MetaboList – October 2017

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Lactate metabolism and transporters
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Lactate Metabolism in Human Lung Tumors
Brandon Faubert, Kevin Y. Li, Ling Cai, Christopher T. Hensley, Jiyeon Kim, Lauren G. Zacharias, Chendong Yang, Quyen N. Do, Sarah Doucette, Daniel Burguete, Hong Li, Giselle Huet, Qing Yuan, Trevor Wigal, Yasmeen Butt, Min Ni, Jose Torrealba, Dwight Oliver, Robert E. Lenkinski, Craig R. Malloy, Jason W. Wachsmann, Jamey D. Young, Kemp Kernstine, Ralph J. DeBerardinis
http://www.cell.com/cell/fulltext/S0092-8674(17)31068-1

Glucose feeds the TCA cycle via circulating lactate
Sheng Hui, Jonathan M. Ghergurovich, Raphael J. Morscher, Cholsoon Jang, Xin Teng, Wenyun Lu, Lourdes A. Esparza, Tannishtha Reya, Le Zhan, Jessie Yanxiang Guo, Eileen White & Joshua D. Rabinowitz
http://www.nature.com/nature/journal/v551/n7678/full/nature24057.html

Monocarboxylate Transporter MCT1 Promotes Tumor Metastasis Independently of Its Activity as a Lactate Transporter
Valéry L. Payen, Myriam Y. Hsu, Kristin S. Rädecke, Elisabeth Wyart, Thibaut Vazeille, Caroline Bouzin, Paolo E. Porporato and Pierre Sonveaux
http://cancerres.aacrjournals.org/content/77/20/5591

Lactate-mediated mitoribosomal defects impair mitochondrial oxidative phosphorylation and promote hepatoma cell invasiveness
Young-Kyoung Lee, Jin J Lim, Un-woo Jeoun, Seongki Min, Eun-beom Lee, So Mee Kwon, Changhan Lee and Gyesoon Yoon
http://www.jbc.org/content/early/2017/10/04/jbc.M117.809012.abstract

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Glucose metabolism
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Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras
Ken Peeters, Frederik Van Leemputte, Baptiste Fischer, Beatriz M. Bonini, Hector Quezada, Maksym Tsytlonok, Dorien Haesen, Ward Vanthienen, Nuno Bernardes, Carmen Bravo Gonzalez-Blas, Veerle Janssens, Peter Tompa, Wim Versées & Johan M. Thevelein
https://www.nature.com/articles/s41467-017-01019-z

PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
Fabao Liu,Fengfei Ma,Yuyuan Wang,Ling Hao,Hao Zeng, Chenxi Jia, Yidan Wang, Peng Liu, Irene M. Ong, Baobin Li, Guojun Chen, Jiaoyang Jiang, Shaoqin Gong, Lingjun Li& Wei Xu
http://www.nature.com/ncb/journal/v19/n11/full/ncb3630.html

DISRUPTING GLUCOSE-6-PHOSPHATE ISOMERASE FULLY SUPPRESSES THE “WARBURG EFFECT” AND ACTIVATES OXPHOS WITH MINIMAL IMPACT ON TUMOR GROWTH EXCEPT IN HYPOXIA
Monique Cunha de Padua, Giulia Delodi, Milica Vučetić, Jérôme Durivault, Valérie Vial, Pascale Bayer, Guilhermina Rodrigues Noleto, Nathalie M. Mazure, Maša Ždralević,  and  Jacques Pouysségur
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=21007&path%5B%5D=66903

Regulation of Glycolytic Metabolism by Autophagy in Liver Cancer Involves Selective Autophagic Degradation of HK2 (hexokinase 2)
Lin Jiao, Hai-Liang Zhang, Dan-Dan Li, Ke-Li Yang, Jun Tang, Xuan Li, Jiao Ji, Yan Yu, Rui-Yan Wu, Senthilkumar Ravichandran, Jian-Jun Liu, Gong-Kan Feng, Min-Shan Chen, Yi-Xin Zeng, Rong Deng & Xiao-Feng Zhu
http://www.tandfonline.com/doi/abs/10.1080/15548627.2017.1381804

