MetaboList – March 2018

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Glycolysis and glycolytic enzymes
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PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth
Mami Morita, Taku Sato, Miyuki Nomura, Yoshimi Sakamoto, Yui Inoue, Ryota Tanaka, Shigemi Ito, Koreyuki Kurosawa, Kazunori Yamaguchi, Yuki Sugiura, Hiroshi Takizaki, Yoji Yamashita, Ryuichi Katakura, Ikuro Sato, Masaaki Kawai, Yoshinori Okada, Hitomi Watanabe, Gen Kondoh, Shoko Matsumoto, Ayako Kishimoto, Miki Obata, Masaki Matsumoto, Tatsuro Fukuhara, Hozumi Motohashi, Makoto Suematsu, Masaaki Komatsu, Keiichi I. Nakayama, Toshio Watanabe, Tomoyoshi Soga, Hiroshi Shima, Makoto Maemondo, Nobuhiro Tanuma
http://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30057-6

Radioresistant Cervical Cancers Are Sensitive to Inhibition of Glycolysis and Redox Metabolism
Ramachandran Rashmi, Xiaojing Huang, John M. Floberg, Adnan E. Elhammali, Michael L. McCormick, Gary J. Patti, Douglas R. Spitz and Julie K. Schwarz
http://cancerres.aacrjournals.org/content/78/6/1392

Cancer cell metabolic plasticity allows resistance to NAMPT inhibition but invariably induces dependence on LDHA
Natthakan Thongon, Chiara Zucal, Vito Giuseppe D’Agostino, Toma Tebaldi, Silvia Ravera, Federica Zamporlini, Francesco Piacente, Ruxanda Moschoi, Nadia Raffaelli, Alessandro Quattrone, Alessio Nencioni, Jean-Francois Peyron and Alessandro Provenzani
https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-018-0174-7

Non-canonical roles of PFKFB3 in regulation of cell cycle through binding to CDK4
Wenzhi Jia, Xiaoping Zhao, Li Zhao, Hui Yan, Jiajin Li, Hao Yang, Gang Huang & Jianjun Liu
https://www.nature.com/articles/s41388-017-0072-4

Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein
Tsu-Yao Cheng, Yi-Chieh Yang, Hsiu-Po Wang, Yu-Wen Tien, Chia-Tung ShunHsin-Yi Huang,Michael Hsiao & Kuo-Tai Hua
https://www.nature.com/articles/s41388-017-0086-y

Glucose metabolism and NRF2 coordinate the antioxidant response in melanoma resistant to MAPK inhibitors
Raeeka Khamari, Anne Trinh, Pierre Elliott Gabert, Paola Corazao-Rozas, Samuel Riveros-Cruz, Stephane Balayssac, Myriam Malet-Martino, Salim Dekiouk, Marie Joncquel Chevalier Curt, Patrice Maboudou, Guillaume Garçon, Laura Ravasi, Pierre Guerreschi, Laurent Mortier, Bruno Quesnel, Philippe Marchetti & Jerome Kluza
https://www.nature.com/articles/s41419-018-0340-4

Transcriptional Regulation of the Warburg Effect in Cancer by SIX1
Ling Li, Yingchun Liang, Lei Kang, Yang Liu, Shan Gao, Siyu Chen, Ying Li, Wenye You, Qian Dong, Tian Hong, Zhifeng Yan, Shuai Jin, Tao Wang, Wei Zhao, Haixing Mai, Jun Huang, Xiao Han, Quanbo Ji, Qi Song, Chao Yang, Shixin Zhao, Xiaojie Xu, Qinong Ye
http://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30010-2

GLYCOGEN DEBRANCHING ENZYME (AGL) IS A NOVEL REGULATOR OF NON-SMALL CELL LUNG CANCER GROWTH
Craig S. Richmond, Darby Oldenburg, Garrett Dancik, David R. Meier, Benjamin Weinhaus, Dan Theodorescu,  and  Sunny Guin
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=24676&path%5B%5D=77411

Molecular link between glucose and glutamine consumption in cancer cells mediated by CtBP and SIRT4
Li Wang, Jing-jing Li, Li-yu Guo, Peipei Li, Zhiqiang Zhao,  Haisheng Zhou & Li-jun Di
https://www.nature.com/articles/s41389-018-0036-8

Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells
Annemarie Schwab, Aarif Siddiqui, Maria Eleni Vazakidou, Francesca Napoli, Martin Böttcher, Bianca Menchicchi, Umar Raza, Özge Saatci, Angela M. Krebs, Fulvia Ferrazzi, Ida Rapa, Katja Dettmer-Wilde, Maximilian J. Waldner, Arif B. Ekici, Suhail Ahmed Kabeer Rasheed, Dimitrios Mougiakakos, Peter J. Oefner, Ozgur Sahin, Marco Volante, Florian R. Greten, Thomas Brabletz and Paolo Ceppi
http://cancerres.aacrjournals.org/content/78/7/1604

Downregulation of Membrane Trafficking Proteins and Lactate Conditioning Determine Loss of Dendritic Cell Function in Lung Cancer
Nicoletta Caronni, Francesca Simoncello, Francesca Stafetta, Corrado Guarnaccia, Juan Sebastian Ruiz-Moreno, Bastian Opitz, Thierry Galli, Veronique Proux-Gillardeaux and Federica Benvenuti
http://cancerres.aacrjournals.org/content/78/7/1685

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Amino acids
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Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism
Xia Gao, Katie Lee, Michael A. Reid, Sydney M. Sanderson, Chuping Qiu, Siqi Li, Juan Liu, Jason W. Locasale
http://www.cell.com/cell-reports/fulltext/S2211-1247(18)30346-2

A Novel l-Asparaginase with low l-Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic Leukemias In Vivo
Hien Anh Nguyen, Ying Su, Jenny Y. Zhang, Aleksandar Antanasijevic, Michael Caffrey, Amanda M. Schalk, Li Liu, Damiano Rondelli, Annie Oh, Dolores L. Mahmud, Maarten C. Bosland, Andre Kajdacsy-Balla, Sofie Peirs, Tim Lammens, Veerle Mondelaers, Barbara De Moerloose, Steven Goossens, Michael J. Schlicht, Kasim K. Kabirov, Alexander V. Lyubimov, Bradley J. Merrill, Yogen Saunthararajah, Pieter Van Vlierberghe and Arnon Lavie
http://cancerres.aacrjournals.org/content/78/6/1549

MYCN drives glutaminolysis in neuroblastoma and confers sensitivity to an ROS augmenting agent
Tingting Wang, Lingling Liu, Xuyong Chen, Yuqing Shen, Gaojian Lian, Nilay Shah, Andrew M Davidoff, Jun Yang & Ruoning Wang
https://www.nature.com/articles/s41419-018-0295-5

Glutamine metabolism regulates FLIP expression and sensitivity to TRAIL in triple-negative breast cancer cells
Marta Mauro-Lizcano & Abelardo López-Rivas
https://www.nature.com/articles/s41419-018-0263-0

Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis
Kate E.R. Hollinshead, Haydn Munford, Katherine L. Eales, Chiara Bardella, Chunjie Li, Cristina Escribano-Gonzalez, Alpesh Thakker, Yannic Nonnenmacher, Katarina Kluckova, Mark Jeeves, Robert Murren, Federica Cuozzo, Dan Ye, Giulio Laurenti, Wei Zhu, Karsten Hiller, David J. Hodson, Wei Hua, Ian P. Tomlinson, Christian Ludwig, Ying Mao, Daniel A. Tennant
http://www.cell.com/cell-reports/fulltext/S2211-1247(18)30294-8

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Lipid metabolism
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Pyruvate kinase M2 interacts with nuclear sterol regulatory element-binding protein 1a and thereby activates lipogenesis and cell proliferation in hepatocellular carcinoma
Xiaoping Zhao, Li Zhao, Hao Yang, Jiajin Li, Xuejie Min, Fajun Yang, Jianjun Liu and Gang Huang
http://www.jbc.org/content/early/2018/03/07/jbc.RA117.000100.abstract

Carnitine palmitoyltransferase 1C regulates cancer cell senescence through mitochondria-associated metabolic reprograming
Yongtao Wang, Yixin Chen, Lihuan Guan, Huizheng Zhang, Yaoyao Huang, Caroline H. Johnson, Zeming Wu, Frank J. Gonzalez, Aiming Yu,Peng Huang, Ying Wang, Shouhui Yang, Pan Chen, Xiaomei Fan, Min Huang & Huichang Bi
https://www.nature.com/articles/s41418-017-0013-3

