MetaboList – July 2018

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Amino acid metabolism
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Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State
Anneleen Daemen, Bonnie Liu, Kyung Song, Mandy Kwong, Min Gao, Rebecca Hong, Michelle Nannini, David Peterson, Bianca M. Liederer, Cecile de la Cruz, Dewakar Sangaraju, Allan Jaochico, Xiaofeng Zhao, Wendy Sandoval, Thomas Hunsaker, Ron Firestein, Sheerin Latham, Deepak Sampath, Marie Evangelista, Georgia Hatzivassiliou
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30385-1

Histidine catabolism is a major determinant of methotrexate sensitivity
Naama Kanarek, Heather R. Keys, Jason R. Cantor, Caroline A. Lewis, Sze Ham Chan, Tenzin Kunchok, Monther Abu-Remaileh, Elizaveta Freinkman, Lawrence D. Schweitzer & David M. Sabatini
https://www.nature.com/articles/s41586-018-0316-7

Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours
Javier Garcia-Bermudez, Lou Baudrier, Konnor La, Xiphias Ge Zhu, Justine Fidelin, Vladislav O. Sviderskiy, Thales Papagiannakopoulos, Henrik Molina, Matija Snuderl, Caroline A. Lewis, Richard L. Possemato & Kıvanç Birsoy
https://www.nature.com/articles/s41556-018-0118-z

Metabolic vulnerability of cisplatin‐resistant cancers
Florine Obrist, Judith Michels, Sylvere Durand, Alexis Chery, Jonathan Pol, Sarah Levesque, Adrien Joseph, Valentina Astesana, Federico Pietrocola, Gen Sheng Wu, Maria Castedo and Guido Kroemer
http://EMBOJ.embopress.org/content/37/14/e98597?etoc

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Glucose metabolism
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Mechanistic insights into GLUT1 activation and clustering revealed by super-resolution imaging
Qiuyan Yan, Yanting Lu, Lulu Zhou, Junling Chen, Haijiao Xu, Mingjun Cai, Yan Shi, Junguang Jiang, Wenyong Xiong, Jing Gao, and Hongda Wang
http://www.pnas.org/content/115/27/7033

MicroRNA-31-5p enhances the Warburg effect via targeting FIH
Biying Zhu, Xiuye Cao, Wenqiang Zhang, Guoping Pan, Qing Yi, Wenbin Zhong, and Daoguang Yan
https://www.fasebj.org/doi/abs/10.1096/fj.201800803R?ai=ts&ui=ly8&af=T

Protein N-glycosylation alteration and glycolysis inhibition both contribute to the antiproliferative action of 2-deoxyglucose in breast cancer cells
Audrey Berthe, Marie Zaffino, Claire Muller, François Foulquier, Marine Houdou, Céline Schulz, Frédéric Bost, Elia De Fay, Sabine Mazerbourg,  Stéphane Flament
https://link.springer.com/article/10.1007%2Fs10549-018-4874-z

Glucose promotes cell growth by suppressing branched-chain amino acid degradation
Dan Shao, Outi Villet, Zhen Zhang, Sung Won Choi, Jie Yan, Julia Ritterhoff, Haiwei Gu, Danijel Djukovic, Danos Christodoulou, Stephen C. Kolwicz Jr, Daniel Raftery & Rong Tian
https://www.nature.com/articles/s41467-018-05362-7

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Nucleotides
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Histidine catabolism is a major determinant of methotrexate sensitivity
Naama Kanarek, Heather R. Keys, Jason R. Cantor, Caroline A. Lewis, Sze Ham Chan, Tenzin Kunchok, Monther Abu-Remaileh, Elizaveta Freinkman, Lawrence D. Schweitzer & David M. Sabatini
https://www.nature.com/articles/s41586-018-0316-7

Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers
Fang Huang, Min Ni, Milind D. Chalishazar, Kenneth E. Huffman, Jiyeon Kim, Ling Cai, Xiaolei Shi, Feng Cai, Lauren G. Zacharias, Abbie S. Ireland, Kailong Li, Wen Gu, Akash K. Kaushik, Xin Liu, Adi F. Gazdar, Trudy G. Oliver, John D. Minna, Zeping Hu, Ralph J. DeBerardinis
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30387-5

