MetaboList – December 2018

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Glycolysis and glucose sensing
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O-GlcNAcylation destabilizes the active tetrameric PKM2 to promote the Warburg effect
Yang Wang, Jia Liu, Xin Jin, Dapeng Zhang, Dongxue Li, Fengqi Hao, Yunpeng Feng, Shan Gu, Fanlin Meng, Miaomiao Tian, Yi Zheng, Ling Xin, Xinbo Zhang, Xue Han, L. Aravind, and Min Wei
http://www.pnas.org/content/114/52/13732.abstract.html

Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells
Yin P Hung, Carolyn Teragawa, Nont Kosaisawe, Taryn E Gillies, Michael Pargett, Marta Minguet, Kevin Distor, Briana L Rocha-Gregg, Jonathan L Coloff, Mark A Keibler, Gregory Stephanopoulos, Gary Yellen, Joan S Brugge and John G Albeck
https://elifesciences.org/articles/27293

The Std1 Activator of the Snf1/AMPK Kinase Controls Glucose Response in Yeast by a Regulated Protein Aggregation
Kobi Simpson-Lavy, Tianchang Xu, Mark Johnston, Martin Kupiec
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30875-4

Fructose and glucose regulate mammalian target of rapamycin complex 1 and can activate lipogenic gene expression via distinct pathways
Yue Hu, Ivana Semova, Xiaowei Sun, Hong Kang, Satyapal Chahar, Anthony N Hollenberg, David Masson, Matthew D Hirschey, Ji Miao and Sudha B Biddinger
http://www.jbc.org/content/early/2017/12/08/jbc.M117.782557.abstract

GLUCOSE-6-PHOSPHATE DEHYDROGENASE AND TRANSKETOLASE MODULATE BREAST CANCER CELL METABOLIC REPROGRAMMING AND CORRELATE WITH POOR PATIENT OUTCOME
Adrián Benito, Ibrahim H. Polat, Véronique Noé, Carlos J. Ciudad, Silvia Marin,  and  Marta Cascante
https://doi.org/10.18632/oncotarget.21601

PYRUVATE KINASE M2 PHOSPHORYLATES H2AX AND PROMOTES GENOMIC INSTABILITY IN HUMAN TUMOR CELLS
Li Xia, Kang Qin, Xin-Ran Wang, Xiao-Ling Wang, Ai-Wu Zhou, Guo-Qiang Chen,  and  Ying Lu
https://doi.org/10.18632/oncotarget.22621

HIGH GLUCOSE ENHANCES THE METASTATIC POTENTIAL OF TONGUE SQUAMOUS CELL CARCINOMA VIA THE PKM2 PATHWAY
Wei Wang, Qianting He, Wangxiang Yan, Jingjing Sun, Zujian Chen, Zhonghua Liu, Zhiyuan Lu, Jinsong Hou, Yisen Shao, Xiaofeng Zhou,  and  Anxun Wang
https://doi.org/10.18632/oncotarget.22907

Glucose impairs tamoxifen responsiveness modulating connective tissue growth factor in breast cancer cells
Maria Rosaria Ambrosio, Vittoria D’Esposito, Valerio Costa, Domenico Liguoro, Francesca Collina, Monica Cantile, Nella Prevete, Carmela Passaro, Giusy Mosca, Michelino De Laurentiis, Maurizio Di Bonito, Gerardo Botti, Renato Franco, Francesco Beguinot, Alfredo Ciccodicola, and Pietro Formisano
https://doi.org/10.18632/oncotarget.22552

The glucose and lipid metabolism reprogramming is gradedependent in clear cell renal cell carcinoma primary cultures and is targetable to modulate cell viability and proliferation
Cristina Bianchi, Chiara Meregalli, Silvia Bombelli, Vitalba Di Stefano, Francesco Salerno, Barbara Torsello, Sofia De Marco, Giorgio Bovo, Ingrid Cifola, Eleonora Mangano, Cristina Battaglia, Guido Strada, Giuseppe Lucarelli, Robert H. Weiss,  and  Roberto A. Perego
https://doi.org/10.18632/oncotarget.23056

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Amino acid metabolism and starvation
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Serine-Dependent Sphingolipid Synthesis Is a Metabolic Liability of Aneuploid Cells
Sunyoung Hwang, H. Tobias Gustafsson, Ciara O’Sullivan, Gianna Bisceglia, Xinhe Huang, Christian Klose, Andrej Schevchenko, Robert C. Dickson, Paola Cavaliere, Noah Dephoure, Eduardo M. Torres
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31787-4