Downregulation of SREBP inhibits tumor growth and initiation by altering cellular metabolism in colon cancer
Yang-An Wen, Xiaopeng Xiong, Yekaterina Y. Zaytseva, Dana L. Napier, Emma Vallee, Austin T. Li, Chi Wang, Heidi L. Weiss, B. Mark Evers & Tianyan Gao
https://www.nature.com/articles/s41419-018-0330-6

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Nucleotides
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A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
Marcus J. G. W. Ladds , Ingeborg M. M. van Leeuwen, Catherine J. Drummond, Su Chu, Alan R. Healy, Gergana Popova, Andrés Pastor Fernández, Tanzina Mollick, Suhas Darekar, Saikiran K. Sedimbi, Marta Nekulova, Marijke C. C. Sachweh, Johanna Campbell, Maureen Higgins, Chloe Tuck, Mihaela Popa, Mireia Mayoral Safont, Pascal Gelebart, Zinayida Fandalyuk, Alastair M. Thompson […] Sonia Laín
https://www.nature.com/articles/s41467-018-03441-3

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Mitochondria
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Pyruvate Dehydrogenase PDH-E1β Controls Tumor Progression by Altering the Metabolic Status of Cancer Cells
Ryo Yonashiro, Kayoko Eguchi, Masaki Wake, Norihiko Takeda and Koh Nakayama
http://cancerres.aacrjournals.org/content/78/7/1592

Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma
Meng-Xi Liu, Lei Jin, Si-Jia Sun, Peng Liu, Xu Feng Zhou-Li Cheng, Wei-Ren Liu, Kun-Liang Guan, Ying-Hong Shi, Hai-Xin Yuan & Yue Xiong
https://www.nature.com/articles/s41388-017-0070-6

Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects
Cyril Corbet, Estelle Bastien, Nihed Draoui, Bastien Doix, Lionel Mignion, Bénédicte F. Jordan, Arnaud Marchand, Jean-Christophe Vanherck, Patrick Chaltin, Olivier Schakman, Holger M. Becker, Olivier Riant & Olivier Feron
https://www.nature.com/articles/s41467-018-03525-0

Krüppel-like factor 4 (KLF4) induces mitochondrial fusion and increases spare respiratory capacity of human glioblastoma cells
Shuyan Wang, Xiaohai Shi, Shuang Wei, Ding Ma, Olutobi Ajala, Sheng-Qing Lv, Mingyao Ying, Yu Alex Zhang, Steven Michael Claypool, Paul Watkins and Shuli Xia
http://www.jbc.org/content/early/2018/03/05/jbc.RA117.001323.abstract

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AMPK family
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Colorectal tumors require NUAK1 for protection from oxidative stress
Jennifer L. F. Port, Nathiya Muthalagu, Meera Raja, Fatih Ceteci, Tiziana Monteverde, Bjorn Kruspig, Ann Hedley, Gabriela Kalna, Sergio Lilla, Lisa Neilson, Martina Brucoli, Katarina Gyuraszova, Jacqueline Tait-Mulder, Mokdad Mezna, Silvija Svambaryte, Amy Bryson, David Sumpton, Allan McVie, Colin Nixon, Martin Drysdale, Hiroyasu Esumi, Graeme I. Murray, Owen J. Sansom, Sara Zanivan and Daniel J. Murphy
http://cancerdiscovery.aacrjournals.org/content/early/2018/03/02/2159-8290.CD-17-0533

AMPK–Akt Double-Negative Feedback Loop in Breast Cancer Cells Regulates Their Adaptation to Matrix Deprivation
Manipa Saha, Saurav Kumar, Shoiab Bukhari, Sai A. Balaji, Prashant Kumar, Sravanth K. Hindupur and Annapoorni Rangarajan
http://cancerres.aacrjournals.org/content/78/6/1497

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mTOR
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Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes
Kuang Shen, Rick K. Huang, Edward J. Brignole, Kendall J. Condon, Max L. Valenstein, Lynne Chantranupong, Aimaiti Bomaliyamu, Abigail Choe, Chuan Hong, Zhiheng Yu& David M. Sabatini
https://www.nature.com/articles/nature26158

Architecture of the human mTORC2 core complex
Edward Stuttfeld, Christopher HS Aylett,  Stefan Imseng,  Daniel Boehringer, Alain Scaiola,  Evelyn Sauer, Michael N Hall, Timm Maier, Nenad Ban
https://elifesciences.org/articles/33101