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Mitochondria
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Early loss of mitochondrial complex I and rewiring of glutathione metabolism in renal oncocytoma
Raj K. Gopal, Sarah E. Calvo, Angela R. Shih, Frances L. Chaves, Declan McGuone, Eran Mick, Kerry A. Pierce, Yang Li, Andrea Garofalo, Eliezer M. Van Allen, Clary B. Clish, Esther Oliva, and Vamsi K. Mootha
http://www.pnas.org/content/115/27/E6283?etoc=

Targeting NAD+/PARP DNA Repair Pathway as a Novel Therapeutic Approach to SDHB-Mutated Cluster I Pheochromocytoma and Paraganglioma
Ying Pang, Yanxin Lu, Veronika Caisova, Yang Liu, Petra Bullova, Thanh-Truc Huynh, Yiqiang Zhou, Di Yu, Zdenek Frysak, Igor Hartmann, David Taïeb, Karel Pacak and Chunzhang Yang
http://clincancerres.aacrjournals.org/content/24/14/3423

The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer
Harvey R. Fernandez, Shreyas M. Gadre, Mingjun Tan, Garrett T. Graham, Rami Mosaoa, Martin S. Ongkeko, Kyu Ah Kim, Rebecca B. Riggins, Erika Parasido, Iacopo Petrini, Simone Pacini, Amrita Cheema, Rency Varghese, Habtom W Ressom, Yuwen Zhang, Christopher Albanese, Aykut Üren, Mikell Paige, Giuseppe Giaccone & Maria Laura Avantaggiati
https://www.nature.com/articles/s41418-018-0101-z

An inhibitor of oxidative phosphorylation exploits cancer vulnerability
Jennifer R. Molina, Yuting Sun, Marina Protopopova, Sonal Gera, Madhavi Bandi et al.  Joseph R. Marszalek
https://www.nature.com/articles/s41591-018-0052-4

Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer
Yonathan Lissanu Deribe, Yuting Sun, Christopher Terranova, Fatima Khan, Juan Martinez-Ledesma et al.[…] P. Andrew Futreal
https://www.nature.com/articles/s41591-018-0019-5

Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity
Yichong Zhang, Ji-Hoon Lee, Tanya T Paull, Sarah Gehrke, Angelo D’Alessandro, Qianhui Dou, Vadim N Gladyshev, Elizabeth A Schroeder, Samantha K Steyl, Brooke E Christian, Gerald S Shadel
http://stke.sciencemag.org/content/11/538/eaaq0702

LonP1 Differently Modulates Mitochondrial Function and Bioenergetics of Primary Versus Metastatic Colon Cancer Cells
Lara Gibellini, Lara Gibellini, Lorena Losi, Lorena Losi, Sara De Biasi, Sara De Biasi, Milena Nasi, Milena Nasi, Domenico Lo Tartaro, Domenico Lo Tartaro, Simone Pecorini, Simone Pecorini, Simone Patergnani, Simone Patergnani, Paolo Pinton, Paolo Pinton, Anna De Gaetano, Anna De Gaetano, Gianluca Carnevale, Gianluca Carnevale, Alessandra Pisciotta, Alessandra Pisciotta, Francesco Mariani, Luca Roncucci, Luca Roncucci, Anna Iannone, Anna Iannone, Andrea Cossarizza, Andrea Cossarizza, Marcello Pinti, and Marcello Pinti
https://www.frontiersin.org/articles/10.3389/fonc.2018.00254/full

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Starvation / diet
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Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells
Alicia M. Darnell, Arvind R. Subramaniam, Erin K. O’Shea
https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30516-1

Control of the polyamine biosynthesis pathway by G2-quadruplexes
Helen Louise Lightfoot, Timo Hagen, Antoine Cléry, Frédéric Hai-Trieu Allain, Jonathan Hall
https://elifesciences.org/articles/36362

Suppression of insulin feedback enhances the efficacy of PI3K inhibitors
Benjamin D. Hopkins, Chantal Pauli, Xing Du, Diana G. Wang, Xiang Li, David Wu, Solomon C. Amadiume, Marcus D. Goncalves, Cindy Hodakoski, Mark R. Lundquist, Rohan Bareja, Yan Ma, Emily M. Harris, Andrea Sboner, Himisha Beltran, Mark A. Rubin, Siddhartha Mukherjee & Lewis C. Cantley
https://www.nature.com/articles/s41586-018-0343-4

