797609

Tumor vessel disintegration by maximum tolerable PFKFB3 blockade
Lena-Christin Conradi, Aleksandra Brajic, Anna Rita Cantelmo, Ann Bouché, Joanna Kalucka, Andreas Pircher, Ulrike Brüning, Laure-Anne Teuwen, Stefan Vinckier, Bart Ghesquière, Mieke Dewerchin, Peter Carmeliet
https://link.springer.com/article/10.1007/s10456-017-9573-6

An engineered photoswitchable mammalian pyruvate kinase
Stefanie Gehrig, Jamie A. Macpherson, Paul C. Driscoll, Alastair Symon, Stephen R. Martin, James I. MacRae, Jens Kleinjung, Franca Fraternali and Dimitrios Anastasiou
http://onlinelibrary.wiley.com/doi/10.1111/febs.14175/abstract

The Warburg effect as an adaptation of cancer cells to rapid fluctuations in energy demand
Tamir Epstein, Robert A. Gatenby, Joel S. Brown
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185085

SLC2A2 (GLUT2) AS A NOVEL PROGNOSTIC FACTOR FOR HEPATOCELLULAR CARCINOMA
Yun Hak Kim, Dae Cheon Jeong, Kyoungjune Pak, Myoung-Eun Han, Ji-Young Kim, Liu Liangwen, Hyun Jin Kim,Tae Woo Kim, Tae Hwa Kim, Dong Woo Hyun, and Sae-Ock Oh
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=20266&path%5B%5D=64619

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Amino acid metabolism or acquired dependency
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Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer
Volkan I Sayin, Sarah E LeBoeuf, Simranjit X Singh, Shawn M Davidson, Douglas Biancur, Betul S Guzelhan, Samantha W Alvarez, Warren L Wu, Triantafyllia R Karakousi, Anastasia Maria Zavitsanou, Julian Ubriaco, Alexander Muir, Dimitris Karagiannis, Patrick J Morris, Craig J Thomas, Richard Possemato, Matthew G Vander Heiden and Thales Papagiannakopoulos
https://elifesciences.org/articles/28083

Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis
Rodrigo Romero, Volkan I Sayin, Shawn M Davidson, Matthew R Bauer, Simranjit X Singh, Sarah E LeBoeuf, Triantafyllia R Karakousi, Donald C Ellis, Arjun Bhutkar, Francisco J Sánchez-Rivera, Lakshmipriya Subbaraj, Britney Martinez, Roderick T Bronson, Justin R Prigge, Edward E Schmidt, Craig J Thomas, Chandra Goparaju, Angela Davies, Igor Dolgalev, Adriana Heguy, Viola Allaj, John T Poirier, Andre L Moreira, Charles M Rudin, Harvey I Pass, Matthew G Vander Heiden, Tyler Jacks & Thales Papagiannakopoulos
http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.4407.html

A metabolic core model elucidates how enhanced utilization of glucose and glutamine, with enhanced glutamine-dependent lactate production, promotes cancer cell growth: The WarburQ effect
Chiara Damiani, Riccardo Colombo, Daniela Gaglio, Fabrizia Mastroianni, Dario Pescini, Hans Victor Westerhoff, Giancarlo Mauri, Marco Vanoni, Lilia Alberghina
http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005758

Bortezomib resistance in multiple myeloma is associated with increased serine synthesis
Esther A. Zaal, Wei Wu, Gerrit Jansen, Sonja Zweegman, Jacqueline Cloos and Celia R. Berkers
https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-017-0169-9

Glutaminase is essential for the growth of triple-negative breast cancer cells with a deregulated glutamine metabolism pathway and its suppression synergizes with mTOR inhibition
Michael Lampa, Heike Arlt, Timothy He, Beatriz Ospina, Jason Reeves, Bailin Zhang, Joshua Murtie, Gejing Deng, Claude Barberis, Dietmar Hoffmann, Hong Cheng, Jack Pollard, Christopher Winter, Victoria Richon, Carlos Garcia-Escheverria, Francisco Adrian, Dmitri Wiederschain, Lakshmi Srinivasan
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185092

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Lipids
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Fatty acid synthase expression and its association with clinico-histopathological features in triple-negative breast cancer
Ariadna Giró-Perafita, Ariadna Sarrats, Ferran Pérez-Bueno, Glòria Oliveras, Maria Buxó, Joan Brunet, Gemma Viñas and Teresa Puig Miquel
http://impactjournals.us9.list-manage.com/track/click?u=133779c099e52b6fa9d4dec2e&id=4b82f887a0&e=923b339f12