Oncogenic MYC Activates a Feedforward Regulatory Loop Promoting Essential Amino Acid Metabolism and Tumorigenesis
Ming Yue, Jue Jiang, Peng Gao, Hudan Liu, Guoliang Qing
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31798-9

Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT
Evan C. Lien, Laura Ghisolfi, Renee C. Geck, John M. Asara, Alex Toker
http://stke.sciencemag.org/content/10/510/eaao6604

Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells
Emmanuel Dornier, Nicolas Rabas, Louise Mitchell, David Novo, Sandeep Dhayade, Sergi Marco, Gillian Mackay, David Sumpton, Maria Pallares, Colin Nixon, Karen Blyth, Iain R. Macpherson, Elena Rainero & Jim C. Norman
https://www.nature.com/articles/s41467-017-02101-2

ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma
Juan F. Linares, Thekla Cordes, Angeles Duran, Miguel Reina-Campos, Tania Valencia, Christopher S. Ahn, Elias A. Castilla, Jorge Moscat, Christian M. Metallo, Maria T. Diaz-Meco
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30552-1

CHAC1 DEGRADATION OF GLUTATHIONE ENHANCES CYSTINE-STARVATION-INDUCED NECROPTOSIS AND FERROPTOSIS IN HUMAN TRIPLE NEGATIVE BREAST CANCER CELLS VIA THE GCN2-EIF2Α-ATF4 PATHWAY
Meng-Shian Chen, Sheng-Fan Wang, Chih-Yi Hsu, Pen-Hui Yin, Tien-Shun Yeh, Hsin-Chen Lee,  and  Ling-Ming Tseng
https://doi.org/10.18632/oncotarget.23055

In Vivo Imaging of Glutamine Metabolism to the Oncometabolite 2-Hydroxyglutarate in IDH1/2 Mutant Tumors
Lucia Salamanca-Cardona, Hardik Shah, Alex J. Poot, Fabian M. Correa, Valentina Di Gialleonardo, Hui Lui, Vesselin Z. Miloushev, Kristin L. Granlund, Sui S. Tee, Justin R. Cross, Craig B. Thompson, Kayvan R. Keshari
http://www.cell.com/cell-metabolism/abstract/S1550-4131(17)30613-7

A natural inhibitor of kidney-type glutaminase: a withanolide from Physalis pubescens with potent anti-tumor activity
Canrong Wu, Mengzhu Zheng, Suyu Gao, Shanshan Luan, Li Cheng, Liqing Wang, Jiachen Li, Lixia Chen,  and  Hua Li
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=23058

IDENTIFICATION OF A CYTOGENETIC AND MOLECULAR SUBGROUP OF ACUTE MYELOID LEUKEMIAS SHOWING SENSITIVITY TO L-ASPARAGINASE
Salvatore Nicola Bertuccio, Salvatore Serravalle, Annalisa Astolfi, Annalisa Lonetti, Valentina Indio, Anna Leszl,Andrea Pession, and  Fraia Melchionda
https://doi.org/10.18632/oncotarget.18565

Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors
Charalambos Kaittanis, Chrysafis Andreou, Haley Hieronymus, Ninghui Mao, Catherine A. Foss, Matthias Eiber, Gregor Weirich, Palak Panchal, Anuradha Gopalan, Juan Zurita, Samuel Achilefu, Gabriela Chiosis, Vladimir Ponomarev, Markus Schwaiger, Brett S. Carver, Martin G. Pomper and Jan Grimm
http://jem.rupress.org/content/215/1/159?etoc

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Lipids
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Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling
Gina Lee, Yuxiang Zheng, Sungyun Cho, Cholsoon Jang, Christina England, Jamie M. Dempsey, Yonghao Yu, Xiaolei Liu, Long He, Paola M. Cavaliere, Andre Chavez, Erik Zhang, Meltem Isik, Anthony Couvillon, Noah E. Dephoure, T. Keith Blackwell, Jane J. Yu, Joshua D. Rabinowitz, Lewis C. Cantley, John Blenis
http://www.cell.com/cell/fulltext/S0092-8674(17)31263-1

mTORC2 Promotes Tumorigenesis via Lipid Synthesis
Yakir Guri, Marco Colombi, Eva Dazert, Sravanth K. Hindupur, Jason Roszik, Suzette Moes, Paul Jenoe, Markus H. Heim, Isabelle Riezman, Howard Riezman, Michael N. Hall
http://www.cell.com/cancer-cell/fulltext/S1535-6108(17)30514-7