The p85 isoform of the kinase S6K1 functions as a secreted oncoprotein to facilitate cell migration and tumor growth
Jianjun Zhang , Jianping Guo, Xing Qin, Bin Wang, Linli Zhang, Yingnan Wang, Wenjian Gan, Pier Paolo Pandofi, Wantao Chen, Wenyi Wei
http://stke.sciencemag.org/content/11/523/eaao1052

Selective mTORC2 Inhibitor Therapeutically Blocks Breast Cancer Cell Growth and Survival
Thomas A. Werfel, Shan Wang, Meredith A. Jackson, Taylor E. Kavanaugh, Meghan Morrison Joly, Linus H. Lee, Donna J. Hicks, Violeta Sanchez, Paula Gonzalez Ericsson, Kameron V. Kilchrist, Somtochukwu C. Dimobi, Samantha M. Sarett, Dana M. Brantley-Sieders, Rebecca S. Cook and Craig L. Duvall
http://cancerres.aacrjournals.org/content/78/7/1845

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Starvation, angiogenesis
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Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production
Alban Longchamp, Teodelinda Mirabella, Alessandro Arduini, Michael R. MacArthur, Abhirup Das, J. Humberto Treviño-Villarreal, Christopher Hine, Issam Ben-Sahra, Nelson H. Knudsen, Lear E. Brace, Justin Reynolds, Pedro Mejia, Ming Tao, Gaurav Sharma, Rui Wang, Jean-Marc Corpataux, Jacques-Antoine Haefliger, Kyo Han Ahn, Chih-Hao Lee, Brendan D. Manning, David A. Sinclair, Christopher S. Chen, C. Keith Ozaki, James R. Mitchell
http://www.cell.com/cell/fulltext/S0092-8674(18)30281-2

Autophagy Sustains Pancreatic Cancer Growth through Both Cell-Autonomous and Nonautonomous Mechanisms
Annan Yang, Grit Herter-Sprie, Haikuo Zhang, Elaine Y. Lin, Douglas Biancur, Xiaoxu Wang, Jiehui Deng, Josephine Hai, Shenghong Yang, Kwok-Kin Wong and Alec C. Kimmelman
http://cancerdiscovery.aacrjournals.org/content/8/3/276

MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB
Cynthia L. Hsu, Elian X. Lee, Kara L. Gordon, Edwin A. Paz, Wen-Chuan Shen, Kohta Ohnishi, Jill Meisenhelder, Tony Hunter & Albert R. La Spada
https://www.nature.com/articles/s41467-018-03340-7

Glucose Starvation Increases V-ATPase Assembly and Activity in Mammalian Cells through AMP Kinase and Phosphatidylinositide 3-Kinase/Akt Signaling
Christina M. McGuire and Michael Forgac
http://www.jbc.org/content/early/2018/03/14/jbc.RA117.001327.abstract

PHD3 Controls Lung Cancer Metastasis and Resistance to EGFR Inhibitors through TGFα
Higinio Dopeso, Hui-Ke Jiao, Angel M. Cuesta, Anne-Theres Henze, Liane Jurida, Michael Kracht, Amparo Acker-Palmer, Boyan K.Garvalov and Till Acker
http://cancerres.aacrjournals.org/content/78/7/1805

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Miscellaneous
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Murine stroma adopts a human-like metabolic phenotype in the PDX model of colorectal cancer and liver metastases
Arnaud Blomme, Gaetan Van Simaeys, Gilles Doumont, Brunella Costanza, Justine Bellier, Yukihiro Otaka, Félicie Sherer, Pierre Lovinfosse, Sébastien Boutry, Ana Perez Palacios, Edwin De Pauw, Touko Hirano, Takehiko Yokobori, Roland Hustinx, Akeila Bellahcène, Philippe Delvenne, Olivier Detry, Serge Goldman, Masahiko Nishiyama, Vincent Castronovo & Andrei Turtoi
https://www.nature.com/articles/s41388-017-0018-x?

