MetaboList – January 2018

———————–
Amino acids
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Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase
Dana M. Gwinn, Alex G. Lee, Marcela Briones-Martin-del-Campo, Crystal S. Conn, David R. Simpson, Anna I. Scott, Anthony Le, Tina M. Cowan, Davide Ruggero, E. Alejandro Sweet-Cordero
http://www.cell.com/cancer-cell/fulltext/S1535-6108(17)30555-X

As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid
Natalya N. Pavlova, Sheng Hui, Jonathan M. Ghergurovich, Jing Fan, Andrew M. Intlekofer, Richard M. White, Joshua D. Rabinowitz, Craig B. Thompson, Ji Zhang
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30716-7

Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells
Emmanuel Dornier, Nicolas Rabas, Louise Mitchell, David Novo, Sandeep Dhayade, Sergi Marco, Gillian Mackay, David Sumpton, Maria Pallares, Colin Nixon, Karen Blyth, Iain R. Macpherson, Elena Rainero & Jim C. Norman
https://www.nature.com/articles/s41467-017-02101-2

SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation
Xin Yang, Zhe Wang, Xin Li, Boya Liu, Minghui Liu, Lu Liu, Shuaiyi Chen, Mengmeng Ren, Yankun Wang, Miao Yu, Bo Wang, Junhua Zou, Wei-Guo Zhu, Yuxin Yin, Wei Gu and Jianyuan Luo
http://cancerres.aacrjournals.org/content/78/2/372

Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations
Xia-Di He, Wei Gong, Jia-Nong Zhang, Ji Nie, Cui-Fang Yao, Fu-Shen Guo, Yan Lin, Xiao-Hui Wu, Feng Li, Jie Li, Wei-Cheng Sun, En-Duo Wang, Yan-Peng An, Hui-Ru Tang, Guo-Quan Yan, Peng-Yuan Yang, Yun Wei, Yun-Zi Mao, Peng-Cheng Lin, Jian-Yuan Zhao, Yanhui Xu, Wei Xu, Shi-Min Zhao
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30629-0

Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism
Qingqiu Huang, Clint Stalnecker, Chengliang Zhang, Lee A. McDermott, Prema Iyer, Jason O’Neill, Shawn Reimer, Richard A. Cerione and William P. Katt
http://www.jbc.org/content/early/2018/01/09/jbc.M117.810101.abstract

The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5)
Yann Cormerais, Pierre André Massard, Milica Vucetic, Sandy Giuliano, Eric Tambutté, Jerome Durivault, Valérie Vial, Hitoshi Endou, Michael F. Wempe, Scott K. Parks and Jacques Pouyssegur
http://www.jbc.org/content/early/2018/01/11/jbc.RA117.001342.abstract

Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5
Amanda J Scopelliti, Josep Font, Robert J Vandenberg, Olga Boudker & Renae M Ryan
https://www.nature.com/articles/s41467-017-02444-w

————————–
Glucose, lactate
—————————

Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin
Dannielle DeWaal, Veronique Nogueira, Alexander R. Terry, Krushna C. Patra, Sang-Min Jeon, Grace Guzman, Jennifer Au, Christopher P. Long, Maciek R. Antoniewicz & Nissim Hay
https://www.nature.com/articles/s41467-017-02733-4

Nuclear factor E2-related factor-2 has a differential impact on MCT1 and MCT4 lactate carrier expression in colonic epithelial cells: a condition favoring metabolic symbiosis between colorectal cancer and stromal cells
K Diehl, L-A Dinges, O Helm, N Ammar, D Plundrich, A Arlt, C Röcken, S Sebens & H Schäfer
https://www.nature.com/articles/onc2017299

Coordinated Regulation of Intracellular pH by Two Glucose Sensing Pathways in Yeast
Daniel G. Isom, Stephani C. Page, Leonard B. Collins, Nicholas J. Kapolka, Geoffrey J. Taghon and Henrik G. Dohlman
http://www.jbc.org/content/early/2017/12/28/jbc.RA117.000422.abstract

GLUCOSE TRANSPORTER-1 AS AN INDEPENDENT PROGNOSTIC MARKER FOR CANCER: A META-ANALYSIS
Zheng-Xiao Zhao, Lin-Wei Lu, Jian Qiu, Qiu-Ping Li, Fei Xu, Bao-Jun Liu, Jing-Cheng Dong,  and  Wei-Yi Gong
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=18964&path%5B%5D=60791

