MetaboList – February 2018

 
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Amino acids / nucleotides
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Asparagine bioavailability governs metastasis in a model of breast cancer
Simon R. V. Knott, Elvin Wagenblast, Showkhin Khan, Sun Y. Kim, Mar Soto, Michel Wagner, Marc-Olivier Turgeon, Lisa Fish, Nicolas Erard, Annika L. Gable, Ashley R. Maceli, Steffen Dickopf, Evangelia K. Papachristou, Clive S. D’Santos, Lisa A. Carey, John E. Wilkinson, J. Chuck Harrell, Charles M. Perou, Hani Goodarzi, George Poulogiannis & Gregory J. Hannon
 
Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models
Michael L Schulte, Allie Fu, Ping Zhao, Jun Li, Ling Geng, Shannon T Smith, Jumpei Kondo, Robert J Coffey, Marc O Johnson, Jeffrey C Rathmell, Joe T Sharick, Melissa C Skala, Jarrod A Smith, Jordan Berlin, M Kay Washington, Michael L Nickels & H Charles Manning
 
Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs
Denise R. Minton, Minwoo Nam, Daniel J. McLaughlin, Jong Shin, Erol C. Bayraktar, Samantha W. Alvarez, Vladislav O. Sviderskiy, Thales Papagiannakopoulos, David M. Sabatini, Kıvanç Birsoy, Richard Possemato
 
Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner
Yun-Qian Wang, Hao-Lian Wang, Jie Xu, Juan Tan, Lin-Na Fu, Ji-Lin Wang, Tian-Hui Zou, Dan-Feng Sun, Qin-Yan Gao, Ying-Xuan Chen & Jing-Yuan Fang
 
Mitochondrial glutamine metabolism via GOT2 supports pancreatic cancer growth through senescence inhibition
Seungyeon Yang, Sunsook Hwang, Minjoong Kim, Sung Bin Seo, Jeong-Hwa Lee & Seung Min Jeong
 
Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3
Karina N. Gonzalez Herrera, Elma Zaganjor, Yoshinori Ishikawa, Jessica B. Spinelli, Haejin Yoon, Jia-Ren Lin, F. Kyle Satterstrom, Alison Ringel, Stacy Mulei, Amanda Souza, Joshua M. Gorham, Craig C. Benson, Jonathan G. Seidman, Peter K. Sorger, Clary B. Clish, Marcia C. Haigis
 
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Glycolysis and PPP
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Combinatorial CRISPR-Cas9 Metabolic Screens Reveal Critical Redox Control Points Dependent on the KEAP1-NRF2 Regulatory Axis
Dongxin Zhao, Mehmet G. Badur, Jens Luebeck, Jose H. Magaña, Amanda Birmingham, Roman Sasik, Christopher S. Ahn, Trey Ideker, Christian M. Metallo, Prashant Mali
 
Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway
Xiaoyu Ma, Xiaoyu Ma, Lin Wang, Lin Wang, De Huang, De Huang, Yunyan Li, Yunyan Li, Dongdong Yang, Dongdong Yang, Tingting Li, Tingting Li, Fudong Li, Fudong Li, Linchong Sun, Linchong Sun, Haoran Wei, Haoran Wei, Kun He, Kun He, Fazhi Yu, Fazhi Yu, Debiao Zhao, Debiao Zhao, Lan Hu, Lan Hu, Songge Xing, Songge Xing, Zhaoji Liu, Zhaoji Liu, Kui Li, Kui Li, Jing Guo, Jing Guo, Zhenye Yang, Zhenye Yang, Xin Pan, Xin Pan, Ailing Li, Ailing Li, Yunyu Shi, Yunyu Shi, Junfeng Wang, Junfeng Wang, Ping Gao, Ping Gao, Huafeng Zhang
 
A Mathematical Model for Enzyme Clustering in Glucose Metabolism
Miji Jeon, Hye-Won Kang & Songon An
 
Hexokinase 2 and nuclear factor erythroid 2-related factor 2 transcriptionally coactivate xanthine oxidoreductase expression in stressed glioma cells
Touseef Sheikh, Piyushi Gupta, Pruthvi Gowda, Shruti Patrick and Ellora Sen
 
Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis
Fu-Long Li, Jin-Ping Liu, Ruo-Xuan Bao, GuoQuan Yan, Xu Feng, Yan-Ping Xu, Yi-Ping Sun, Weili Yan, Zhi-Qiang Ling, Yue Xiong, Kun-Liang Guan & Hai-Xin Yuan
 
