MetaboList – April 2018

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Metabolism and anti-cancer immunity
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Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance
Camila Rubio-Patiño, Jozef P. Bossowski , Gian Marco De Donatis, Laura Mondragón, Elodie Villa, Lazaro E. Aira, Johanna Chiche, Rana Mhaidly, Cynthia Lebeaupin, Sandrine Marchetti, Konstantinos Voutetakis, Aristotelis Chatziioannou, Florence A. Castelli, Patricia Lamourette, Emeline Chu-Van, François Fenaille, Tony Avril, Thierry Passeron, John B. Patterson, Els Verhoeyen, Béatrice Bailly-Maitre, Eric Chevet, Jean-Ehrland Ricci
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30120-7

Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy
Tina Cascone,  Jodi A. McKenzie […], Patrick Hwu, Weiyi Peng
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30178-5

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity
Michael D. Kornberg, Pavan Bhargava, Paul M. Kim, Vasanta Putluri, Adele M. Snowman, Nagireddy Putluri, Peter A Calabresi, Solomon H. Snyder
http://science.sciencemag.org/content/360/6387/449

Amino acid starvation sensing dampens IL-1β production by activating riboclustering and autophagy
Srikanth Battu, Sumbul Afroz, Jeevan Giddaluru, Saima Naz, Weishan Huang, Saratchandra Singh Khumukcham, Rafiq Ahmad Khan, Saleem Yousuf Bhat, Insaf Ahmed Qureshi, Bramanandam Manavathi, Aleem Ahmed Khan, Avery August, Seyed Ehtesham Hasnain, Nooruddin Khan
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2005317

Tumor-associated macrophages promote progression and the Warburg effect via CCL18/NF-kB/VCAM-1 pathway in pancreatic ductal adenocarcinoma
Huilin Ye, Quanbo Zhou, Shangyou Zheng, Guolin Li, Qing Lin, Lusheng Wei, Zhiqiang Fu, Bin Zhang, Yimin Liu, Zhihua Li & Rufu Chen
https://www.nature.com/articles/s41419-018-0486-0

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Glucose metabolism
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B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies
Gang Xiao, Lai N. Chan, Lars Klemm, Daniel Braas, Zhengshan Chen, Huimin Geng, Qiuyi Chen Zhang, Ali Aghajanirefah, Kadriye Nehir Cosgun, Teresa Sadras, Jaewoong Lee, Tamara Mirzapoiazova, Ravi Salgia, Thomas Ernst, Andreas Hochhaus, Hassan Jumaa, Xiaoyan Jiang, David M. Weinstock, Thomas G. Graeber, Markus Müschen
http://www.cell.com/cell/fulltext/S0092-8674(18)30225-3

HOXA9 inhibits HIF-1α-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development
Liang Zhou, Yinghui Wang, Meijuan Zhou, Ying Zhang, Pengfei Wang, Xiaoxing Li, Jing Yang, Hongmei Wang & Zhenhua Ding
https://www.nature.com/articles/s41467-018-03914-5?

Inhibition of the Hexosamine Biosynthetic Pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis
Francesca Ricciardiello, Giuseppina Votta, Roberta Palorini, Isabella Raccagni, Laura Brunelli, Alice Paiotta, Francesca Tinelli, Giuseppe D’Orazio, Silvia Valtorta, Luca De Gioia, Roberta Pastorelli, Rosa Maria Moresco, Barbara La Ferla & Ferdinando Chiaradonna
https://www.nature.com/articles/s41419-018-0405-4

The fructose-2,6-bisphosphatase TIGAR suppresses NF-κB signaling by directly inhibiting the linear ubiquitin assembly complex LUBAC
Yan Tang, Hyokjoon Kwon, Brian A Neel, Michal Kasher-Meron, Jacob Pessin, Eijiro Yamada and Jeffrey E Pessin
http://www.jbc.org/content/early/2018/04/12/jbc.RA118.002727.abstract

RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma
Thibault Houles, Simon-Pierre Gravel, Geneviève Lavoie, Sejeong Shin, Mathilde Savall, Antoine Méant, Benoit Grondin, Louis Gaboury, Sang-Oh Yoon, Julie St-Pierre, and Philippe P. Roux
http://cancerres.aacrjournals.org/content/78/9/2191

Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer
Subhamoy Dasgupta, Kimal Rajapakshe, Bokai Zhu, Bryan C. Nikolai, Ping Yi, Nagireddy Putluri, Jong Min Choi, Sung Y. Jung, Cristian Coarfa, Thomas F. Westbrook, Xiang H.-F. Zhang, Charles E. Foulds, Sophia Y. Tsai, Ming-Jer Tsai & Bert W. O’Malley
https://www.nature.com/articles/s41586-018-0018-1

Pyruvate kinase M2 interacts with nuclear sterol regulatory element–binding protein 1a and thereby activates lipogenesis and cell proliferation in hepatocellular carcinoma
Xiaoping Zhao, Li Zhao, Hao Yang, Jiajin Li, Xuejie Min, Fajun Yang, Jianjun Liu and Gang Huang
http://www.jbc.org/content/293/17/6623.abstract.html

Oncogenic Kinase–Induced PKM2 Tyrosine 105 Phosphorylation Converts Nononcogenic PKM2 to a Tumor Promoter and Induces Cancer Stem–like Cells
Zhifen Zhou, Min Li, Lin Zhang, Hong Zhao, Özgür Şahin, Jing Chen, Jean J. Zhao, Zhou Songyang, and Dihua Yu
http://cancerres.aacrjournals.org/content/78/9/2248

Synergy between the KEAP1/NRF2 and PI3K Pathways Drives Non-Small-Cell Lung Cancer with an Altered Immune Microenvironment
[pentose phosphate pathway]
Sarah A. Best, David P. De Souza, Ariena Kersbergen, Antonia N. Policheni, Saravanan Dayalan, Dedreia Tull, Vivek Rathi, Daniel H. Gray, Matthew E. Ritchie, Malcolm J. McConville, Kate D. Sutherland
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30117-7

Expression and function of hexose transporters GLUT1, GLUT2, and GLUT5 in breast cancer—effects of hypoxia
Ingrit Hamann, Daniel Krys, Darryl Glubrecht, Vincent Bouvet, Alison Marshall, Larissa Vos, John R. Mackey, Melinda Wuest, and Frank Wuest
http://www.fasebj.org/doi/abs/10.1096/fj.201800360R?ai=ts&ui=ly8&af=T

GLUCOSE TRANSPORTER 1 EXPRESSION AS A MARKER OF PROGNOSIS IN OESOPHAGEAL ADENOCARCINOMA
Jaine K. Blayney, Lauren Cairns, Gerald Li, Niamh McCabe, Leanne Stevenson, Christopher J. Peters, Nathan B. Reid, Veronica J. Spence, Chintapuza Chisambo, Damian McManus, Jacqueline James, Stephen McQuaid,Stephanie Craig, Kenneth Arthur, Darragh McArt, Chin-Ann J. Ong, Pierre Lao-Sirieix, Peter Hamilton, Manuel Salto-Tellez, Martin Eatock, Helen G. Coleman, Rebecca C. Fitzgerald, Richard D. Kennedy, Richard C. Turkington, and  On behalf of the Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Study Group
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=24906&path%5B%5D=78092

THE DECREASE OF GLYCOLYTIC ENZYME HEXOKINASE 1 ACCELERATES TUMOR MALIGNANCY VIA DEREGULATING ENERGY METABOLISM BUT SENSITIZES CANCER CELLS TO 2-DEOXYGLUCOSE INHIBITION
Po-Lin Tseng, Chih-Wei Chen, Keng-Hsun Hu, Hung-Chi Cheng, Yuan-Ho Lin, Wen-Hui Tsai, Tain-Junn Cheng,Wei-Hsuan Wu, Chin-Wei Yeh, Chin-Chih Lin, Hui-Ju Tsai, Hao-Chun Chang, Jiin-Haur Chuang, Yan-Shen Shan, and  Wen-Tsan Chang
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=24855&path%5B%5D=77938

