MetaboList – May 2018

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Amino  acid metabolism
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The  GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma
Milica  Momcilovic, Sean T. Bailey, Jason T. Lee, Michael C. Fishbein, Daniel Braas, James Go, Thomas G. Graeber, Francesco Parlati, Susan Demo, Rui Li, Tonya C. Walser, Michael Gricowski, Robert Shuman, Julio Ibarra, Deborah Fridman, Michael E. Phelps, Karam Badran,  Maie St. John, Nicholas M. Bernthal, Noah Federman, Jane Yanagawa, Steven M. Dubinett, Saman Sadeghi, Heather R. Christofk, David B. Shackelford
https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30173-9

xCT  (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression
Xiangming  Ji, Jun Qian, S. M. Jamshedur Rahman, Peter J. Siska, Yong Zou, Bradford K. Harris, Megan D. Hoeksema, Irina A. Trenary, Chen Heidi, Rosana Eisenberg, Jeffrey C. Rathmell, Jamey D. Young & Pierre P. Massion
https://www.nature.com/articles/s41388-018-0307-z

Methionine  metabolism influences genomic architecture and gene expression through H3K4me3 peak width
Ziwei  Dai, Samantha J. Mentch, Xia Gao, Sailendra N. Nichenametla & Jason W. Locasale
https://www.nature.com/articles/s41467-018-04426-y

ATF4  Regulates CD4+ T Cell Immune Responses through Metabolic Reprogramming
Xi  Yang, Rui Xia, Cuihua Yue, Wensi Zhai, Wenwen Du, Qianting Yang, Huiling Cao, Xiaojuan Chen, Danielle Obando, Yibei Zhu, Xinchun Chen, Jane-Jane Chen, Jon Piganelli, Peter Wipf, Yu Jiang, Guozhi Xiao, Changping Wu, Jingting Jiang, Binfeng Lu
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30576-X

Elevated  mitochondrial SLC25A29 in cancer modulates metabolic status by increasing mitochondria-derived nitric oxide
Huiyuan  Zhang, Qinyi Wang, Junzhong Gu, Le Yin, Shenghui Liang, Lida Wu, Hao Xu, Chao Zhao & Yuchun Gu
https://www.nature.com/articles/s41388-018-0139-x

Restoration  of hydroxyindole O-methyltransferase levels in human cancer cells induces a tryptophan metabolic switch and attenuates cancer progression
Hua-Ling  Chen, Chao-Yun Yuan, Huei-Hsuan Cheng, Tzu-Ching Chang, Shau-Ku Huang, Cheng-Chin Kuo and Kenneth K Wu
http://www.jbc.org/content/early/2018/05/24/jbc.RA117.000597.abstract

Serine  catabolism is essential to maintain mitochondrial respiration in  mammalian cells
Stephanie  Lucas, Guohua Chen, Siddhesh Aras and Jian Wang
http://life-science-alliance.org//content/1/2/e201800036.abstract?etoc

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Glucose  metabolism
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Regulation  of glycolytic metabolism by autophagy in liver cancer involves selective autophagic degradation of HK2 (hexokinase 2)
Lin  Jiao, Hai-Liang Zhang, Dan-Dan Li, Ke-Li Yang, Jun Tang, Xuan Li, Jiao Ji, Yan Yu, Rui-Yan Wu, Senthilkumar Ravichandran, Jian-Jun Liu, Gong-Kan Feng, Min-Shan Chen, Yi-Xin Zeng, Rong Deng & Xiao-Feng Zhu
https://www.tandfonline.com/doi/full/10.1080/15548627.2017.1381804

METABOLITE  PROFILING IDENTIFIES A SIGNATURE OF TUMORIGENICITY IN HEPATOCELLULAR CARCINOMA
Shamir  Cassim, Valérie-Ann Raymond, Benoit Lacoste, Pascal Lapierre,  and  Marc Bilodeau
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=25525&path%5B%5D=79918

EP300-Mediated Lysine 2-Hydroxyisobutyrylation  Regulates Glycolysis
He  Huang, Shuang Tang, Ming Ji, Zhanyun Tang, Miho Shimada, Xiaojing Liu, Shankang Qi, Jason W. Locasale, Robert G. Roeder, Yingming Zhao,  Xiaoling Li
https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30307-1

Targeting  PFKFB3 sensitizes chronic myelogenous leukemia cells to tyrosine kinase inhibitor
Yu  Zhu, Luo Lu, Chun Qiao, Yi Shan, Huapeng Li, Sixuan Qian, Ming Hong, Huihui Zhao, Jianyong Li , Zhongfa Yang & Yaoyu Chen
http://www.nature.com/articles/s41388-018-0157-8