Reversible protein aggregation is a protective mechanism to ensure cell cycle restart after stress
Shady Saad,Gea Cereghetti,Yuehan Feng,Paola Picotti,Matthias Peter& Reinhard Dechant
http://www.nature.com/ncb/journal/v19/n10/full/ncb3600.html

Srebp-controlled glucose metabolism is essential for NK cell functional responses
Nadine Assmann, Katie L O’Brien, Raymond P Donnelly, Lydia Dyck, Vanessa Zaiatz-Bittencourt, Róisín M Loftus, Paul Heinrich, Peter J Oefner, Lydia Lynch, Clair M Gardiner, Katja Dettmer & David K Finlay
https://www.nature.com/articles/ni.3838

TGF-β1 targets Smad, p38 MAPK, and PI3K/Akt signaling pathways to induce PFKFB3 gene expression and glycolysis in glioblastoma cells
Ana Rodríguez-García, Paula Samsó, Pere Fontova, Helga Simon-Molas, Anna Manzano, Esther Castaño, Jose Luis Rosa, Ubaldo Martinez-Outshoorn, Francesc Ventura, Àurea Navarro-Sabaté and Ramon Bartrons
http://onlinelibrary.wiley.com/doi/10.1111/febs.14201/abstract?campaign=woletoc

Msn2/4 regulate expression of glycolytic enzymes and control transition from quiescence to growth
[yeast]
Zheng Kuang, Sudarshan Pinglay, Hongkai Ji and Jef D Boeke
https://elifesciences.org/articles/29938

Intragenic DNA methylation and BORIS-mediated cancer-specific splicing contribute to the Warburg effect
Smriti Singh, Sathiya Pandi Narayanan, Kajal Biswas, Amit Gupta, Neha Ahuja, Sandhya Yadav, Rajendra Kumar Panday, Atul Samaiya, Shyam K. Sharan, and Sanjeev Shukla
http://www.pnas.org/content/114/43/11440.abstract.html?etoc

PKM2 ACTIVATION SENSITIZES CANCER CELLS TO GROWTH INHIBITION BY 2-DEOXY-D-GLUCOSE
Sui Seng Tee, Jae Mo Park, Ralph E. Hurd, Kyle R. Brimacombe, Matthew B. Boxer, Tarik F. Massoud, Brian K. Rutt,  and  Daniel M. Spielman
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=19630&path[]=62716

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Amino acids / proteins / Glutathione
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mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient
Gregory A. Wyant, Monther Abu-Remaileh, Rachel L. Wolfson, Walter W. Chen, Elizaveta Freinkman, Laura V. Danai, Matthew G. Vander Heiden, David M. Sabatini
http://www.cell.com/cell/fulltext/S0092-8674(17)31140-6

Critical role for PI3-kinase in regulating the use of proteins as an amino acid source
Wilhelm Palm, Jingwen Araki, Bryan King, Raymond G. DeMatteo, and Craig B. Thompson
http://www.pnas.org/content/114/41/E8628.abstract.html?etoc

Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma
Gregory S. Ducker, Jonathan M. Ghergurovich, Nello Mainolfi, Vipin Suri, Stephanie K. Jeong, Sophia Hsin-Jung Li, Adam Friedman, Mark G. Manfredi, Zemer Gitai, Hahn Kim, and Joshua D. Rabinowitz
http://www.pnas.org/content/114/43/11404.abstract.html?etoc

TAp73 is a marker of glutamine addiction in medulloblastoma
Maria Victoria Niklison-Chirou, Ida Erngren, Mikael Engskog, Jakob Haglöf, Daniel Picard, Marc Remke, Phelim Hugh Redmond McPolin, Matthew Selby, Daniel Williamson, Steven C. Clifford, David Michod, Michalis Hadjiandreou, Torbjörn Arvidsson, Curt Pettersson, Gerry Melino and Silvia Marino
http://genesdev.cshlp.org/content/31/17/1738.abstract?etoc