Classical NF-κB Metabolically Reprograms Sarcoma Cells Through Regulation of Hexokinase 2
Priya Londhe, Peter Y. Yu, Yuichi Ijiri, Katherine J. Ladner, Joelle M. Fenger, Cheryl London, Peter J. Houghton, and Denis C. Guttridge
https://www.frontiersin.org/articles/10.3389/fonc.2018.00104/full

A functional interplay between Δ133p53 and ΔNp63 in promoting glycolytic metabolism to fuel cancer cell proliferation
Lu Gong, Xiao Pan, Chuan-Bian Lim, Anna de Polo, John B. Little & Zhi-Min Yuan
http://www.nature.com/articles/s41388-017-0117-8

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Amino acid metabolism
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Cooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression
Maren Feist, Philipp Schwarzfischer, Paul Heinrich, Xueni Sun, Judith Kemper, Frederike von Bonin, Paula Perez-Rubio, Franziska Taruttis, Thorsten Rehberg, Katja Dettmer, Wolfram Gronwald, Jörg Reinders, Julia C. Engelmann, Jan Dudek, Wolfram Klapper, Lorenz Trümper, Rainer Spang, Peter J. Oefner & Dieter Kube
https://www.nature.com/articles/s41467-018-03803-x

Glutaminolysis is a metabolic dependency in FLT3^ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition
Paolo Gallipoli, George Giotopoulos, Konstantinos Tzelepis, Ana S. H. Costa, Shabana Vohra, Paula Medina-Perez, Faisal Basheer, Ludovica Marando, Lorena Di Lisio, Joao M. L. Dias, Haiyang Yun, Daniel Sasca, Sarah J. Horton, George Vassiliou, Christian Frezza and Brian J. P. Huntly
http://bloodjournal.org/content/131/15/1639.abstract?etoc

Increased formate overflow is a hallmark of oxidative cancer
Johannes Meiser, Anne Schuster, Matthias Pietzke, Johan Vande Voorde, Dimitris Athineos, Kristell Oizel, Guillermo Burgos-Barragan, Niek Wit, Sandeep Dhayade, Jennifer P. Morton, Emmanuel Dornier, David Sumpton, Gillian M. Mackay, Karen Blyth, Ketan J. Patel, Simone P. Niclou & Alexei Vazquez
https://www.nature.com/articles/s41467-018-03777-w

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Lipid metabolism
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Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy
Mark R. Lundquist, Marcus D. Goncalves, Ryan M. Loughran, Elite Possik, Tarika Vijayaraghavan, Annan Yang, Chantal Pauli, Archna Ravi, Akanksha Verma, Zhiwei Yang, Jared L. Johnson, Jenny C.Y. Wong, Yilun Ma, Katie Seo-Kyoung Hwang, David Weinkove, Nullin Divecha, John M. Asara, Olivier Elemento, Mark A. Rubin, Alec C. Kimmelman, Arnim Pause, Lewis C. Cantley, Brooke M. Emerling
https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30268-5

Identifying off-target effects of etomoxir reveals that carnitine palmitoyltransferase I is essential for cancer cell proliferation independent of β-oxidation
Cong-Hui Yao, Gao-Yuan Liu, Rencheng Wang, Sung Ho Moon, Richard W. Gross, Gary J. Patti
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2003782

Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis
Andras Ladanyi, Abir Mukherjee, Hilary A. Kenny, Alyssa Johnson, Anirban K. Mitra, Sinju Sundaresan , Kristin M. Nieman , Gloria Pascual , Salvador Aznar Benitah , Anthony Montag , S. Diane Yamada , Nada A. Abumrad & Ernst Lengyel
http://www.nature.com/articles/s41388-017-0093-z