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Hypoxia
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Hypoxia-induced exosomes contribute to a more aggressive and chemoresistant ovarian cancer phenotype: a novel mechanism linking STAT3/Rab proteins
Kalpana Deepa Priya Dorayappan, Ross Wanner, John J. Wallbillich, Uksha Saini, Roman Zingarelli, Adrian A. Suarez, David E. Cohn & Karuppaiyah Selvendiran
https://www.nature.com/articles/s41388-018-0189-0

Immunosuppressive effects of hypoxia-induced glioma exosomes through myeloid-derived suppressor cells via the miR-10a/Rora and miR-21/Pten Pathways
Xiaofan Guo, Wei Qiu, Qinglin Liu, Mingyu Qian, Shaobo Wang, Zongpu Zhang, Xiao Gao, Zihang Chen, Hao Xue & Gang Li
https://www.nature.com/articles/s41388-018-0261-9

Intermittent hypoxia induces a metastatic phenotype in breast cancer
Anna Chen, Jaclyn Sceneay, Nathan Gödde, Tanja Kinwel, Sunyoung Ham, Erik W Thompson, Patrick O Humbert & Andreas Möller
https://www.nature.com/articles/s41388-018-0259-3?

Identification of a MET-eIF4G1 translational regulation axis that controls HIF-1α levels under hypoxia
Astrid A. Glück, Eleonora Orlando, Dominic Leiser, Michaela Poliaková, Lluís Nisa, Aurélie Quintin, Jacopo Gavini, Deborah M. Stroka, Sabina Berezowska, Lukas Bubendorf, Andree Blaukat, Daniel M. Aebersold, Michaela Medová & Yitzhak Zimmer
https://www.nature.com/articles/s41388-018-0256-6

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AMPK and LKB1
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LKB1 deficiency in T cells promotes the development of gastrointestinal polyposis
M C Poffenberger, A Metcalfe-Roach, E Aguilar, J Chen, B E Hsu, A H Wong, R M Johnson, B Flynn, B Samborska, E H Ma, S P Gravel, L Tonelli, L Devorkin, P Kim, A Hall, S Izreig, E Loginicheva, N Beauchemin, P M Siegel, M N Artyomov, J J Lum, G Zogopoulos, J Blagih, R G Jones
http://science.sciencemag.org/content/361/6400/406.full

AMP kinase promotes glioblastoma bioenergetics and tumour growth
Rishi Raj Chhipa, Qiang Fan, Jane Anderson, Ranjithmenon Muraleedharan, Yan Huang, Georgianne Ciraolo, Xiaoting Chen, Ronald Waclaw, Lionel M. Chow, Zaza Khuchua, Matthew Kofron, Matthew T. Weirauch, Ady Kendler, Christopher McPherson, Nancy Ratner, Ichiro Nakano, Nupur Dasgupta, Kakajan Komurov & Biplab Dasgupta
https://www.nature.com/articles/s41556-018-0126-z

IKK promotes cytokine-induced and cancer-associated AMPK activity and attenuates phenformin-induced cell death in LKB1-deficient cells
RICARDO J. ANTONIA, ALBERT S. BALDWIN
http://stke.sciencemag.org/content/11/538/eaan5850

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mTOR
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mTORC1 Upregulation Leads to Accumulation of the Oncometabolite Fumarate in a Mouse Model of Renal Cell Carcinoma
Luca Drusian, Elisa Agnese Nigro, Valeria Mannella, Roberto Pagliarini, Monika Pema, Ana S.H. Costa, Fabio Benigni, Alessandro Larcher, Marco Chiaravalli, Edoardo Gaude, Francesco Montorsi, Umberto Capitanio, Giovanna Musco, Christian Frezza, Alessandra Boletta
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31048-9

TORC1 inhibition enhances immune function and reduces infections in the elderly
Joan B. Mannick, Melody Morris, Hans-Ulrich P. Hockey, Guglielmo Roma, Martin Beibel, Kenneth Kulmatycki, Mollie Watkins1, Tea Shavlakadze1, Weihua Zhou1, Dean Quinn, David J. Glass1 and Lloyd B. Klickstein
http://stm.sciencemag.org/content/10/449/eaaq1564