Metabolite profiling reveals the glutathione biosynthetic pathway as a therapeutic target in triple negative breast cancer
Alexander Beatty, Lauren S. Fink, Tanu Singh, Alexander Strigun, Erik Peter, Christina M. Ferrer, Emmanuelle Nicolas, Kathy Q. Cai, Timothy P. Moran, Mauricio J. Reginato, Ulrike Rennefahrt and Jeffrey R. Peterson
http://mct.aacrjournals.org/content/early/2017/10/11/1535-7163.MCT-17-0407.long

AUTOPHAGY SUPPRESSION POTENTIATES THE ANTI-GLIOBLASTOMA EFFECT OF ASPARAGINASE IN VITRO AND IN VIVO
Qicheng Chen, Li Ye, Jiajun Fan, Xuyao Zhang, Huan Wang, Siyang Liao, Ping Song, Ziyu Wang, Shaofei Wang, Yubin Li, Jingyun Luan, Yichen Wang, Wei Chen, Wenjing Zai, Ping Yang, Zhonglian Cao,  and  Dianwen Ju
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=19409&path[]=62078

Genome-wide loss-of-function genetic screening identifies opioid receptor μ1 as a key regulator of L-asparaginase resistance in pediatric acute lymphoblastic leukemia
S M Kang, J L Rosales, V Meier-Stephenson, S Kim, K Y Lee and A Narendran
http://www.nature.com/onc/journal/v36/n42/abs/onc2017211a.html

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Mitochondria and ROS
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Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells
Elodie M Kuntz, Pablo Baquero, Alison M Michie, Karen Dunn,Saverio Tardito, Tessa L Holyoake, G Vignir Helgason & Eyal Gottlieb
http://www.nature.com/nm/journal/v23/n10/full/nm.4399.html

Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects
Petros A. Tyrakis, Marie E. Yurkovich, Marco Sciacovelli, Evangelia K. Papachristou, Hannah R. Bridges, Edoardo Gaude, Alexander Schreiner, Clive D’Santos, Judy Hirst, Juan Hernandez-Fernaud, Roger Springett, John R. Griffiths, Christian Frezza
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31412-2

Pyruvate dehydrogenase complex (PDC) subunits moonlight as interaction partners of phosphorylated STAT5 in adipocytes and adipose tissue
Allison J. Richard, Hardy Hang and Jacqueline M. Stephens
http://www.jbc.org/content/early/2017/10/05/jbc.M117.811794.abstract

Succinate promotes stem cell migration through the GPR91-dependent regulation of DRP1-mediated mitochondrial fission
So Hee Ko, Gee Euhn Choi, Ji Young Oh, Hyun Jik Lee, Jun Sung Kim, Chang Woo Chae, Diana Choi & Ho Jae Han
https://www.nature.com/articles/s41598-017-12692-x

NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance
Karthigayan Shanmugasundaram, Bijaya K. Nayak, William E. Friedrichs, Dharam Kaushik, Ronald Rodriguez & Karen Block
https://www.nature.com/articles/s41467-017-01106-1

A CRISPR screen identifies a pathway required for paraquat-induced cell death
Colleen R Reczek, Kivanc¸ Birsoy, Hyewon Kong, Inmaculada Martínez-Reyes, Tim Wang,Peng Gao, David M Sabatini& Navdeep S Chandel
https://www.nature.com/articles/nchembio.2499

NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts
Christopher R. Marlein, Lyubov Zaitseva, Rachel E. Piddock, Stephen D. Robinson, Dylan R. Edwards, Manar S. Shafat, Zhigang Zhou, Matthew Lawes, Kristian M. Bowles and Stuart A. Rushworth
http://bloodjournal.org/content/130/14/1649.abstract?etoc

A novel Fer/FerT targeting compound selectively evokes metabolic stress and necrotic death in malignant cells
Yoav Elkis, Moshe Cohen, Etai Yaffe, Shirly Satmary-Tusk, Tal Feldman, Elad Hikri, Abraham Nyska, Ariel Feiglin, Yanay Ofran, Sally Shpungin & Uri Nir
https://www.nature.com/articles/s41467-017-00832-w