STAT3-ACTIVATED CD36 FACILITATES FATTY ACID UPTAKE IN CHRONIC LYMPHOCYTIC LEUKEMIA CELLS
Uri Rozovski, David M. Harris, Ping Li, Zhiming Liu, Preetesh Jain, Alessandra Ferrajoli, Jan Burger, Phillip Thompson, Nitin Jain, William Wierda, Michael J. Keating,  and  Zeev Estrov
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=25066

Pyruvate kinase M2 interacts with nuclear sterol regulatory element–binding protein 1a and thereby activates lipogenesis and cell proliferation in hepatocellular carcinoma
Xiaoping Zhao, Li Zhao, Hao Yang, Jiajin Li, Xuejie Min, Fajun Yang, Jianjun Liu and Gang Huang
http://www.jbc.org/content/293/17/6623.abstract.html

Inhibition of the mevalonate pathway enhances cancer cell oncolysis mediated by M1 virus
Jiankai Liang, Li Guo, Kai Li, Xiao Xiao, Wenbo Zhu, Xiaoke Zheng, Jun Hu, Haipeng Zhang, Jing Cai, Yaya Yu, Yaqian Tan, Chuntao Li, Xincheng Liu, Cheng Hu, Ying Liu, Pengxin Qiu, Xingwen Su, Songmin He, Yuan Lin & Guangmei Yan
https://www.nature.com/articles/s41467-018-03913-6

TARGETING THE MEVALONATE PATHWAY IS A NOVEL THERAPEUTIC APPROACH TO INHIBIT ONCOGENIC FOXM1 TRANSCRIPTION FACTOR IN HUMAN HEPATOCELLULAR CARCINOMA
Satoshi Ogura, Yuichi Yoshida, Tomohide Kurahashi, Mayumi Egawa, Kunimaro Furuta, Shinichi Kiso, Yoshihiro Kamada, Hayato Hikita, Hidetoshi Eguchi, Hisakazu Ogita, Yuichiro Doki, Masaki Mori, Tomohide Tatsumi,  and  Tetsuo Takehara
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=24781

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Nucleotides and one carbon metabolism
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Metabolic Determinants of Sensitivity to Phosphatidylinositol 3-Kinase Pathway Inhibitor in Small-Cell Lung Carcinoma
Hideki Makinoshima, Shigeki Umemura, Ayako Suzuki, Hiroki Nakanishi, Ami Maruyama, Hibiki Udagawa, Sachiyo Mimaki, Shingo Matsumoto, Seiji Niho, Genichiro Ishii, Masahiro Tsuboi, Atsushi Ochiai, Hiroyasu Esumi, Takehiko Sasaki, Koichi Goto, and Katsuya Tsuchihara
http://cancerres.aacrjournals.org/content/78/9/2179

One-carbon metabolism biomarkers and genetic variants in relation to colorectal cancer risk by KRAS and BRAF mutation status
Robin Myte , Björn Gylling, Jenny Häggström, Jörn Schneede, Anna Löfgren-Burström, Jeroen R. Huyghe, Göran Hallmans, Klaus Meyer, Ingegerd Johansson, Per Magne Ueland, Richard Palmqvist, Bethany Van Guelpen
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0196233

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Mitochondria
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Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells
Adam Naguib, Grinu Mathew, Colleen R. Reczek, Kaitlin Watrud, Alexandra Ambrico, Tali Herzka, Irene Casanova Salas, Matthew F. Lee, Nour El-Amine, Wu Zheng, M. Emilia Di Francesco, Joseph R. Marszalek, Darryl J. Pappin, Navdeep S. Chandel, Lloyd C. Trotman
http://www.cell.com/cell-reports/fulltext/S2211-1247(18)30374-7

Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations
Qiuying Chen, Kathryne Kirk, Yevgeniya I. Shurubor, Dazhi Zhao, Andrea J. Arreguin, Ifrah Shahi, Federica Valsecchi, Guido Primiano, Elizabeth L. Calder, Valerio Carelli, Travis T. Denton, M. Flint Beal, Steven S. Gross, Giovanni Manfredi, Marilena D’Aurelio
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30180-3

Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors
Grace R. Anderson, Suzanne E. Wardell, Merve Cakir, Catherine Yip, Yeong-ran Ahn, Moiez Ali, Alexander P. Yllanes, Christina A. Chao, Donald P. McDonnell & Kris C. Wood
https://www.nature.com/articles/s41467-018-04033-x

PGC1α promotes cholangiocarcinoma metastasis by upregulating PDHA1 and MPC1 expression to reverse the Warburg effect
Dan Li, Chaoqun Wang, Panfei Ma, Qingan Yu, Mingqi Gu, Liqian Dong, Wenjing Jiang, Shangha Pan, Changming Xie, Jihua Han, Yaliang Lan, Jing Sun, Ping Sheng, Kunpeng Liu, Yaohua Wu, Lianxin Liu, Yong Ma & Hongchi Jiang
https://www.nature.com/articles/s41419-018-0494-0

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Starvation / nutrient sensing
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Sestrin2 facilitates glutamine‐dependent transcription of PGC‐1α and survival of liver cancer cells under glucose limitation
Ashish Kumar, Sagnik Giri, Chandrima Shaha
https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.14406?campaign=woletoc

AMPK Inhibits ULK1-Dependent Autophagosome Formation and Lysosomal Acidification via Distinct Mechanisms
[Glc deprivation inhibits autophagy]
Chinwendu Nwadike, Leon E. Williamson, Laura E. Gallagher, Jun-Lin Guan and Edmond Y. W. Chan
http://mcb.asm.org/content/38/10/e00023-18.abstract?etoc

GRASP55 Senses Glucose Deprivation through O-GlcNAcylation to Promote Autophagosome-Lysosome Fusion
[Glc deprivation induces autophagy]
Xiaoyan Zhang, Leibin Wang, Behnam Lak, Jie Li, Eija Jokitalo, Yanzhuang Wang
https://www.cell.com/developmental-cell/fulltext/S1534-5807(18)30243-0

Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy
Ruth Shiloh, Yuval Gilad, Yaara Ber, Miriam Eisenstein, Dina Aweida, Shani Bialik, Shenhav Cohen & Adi Kimchi
https://www.nature.com/articles/s41467-018-03907-4

Suppressed translation as a mechanism of initiation of CASP8 (caspase 8)-dependent apoptosis in autophagy-deficient NSCLC cells under nutrient limitation
Giulia Allavena, Francesca Cuomo, Georg Baumgartner, Tadeja Bele, Alexander Yarar Sellgren, Kyaw Soe Oo, Kaylee Johnson, Vladimir Gogvadze, Boris Zhivotovsky & Vitaliy O Kaminskyy
https://www.tandfonline.com/doi/full/10.1080/15548627.2017.1405192

HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution
Marc J. Tol, Martijn J.C. van der Lienden, Tanit L. Gabriel, Jacob J. Hagen, Saskia Scheij, Tineke Veenendaal, Judith Klumperman, Wilma E. Donker-Koopman, Arthur J. Verhoeve, Hermen Overkleeft, Johannes M. Aerts, Carmen A. Argmann & Marco van Eijk
https://www.tandfonline.com/doi/full/10.1080/15548627.2017.1419118

Gtr/Ego-independent TORC1 activation is achieved through a glutamine-sensitive interaction with Pib2 on the vacuolar membrane
Hirofumi Ukai, Yasuhiro Araki, Shintaro Kira, Yu Oikawa, Alexander I. May, Takeshi Noda
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007334

FoxO restricts growth and differentiation of cells with elevated TORC1 activity under nutrient restriction
Katarzyna Nowak, Avantika Gupta, Hugo Stocker
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007347