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Mitochondria
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MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation
Kyung-min Lee, Jennifer M. Giltnane, Justin M. Balko, Luis J. Schwarz, Angel L. Guerrero-Zotano, Katherine E. Hutchinson, Mellissa J. Nixon, Mónica V. Estrada, Violeta Sánchez, Melinda E. Sanders, Taekyu Lee, Henry Gómez, Ana Lluch, J. Alejandro Pérez-Fidalgo, Melissa Magdalene Wolf, Gabriela Andrejeva, Jeffrey C. Rathmell, Stephen W. Fesik, Carlos L. Arteaga
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30560-0

Architecture of Human Mitochondrial Respiratory Megacomplex I2 III2 IV2
Runyu Guo, Shuai Zong, Meng Wu, Jinke Gu, Maojun Yang
http://www.cell.com/cell/fulltext/S0092-8674(17)30887-5

Comprehensive mathematical model of oxidative phosphorylation valid for physiological and pathological conditions
Margit Heiske, Thierry Letellier, Edda Klipp
http://onlinelibrary.wiley.com/doi/10.1111/febs.14151/full

Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells
Elodie Villa, Emma Proïcs, Camila Rubio-Patiño, Sandrine Obba, Barbara Zunino, Jozef P. Bossowski, Romain M. Rozier, Johanna Chiche, Laura Mondragón, Joel S. Riley, Sandrine Marchetti, Els Verhoeyen, Stephen W.G. Tait, Jean-Ehrland Ricci
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31229-9

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Nucleotides
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Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC
Kiyotoshi Satoh, Shinichi Yachida, Masahiro Sugimoto, Minoru Oshima, Toshitaka Nakagawa, Shintaro Akamoto, Sho Tabata, Kaori Saitoh, Keiko Kato, Saya Sato, Kaori Igarashi, Yumi Aizawa, Rie Kajino-Sakamoto, Yasushi Kojima, Teruaki Fujishita, Ayame Enomoto, Akiyoshi Hirayama, Takamasa Ishikawa, Makoto Mark Taketo, Yoshio Kushida, Reiji Haba, Keiichi Okano, Masaru Tomita, Yasuyuki Suzuki, Shinji Fukuda, Masahiro Aoki, and Tomoyoshi Soga
http://pnas.org/content/114/37/E7697.abstract.html?etoc

An in-silico approach to predict and exploit synthetic lethality in cancer metabolism
Iñigo Apaolaza, Edurne San José-Eneriz, Luis Tobalina, Estíbaliz Miranda, Leire Garate, Xabier Agirre, Felipe Prósper & Francisco J. Planes
[Ribonucleotide reductase in multiple myeloma]
https://www.nature.com/articles/s41467-017-00555-y

Pyrimidine metabolic rate limiting enzymes in poorly-differentiated hepatocellular carcinoma are signature genes of cancer stemness and associated with poor prognosis
Hsi-Wen Yeh, Szu-Shuo Lee, Chieh-Yu Chang, Chun-Mei Hu and Yuh-Shan Jou
http://impactjournals.us9.list-manage1.com/track/click?u=133779c099e52b6fa9d4dec2e&id=609b9c4ccf&e=923b339f12

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Hypoxia
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Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma
David Kung-Chun Chiu, Aki Pui-Wah Tse, Iris Ming-Jing Xu, Jane Cui, Robin Kit-Ho Lai, Lynna Lan Li, Hui-Yu Koh, Felice Ho-Ching Tsang, Larry Lai Wei, Chun-Ming Wong, Irene Oi-Lin Ng & Carmen Chak-Lui Wong
https://www.nature.com/articles/s41467-017-00530-7

Accelerated tumor growth under intermittent hypoxia is associated with hypoxia-inducible factor-1-dependent adaptive responses to hypoxia
Dae Wui Yoon, Daeho So, Sra Min, Jiyoung Kim1, Mingyu Lee, Roza Khalmuratova1, Chung-Hyun Cho, Jong-Wan Park and Hyun-Woo Shin
http://impactjournals.us9.list-manage.com/track/click?u=133779c099e52b6fa9d4dec2e&id=504ebfc61a&e=923b339f12

Lactate stimulates CA IX expression in normoxic cancer cells
Elena Panisova, Martin Kery, Olga Sedlakova, Lucie Brisson, Michaela Debreova, Martina Sboarina, Pierre Sonveaux, Silvia Pastorekova and Eliska Svastova
http://impactjournals.us9.list-manage.com/track/click?u=133779c099e52b6fa9d4dec2e&id=12b16e857e&e=923b339f12