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Metabolism and chromatin
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Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer
Di Wu, Di Hu, […] Yujiang Geno Shi
https://www.nature.com/articles/s41586-018-0350-5

Inflammation-induced DNA methylation of DNA polymerase gamma alters the metabolic profile of colon tumors
Ashley R. Maiuri, Hongde Li, Barry D. Stein, Jason M. Tennessen and Heather M. O’Hagan
https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-018-0182-7

α-ketoglutarate dehydrogenase inhibition counteracts breast cancer-associated lung metastasis
Sandra Atlante, Alessia Visintin, Elisabetta Marini, Matteo Savoia, Chiara Dianzani Marta Giorgis, Duran Sürün,Federica Maione, Frank Schnütgen, Antonella Farsetti, Andreas M. Zeiher, Massimo Bertinaria, Enrico Giraudo, Francesco Spallotta, Chiara Cencioni & Carlo Gaetano
https://www.nature.com/articles/s41419-018-0802-8

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Metabolic cell-cell cross-talk
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Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression
Dhruv Kumar, Jacob New, Vikalp Vishwakarma, Radhika Joshi, Jonathan Enders, Fangchen Lin, Sumana Dasari, Wade R. Gutierrez, George Leef, Sivapriya Ponnurangam, Hemantkumar Chavan, Lydia Ganaden, Mackenzie M. Thornton, Hongying Dai, Ossama Tawfik, Jeffrey Straub, Yelizaveta Shnayder, Kiran Kakarala, Terance Ted Tsue, Douglas A. Girod, Bennett Van Houten, Shrikant Anant, Partha Krishnamurthy and Sufi Mary Thomas
http://cancerres.aacrjournals.org/content/78/14/3769

Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer
Wei Li, Takashi Tanikawa, Ilona Kryczek, Houjun Xia, Gaopeng Li, Ke Wu, Shuang Wei, Lili Zhao, Linda Vatan, Bo Wen, Pan Shu, Duxin Sun, Celina Kleer, Max Wicha, Michael Sabel, Kaixiong Tao, Guobin Wang, Weiping Zou
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30306-1

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In vivo imaging
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Metabolic Imaging of the Human Brain with Hyperpolarized 13C Pyruvate Demonstrates 13C Lactate Production in Brain Tumor Patients
Vesselin Z. Miloushev, Kristin L. Granlund, Rostislav Boltyanskiy, Serge K. Lyashchenko, Lisa M. DeAngelis, Ingo K. Mellinghoff, Cameron W. Brennan, Vivian Tabar, T. Jonathan Yang, Andrei I. Holodny, Ramon E. Sosa, YanWei W. Guo, Albert P. Chen, James Tropp, Fraser Robb and Kayvan R. Keshari
http://cancerres.aacrjournals.org/content/78/14/3755

Hyperpolarized [1-13C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate Cancer In Vivo Predicts Efficacy of Targeting the Warburg Effect
Bradley T. Scroggins, Masayuki Matsuo, Ayla O. White, Keita Saito, Jeeva P. Munasinghe, Carole Sourbier, Kazutoshi Yamamoto, Vivian Diaz, Yoichi Takakusagi, Kazuhiro Ichikawa, James B. Mitchell, Murali C. Krishna and Deborah E. Citrin
http://clincancerres.aacrjournals.org/content/24/13/3137

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Miscellaneous
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Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer
Yongliang Wang, Ali R. Nasiri, William E. Damsky, Curtis J. Perry, Xian-Man Zhang, Aviva Rabin-Court, Michael N. Pollak, Gerald I. Shulman, Rachel J. Perry
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30903-3

Isocitrate dehydrogenase 1–mutated human gliomas depend on lactate and glutamate to alleviate metabolic stress
Krissie Lenting, Mohammed Khurshed, Tom H. Peeters, Corina N. A. M. van den Heuvel, Sanne A. M. van Lith, Tessa de Bitter, Wiljan Hendriks, Paul N. Span, Remco J. Molenaar, Dennis Botman, Kiek Verrijp, Arend Heerschap, Mark ter Laan, Benno Kusters, Anne van Ewijk, Martijn A. Huynen, Cornelis J. F. van Noorden, and William P. J. Leenders
https://www.fasebj.org/doi/abs/10.1096/fj.201800907RR?ai=ts&ui=ly8&af=T