Acetyl-CoA Carboxylase 1-Dependent Protein Acetylation Controls Breast Cancer Metastasis and Recurrence
Marcos Rios Garcia, Brigitte Steinbauer, Kshitij Srivastava, Mahak Singhal, Frits Mattijssen, Adriano Maida, Sven Christian, Holger Hess-Stumpp, Hellmut G. Augustin, Karin Müller-Decker, Peter P. Nawroth, Stephan Herzig, Mauricio Berriel Diaz
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30570-3

High-grade ovarian serous carcinoma patients exhibit profound alterations in lipid metabolism
Elena Ioana Braicu, Silvia Darb-Esfahani, […], and Mika Hilvo
https://doi.org/10.18632/oncotarget.22076

Cilia loss sensitizes cells to transformation by activating the mevalonate pathway
Yue-Zhen Deng, Zhen Cai, Shuo Shi, Hao Jiang, Yu-Rong Shang, Ning Ma, Jing-Jing Wang, Dong-Xian Guan, Tian-Wei Chen, Ye-Fei Rong, Zhen-Yu Qian, Er-Bin Zhang, Dan Feng, Quan-Li Zhou, Yi-Nan Du, Dong-Ping Liu, Xing-Xu Huang, Lu-Ming Liu, Eugene Chin, Dang-Sheng Li, Xiao-Fan Wang, Xue-Li Zhang and Dong Xie
http://jem.rupress.org/content/215/1/177?etoc

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Mitochondria / Nucleotides
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Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects
Petros A. Tyrakis, Marie E. Yurkovich, Marco Sciacovelli, Evangelia K. Papachristou, Hannah R. Bridges, Edoardo Gaude, Alexander Schreiner, Clive D’Santos, Judy Hirst, Juan Hernandez-Fernaud, Roger Springett, John R. Griffiths,  Christian Frezza
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31412-2

Identification of New Activators of Mitochondrial Fusion Reveals a Link between Mitochondrial Morphology and Pyrimidine Metabolism
Laia Miret-Casals, David Sebastián, José Brea, Eva M. Rico-Leo, Manuel Palacín, Pedro M. Fernández-Salguero, M. Isabel Loza, Fernando Albericio,  Antonio Zorzano
http://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(17)30428-2

Purine nucleotide metabolism regulates expression of the human immune ligand MICA.
Michael T McCarthy, Gerald Moncayo, Thomas K Hiron, Niels A Jakobsen, Alessandro Vali, Tomoyoshi Soga, Julie Adam and Christopher A O’Callaghan
http://www.jbc.org/content/early/2017/12/26/jbc.M117.809459.abstract

Mitochondrial Haplotype Alters Mammary Cancer Tumorigenicity and Metastasis in an Oncogenic Driver–Dependent Manner
Amanda E. Brinker, Carolyn J. Vivian, Devin C. Koestler, Trevor T. Tsue, Roy A. Jensen and Danny R. Welch
http://cancerres.aacrjournals.org/content/77/24/6941

Alteration of mitochondrial biogenesis promotes disease progression in multiple myeloma
Xin Zhan, Wenjie Yu, Reinaldo Franqui-Machin, Melissa L. Bates, Kalyan Nadiminti, Huojun Cao, Brad A. Amendt, Yogesh Jethava, Ivana Frech, Fenghuang Zhan, and Guido Tricot
https://doi.org/10.18632/oncotarget.22740

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mTOR
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Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex
Ming-Yuan Su, Kyle L. Morris, Do Jin Kim, Yangxue Fu, Rosalie Lawrence, Goran Stjepanovic, Roberto Zoncu, James H. Hurley
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30791-8

Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40
Haijuan Yang, Xiaolu Jiang, Buren Li, Hyo J. Yang, Meredith Miller, Angela Yang, Ankita Dhar & Nikola P. Pavletich
https://www.nature.com/articles/nature25023

Tumor suppressor Tsc1 is a new Hsp90 co‐chaperone that facilitates folding of kinase and non‐kinase clients
Mark R Woodford, Rebecca A Sager, Elijah Marris, Diana M Dunn, Adam R Blanden, Ryan L Murphy, Nicholas Rensing, Oleg Shapiro, Barry Panaretou, Chrisostomos Prodromou, Stewart N Loh, David H Gutmann, Dimitra Bourboulia, Gennady Bratslavsky, Michael Wong, View ORCID ProfileMehdi Mollapour
http://emboj.embopress.org/content/36/24/3650?etoc