The responsively decreased PKM2 facilitates the survival of pancreatic cancer cells in hypoglucose
Xiang Li, Shichang Deng, Mingliang Liu, Yan Jin, Shuai Zhu, Shijiang Deng, Jingyuan Chen, Chi He, Qi Qin, Chunyou Wang & Gang Zhao
 
SLC2A5 promotes lung adenocarcinoma cell growth and metastasis by enhancing fructose utilization
Yuanyuan Weng, Xueyu Fan, Yongfeng Bai, Siwei Wang, Hui Huang, Huimin Yang, Jin Zhu & Feng Zhang
 
 
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Lipids
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IRE1α RNase-dependent lipid homeostasis promotes survival in Myc-transformed cancers
Hong Xie, Chih-Hang Anthony Tang, Jun H. Song, Anthony Mancuso, Juan R. Del Valle, Jin Cao, Yan Xiang,Chi V. Dang, Roy Lan, Danielle J. Sanchez, Brian Keith, Chih-Chi Andrew Hu, and M. Celeste Simon
 
An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer
Ming Chen, Jiangwen Zhang, Katia Sampieri, John G. Clohessy, Lourdes Mendez, Enrique Gonzalez-Billalabeitia, Xue-Song Liu, Yu-Ru Lee, Jacqueline Fung, Jesse M. Katon, Archita Venugopal Menon, Kaitlyn A. Webster, Christopher Ng, Maria Dilia Palumbieri, Moussa S. Diolombi, Susanne B. Breitkopf, Julie Teruya-Feldstein, Sabina Signoretti, Roderick T. Bronson, John M. Asara, Mireia Castillo-Martin, Carlos Cordon-Cardo & Pier Paolo Pandolfi
 
Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer
Jingjing Chen, Ilaria Guccini, Diletta Di Mitri, Daniela Brina, Ajinkya Revandkar, Manuela Sarti, Emiliano Pasquini, Abdullah Alajati, Sandra Pinton, Marco Losa, Gianluca Civenni, Carlo V. Catapano, Jacopo Sgrignani, Andrea Cavalli, Rocco D’Antuono, John M. Asara, Andrea Morandi, Paola Chiarugi, Sara Crotti, Marco Agostini, Monica Montopoli, Ionica Masgras, Andrea Rasola, Ramon Garcia-Escudero, Nicolas Delaleu, Andrea Rinaldi, Francesco Bertoni, Johann de Bono, Arkaitz Carracedo & Andrea Alimonti
 
Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD
Silvia Escudero, Elma Zaganjor, Susan Lee, Christopher P. Mill, Ann M. Morgan, Emily B. Crawford, Jiahao Chen, Thomas E. Wales, Rida Mourtada, James Luccarelli, Gregory H. Bird, Ulrich Steidl, John R. Engen, Marcia C. Haigis, Joseph T. Opferman, Loren D. Walensky
 
Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL
Bandish Kapadia, Nahid M. Nanaji, Kavita Bhalla, Binny Bhandary, Rena Lapidus, Afshin Beheshti, Andrew M. Evens & Ronald B. Gartenhaus
 
Reactivation of androgen receptor-regulated lipid biosynthesis drives the progression of castration-resistant prostate cancer
W Han, S Gao, D Barrett, M Ahmed, D Han, J A Macoska, H H He and C Cai
 
Nutrient sensor O-GlcNAc transferase controls cancer lipid metabolism via SREBP-1 regulation
V L Sodi, Z A Bacigalupa, C M Ferrer, J V Lee, W A Gocal, D Mukhopadhyay, K E Wellen, M Ivan & M J Reginato
 
LNMICC Promotes Nodal Metastasis of Cervical Cancer by Reprogramming Fatty Acid Metabolism
Chunliang Shang, Wei Wang, Yuandong Liao, Yili Chen, Tianyu Liu, Qiqiao Du, Jiaming Huang, Yanchun Liang, Junxiu Liu, Yunhe Zhao, Luyan Guo, Zheng Hu and Shuzhong Yao
 
A Metabolic Basis for Endothelial-to-Mesenchymal Transition
Jianhua Xiong, Hiroyuki Kawagishi, Ye Yan, Jie Liu, Quinn S. Wells, Lia R. Edmunds, Maria M. Fergusson, Zu-Xi Yu, Ilsa I. Rovira, Evan L. Brittain, Michael J. Wolfgang, Michael J. Jurczak, Joshua P. Fessel, Toren Finkel
 