Metformin-Induced Reduction of CD39 and CD73 Blocks Myeloid-Derived Suppressor Cell Activity in Patients with Ovarian Cancer
Lifeng Li, Liping Wang, Jieyao Li, Zhirui Fan, Li Yang, Zhen Zhang, Chaoqi Zhang, Dongli Yue, Guohui Qin, Tengfei Zhang, Feng Li, Xinfeng Chen, Yu Ping, Dan Wang, Qun Gao, Qianyi He, Lan Huang, Hong Li, Jianmin Huang, Xuan Zhao, Wenhua Xue, Zhi Sun, Jingli Lu, Jane J. Yu, Jie Zhao, Bin Zhang and Yi Zhang
http://cancerres.aacrjournals.org/content/78/7/1779

ROS-independent ER stress-mediated NRF2 activation promotes warburg effect to maintain stemness-associated properties of cancer-initiating cells
Ching-Wen Chang, Yu-Syuan Chen, Yeou-Guang Tsay, Chia-Li Han, Yu-Ju Chen, Cheng-Chieh Yang, Kai-Feng Hung, Chao-Hsiung Lin, Tsung-Yen Huang, Shou-Yen Kao, Te-Chang Lee & Jeng-Fan Lo
https://www.nature.com/articles/s41419-017-0250-x

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag, Dina Dikovskaya, Deepthi Menon, Zbigniew Zaslona, Mark P. Jedrychowski, Ana S. H. Costa, Maureen Higgins, Emily Hams, John Szpyt, Marah C. Runtsch, Martin S. King, Joanna F. McGouran, Roman Fischer, Benedikt M. Kessler, Anne F. McGettrick, Mark M. Hughes, Richard G. Carroll, Lee M. Booty, Elena V. Knatko, Paul J. Meakin, Michael L. J. Ashford, Louise K. Modis, Gino Brunori, Daniel C. Sévin, Padraic G. Fallon, Stuart T. Caldwell, Edmund R. S. Kunji, Edward T. Chouchani, Christian Frezza, Albena T. Dinkova-Kostova, Richard C. Hartley, Michael P. Murphy& Luke A. O’Neill
https://www.nature.com/articles/nature25986

Unravelling the metabolic progression of breast cancer cells to bone metastasis by coupling Raman spectroscopy and a novel use of MCR-ALS algorithm
Monica Marro, Claudia Nieva, Anna De Juan, and Angels Sierra
https://pubs.acs.org/doi/10.1021/acs.analchem.7b04527

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Reviews
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Metabolism – A cornerstone of cancer initiation, progression, immune evasion and treatment response
Sophia Y. Lunt, Sarah-Maria Fendt
https://www.sciencedirect.com/science/article/pii/S245231001730183X

Metabolic exhaustion in infection, cancer and autoimmunity
E. F. McKinney & K. G. C. Smith
https://www.nature.com/articles/s41590-018-0045-y

The Role of Mitochondrial H+-ATP Synthase in Cancer
Pau Esparza-Moltó, and Jose Cuezva
https://www.frontiersin.org/articles/10.3389/fonc.2018.00053/full

The carnitine system and cancer metabolic plasticity
Melone Mariarosa Anna Beatrice, Valentino Anna, Margarucci Sabrina, Galderisi Umberto, Giordano Antonio
https://www.nature.com/articles/s41419-018-0313-7

Targeting angiogenic metabolism in disease
Xuri Li, Peter Carmeliet
http://science.sciencemag.org/content/359/6382/1335

Crosstalks between translation and metabolism in cancer
Stefano Biffo, Nicola Manfrini, Sara Ricciardi
https://www.sciencedirect.com/science/article/pii/S0959437X17300849

Cross-talk between protein synthesis, energy metabolism and autophagy in cancer
Lisa M Lindqvist, Kristofferson Tandoc, Ivan Topisirovic, Luc Furic
https://www.sciencedirect.com/science/article/pii/S0959437X17301508

Metabolic Kinases Moonlighting as Protein Kinases
Zhimin Lu, Tony Hunter
http://www.cell.com/trends/biochemical-sciences/abstract/S0968-0004(18)30020-3

Extracellular matrix internalization links nutrient signalling to invasive migration
Elena Rainero
https://onlinelibrary.wiley.com/doi/abs/10.1111/iep.12265

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Comments
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Glucose Metabolism in Cancer: The Saga of Pyruvate Kinase Continues
Annamarie E. Allen, Jason W. Locasale
http://www.cell.com.sire.ub.edu/cancer-cell/fulltext/S1535-6108(18)30061-8

Autophagy in the Tumor or in the Host: Which Plays a Greater Supportive Role?
Estela Noguera-Ortega and Ravi K. Amaravadi
http://cancerdiscovery.aacrjournals.org/content/8/3/266

Asparagine Bioavailability Drives Breast Cancer Metastasis
http://cancerdiscovery.aacrjournals.org/content/8/4/381.2

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