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Angiogenesis / hypoxia / starvation
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Loss of Caveolin-1 in Metastasis-Associated Macrophages Drives Lung Metastatic Growth through Increased Angiogenesis
Ward Celus, Giusy Di Conza, Ana Isabel Oliveira, Manuel Ehling, Bruno M. Costa, Mathias Wenes, Massimiliano Mazzone
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31671-6

The role of the ATPase inhibitor factor 1 (IF1) in cancer cells adaptation to hypoxia and anoxia
G. Sgarbi, S. Barbato, A. Costanzini, G. Solaini, A. Baracca
https://www.sciencedirect.com/science/article/pii/S0005272817301597

Stress-response transcription factors Msn2 and Msn4 couple TORC2-Ypk1 signaling and mitochondrial respiration to ATG8 gene expression and autophagy
[yeast]
Ariadne Vlahakis, Nerea Lopez Muniozguren & Ted Powers
http://www.tandfonline.com/doi/full/10.1080/15548627.2017.1356949

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Epigenetics / IDH
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ATP Citrate Lyase Regulates Myofiber Differentiation and Increases Regeneration by Altering Histone Acetylation
Suman Das, Frederic Morvan, Giulio Morozzi, Benjamin Jourde, Giulia C. Minetti, Peter Kahle, Helene Rivet, Pascale Brebbia, Gauthier Toussaint, David J. Glass, Mara Fornaro
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31675-3

Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence
Sevin Turcan, Vladimir Makarov, Julian Taranda, Yuxiang Wang, Armida W. M. Fabius, Wei Wu, Yupeng Zheng, Nour El-Amine, Sara Haddock, Gouri Nanjangud, H. Carl LeKaye, Cameron Brennan, Justin Cross, Jason T. Huse, Neil L. Kelleher, Pavel Osten, Craig B. Thompson & Timothy A. Chan
https://www.nature.com/articles/s41588-017-0001-z

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Miscellaneous
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Comprehensive Mapping of Pluripotent Stem Cell Metabolism Using Dynamic Genome-Scale Network Modeling
Sriram Chandrasekaran, Jin Zhang, Zhen Sun, Li Zhang, Christian A. Ross, Yu-Chung Huang, John M. Asara, Hu Li, George Q. Daley, James J. Collins
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31027-6

ADHFE1 is a breast cancer oncogene and induces metabolic reprogramming
Prachi Mishra, Wei Tang, Vasanta Putluri, Tiffany H. Dorsey, Feng Jin, Fang Wang, Donewei Zhu, Lauren Amable, Tao Deng, Shaofei Zhang, J. Keith Killian, Yonghong Wang, Tsion Z. Minas, Harry G. Yfantis, Dong H. Lee, Arun Sreekumar, Michael Bustin, Wei Liu, Nagireddy Putluri, and Stefan Ambs
https://www.jci.org/articles/view/93815#.WiftNPQ8t4M.facebook

Energy metabolism in glioblastoma stem cells: PPARα a metabolic adaptor to intratumoral microenvironment
Alessia Fidoamore, Loredana Cristiano, Chiara Laezza, Renato Galzio, Elisabetta Benedetti, Benedetta Cinque, Andrea Antonosante, Michele d’Angelo, Vanessa Castelli, Maria Grazia Cifone, Rodolfo Ippoliti, Antonio Giordano,  and  Annamaria Cimini
https://doi.org/10.18632/oncotarget.19086

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Reviews
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Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism
Christopher T. Walsh, Benjamin P. Tu, and Yi Tang
http://pubs.acs.org/doi/10.1021/acs.chemrev.7b00510

AMPK: Sensing Glucose as well as Cellular Energy Status
Sheng-Cai Lin, D. Grahame Hardie
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30622-8

Advances in Hypoxia-Inducible Factor Biology
Hani Choudhry, Adrian L. Harris
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30617-4

Ribosome biogenesis in cancer: new players and therapeutic avenues
Joffrey Pelletier, George Thomas & Sinisa Volarevic
https://www.nature.com/articles/nrc.2017.104

Sphingolipid metabolism in cancer signalling and therapy
Besim Ogretmen
https://www.nature.com/articles/nrc.2017.96