Metabolic Profile of Oral Squamous Carcinoma Cell Lines Relies on a Higher Demand of Lipid Metabolism in Metastatic Cells
Ana Carolina Sant´Anna-Silva, Gilson Costa dos Santos Junior, Samir Campos, Andre Gomes, Juan Pérez-Valencia, and Franklin Rumjanek
 
Carnitine Palmitoyltransferase 1A Has a Lysine Succinyltransferase Activity
Kiran Kurmi, Sadae Hitosugi, Elizabeth K. Wiese, Felix Boakye-Agyeman, Wilson I. Gonsalves, Zhenkun Lou, Larry M. Karnitz, Matthew P. Goetz, Taro Hitosugi
 
 
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Mitochondria
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NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction
Edoardo Gaude, Christina Schmidt, Payam A. Gammage, Aurelien Dugourd, Thomas Blacker, Sew Peak Chew, Julio Saez-Rodriguez, John S. O’Neill, Gyorgy Szabadkai, Michal Minczuk, Christian Frezza
 
Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53
Giuseppe Arena, Madi Yann Cissé, Samuel Pyrdziak, Laurent Chatre, Romain Riscal, Maryse Fuentes, Jamie Jon Arnold, Markus Kastner, Laurie Gayte, Christelle Bertrand-Gaday, Kevin Nay, Claire Angebault-Prouteau, Kerren Murray, Beatrice Chabi, Christelle Koechlin-Ramonatxo, Béatrice Orsetti, Charles Vincent, François Casas, Jean-Christophe Marine, Sandrine Etienne-Manneville, Florence Bernex, Anne Lombès, Craig Eugene Cameron, Hervé Dubouchaud, Miria Ricchetti, Laetitia Karine Linares, Laurent Le Cam
 
Metabolomics and transcriptomics profiles reveal the dysregulation of the tricarboxylic acid cycle and related mechanisms in prostate cancer
Yaping Shao, Guozhu Ye, Shancheng Ren, Hai-long Piao, Xinjie Zhao, Xin Lu, Fubo Wang, Wang Ma, Jia Li, Peiyuan Yin, Tian Xia, Chuanliang Xu, Jane J. Yu, Yinghao Sun, Guowang Xu
 
Mutant p53 controls tumor metabolism and metastasis by regulating PGC-1α
Subhasree Basu, Keerthana Gnanapradeepan, Thibaut Barnoud, Che-Pei Kung, Michele Tavecchio, Jeremy Scott, Andrea Watters, Qing Chen, Andrew V. Kossenkov and Maureen E. Murphy
 
 
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Hypoxia and HIFs
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Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer
Felipe Paredes, Kely Sheldon, Bernard Lassègue, Holly C. Williams, Elizabeth A. Faidley, Gloria A. Benavides, Gloria Torres, Fernanda Sanhueza-Olivares, Samantha M. Yeligar, Kathy K. Griendling, Victor Darley-Usmar, and Alejandra San Martin
 
Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia
F Peng, J-H Wang, W-J Fan, Y-T Meng, M-M Li, T-T Li, B Cui, H-F Wang, Y Zhao, F An, T Guo, X-F Liu, L Zhang, L Lv, D-K Lv, L-Z Xu, J-J Xie, W-X Lin, E W-F Lam, J Xu & Q Liu
 
Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α
Qirui Wang, Zhenqiang He, Menggui Huang, Tianrun Liu, Yanling Wang, Haineng Xu, Hao Duan, Peihong Ma, Lin Zhang, Scott S. Zamvil, Juan Hidalgo, Zhenfeng Zhang, Donald M. O’Rourke, Nadia Dahmane, Steven Brem, Yonggao Mou, Yanqing Gong & Yi Fan
 
Secretion-mediated STAT3 activation promotes self-renewal of glioma stem-like cells during hypoxia
D A Almiron Bonnin, M C Havrda, M C Lee, H Liu, Z Zhang, L N Nguyen, L X Harrington, S Hassanpour, C Cheng & M A Israel
 
The ST6Gal-I sialyltransferase protects tumor cells against hypoxia by enhancing HIF-1α signaling
Robert B. Jones, Kaitlyn A. Dorsett, Anita B Hjelmeland and Susan L. Bellis
 