Culturing CTLs under Hypoxic Conditions Enhances Their Cytolysis and Improves Their Anti-tumor Function
Yael Gropper, Tali Feferman, Tali Shalit, Tomer-Meir Salame, Ziv Porat, Guy Shakhar
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31213-5

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Starvation, mTOR
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mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein
Michel Nofal, Kevin Zhang, Seunghun Han, Joshua D. Rabinowitz
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30608-1

Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients
Ya-Kun Zhang, Yuan-Yuan Qu, Yan Lin, Xiao-Hui Wu, Hou-Zao Chen, Xu Wang, Kai-Qiang Zhou, Yun Wei, Fushen Guo, Cui-Fang Yao, Xia-Di He, Li-Xia Liu, Chen Yang, Zong-Yuan Guan, Shi-Dong Wang, Jianyuan Zhao, De-Pei Liu, Shi-Min Zhao & Wei Xu
https://www.nature.com/articles/s41467-017-00489-5

Activation of the unfolded protein response in sarcoma cells treated with rapamycin or temsirolimus
Joseph W. Briggs ,Ling Ren, Kristi R. Chakrabarti, Yien Che Tsai, Allan M. Weissman, Ryan J. Hansen, Daniel L. Gustafson, Yousuf A. Khan, Jonathan D. Dinman, Chand Khanna
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185089

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AMPK
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AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species
Rebecca C. Rabinovitch, Bozena Samborska, Brandon Faubert, Eric H. Ma, Simon-Pierre Gravel, Sylvia Andrzejewski, Thomas C. Raissi, Arnim Pause, Julie St.-Pierre, Russell G. Jones
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31301-3

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs
Toby A. Dite, Naomi X. Y. Ling, John W. Scott, Ashfaqul Hoque, Sandra Galic, Benjamin L. Parker, Kevin R. W. Ngoei, Christopher G. Langendorf, Matthew T. O’Brien, Mondira Kundu, Benoit Viollet, Gregory R. Steinberg, Kei Sakamoto, Bruce E. Kemp & Jonathan S. Oakhill
https://www.nature.com/articles/s41467-017-00628-y

Fyn phosphorylates AMPK to inhibit AMPK activity and AMP-dependent activation of autophagy
Eijiro Yamada, Shuichi Okada, Claire C. Bastie2, Manu Vatish4, Yasuyo Nakajima1, Ryo Shibusawa1, Atsushi Ozawa1, Jeffrey E. Pessin and Masanobu Yamada
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=11916&path%5B%5D=37725

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Metformin
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Metformin partially reverses the carboplatin-resistance in NSCLC by inhibiting glucose metabolism
Yong Liu, Chunxi He and Xianping Huang
http://impactjournals.us9.list-manage.com/track/click?u=133779c099e52b6fa9d4dec2e&id=28317ddf66&e=923b339f12

METFORMIN REQUIRES 4E-BPS TO INDUCE APOPTOSIS AND REPRESS TRANSLATION OF MCL-1 IN HEPATOCELLULAR CARCINOMA CELLS
Mamatha Bhat, Akiko Yanagiya, Tyson Graber, Nataliya Razumilava, Steve Bronk, Domenick Zammit, Yunhao Zhao, Chadi Zakaria, Peter Metrakos, Michael Pollak, Nahum Sonenberg, Gregory Gores, Maritza Jaramillo,Masahiro Morita, and Tommy Alain
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=10671&path%5B%5D=33785

METFORMIN USE AND SURVIVAL OUTCOMES IN ENDOMETRIAL CANCER: A SYSTEMATIC REVIEW AND META-ANALYSIS
Weimin Xie, Tianjia Li, Jing Yang, Mengmeng Shang, Ying Xiao, Qian Li, and Jiaxin Yang
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=20388&path%5B%5D=64983

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Miscellaneous
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A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress
[free fatty acids]
Shashi Kant, Claire L. Standen, Caroline Morel, Dae Young Jung, Jason K. Kim, Wojciech Swat, Richard A. Flavell, Roger J. Davis
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31132-4

Fasting inhibits colorectal cancer growth by reducing M2 polarization of tumor-associated macrophages
Pengfei Sun, Huihui Wang, Zhiyong He, Xiangyuan Chen, Qichao Wu, Wankun Chen, Zhirong Sun, Meilin Weng, Minmin Zhu, Duan Ma and Changhong Miao
http://impactjournals.us9.list-manage.com/track/click?u=133779c099e52b6fa9d4dec2e&id=893e718d86&e=923b339f12