A  new inhibitor of glucose-6-phosphate dehydrogenase blocks pentose phosphate pathway and suppresses malignant proliferation and metastasis in vivo
Luigi  Mele, Francesca Paino, Federica Papaccio, Tarik Regad, David Boocock, Paola Stiuso, Angela Lombardi, Davide Liccardo, Gabriella Aquino, Antonio Barbieri, Claudio Arra, Clare Coveney, Marcella La Noce, Gianpaolo Papaccio, Michele Caraglia, Virginia Tirino &  Vincenzo Desiderio
https://www.nature.com/articles/s41419-018-0635-5

Transketolase  Regulates the Metabolic Switch to Control Breast Cancer Cell Metastasis via the α-Ketoglutarate Signaling Pathway
Chien-Wei  Tseng, Wen-Hung Kuo, Shih-Hsuan Chan, Hong-Lin Chan, King-Jen Chang and Lu-Hai Wang
http://cancerres.aacrjournals.org/content/78/11/2799

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Lipid  metabolism / citrate
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Cancer  Lipid Metabolism Confers Antiangiogenic Drug Resistance
Hideki  Iwamoto, Mitsuhiko Abe, Yunlong Yang, Dongmei Cui, Takahiro Seki, Masaki Nakamura, Kayoko Hosaka, Sharon Lim, Jieyu Wu, Xingkang He, Xiaoting Sun, Yongtian Lu, Qingjun Zhou, Weiyun Shi, Takuji Torimura, Guohui Nie, Qi Li, Yihai Cao
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30312-7

Extracellular  Citrate Affects Critical Elements of Cancer Cell Metabolism and Supports Cancer Development In Vivo
Maria  E. Mycielska, Katja Dettmer, Petra Rümmele, Katharina Schmidt, Cornelia Prehn, Vladimir M. Milenkovic, Wolfgang Jagla, Gregor M. Madej, Margareta Lantow, Moritz Schladt, Alexander Cecil, Gudrun E. Koehl, Elke Eggenhofer, Christian J. Wachsmuth, Vadivel Ganapathy,  Hans J. Schlitt, Karl Kunzelmann, Christine Ziegler, Christian H. Wetzel, Andreas Gaumann, Sven A. Lang, Jerzy Adamski, Peter J. Oefner and Edward K. Geissler
http://cancerres.aacrjournals.org/content/78/10/2513

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Nucleotides and NAD
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Metabolic regulation of transcription through compartmentalized NAD+ biosynthesis
Keun Woo Ryu, Tulip Nandu, Jiyeon Kim, Sridevi Challa, Ralph J. DeBerardinis, W. Lee Kraus
http://science.sciencemag.org/content/360/6389/eaan5780

dNTP metabolism links mechanical cues and YAP/TAZ to cell growth and oncogene‐induced senescence
Giulia Santinon, Irene Brian, Arianna Pocaterra, Patrizia Romani, Elisa Franzolin, Chiara Rampazzo, Silvio Bicciato and Sirio Dupont
http://EMBOJ.embopress.org/content/37/11/e97780?etoc

AICAR Antiproliferative Properties Involve the AMPK-Independent Activation of the Tumor Suppressors LATS 1 and 2.
Philippe C, Pinson B, Dompierre J, Pantesco V, Viollet B, Daignan-Fornier B, Moenner M.
https://doi.org/10.1016/j.neo.2018.03.006

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Acetyl-CoA
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Organelle-Derived Acetyl-CoA Promotes Prostate Cancer Cell Survival, Migration, and Metastasis via Activation of Calmodulin Kinase II
Guoyu Yu, Chien-Jui Cheng, Song-Chang Lin, Yu-Chen Lee, Daniel E. Frigo, Li-Yuan Yu-Lee, Gary E. Gallick, Mark A. Titus, Leta K. Nutt and Sue-Hwa Lin
http://cancerres.aacrjournals.org/content/78/10/2490

Acetyl-CoA promotes glioblastoma cell adhesion and migration through Ca2+–NFAT signaling
Joyce V. Lee, Corbett T. Berry, Karla Kim, Payel Sen, Taehyong Kim, Alessandro Carrer, Sophie Trefely, Steven Zhao, Sully Fernandez, Lauren E. Barney, Alyssa D. Schwartz, Shelly R. Peyton, Nathaniel W. Snyder, Shelley L. Berger,  Bruce D. Freedman and Kathryn E. Wellen
http://genesdev.cshlp.org/content/early/2018/04/19/gad.311027.117

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Starvation / nutrient sensing
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NUFIP1 is a ribosome receptor for starvation-induced ribophagy
Gregory A. Wyant, Monther Abu-Remaileh, Evgeni M. Frenkel, Nouf N. Laqtom, Vimisha Dharamdasani, Caroline A. Lewis, Sze Ham Chan, Ivonne Heinze, Alessandro Ori, David M. Sabatini
http://science.sciencemag.org/content/360/6390/751

KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing
Jie Chen, Yuhui Ou, Yanyan Yang, Wen Li, Ye Xu, Yuntao Xie & Ying Liu
https://www.nature.com/articles/s41586-018-0128-9

The Gcn2–eIF2α pathway connects iron and amino acid homeostasis in Saccharomyces cerevisiae
Marcos Caballero-Molada, María D. Planes, Helena Benlloch, Sergio Atares,Miguel A. Naranjo and Ramón Serrano
http://www.biochemj.org/content/475/8/1523?etoc

Proteasome storage granules protect proteasomes from autophagic degradation upon carbon starvation
Richard S Marshall, Richard D Vierstra
https://elifesciences.org/articles/34532

Hierarchical mechanism of amino acid sensing by the T-box riboswitch
Krishna C. Suddala, Javier Cabello-Villegas, Malgorzata Michnicka, Collin Marshall, Edward P. Nikonowicz & Nils G. Walter
https://www.nature.com/articles/s41467-018-04305-6

CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy
Xavier Roa-Mansergas, Rut Fadó, Maher Atari, Joan F. Mir, Helena Muley, Dolors Serra & Núria Casals
https://www.nature.com/articles/s41598-018-25485-7

Accelerated lipid catabolism and autophagy are cancer survival mechanisms under inhibited glutaminolysis.
Halama A, Kulinski M, Dib SS, Zaghlool SB, Siveen KS, Iskandarani A, Zierer J, Prabhu KS, Satheesh NJ, Bhagwat AM, Uddin S, Kastenmüller G, Elemento O, Gross SS, Suhre K.
https://www.cancerletters.info/article/S0304-3835(18)30342-2/fulltext

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Hypoxia / ischemia
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Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR
Zandra E. Walton, Chirag H. Patel, Rebekah C. Brooks, Yongjun Yu, Arig Ibrahim-Hashim, Malini Riddle, Alessandra Porcu, Tianying Jiang, Brett L. Ecker, Feven Tameire, Constantinos Koumenis, Ashani T. Weeraratna, David K. Welsh,  Robert Gillies, James C. Alwine, Lin Zhang, Jonathan D. Powell, Chi V. Dang
https://www.cell.com/cell/fulltext/S0092-8674(18)30586-5

Accumulation of Succinate in Cardiac Ischemia Primarily Occurs via Canonical Krebs Cycle Activity
Jimmy Zhang, Yves T. Wang, James H. Miller, Mary M. Day, Joshua C. Munger, Paul S. Brookes
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30702-2

HIF1α drives chemokine factor pro-tumoral signaling pathways in acute myeloid leukemia
Amina M. Abdul-Aziz, Manar S. Shafat, Yu Sun, Christopher R. Marlein, Rachel E. Piddock, Stephen D. Robinson, Dylan R. Edwards, Zhigang Zhou, Angela Collins, Kristian M. Bowles & Stuart A. Rushworth
https://www.nature.com/articles/s41388-018-0151-1

Regulation of Hypoxia-Inducible Factor 1α during Hypoxia by DAP5-Induced Translation of PHD2
Jeffrey D. Bryant, Michael C. Brown, Mikhail I. Dobrikov, Elena Y. Dobrikova, Sarah L. Gemberling, Qing Zhang and Matthias Gromeier
http://mcb.asm.org/content/38/11/e00647-17.abstract?etoc

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IDH
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IDH1 R132 mutant promotes tumor formation through downregulating p53
Bin Jiang, Wentao Zhao, Minggang Shi, Jia Zhang, Ai Chen, Huanhuan Ma, Muhammad Suleman, Furong Lin, Lin Zhou, Jinyang Wang, Yan Zhang, Mengjue Liu, Shixiong Wen, Cong Ouyang, Huihui Wang, Xiumin Huang, Huamin Zhou and Qinxi  Li
http://www.jbc.org/content/early/2018/05/09/jbc.RA117.001385.abstract

Mutant IDH1 Cooperates with ATRX Loss to Drive the Alternative Lengthening of Telomere Phenotype in Glioma
Joydeep Mukherjee, Tor-Christian Johannessen, Shigeo Ohba, Tracy T. Chow, Lindsey Jones, Ajay Pandita and Russell O. Pieper
http://cancerres.aacrjournals.org/content/78/11/2966

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Miscellaneous
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mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation
Long He, Ana P. Gomes, Xin Wang, Sang Oh Yoon, Gina Lee, Michal J. Nagiec, Sungyun Cho, Andre Chavez, Tasnia Islam, Yonghao Yu, John M. Asara, Bo Yeon Kim, John Blenis
https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30346-0

The AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation-associated cachectic muscle wasting
Hall, D. T., Griss, T., Ma, J. F., Sanchez, B. J., Sadek, J., Tremblay, A. M. K., Mubaid, S., Omer, A., Ford, R. J., Bedard, N., Pause, A., Wing, S. S., Di Marco, S., Steinberg, G. R., Jones, R. G., Gallouzi, I.-E.
http://EMBOMolMed.embopress.org/cgi/content/abstract/emmm.201708307v1?ct

Visualization of Breast Cancer Metabolism Using Multimodal Nonlinear Optical Microscopy of Cellular Lipids and Redox State
Jue Hou, Joshua Williams, Elliot L. Botvinick, Eric O. Potma and Bruce J. Tromberg
http://cancerres.aacrjournals.org/content/78/10/2503

A Novel Inhibitor of Pyruvate Dehydrogenase Kinase Stimulates Myocardial Carbohydrate Oxidation in Diet-Induced Obesity
Cheng-Yang Wu, Santhosh Satapati, Wenjun Gui, Richard M. Wynn, Gaurav Sharma, Mingliang Lou, Xiangbing Qi, Shawn C. Burgess, Craig Malloy, Chalermchai Khemtong, A. Dean Sherry, David Chuang and Matthew E. Merritt
http://www.jbc.org/content/early/2018/05/08/jbc.RA118.002838.abstract

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Reviews
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Cancer metabolism gets physical
Peter DelNero, Benjamin D. Hopkins, Lewis C. Cantley and Claudia Fischbach
http://stm.sciencemag.org/content/10/442/eaaq1011

Metabolic Hallmarks of Metastasis Formation
Ilaria Elia, Ginevra Doglioni, Sarah-Maria Fendt
https://www.sciencedirect.com/science/article/pii/S0962892418300655

Metabolic Regulation of Hypoxia-Inducible Transcription Factors: The Role of Small Molecule Metabolites and Iron
Peter S. J. Bailey and James A. Nathan
http://www.mdpi.com/2227-9059/6/2/60

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Comments
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Metabolite Depletion Affects Flux Profiling of Cell Lines
A. Nilsson, J.R. Haanstra, B. Teusink, J. Nielsen
https://www-cell-com.sire.ub.edu/trends/biochemical-sciences/fulltext/S0968-0004(18)30063-X

Metabolite regulates differentiation
Sophie Trefely, Kathryn E. Wellen
http://science.sciencemag.org/content/360/6389/603

Acetyl-CoA-directed gene transcription in cancer cells
Inmaculada Martínez-Reyes and Navdeep S. Chandel
http://genesdev.cshlp.org/content/32/7-8/463.abstract

Targeting Therapy Resistance: When Glutamine Catabolism Becomes Essential
Michael J. Lukey, William P. Katt, Richard A. Cerione
https://www-cell-com/cancer-cell/fulltext/S1535-6108(18)30180-6

Ribosomes on the night shift
Michel Nofal, Joshua D. Rabinowitz
http://science.sciencemag.org/content/360/6390/710

Dual targeting of EGFR and glutaminase in lung cancer
Milica Momcilovic & David B. Shackelford
https://www.tandfonline.com/doi/abs/10.1080/23723556.2017.1297883?journalCode=kmco20

Nutrient availability dictates the regulation of metabolism by the ribosomal protein-MDM2-p53 pathway
Derek Franklin & Yanping Zhang
https://www.tandfonline.com/doi/full/10.1080/23723556.2017.1302904

Asparagine, a critical limiting metabolite during glutamine starvation
Jie Jiang, Natalya N Pavlova & Ji Zhang
https://www.tandfonline.com/doi/full/10.1080/23723556.2018.1441633

Metabolic Regulation of Hypoxia-Inducible Transcription Factors: The Role of Small Molecule Metabolites and Iron
Peter S. J. Bailey  and James A. Nathan
http://www.mdpi.com/2227-9059/6/2/60

l-Lactate Transport and Metabolism in Mitochondria of Hep G2 Cells—The Cori Cycle Revisited
Salvatore Passarella and Avital Schurr
https://www.frontiersin.org/articles/10.3389/fonc.2018.00120/full

Pushing the Limits of Cancer Therapy: The Nutrient Game
Daniele Lettieri-Barbato and Katia Aquilano
https://www.frontiersin.org/articles/10.3389/fonc.2018.00148/full

Fructose fuels lung adenocarcinoma through GLUT5
Yuanyuan Weng, Jin Zhu, Zhenhong Chen, Jingqi Fu & Feng Zhang
https://www.nature.com/articles/s41419-018-0630-x

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