———————————————
NAD, NADP, nucleotides
———————————————

Conversion of PRPS Hexamer to Monomer by AMPK-Mediated Phosphorylation Inhibits Nucleotide Synthesis in Response to Energy Stress
Xu Qian, Xinjian Li, Lin Tan, Jong-Ho Lee, Yan Xia, Qingsong Cai, Yanhua Zheng, Hongxia Wang, Philip L. Lorenzi and Zhimin Lu
http://cancerdiscovery.aacrjournals.org/content/8/1/94

Extraction and Quantitation of Nicotinamide Adenine Dinucleotide Redox Cofactors
Wenyun Lu, Lin Wang, Li Chen, Sheng Hui, and Joshua D. Rabinowitz
http://online.liebertpub.com/doi/10.1089/ars.2017.7014

Consumption of NADPH for 2-HG Synthesis Increases Pentose Phosphate Pathway Flux and Sensitizes Cells to Oxidative Stress
Susan J. Gelman, Fuad Naser, Nathaniel G. Mahieu, Lisa D. McKenzie, Gavin P. Dunn, Milan G. Chheda, Gary J. Patti
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31874-0

Purine nucleotide metabolism regulates expression of the human immune ligand MICA.
Michael T McCarthy, Gerald Moncayo, Thomas K Hiron, Niels A Jakobsen, Alessandro Valli, Tomoyoshi Soga, Julie Adam and Christopher A O’Callaghan
http://www.jbc.org/content/early/2018/01/03/jbc.M117.809459.abstract

————–
Lipids
————–

LOW-DOSE STATIN TREATMENT INCREASES PROSTATE CANCER AGGRESSIVENESS
Alfredo Caro-Maldonado, Laura Camacho, Amaia Zabala-Letona, Verónica Torrano, Sonia Fernández-Ruiz, Kepa Zamacola-Bascaran, Leire Arreal, Lorea Valcárcel-Jiménez, Natalia Martín-Martín, Juana M. Flores, Ana R. Cortazar, Patricia Zúñiga-García, Amaia Arruabarrena-Aristorena, Fabienne Guillaumond, Diana Cabrera, Juan M. Falcón-Perez, Ana M. Aransay, Antonio Gomez-Muñoz, Mireia Olivan, Juan Morote,  and  Arkaitz Carracedo
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=22217&path%5B%5D=70335

JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance
Tianyi Wang, Johannes Francois Fahrmann, Heehyoung Lee, Yi-Jia Li, Satyendra C. Tripathi, Chanyu Yue, Chunyan Zhang, Veronica Lifshitz, Jieun Song, Yuan Yuan, George Somlo, Rahul Jandial, David Ann, Samir Hanash, Richard Jove, Hua Yu
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30669-1

Lipid Homeostasis Is Maintained by Dual Targeting of the Mitochondrial PE Biosynthesis Enzyme to the ER
Jonathan R. Friedman, Muthukumar Kannan, Alexandre Toulmay, Calvin H. Jan, Jonathan S. Weissman, William A. Prinz, Jodi Nunnari
http://www.cell.com/developmental-cell/fulltext/S1534-5807(17)30984-X

————————
Hypoxia, HIF
————————

Inhibition of intracellular lipolysis promotes human cancer cell adaptation to hypoxia
Xiaodong Zhang, Alicia M Saarinen, Taro Hitosugi, Zhenghe Wang, Liguo Wang, Thai H Ho, Jun Liu
https://elifesciences.org/articles/31132

Hypoxia-induced upregulation of BMX kinase mediates therapeutic resistance in acute myeloid leukemia
Jolieke G. van Oosterwijk, Daelynn R. Buelow, Christina D. Drenberg, Aksana Vasilyeva, Lie Li, Lei Shi, Yong-Dong Wang, David Finkelstein, Sheila A. Shurtleff, Laura J. Janke, Stanley Pounds, Jeffrey E. Rubnitz, Hiroto Inaba, Navjotsingh Pabla, and Sharyn D. Baker
https://www.jci.org/articles/view/91893

VBP1 represses cancer metastasis by enhancing HIF-1α degradation induced by pVHL
Ji Ae Kim, Da Kyung Choi, Jung Sun Min, Inho Kang, Jin Chul Kim, Semi Kim and Jeong Keun Ahn
http://onlinelibrary.wiley.com/doi/10.1111/febs.14322/abstract

HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice
Claire-Sophie Devignes, Yetki Aslan, Audrey Brenot, Audrey Devillers, Koen Schepers, Stéphanie Fabre, Jonathan Chou, Amy-Jo Casbon, Zena Werb, and Sylvain Provot
http://www.pnas.org/content/115/5/E992?etoc=