Mitochondrial metabolism and cancer
Paolo Ettore Porporato, Nicoletta Filigheddu, José Manuel Bravo-San Pedro, Guido Kroemer & Lorenzo Galluzzi
https://www.nature.com/articles/cr2017155

Cofactors As Metabolic Sensors Driving Cell Adaptation in Physiology and Disease
Nabil Rabhi, Sarah Anissa Hannou, Philippe Froguel and Jean-Sébastien Annicotte
https://www.frontiersin.org/articles/10.3389/fendo.2017.00304/full

Exploring Non-Metabolic Functions of Glycolytic Enzymes in Immunity
Scott M. Seki and Alban Gaultier
https://www.frontiersin.org/articles/10.3389/fimmu.2017.01549/full

Asparagine synthetase: Function, structure, and role in disease
Carrie L. Lomelino, Jacob T. Andring, Robert McKenna and Michael S. Kilberg
http://www.jbc.org/content/292/49/19952.abstract.html

Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases
Niamh M. C. Connolly, Pierre Theurey, […] Jochen H. M. Prehn
https://www.nature.com/articles/s41418-017-0020-4

Lipoic acid metabolism and mitochondrial redox regulation
Ashley D Solmonson and Ralph J. DeBerardinis
http://www.jbc.org/content/early/2017/11/29/jbc.TM117.000259.abstract

Evaluating Cell Metabolism Through Autofluorescence Imaging of NAD(P)H and FAD
Olivia I. Kolenc and Kyle P. Quinn.
http://online.liebertpub.com/doi/10.1089/ars.2017.7451

Do lipids shape the eukaryotic cell cycle?
Samuel Furse, Gemma C. Shearman
https://www.sciencedirect.com/science/article/pii/S1388198117302032

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Comments
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When Cancer Cells Are Given Lemo[NH3]s, They Make Lemo[NH3]ade
Mengrou Shan, Costas A. Lyssiotis
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30676-9

Waste Not, Want Not: Lactate Oxidation Fuels the TCA Cycle
Inmaculada Martínez-Reyes, Navdeep S. Chandel
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30673-3

A cholesterol-sensing mechanism unfolds
William A. Prinz
http://www.jbc.org/content/292/49/19974.abstract.html

Glut3 Addiction: A Druggable Vulnerability in Glioblastoma
Severa Bunda, Gelareh Zadeh, Kenneth D. Aldape
http://www.cell.com/cancer-cell/abstract/S1535-6108(17)30520-2

Encoding Allostery in mTOR Signaling: The Structure of the Rag GTPase/Ragulator Complex
Jacqueline Cherfils
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30886-9

PSMA brings new flavors to PI3K signaling: A role for glutamate in prostate cancer
Lavinia Palamiuc and Brooke M. Emerling
http://jem.rupress.org/content/215/1/17?etoc

Keap1 Loss Drives Kras-Mutant Lung Cancer and Glutaminolysis Dependency
http://cancerdiscovery.aacrjournals.org/content/7/12/OF8

Glucose Indirectly Fuels the TCA Cycle in Tumors via Lactate
http://cancerdiscovery.aacrjournals.org/content/7/12/OF9

Breast Cancer Cells Recycle Ammonia to Generate Amino Acids
http://cancerdiscovery.aacrjournals.org/content/7/12/1364.2

Lactate Fuels the TCA Cycle in Non–Small Cell Lung Cancer
http://cancerdiscovery.aacrjournals.org/content/7/12/OF10

SLC38A9 Links mTORC1 Activity to Lysosomal Amino Acid Release
http://cancerdiscovery.aacrjournals.org/content/7/12/OF12

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Resources
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Conference on Cancer Metabolism organized by A Carracedo, N Chandel, R DeBerardinins, J Seoane, J Carmona and A. Efeyan in Bilbao, Spain, 09-11 Oct 2018.
https://www.eacr.org/conference/cancermetabolism2018/scientific-programme

Conference on Metabolism in Cancer and Stromal Cells  Peter Carmeliet, Sarah-Maria Fendt, Massimiliano Mazzone,
Jo Van Ginderachter, Bart Ghesquière in Leuven, Belgium, 26-27 Nov 2018
https://vibconferences.be/event/metabolism-in-cancer-and-stromal-cells-2nd-edition

LinkedIn group / job posts
https://www.linkedin.com/groups/3694095

Facebook Cancer Metabolism page
https://www.facebook.com/CancerMetabolism

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