Systems analysis of intracellular pH vulnerabilities for cancer therapy
Erez Persi, Miquel Duran-Frigola, Mehdi Damaghi, William R. Roush, Patrick Aloy, John L. Cleveland, Robert J. Gillies & Eytan Ruppin
https://www.nature.com/articles/s41467-018-05261-x

Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis
Ajit S. Divakaruni, Wei Yuan Hsieh, […], Steven J. Bensinger, Anne N. Murphy
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30383-8

FABP4 as a key determinant of metastatic potential of ovarian cancer
Kshipra M. Gharpure, Sunila Pradeep, […] Anil K. Sood
https://www.nature.com/articles/s41467-018-04987-y

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Reviews
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Metabolic Signaling to the Nucleus in Cancer
Sydney L. Campbell, Kathryn E. Wellen
https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30584-7

Metabolic regulation of chromatin modifications and gene expression
Juan Manuel Schvartzman, Craig B. Thompson, Lydia W.S. Finley
http://jcb.rupress.org/content/217/7/2247

The nutrient environment affects therapy
BY ALEXANDER MUIR, MATTHEW G. VANDER HEIDEN
http://science.sciencemag.org/content/360/6392

The multifaceted contributions of mitochondria to cellular metabolism
Jessica B. Spinelli & Marcia C. Haigis
https://www.nature.com/articles/s41556-018-0124-1

Unraveling the Role of Angiogenesis in Cancer Ecosystems
Iratxe Zuazo-Gaztelu, and Oriol Casanovas
https://www.frontiersin.org/articles/10.3389/fonc.2018.00248/full

Mitochondrial dynamics in adaptive and maladaptive cellular stress responses
Verónica Eisner, Martin Picard & György Hajnóczky
https://www.nature.com/articles/s41556-018-0133-0

NRF2 and the Hallmarks of Cancer
Montserrat Rojo de la Vega, Eli Chapman, Donna D. Zhang
https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30127-2

Modulation of the secretory pathway by amino-acid starvation
Wessel van Leeuwen, Felix van der Krift, Catherine Rabouille
http://jcb.rupress.org/content/217/7/2261

Glutathione metabolism in cancer progression and treatment resistance
Ankita Bansal, M. Celeste Simon
http://jcb.rupress.org/content/217/7/2291

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Comments / other
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Histidine metabolism boosts cancer therapy
Christian Frezza
https://www.nature.com/articles/d41586-018-05573-4

Pro-tumorigenic AMPK in glioblastoma
Nektaria Maria Leli & Constantinos Koumenis
https://www.nature.com/articles/s41556-018-0129-9

Periodic fasting starves cisplatin‐resistant cancers to death
Novella Guidi and Valter D Longo
http://EMBOJ.embopress.org/content/37/14/e99815?etoc

Grasping for aspartate in tumour metabolism
Accalia Fu & Nika N. Danial
https://www.nature.com/articles/s41556-018-0137-9

A Glycolysis Outsider Steps into the Cancer Spotlight
Marcus D. Goncalves, Lewis C. Cantley
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30399-1

Spoon-Feeding Ribosomes to Autophagy
Hitoshi Nakatogawa
https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30550-1

BNIP3L/NIX-dependent mitophagy regulates cell differentiation via metabolic reprogramming
Lorena Esteban-Martínez & Patricia Boya
https://www.tandfonline.com/doi/full/10.1080/15548627.2017.1332567

How to eliminate MYCN-positive hepatic cancer stem cells to prevent the recurrence?
Go J. Yoshida – http://www.pnas.org/content/115/28/E6388?etoc=
Reply to Yoshida: Liver cancer stem cells: Identification and lipid metabolic reprogramming
Xian-Yang Qin, Naoshi Dohmae, and Soichi Kojima – http://www.pnas.org/content/115/28/E6390?etoc=

Q & A – Karen Vousden
https://www.cell.com/current-biology/fulltext/S0960-9822(18)30675-4

Finding clues in the p53 maze: an interview with Karen Vousden
http://dmm.biologists.org/content/11/8/dmm035675

Erika Pearce: Fitting metabolism and immunity together, to a T
http://jcb.rupress.org/content/217/7/2223

Jerry Chipuk: A powerhouse for mitochondrial biology
http://jcb.rupress.org/content/early/2018/07/09/jcb.201807034

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