Clonal expansion and epigenetic reprogramming following deletion or amplification of mutant IDH1
Tali Mazor, Charles Chesnelong, Aleksandr Pankov, Llewellyn E. Jalbert, Chibo Hong, Josie Hayes, Ivan V. Smirnov, Roxanne Marshall, Camila F. Souza, Yaoqing Shen, Pavithra Viswanath, Houtan Noushmehr, Sabrina M. Ronen, Steven J. M. Jones, Marco A. Marra, J. Gregory Cairncross, Arie Perry, Sarah J. Nelson, Susan M. Chang, Andrew W. Bollen, Annette M. Molinaro, Henrik Bengtsson, Adam B. Olshen, Samuel Weiss, Joanna J. Phillips, H. Artee Luchman, and Joseph F. Costello
http://www.pnas.org/content/114/40/10743.abstract.html?etoc

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Reviews
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Targeting Metabolism for Cancer Therapy
Alba Luengo, Dan Y. Gui, Matthew G. Vander Heiden
http://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(17)30326-4

TOR, the Gateway to Cellular Metabolism, Cell Growth, and Disease
John Blenis
http://www.cell.com/cell/fulltext/S0092-8674(17)30944-3

Game of TOR – The Target of Rapamycin Rules Four Kingdoms.
Manning BD.
http://www.nejm.org/doi/full/10.1056/NEJMcibr1709384

Mitochondrial Metabolism: Yin and Yang for Tumor Progression
Lorea Valcarcel-Jimenez, Edoardo Gaude, Veronica Torrano, Christian Frezza, Arkaitz Carracedo
http://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760%2817%2930087-5

Breaking fat: The regulation and mechanisms of lipophagy
Ryan J. Schulze, Aishwarya Sathyanarayan, Douglas G. Mashek
http://www.sciencedirect.com/science/article/pii/S1388198117301129?dgcid=raven_sd_via_email

Metabolism shapes the tumor microenvironment
Miguel Reina-Campos, Jorge Moscat, Maria Diaz-Meco
http://www.sciencedirect.com/science/article/pii/S0955067416301636

Integration of hypoxic HIF-α signaling in blood cancers
L Schito, S Rey and M Konopleva
http://www.nature.com/onc/journal/v36/n38/abs/onc2017119a.html

Oncogenic Activities of IDH1/2 Mutations: From Epigenetics to Cellular Signaling
Laurence M. Gagné, Karine Boulay, Ivan Topisirovic, Marc-Étienne Huot, Frédérick A. Mallette
http://www.cell.com/trends/cell-biology/fulltext/S0962-8924(17)30101-0

Tumour acidosis: from the passenger to the driver’s seat
Cyril Corbet, Olivier Feron
http://www.nature.com/nrc/journal/v17/n10/abs/nrc.2017.77.html?lang=en

Exercise-dependent regulation of the tumour microenvironment
Graeme J. Koelwyn, Daniela F. Quail, Xiang Zhang, Richard M. White & Lee W. Jones
http://www.nature.com/nrc/journal/v17/n10/full/nrc.2017.78.html?WT.mc_id=FBK_NatureReviews&foxtrotcallback=true

Obesity and Cancer Metabolism: A Perspective on Interacting Tumor–Intrinsic and Extrinsic Factors
Steven S. Doerstling, Ciara H. O’Flanagan and Stephen D. Hursting
https://www.frontiersin.org/articles/10.3389/fonc.2017.00216/full

Cytosolic Proteostasis Networks of the Mitochondrial Stress Response
Davide D’Amico, Vincenzo Sorrentino, Johan Auwerx
http://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(17)30090-7

Focus: Metabolism: Modulating NAD^+ metabolism, from bench to bedside
Elena Katsyuba and Johan Auwerx
http://EMBOJ.embopress.org/content/36/18/2670?etoc

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Comments / Other
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In the news: The Lasker goes to Michael Hall
http://www.nature.com/nrm/journal/v18/n10/full/nrm.2017.97.html

An Amazing Turn of Events
Michael N. Hall
http://www.cell.com/cell/fulltext/S0092-8674(17)30946-7

The Ire1 Twist that Links Proteostatic with Lipostatic Control of the Endoplasmic Reticulum
Tomás Aragón, Eelco van Anken
http://www.cell.com/trends/cell-biology/fulltext/S0962-8924(17)30147-2

No Oxygen? No Glucose? No Problem: Fatty Acid Catabolism Enhances Effector CD8+ TILs
Will Bailis, Justin A. Shyer, Michael Chiorazzi, Richard A. Flavell
http://www.cell.com/cancer-cell/fulltext/S1535-6108(17)30358-6

PON2 Promotes Glucose Uptake to Support PDAC Growth and Metastasis
http://cancerdiscovery.aacrjournals.org/content/7/10/1058.2

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