SOD1 Phosphorylation by mTORC1 Couples Nutrient Sensing and Redox Regulation
Chi Kwan Tsang, Miao Chen, Xin Cheng, Yanmei Qi, Yin Chen, Ishani Das, Xiaoxing Li, Brinda Vallat, Li-Wu Fu, Chao-Nan Qian, Hui-Yun Wang, Eileen White, Stephen K. Burley, X.F. Steven Zheng
https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30232-6

AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965
Toby A. Dite, Christopher G. Langendorf, Ashfaqul Hoque, Sandra Galic, Richard J. Rebello, Ashley J. Ovens, Lisa M. Lindqvist, Kevin R.W. Ngoei, Naomi X. Y. Ling, Luc Furic, Bruce E. Kemp, John Walter Scott and Jonathan S. Oakhill
http://www.jbc.org/content/early/2018/04/25/jbc.RA118.003547.abstract

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IDH
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Mutant IDH1 Promotes Glioma Formation In Vivo
Beatrice Philip, Diana X. Yu, Mark R. Silvis, Clifford H. Shin, James P. Robinson, Gemma L. Robinson, Adam E. Welker, Stephanie N. Angel, Sheryl R. Tripp, Joshua A. Sonnen, Matthew W. VanBrocklin, Richard J. Gibbons, Ryan E. Looper, Howard Colman, Sheri L. Holmen
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30521-7

Pharmacodynamics of mutant-IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate
Ovidiu C. Andronesi, Isabel C. Arrillaga-Romany, K. Ina Ly, Wolfgang Bogner, Eva M. Ratai, Kara Reitz, A. John Iafrate, Jorg Dietrich, Elizabeth R. Gerstner, Andrew S. Chi, Bruce R. Rosen, Patrick Y. Wen, Daniel P. Cahill & Tracy T. Batchelor
https://www.nature.com/articles/s41467-018-03905-6

Mutant IDH1 gliomas downregulate phosphocholine and phosphoethanolamine synthesis in a 2-hydroxyglutarate-dependent manner
Pavithra Viswanath, Marina Radoul, Jose Luis Izquierdo-Garcia, Hema Artee Luchman, J. Gregory Cairncross, Russell O. Pieper, Joanna J. Phillips and Sabrina M. Ronen
https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-018-0178-3

2-Hydroxyglutarate-Mediated Autophagy of the Endoplasmic Reticulum Leads to an Unusual Downregulation of Phospholipid Biosynthesis in Mutant IDH1 Gliomas
Pavithra Viswanath, Marina Radoul, Jose Luis Izquierdo-Garcia, Wei Qiang Ong, Hema Artee Luchman, J. Gregory Cairncross, Bo Huang, Russell O. Pieper, Joanna J. Phillips, and Sabrina M. Ronen
http://cancerres.aacrjournals.org/content/78/9/2290

Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities
Matthew Garrett, Jantzen Sperry, Daniel Braas, Weihong Yan, Thuc M. Le, Jack Mottahedeh, Kirsten Ludwig, Ascia Eskin, Yue Qin, Rachelle Levy, Joshua J. Breunig, Frank Pajonk, Thomas G. Graeber, Caius G. Radu, Heather Christofk, Robert M. Prins, Albert Lai, Linda M. Liau, Giovanni Coppola and Harley I. Kornblum
https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-018-0177-4

Mutant Isocitrate Dehydrogenase 1 Disrupts PKM2–β-Catenin–BRG1 Transcriptional Network-Driven CD47 Expression
Pruthvi Gowda, Shruti Patrick, Ankita Singh, Touseef Sheikh and Ellora Sen
http://mcb.asm.org/content/38/9/e00001-18.abstract?etoc

Wild-type and mutated IDH1/2 enzymes and therapy responses
Remco J. Molenaar, Jaroslaw P. Maciejewski, Johanna W. Wilmink & Cornelis J. F. van Noorden
https://www.nature.com/articles/s41388-017-0077-z