FIH Is an Oxygen Sensor in Ovarian Cancer for G9a/GLP-Driven Epigenetic Regulation of Metastasis-Related Genes
Jengmin Kang, Seung-Hyun Shin, Haejin Yoon, June Huh, Hyun-Woo Shin, Yang-Sook Chun and Jong-Wan Park
 
LncRNA IDH1-AS1 links the functions of c-Myc and HIF1α via IDH1 to regulate the Warburg effect
Shaoxun Xiang, Hao Gu, Lei Jin, Rick F. Thorne, Xu Dong Zhang, and Mian Wu
 
 
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mTOR
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Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver
Inna A. Nikonorova, Emily T. Mirek, Christina C. Signore, Michael P. Goudie, Ronald C. Wek and Tracy G. Anthony
 
A small molecule inhibitor of Rheb selectively targets mTORC1 signaling
Sarah J. Mahoney, Sridhar Narayan, Lisa Molz, Lauren A. Berstler, Seong A. Kang, George P. Vlasuk & Eddine Saiah
 
The mTOR–S6K pathway links growth signalling to DNA damage response by targeting RNF168
Xiaoduo Xie, Hongli Hu, […] Daming Gao
 
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AMPK family
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Phosphorylation of Cdc25C by AMP-activated protein kinase mediates a metabolic checkpoint during cell cycle G2/M phase transition
Yuqing Shen, John William Sherman, Xuyong Chen and Ruoning Wang
 
Calcium signalling links MYC to NUAK1
T Monteverde, J Tait-Mulder, A Hedley, J R Knight, O J Sansom & D J Murphy
 
AMPK promotes survival of c‐Myc‐positive melanoma cells by suppressing oxidative stress
Alain Kfoury, Marzia Armaro, Caterina Collodet, Jessica Sordet‐Dessimoz, Maria Pilar Giner, Stefan Christen, Sofia Moco, Marion Leleu, Laurence de Leval, Ute Koch, Andreas Trumpp, Kei Sakamoto, Friedrich Beermann and Freddy Radtke
 
Phosphorylation of ULK1 by AMPK is essential for mouse embryonic stem cell self-renewal and pluripotency
Jiaqi Gong, Haifeng Gu, Lin Zhao, Liang Wang, Pinglei Liu, Fuping Wang, Haoyu Xu & Tongbiao Zhao
 
Kinase Activity Determination of Specific AMPK Complexes/Heterotrimers in the Skeletal Muscle
Jesper B. Birk, Jørgen F. P. Wojtaszewski
 
 
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Starvation, drugs
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N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response
[amino acid deprivation]
Jun Zhou, Ji Wan, Xin Erica Shu, Yuanhui Mao, Xiao-Min Liu, Xin Yuan, Xingqian Zhang, Martin E. Hess, Jens C. Brüning, Shu-Bing Qian
 
Metformin regulates global DNA methylation via mitochondrial one-carbon metabolism
E Cuyàs, S Fernández-Arroyo, S Verdura, R Á-F García, J Stursa, L Werner, E Blanco-González, M Montes-Bayón, J Joven, B Viollet, J Neuzil & J A Menendez
 
Statin-Induced Cancer Cell Death Can Be Mechanistically Uncoupled from Prenylation of RAS Family Proteins
Rosemary Yu, Joseph Longo, Jenna E. van Leeuwen, Peter J. Mullen, Wail Ba-Alawi, Benjamin Haibe-Kains and Linda Z. Penn
 
 
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Miscellaneous
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Upregulation of the ALDOA/DNA-PK/p53 pathway by dietary restriction suppresses tumor growth
D Ma, X Chen, P-Y Zhang, H Zhang, L-J Wei, S Hu, J-Z Tang, M-T Zhou, C Xie, R Ou, Y Xu & K-F Tang
 
Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1α Transactivation in Steatohepatitis
Xinshou Ouyang, Sheng-Na Han, Ji-Yuan Zhang, Balazs Tamas Nemeth, Pal Pacher, Dechun Feng, Ramon Bataller, Joaquin Cabezas, Peter Stärkel, Joan Caballeria, Rebecca LePine Pongratz, Shi-Ying Cai, Bernd Schnabl, Rafaz Hoque, Yonglin Chen, Wei-hong Yang, Irma Garcia Martinez, Fu-Sheng Wang, Bin Gao, Natalie Julia Torok, Richard Glenn Kibbey, Wajahat Zafar Mehal
 