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Nucleotide metabolism
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mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability.
Alexander J. Valvezan, MarcTurner, Amine Belaid, Hilaire C. Lam, Spencer K. Miller, Molly C.McNamara, Christian Baglini, Benjamin E. Housden, Norbert Perrimon, David J.Kwiatkowski, John M.Asara, Elizabeth P.Henske, Brendan D. Manning
http://www.cell.com/cancer-cell/abstract/S1535-6108(17)30417-8

Molecular features that predict the response to antimetabolite chemotherapies
Mahya Mehrmohamadi, Seong Ho Jeong and Jason W. Locasale
https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-017-0170-3

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Fatty acids / cholesterol
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De Novo Lipid Synthesis Facilitates Gemcitabine Resistance through Endoplasmic Reticulum Stress in Pancreatic Cancer
Saber Tadros, Surendra K. Shukla, Ryan J. King, Venugopal Gunda, Enza Vernucci, Jaime Abrego, Nina V. Chaika, Fang Yu, Audrey J. Lazenby, Lyudmyla Berim, Jean Grem, Aaron R. Sasson and Pankaj K. Singh
http://cancerres.aacrjournals.org/content/77/20/5503

Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptor
Maud Voisin, Philippe de Medina, Arnaud Mallinger, Florence Dalenc, Emilie Huc-Claustre, Julie Leignadier, Nizar Serhan, Régis Soules, Grégory Ségala, Aurélie Mougel, Emmanuel Noguer, Loubna Mhamdi, Elodie Bacquié, Luigi Iuliano, Chiara Zerbinati, Magali Lacroix-Triki, Léonor Chaltiel, Thomas Filleron, Vincent Cavaillès, Talal Al Saati, Philippe Rochaix, Raphaelle Duprez-Paumier, Camille Franchet, Laetitia Ligat, Fréderic Lopez, Michel Record, Marc Poirot, and Sandrine Silvente-Poirot
http://www.pnas.org/content/114/44/E9346.abstract.html?etoc

The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells
Amy E. Baek, Yen-Rei A. Yu, Sisi He, Suzanne E. Wardell, Ching-Yi Chang, Sanghoon Kwon, Ruchita V. Pillai, Hannah B. McDowell, J. Will Thompson, Laura G. Dubois, Patrick M. Sullivan, Jongsook K. Kemper, Michael D. Gunn, Donald P. McDonnell & Erik R. Nelson
https://www.nature.com/articles/s41467-017-00910-z

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Nutrient sensing / starvation
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The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels
Gerta Hoxhaj, James Hughes-Hallett, Rebecca C. Timson, Erika Ilagan, Min Yuan, John M. Asara, Issam Ben-Sahra, Brendan D. Manning
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31461-4

Autophagy induction under carbon starvation conditions is negatively regulated by carbon catabolite repression.
Atsuhiro Adachi, Michiko Koizumi and Yoshinori Ohsumi
http://www.jbc.org/content/early/2017/10/17/jbc.M117.817510.abstract

Cystine uptake through the cystine/glutamate antiporter xCT triggers glioblastoma cell death under glucose deprivation
Takeo Goji, Kazuhiko Takahara, Manabu Negishi and Hironori Katoh
http://www.jbc.org/content/early/2017/10/16/jbc.M117.814392.abstract

Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development
Zhen-Dong Xiao, Leng Han, Hyemin Lee, Li Zhuang, Yilei Zhang, Joelle Baddour, Deepak Nagrath, Christopher G. Wood, Jian Gu, Xifeng Wu, Han Liang & Boyi Gan
https://www.nature.com/articles/s41467-017-00902-z

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Hypoxia, HIFs
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Transcriptome analysis of hypoxic cancer cells uncovers intron retention in EIF2B5 as a mechanism to inhibit translation
Lauren K. Brady, Hejia Wang, Caleb M. Radens, Yue Bi, Milan Radovich, Amit Maity, Cristina Ivan, Mircea Ivan, Yoseph Barash, Constantinos Koumenis
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2002623

HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Kate Vandyke, Mara N. Zeissig, Duncan R. Hewett, Sally K. Martin, Krzysztof M. Mrozik, Chee Man Cheong, Peter Diamond, L. BikTo, Stan Gronthos, Daniel J. Peet, Peter I. Croucher and Andrew C.W. Zannettino
http://cancerres.aacrjournals.org/content/77/20/5452

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Angiogenesis
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Adrenergic nerves activate an angio-metabolic switch in prostate cancer
Ali H. Zahalka, Anna Arnal-Estapé, Maria Maryanovich, Fumio Nakahara, Cristian D. Cruz, Lydia W. S. Finley, Paul S. Frenette
http://science.sciencemag.org/content/358/6361/321

ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner
D Chen, Z Fan, M Rauh, M Buchfelder, I Y Eyupoglu and N Savaskan
http://www.nature.com/onc/journal/v36/n40/abs/onc2017146a.html

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Tor
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Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling
Mariana E. G. de Araujo , Andreas Naschberger, Barbara G. Fürnrohr, Taras Stasyk, Theresia Dunzendorfer-Matt, Stefan Lechner, Stefan Welti, Leopold Kremser, Giridhar Shivalingaiah, Martin Offterdinger, Herbert H. Lindner, Lukas A. Huber, Klaus Scheffzek
http://science.sciencemag.org/content/358/6361/377

TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity
Manoël Prouteau, Ambroise Desfosses, Christian Sieben, Clélia Bourgoint, Nour Lydia Mozaffari, Davide Demurtas, Alok K. Mitra, Paul Guichard, Suliana Manley & Robbie Loewith
http://www.nature.com/nature/journal/vaop/ncurrent/full

Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction
Jong Hyun Kim, Chulho Lee, […], Sunghoon Kim
https://www.nature.com/articles/s41467-017-00785-0

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AMPK
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CDK4 Phosphorylates AMPKα2 to Inhibit Its Activity and Repress Fatty Acid Oxidation
Isabel C. Lopez-Mejia, Sylviane Lagarrigue, Albert Giralt, Laia Martinez-Carreres, Nadège Zanou, Pierre-Damien Denechaud, Judit Castillo-Armengol, Carine Chavey, Meritxell Orpinell, Brigitte Delacuisine, Anita Nasrallah, Caterina Collodet, Lianjun Zhang, Benoît Viollet, D. Grahame Hardie, Lluis Fajas
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30712-8

AMP-activated protein kinase-mediated feedback phosphorylation controls the Ca2+/calmodulin (CaM) dependence of Ca2+/CaM-dependent protein kinase kinase β
Akihiro Nakanishi, Naoya Hatano, Yuya Fujiwara, Arian Bin Shari, Shota Takabatake, Hiroki Akano, Naoki Kanayama, Masaki Magari, Naohito Nozaki and Hiroshi Tokumitsu
http://www.jbc.org/content/early/2017/10/03/jbc.M117.805085.abstract

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Miscellaneous
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Mitochondrial Priming by CD28
Ramon I. Klein Geltink, David O’Sullivan, Mauro Corrado, Anna Bremser, Michael D. Buck, Joerg M. Buescher, Elke Firat, Xuekai Zhu, Gabriele Niedermann, George Caputa, Beth Kelly, Ursula Warthorst, Anne Rensing-Ehl, Ryan L. Kyle, Lana Vandersarren, Jonathan D. Curtis, Annette E. Patterson, Simon Lawless, Katarzyna Grzes, Jing Qiu, David E. Sanin, Oliver Kretz, Tobias B. Huber, Sophie Janssens, Bart N. Lambrecht, Angelika S. Rambold, Edward J. Pearce, Erika L. Pearce
http://www.cell.com/cell/fulltext/S0092-8674(17)30943-1

Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL
Georg Karpel-Massler, Chiaki Tsuge Ishida, Elena Bianchetti, Yiru Zhang, Chang Shu, Takashi Tsujiuchi, Matei A. Banu, Franklin Garcia, Kevin A. Roth, Jeffrey N. Bruce, Peter Canoll & Markus D. Siegelin
https://www.nature.com/articles/s41467-017-00984-9