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Hypoxia
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LPA Induces Metabolic Reprogramming in Ovarian Cancer via a Pseudohypoxic Response
Ji Hee Ha, Rangasudhagar Radhakrishnan, Muralidharan Jayaraman, Mingda Yan, Jeremy D. Ward, Kar-Ming Fung, Katherine Moxley, Anil K. Sood, Ciro Isidoro, Priyabrata Mukherjee, Yong Sang Song and Danny N. Dhanasekaran
http://cancerres.aacrjournals.org/content/78/8/1923

ZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis
Yan Chen, Bo Zhang, Lei Bao, Lai Jin, Mingming Yang, Yan Peng, Ashwani Kumar, Jennifer E. Wang, Chenliang Wang, Xuan Zou, Chao Xing, Yingfei Wang, and Weibo Luo
https://www.jci.org/articles/view/95089

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Miscellaneous
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Proteome-wide analysis of cysteine oxidation reveals metabolic sensitivity to redox stress
Jiska van der Reest, Sergio Lilla, Liang Zheng, Sara Zanivan & Eyal Gottlieb
http://www.nature.com/articles/s41467-018-04003-3

Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress
Jennifer Port, Nathiya Muthalagu, Meera Raja, Fatih Ceteci, Tiziana Monteverde, Björn Kruspig, Ann Hedley, Gabriela Kalna, Sergio Lilla, Lisa Neilson, Martina Brucoli, Katarina Gyuraszova, Jacqueline Tait-Mulder, Mokdad Mezna, Silvija Svambaryte, Amy Bryson, David Sumpton, Allan McVie, Colin Nixon, Martin Drysdale, Hiroyasu Esumi, Graeme I. Murray, Owen J. Sansom, Sara R. Zanivan, and Daniel J. Murphy
http://cancerdiscovery.aacrjournals.org/content/8/5/632

Metabolomics of oncogene-specific metabolic reprogramming during breast cancer
Chen Dai, Jennifer Arceo, James Arnold, Arun Sreekumar, Norman J. Dovichi, Jun Li and Laurie E. Littlepage
https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-018-0175-6

Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells
Wei Yan , Xiwei Wu , Weiying Zhou , Miranda Y. Fong , Minghui Cao ,Juan Liu , Xiaojing Liu ,Chih-Hong Chen , Oluwole Fadare, Donald P. Pizzo ,Jiawen Wu , Liang Liu ,Xuxiang Liu, Andrew R. Chin & &, Xiubao Ren ,Yuan Chen , Jason W. Locasale & Shizhen Emily Wang
http://www.nature.com/articles/s41556-018-0083-6

Differential Reliance on Lipid Metabolism as a Salvage Pathway Underlies Functional Differences of T Cell Subsets in Poor Nutrient Environments
Christopher Ecker, Lili Guo, Stefana Voicu, Luis Gil-de-Gómez, Andrew Medvec, Luis Cortina, Jackie Pajda, Melanie Andolina, Maria Torres-Castillo, Jennifer L. Donato, Sarya Mansour, Evan R. Zynda, Pei-Yi Lin, Angel Varela-Rohena, Ian A. Blair, James L. Riley
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30445-5

Adipocyte p62/SQSTM1 Suppresses Tumorigenesis through Opposite Regulations of Metabolism in Adipose Tissue and Tumor
Jianfeng Huang, Angeles Duran, Miguel Reina-Campos, Tania Valencia, Elias A. Castilla, Timo D. Müller, Matthias H. Tschöp, Jorge Moscat, Maria T. Diaz-Meco
https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30069-2

Obesity Suppresses Cell-Competition-Mediated Apical Elimination of RasV12-Transformed Cells from Epithelial Tissues
Ayana Sasaki, Takahiro Nagatake, Riku Egami, Guoqiang Gu, Ichigaku Takigawa, Wataru Ikeda, Tomoya Nakatani, Jun Kunisawa, Yasuyuki Fujita
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30480-7