HIF-1α promotes autophagic proteolysis of Dicer and enhances tumor metastasis
Hui-Huang Lai, Jie-Ning Li, Ming-Yang Wang, Hsin-Yi Huang, Carlo M. Croce, Hui-Lung Sun, Yu-Jhen Lyu, Jui-Wen Kang, Ching-Feng Chiu, Mien-Chie Hung, Hiroshi I. Suzuki, and Pai-Sheng Chen
https://www.jci.org/articles/view/89212

———————–
Starvation
———————–

Ca2+-dependent demethylation of phosphatase PP2Ac promotes glucose deprivation-induced cell death independently of inhibiting glycolysis
Ha Yin Lee , Yoko Itahana, Stefan Schuechner, Masahiro Fukuda, H. Shawn Je, Egon Ogris, David M. Virshup, Koji Itahana
http://stke.sciencemag.org/content/11/512/eaam7893

Nuclear Receptor Nur77 Facilitates Melanoma Cell Survival under Metabolic Stress by Protecting Fatty Acid Oxidation
Xiao-xue Li, Zhi-jing Wang, Yu Zheng, Yun-feng Guan, Peng-bo Yang, Xiang Chen, Cong Peng, Jian-ping He, Yuan-li Ai, Sheng-fu Wu, Kun-Yi Chien, Qiao Wu, Hang-zi Chen
http://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30001-7

TM9SF4 is a novel factor promoting autophagic flux under amino acid starvation
Lei Sun, Zhaoyue Meng, Yifei Zhu, Jun Lu, Zhichao Li et al.
https://www.nature.com/articles/cdd2017166

Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy
Heeseon An & J. Wade Harper
http://www.nature.com/articles/s41556-017-0007-x

Lipid droplet biogenesis is spatially coordinated at ER–vacuole contacts under nutritional stress
Hanaa Hariri, Sean Rogers, Rupali Ugrankar, Yang Lydia Liu, J Ryan Feathers and W Mike Henne
http://EMBOr.embopress.org/content/19/1/57?etoc

Glucose deprivation induces primary cilium formation through mTORC1 inactivation
Kengo Takahashi, Tomoaki Nagai, Shuhei Chiba, Keiko Nakayama and Kensak Mizuno
http://jcs.biologists.org/content/131/1/jcs213181?etoc

Role of JMJD2B in colon cancer cell survival under glucose-deprived conditions and the underlying mechanisms
L-N Fu, Y-Q Wang, J Tan, J Xu, Q-Y Gao, Y-X Chen& J-Y Fang
https://www.nature.com/articles/onc2017345

Dynamin inhibitors block activation of mTORC1 by amino acids independently of dynamin
Avinash Persaud, Yann Cormerais, Jacques Pouyssegur and Daniela Rotin
http://jcs.biologists.org/content/131/1/jcs211755?etoc

Puromycin labeling does not allow protein synthesis to be measured in energy-starved cells
Ran Marciano, Gabriel Leprivier & Barak Rotblat
https://www.nature.com/articles/s41419-017-0056-x

p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells
Amy Tarangelo, Leslie Magtanong, Kathryn T. Bieging-Rolett, Yang Li, Jiangbin Ye, Laura D. Attardi, Scott J. Dixon
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31914-9

———————-
Mitochondria
———————-

A metabolic function of FGFR3-TACC3 gene fusions in cancer
Véronique Frattini, Stefano M. Pagnotta, Tala, Jerry J. Fan, Marco V. Russo, Sang Bae Lee, Luciano Garofano, Jing Zhang, Peiguo Shi, Genevieve Lewis, Heloise Sanson, Vanessa Frederick, Angelica M. Castano, Luigi Cerulo, Delphine C. M. Rolland, Raghvendra Mall, Karima Mokhtari, Kojo S. J. Elenitoba-Johnson, Marc Sanson, Xi Huang, Michele Ceccarelli, Anna Lasorella & Antonio Iavarone
https://www.nature.com/articles/nature25171

Mitochondria are physiologically maintained at close to 50 °C
Dominique Chrétien, Paule Bénit, Hyung-Ho Ha, Susanne Keipert, Riyad El-Khoury, Young-Tae Chang, Martin Jastroch, Howard T. Jacobs, Pierre Rustin, Malgorzata Rak
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2003992

Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance
Allyson L. Anding, Chunxin Wang, Tsun-Kai Chang, Danielle A. Sliter, Christine M. Powers, Kay Hofmann, Richard J. Youle, Eric H. Baehrecke
http://www.cell.com/current-biology/fulltext/S0960-9822(17)31589-0

Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression
Silvia Márquez-Jurado, Juan Díaz-Colunga, Ricardo Pires das Neves, Antonio Martinez-Lorente, Fernando Almazán, Raúl Guantes & Francisco J. Iborra
https://www.nature.com/articles/s41467-017-02787-4

—————————-
mTOR / AMPK
—————————-

mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis
Marta Brandt, Tatiana P. Grazioso, Mohamad-Ali Fawal, Krishna S. Tummala, Raul Torres-Ruiz, Sandra Rodriguez-Perales, Cristian Perna, Nabil Djouder
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30674-5

Ragulator and GATOR1 complexes promote fission yeast growth by attenuating TOR complex 1 through Rag GTPases
Kim Hou Chia, Tomoyuki Fukuda, Fajar Sofyantoro, Takato Matsuda, Takamitsu Amai, Kazuhiro Shiozaki
https://elifesciences.org/articles/30880

The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer
Lingtao Jin, Jaemoo Chun, Chaoyun Pan, Avi Kumar, Guojing Zhang, Youna Ha, Dan Li, Gina N. Alesi, Yibin Kang, Lu Zhou, Wen-Mei Yu, Kelly R. Magliocca, Fadlo R. Khuri, Cheng-Kui Qu, Christian Metallo, Taofeek K. Owonikoko, Sumin Kang
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30884-5

————
IDH
————

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling
Rui Su, Lei Dong, Chenying Li, Sigrid Nachtergaele, Mark Wunderlich, Ying Qing, Xiaolan Deng, Yungui Wang, Xiaocheng Weng, Chao Hu, Mengxia Yu, Jennifer Skibbe, Qing Dai, Dongling Zou, Tong Wu, Kangkang Yu, Hengyou Weng, Huilin Huang, Kyle Ferchen, Xi Qin, Bin Zhang, Jun Qi, Atsuo T. Sasaki, David R. Plas, James E. Bradner, Minjie Wei, Guido Marcucci, Xi Jiang, James C. Mulloy, Jie Jin, Chuan He, Jianjun Chen
http://www.cell.com/cell/fulltext/S0092-8674(17)31382-X

Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities
Matthew S. Waitkus, Christopher J. Pirozzi, Casey J. Moure, Bill H. Diplas, Landon J. Hansen, Austin B. Carpenter, Rui Yang, Zhaohui Wang, Brian O. Ingram, Edward D. Karoly, Robert P. Mohney, Ivan Spasojevic, Roger E. McLendon, Henry S. Friedman, Yiping He, Darell D. Bigner and Hai Yan
http://cancerres.aacrjournals.org/content/78/1/36

—————————–
Miscellaneous
—————————–

A Landscape of Metabolic Variation across Tumor Types
Ed Reznik, Augustin Luna, Bulent Arman Aksoy, Eric Minwei Liu, Konnor La, Irina Ostrovnaya, Chad J. Creighton, A. Ari Hakimi, Chris Sander
http://www.cell.com/pb-assets/journals/research/cell-systems/CELS394.pdf

Fenofibrate prevents skeletal muscle loss in mice with lung cancer
Marcus D. Goncalves, Seo-Kyoung Hwang, Chantal Pauli, Charles J. Murphy, Zhe Cheng, Benjamin D. Hopkins, David Wu, Ryan M. Loughran, Brooke M. Emerling, Guoan Zhang, Douglas T. Fearon and Lewis C. Cantley
http://www.pnas.org/content/115/4/E743?etoc=

METABOLOMIC ALTERATIONS IN INVASIVE DUCTAL CARCINOMA OF BREAST: A COMPREHENSIVE METABOLOMIC STUDY USING TISSUE AND SERUM SAMPLES
Tushar H. More, Sourav RoyChoudhury, Joel Christie, Khushman Taunk, Anupama Mane, Manas K. Santra, Koel Chaudhury,  and  Srikanth Rapole
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=23626&path%5B%5D=74389

———————
Reviews
———————

AMPK: guardian of metabolism and mitochondrial homeostasis
Sebastien Herzig & Reuben J. Shaw
https://www.nature.com/articles/nrm.2017.95?lang=en

Regulation of redox balance in cancer and T cells
Hyewon Kong and Navdeep S. Chandel
http://www.jbc.org/content/early/2018/01/03/jbc.TM117.000257.abstract

Metabolic rewiring in mutant Kras lung cancer
Emma M. Kerr and Carla P. Martins
http://onlinelibrary.wiley.com/doi/10.1111/febs.14125/full