Metabolic modulation of Ewing sarcoma cells inhibits tumor growth and stem cell properties
Atreyi Dasgupta, Matteo Trucco, Nino Rainusso, Ronald J. Bernardi, Ryan Shuck, Lyazat Kurenbekova, David M. Loeb and Jason T. Yustein
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=20467

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Reviews
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The impact of cellular metabolism on chromatin dynamics and epigenetics
Michael A. Reid, Ziwei Dai and Jason W. Locasale
http://www.nature.com/ncb/journal/v19/n11/full/ncb3629.html

AMPK: guardian of metabolism and mitochondrial homeostasis
Sébastien Herzig & Reuben J. Shaw
https://www.nature.com/nrm/journal/vaop/ncurrent/full/nrm.2017.95.html

Metabolic reprogramming and epithelial-to-mesenchymal transition in cancer
Marco Sciacovelli and Christian Frezza
http://onlinelibrary.wiley.com/doi/10.1111/febs.14090/abstract

Metabolic Interactions in the Tumor Microenvironment
Costas A. Lyssiotis, Alec C. Kimmelman
http://www.cell.com/trends/cell-biology/fulltext/S0962-8924(17)30102-2

Emerging Roles for the Lysosome in Lipid Metabolism
Ashley M. Thelen, Roberto Zoncu
http://www.cell.com/trends/cell-biology/fulltext/S0962-8924(17)30124-1

Editorial: Cancer Metabolism: Molecular Targeting and Implications for Therapy
Shanmugasundaram Ganapathy-Kanniappan
https://www.frontiersin.org/articles/10.3389/fonc.2017.00232/full

The Linkage between Breast Cancer, Hypoxia, and Adipose Tissue
Linda Rausch, Nikolaus Netzer, Josef Hoegel, and Stephan Pramsohler
https://www.frontiersin.org/articles/10.3389/fonc.2017.00211/full

Oxygen availability and metabolic reprogramming in cancer
Hong Xie and M. Celeste Simon
http://www.jbc.org/content/292/41/16825.abstract

Stress-sensing mechanisms and the physiological roles of the Keap1–Nrf2 system during cellular stress
Takafumi Suzuki and Masayuki Yamamoto
http://www.jbc.org/content/292/41/16817.abstract.html

Precision Nutrition for Targeting Lipid Metabolism in Colorectal Cancer
Cristina Aguirre-Portolés, Lara P. Fernández and Ana Ramírez de Molina
http://www.mdpi.com/2072-6643/9/10/1076

Fumarase Deficiency: A Safe and Potentially Disease Modifying Effect of High Fat/Low Carbohydrate Diet
B. Ryder, F. Moore, A. Mitchell, S. Thompson, J. Christodoulou, S. Balasubramaniam
https://link.springer.com/chapter/10.1007/8904_2017_65

Lipid metabolism fattens up hedgehog signaling
Robert Blassberg and John Jacob
https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-017-0442-y

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Previews / other
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Twenty-five years of mTOR: Uncovering the link from nutrients to growth
David M. Sabatini
http://www.pnas.org/content/early/2017/10/17/1716173114.abstract

Another case for diet restriction: TAp73-expressing medulloblastomas are stunted by glutamine withdrawal
Marco Napoli and Elsa R. Flores
http://genesdev.cshlp.org/content/31/17/1715.abstract?etoc

Mitochondria on the move: BMSCs fuel AML energy
Rosa Lapalombella
http://bloodjournal.org/content/130/14/1603?etoc

Lessons from Yeast on How to Avoid Stress Eating
Jean A. Smith, Amy S. Gladfelter
http://www.cell.com/developmental-cell/fulltext/S1534-5807(17)30767-0

Mitophagy, metabolism, and cell fate
Lorena Esteban-Martínez, Elena Sierra-Filardi & Patricia Boya
http://www.tandfonline.com/doi/full/10.1080/23723556.2017.1353854

Profile of Michael N. Hall, 2017 Albert Lasker Basic Medical Research Awardee: Target of rapamycin, cell growth, and translational control
Nahum Sonenberg
http://www.pnas.org/content/114/44/11564.extract.html?etoc

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