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Reviews
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Deoxyribonucleotide Triphosphate Metabolism in Cancer and Metabolic Disease
Raquel Buj and Katherine M. Aird
https://www.frontiersin.org/articles/10.3389/fendo.2018.00177/full

New links between lipid accumulation and cancer progression
Joseph T. Nickels Jr.
http://www.jbc.org/content/293/17/6635.abstract.html

SREBPs in Lipid Metabolism, Insulin Signaling, and Beyond
Russell A. DeBose-Boyd, Jin Ye
https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(18)30005-7

Deciphering the Dichotomous Effects of PGC-1α on Tumorigenesis and Metastasis
Simon-Pierre Gravel
https://www.frontiersin.org/articles/10.3389/fonc.2018.00075/full

Metabolic Reprogramming During Multidrug Resistance in Leukemias
Raphael Vidal, Julia Quarti, Franklin Rumjanek, and Vivian Rumjanek
https://www.frontiersin.org/articles/10.3389/fonc.2018.00090/full

Metabolic Reprogramming in Thyroid Carcinoma
Raquel Coelho, Rodrigo Fortunato, and Denise Carvalho
https://www.frontiersin.org/articles/10.3389/fonc.2018.00082/full

Metabolic Symbiosis and Immunomodulation: How Tumor Cell-Derived Lactate May Disturb Innate and Adaptive Immune Responses
Alexandre Morrot, Leonardo Marques da Fonseca, Eduardo Salustiano, Luciana Gentile, Luciana Conde Rodrigues Maia, Alessandra Filardy, Tatiany Franklim, Kelli da Costa, Celio Freire-de-Lima, and Leonardo Freire-de-Lima
https://www.frontiersin.org/articles/10.3389/fonc.2018.00081/full

Impact of l-Arginine Metabolism on Immune Response and Anticancer Immunotherapy
Sun-Hee Kim, Jason Roszik, Elizabeth Grimm, and Suhendan Ekmekcioglu
https://www.frontiersin.org/articles/10.3389/fonc.2018.00067/full

The Proline Cycle As a Potential Cancer Therapy Target.
Tanner JJ, Fendt SM, Becker DF.
https://pubs.acs.org/doi/10.1021/acs.biochem.8b00215

Metabolic features of cancer stem cells: the emerging role of lipid metabolism
Rita Mancini, Alessia Noto, Maria Elena Pisanu, Claudia De Vitis, Marcello Maugeri-Saccà & Gennaro Ciliberto
https://www.nature.com/articles/s41388-018-0141-3

Metabolomics and Isotope Tracing
Cholsoon Jang, Li Chen, Joshua D. Rabinowitz
https://www.cell.com/cell/fulltext/S0092-8674(18)30387-8

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Comments
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Eating the Beast: Dietary Protein and Anticancer Immunity
Douglas R. Green
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30184-0

To Claim Growth Turf, mTOR Says SOD Off
Hyewon Kong, Navdeep S. Chandel
https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30311-3

Immune Evasion in Tumor’s Own Sweet Way
Haidong Tang, Yang-Xin Fu
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30191-8

The Science and Translation of Lactate Shuttle Theory
George A. Brooks
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30186-4

Metabolic strugGLS after FLT3 inhibition in AML
Samuel J. Taylor and Ulrich Steidl
http://www.bloodjournal.org/content/131/15/1631

Breast cancer: Obesity: tipping the scales of resistance
Conor A. Bradley
http://www.nature.com/articles/nrc.2018.31

Fatty Acid Oxidation Regulates the Activation of Endothelial-to-Mesenchymal Transition
Sara Lovisa, Raghu Kalluri
https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(18)30049-2

MYC sets a tumour-stroma metabolic loop
Hilary A. Coller
http://www.nature.com/articles/s41556-018-0096-1

When ER stress is bad for cancer
http://stke.sciencemag.org/content/11/528/eaau0066

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