Metabolism and Transcription in Cancer: Merging Two Classic Tales
Natalia Martín-Martín, Arkaitz Carracedo and Verónica Torrano
https://www.frontiersin.org/articles/10.3389/fcell.2017.00119/full

Targeting the Warburg effect for Cancer Treatment: Ketogenic Diets for Management of Glioma.
Poff A, Kourtnik A, Egan KM, Sahebjum S, D’Agostino D, Kumar NB
http://www.sciencedirect.com/science/article/pii/S1044579X17301244

Cell-Autonomous Metabolic Reprogramming in Hypoxia
Luana Schito, Sergio Rey
http://www.cell.com/trends/cell-biology/fulltext/S0962-8924(17)30197-6

The HIF and other quandaries in VHL disease
D Tarade and M Ohh
https://www.nature.com/articles/onc2017338

Lactate metabolism: historical context, prior misinterpretations, and current understanding
Brian S. Ferguson, Matthew J. Rogatzki, Matthew L. Goodwin, Daniel A. Kane, Zachary Rightmire, L. Bruce Gladden
https://link.springer.com/article/10.1007/s00421-017-3795-6

Metabolic Plasiticy in Cancers—Distinct Role of Glycolytic Enzymes GPI, LDHs or Membrane Transporters MCTs
Masa Zdralevic, Ibtissam Marchiq, Monique Meyenberg Cunha de Padua, Scott Parks, and Jacques Pouysségur
https://www.frontiersin.org/articles/10.3389/fonc.2017.00313/full

Mechanisms of redox metabolism and cancer cell survival during extracellular matrix detachment
Mark A Hawk and Zachary T Schafer
http://www.jbc.org/content/early/2018/01/16/jbc.TM117.000260.abstract

The redox requirements of proliferating mammalian cells
Aaron M Hosios and Matthew G Vander Heiden
http://www.jbc.org/content/early/2018/01/16/jbc.TM117.000239.abstract

The hypoxic tumour microenvironment
Varvara Petrova, Margherita Annicchiarico-Petruzzelli, Gerry Melino & Ivano Amelio
https://www.nature.com/articles/s41389-017-0011-9

Lipid-mediated signals that regulate mitochondrial biology
Jason R Nielson and Jared P Rutter
http://www.jbc.org/content/early/2018/01/18/jbc.R117.001655.abstract

Spermidine in health and disease
Frank Madeo, Tobias Eisenberg, Federico Pietrocola, Guido Kroemer
http://science.sciencemag.org/content/359/6374/eaan2788


Special Issue in Seminars in Cancer Biology
Mitochondria in Cancer
https://www.sciencedirect.com/science/journal/1044579X
Editorial by Keshav K Singh, Josephine S. Modica-Napolitano: http://www.sciencedirect.com/science/article/pii/S1044579X17302614

Research Topic in  Front. Endocrinol
Metabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions
https://www.frontiersin.org/research-topics/4124/metabolic-adaptation-to-cell-growth-and-proliferation-in-normal-and-pathological-conditions
Editorial:  Albert Giralt and Lluis Fajas
https://www.frontiersin.org/articles/10.3389/fendo.2017.00362/full

——————————
Comments, other
——————————

Glutamate Dehydrogenase to the Rescue
Jonathan L. Coloff
http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30967-X

Fountain of youth of pancreatic cancer cells: the extracellular matrix
Victoire Gouirand & Sophie Vasseur
https://www.nature.com/articles/s41420-017-0004-7

Journal Club: Mitochondria: back to the future
Navdeep S. Chandel
https://www.nature.com/articles/nrm.2017.133

Profile of David M. Sabatini
Jennifer Viegas
http://www.pnas.org/content/115/3/438

Mutant IDH1R132H Induces Transcriptional and Epigenomic Reprogramming
http://cancerdiscovery.aacrjournals.org/content/8/1/10.2

R-2HG Targets FTO to Increase m6A Levels and Suppress Tumor Growth
http://cancerdiscovery.aacrjournals.org/content/8/2/137.2

SRPK2 Acts Downstream of MTORC1 to Promote De Novo Lipogenesis
http://cancerdiscovery.aacrjournals.org/content/8/1/OF18

mTORC2-Driven Lipid Synthesis Promotes Liver Tumorigenesis
http://cancerdiscovery.aacrjournals.org/content/8/2/OF9

FGFR3–TACC3 Activates Mitochondrial Respiration via PIN4 Phosphorylation
http://cancerdiscovery.aacrjournals.org/content/8/2/139.1

Glutaminolysis Drives Lung Cancer Metastasis via the PLAG1–GDH1 Axis
http://cancerdiscovery.aacrjournals.org/content/8/2/OF11

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