DIMETHYL FUMARATE IS HIGHLY CYTOTOXIC IN KRAS MUTATED CANCER CELLS BUT SPARES NON-TUMORIGENIC CELLS
Nathaniel Edward Bennett Saidu, Marie Bretagne, Audrey Lupo Mansuet, Pierre-Alexandre Just, Karen Leroy,Olivier Cerles, Sandrine Chouzenoux, Carole Nicco, Diane Damotte, Marco Alifano, Bruno Borghese, François Goldwasser, Frédéric Batteux,  and  Jérôme Alexandre
 
Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival
Marco Segatto, Raffaella Fittipaldi, Fabrizio Pin, Roberta Sartori, Kyung Dae Ko, Hossein Zare, Claudio Fenizia, Gianpietro Zanchettin, Elisa Sefora Pierobon, Shinji Hatakeyama, Cosimo Sperti, Stefano Merigliano, Marco Sandri, Panagis Filippakopoulos, Paola Costelli, Vittorio Sartorelli & Giuseppina Caretti
 
 
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Reviews
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Advances in Hypoxia-Inducible Factor Biology
Hani Choudhry, Adrian L. Harris
 
Exploiting Metabolic Vulnerabilities of Cancer with Precision and Accuracy
Adam J. Wolpaw, Chi V. Dang
 
From the unfolded protein response to metabolic diseases – lipids under the spotlight
Nurulain Ho, Chengchao Xu and Guillaume Thibault
 
Ketogenic diet in cancer therapy
Daniela D. Weber, Sepideh Aminazdeh-Gohari, Barbara Kofler
 
Endothelial Cell Metabolism in Health and Disease
Katerina Rohlenova, Koen Veys, Ines Miranda-Santos, Katrien De Bock, Peter Carmeliet
 
FOXO Family in regulating Cancer and Metabolism
Ma J1, Matkar S2, He X3, Hua X4.
 
B-Cell Metabolic Remodeling and Cancer
Davide G. Franchina, Melanie Grusdat, Dirk Brenner
 
Metabolism, Activity, and Targeting of D- and L-2-Hydroxyglutarates
Dan Ye, Kun-Liang Guan, Yue Xiong
 
Metabolism in pluripotency: Both driver and passenger?
Perrine Dahan, Vivian Lu, Robert M.T. Nguyen, Stephanie A.L. Kennedy and Michael A. Teitell
 
Aberrant lipid metabolism in cancer cells – the role of oncolipid‐activated signaling
Upasana Ray, Sib Sankar Roy
 
DNA Damage, Repair, and Cancer Metabolism
Marc-Olivier Turgeon, Nicholas J. S. Perry and George Poulogiannis
 
Defining the role of the tumor vasculature in antitumor immunity and immunotherapy
Marco B. Schaaf, Abhishek D. Garg & Patrizia Agostinis
 
Metabolism and TAM functions—it takes two to tango
Massimiliano Mazzone, Alessio Menga and Alessandra Castegna
 
Tumor-associated myeloid cells: new understandings on their metabolic regulation and their influence in cancer immunotherapy
Chiara Porta, Antonio Sica and Elena Riboldi
 
Posttranslational Modifications of Pyruvate Kinase M2: Tweaks that Benefit Cancer
Gopinath Prakasam, Mohammad Iqbal, Rameshwar Bamezai, and Sybille Mazurek
 
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Comments, other
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The Sympathetic Nervous System Drives Tumor Angiogenesis
Hubert Hondermarck, Phillip Jobling
 
m6A and eIF2α-ⓟ Team Up to Tackle ATF4 Translation during Stress
Emily Nicole Powers, Gloria Ann Brar
 
Genetics of lipid metabolism in prostate cancer
Ninu Poulose, Francesca Amoroso, Rebecca E. Steele, Reema Singh, Chee Wee Ong & Ian G. Mills
 
Glutamine metabolism, the Achilles heel for medulloblastoma tumor
Maria Victoria Niklison-Chirou
 
GCN2 controls the cellular checkpoint: potential target for regulating inflammation
Xiaojing Xia, Liancheng Lei, Wanhai Qin, Lei Wang, Gaiping Zhang & Jianhe Hu
 
The interplay between mutant p53 and the mevalonate pathway
Alejandro Parrales, Elizabeth Thoenen & Tomoo Iwakuma
 
 
Free Webinar: Oxygen Sensing in Cancer and Metabolism
Speakers: Celeste Simon, Cullen Taniguchi and Othon Iliopoulos.

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