MetaboList – August 2018

 


Glucose metabolism / Lactate


Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies – Maria Apicella, Elisa Giannoni, Stephany Fiore, Karin Johanna Ferrari, Daniel Fernández-Pérez, Claudio Isella, Carlotta Granchi, Filippo Minutolo, Antonino Sottile, Paolo Maria Comoglio, Enzo Medico, Filippo Pietrantonio, Marco Volante, Diego Pasini, Paola Chiarugi, Silvia Giordano, Simona Corso. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30507-2

Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo – Kevin D. Courtney, Divya Bezwada, Tomoyuki Mashimo, Kumar Pichumani, Vamsidhara Vemireddy, Alexander M. Funk, Jennifer Wimberly, Sarah S. McNeil, Payal Kapur, Yair Lotan, Vitaly Margulis, Jeffrey A. Cadeddu, Ivan Pedrosa, Ralph J. DeBerardinis, Craig R. Malloy, Robert M. Bachoo, Elizabeth A. Maher. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30463-7

Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis – Marion Curtis, Hilary A. Kenny, Bradley Ashcroft, Abir Mukherjee, Alyssa Johnson, Yilin Zhang, Ynes Helou, Raquel Batlle, Xiaojing Liu, Nuria Gutierrez, Xia Gao, S. Diane Yamada, Ricardo Lastra, Anthony Montag, Nagib Ahsan, Jason W. Locasale, Arthur R. Salomon, Angel R. Nebreda, Ernst Lengyel. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30508-4

Double genetic disruption of lactate dehydrogenase A and B is required to ablate the ‘Warburg effect’ restricting tumor growth to oxidative metabolism – Maša Ždralević, Almut Brand, Lorenza Di Ianni, Katja Dettmer, Jörg Reinders, Katrin Singer, Katrin Peter, Annette Schnell, Christina Bruss, Sonja-Maria Decking, Gudrun Koehl, Blanca Felipe-Abrio, Jérôme Durivault, Pascale Bayer, Marie Evangelista, Thomas O’Brien, Peter J. Oefner, Kathrin Renner, Jacques Pouysségur and Marina Kreutz. http://www.jbc.org/content/early/2018/08/28/jbc.RA118.004180.abstract

GAPDH with NAD+-binding site mutation competitively inhibits the wild-type and affects glucose metabolism in cancer – Kunjithapatham R, Ganapathy-Kanniappan S. https://www.sciencedirect.com/science/article/pii/S0304416518302423?via%3Dihub

O-GlcNAcylation Signal Mediates Proteasome Inhibitor Resistance in Cancer Cells by Stabilizing NRF1 – Hiroki Sekine, Keito Okazaki, Koichiro Kato, M. Morshedul Alam, Hiroki Shima, Fumiki Katsuoka, Tadayuki Tsujita, Norio Suzuki, Akira Kobayashi, Kazuhiko Igarashi, Masayuki Yamamoto, Hozumi Motohashi. https://mcb.asm.org/content/38/17/e00252-18


Amino acid metabolism


Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting – Furkan Alkan, Katharina E. Walter, Alba Luengo, Corina T. Madreiter-Sokolowski, Sarah Stryeck, Allison N. Lau, Wael Al-Zoughbi, Caroline A. Lewis, Craig J. Thomas, Gerald Hoefler, Wolfgang F. Graier, Tobias Madl, Matthew G. Vander Heiden, Juliane G. Bogner-Strauss. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30464-9

A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3 – Mylène Tajan, Andreas K. Hock, Julianna Blagih, Neil A. Robertson, Christiaan F. Labuschagne, Flore Kruiswijk, Timothy J. Humpton, Peter D. Adams, Karen H. Vousden. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30448-0

Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response – Akito Nakamura, Tadahiro Nambu, Shunsuke Ebara, Yuka Hasegawa, Kosei Toyoshima, Yasuko Tsuchiya, Daisuke Tomita, Jun Fujimoto, Osamu Kurasawa, Chisato Takahara, Ayumi Ando, Ryuichi Nishigaki, Yoshinori Satomi, Akito Hata, and Takahito Hara. http://www.pnas.org/content/115/33/E7776

Role of glutamine synthetase in angiogenesis beyond glutamine synthesis – Guy Eelen, Charlotte Dubois, […] Peter Carmeliet. https://www.nature.com/articles/s41586-018-0466-7

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc – Activity – Xinxin Song, Shan Zhu, Pan Chen, Wen Hou, Qirong Wen, Jiao Liu, Yangchun Xie, Jinbao Liu, Daniel J. Klionsky, Guido Kroemer, Michael T. Lotze, Herbert J. Zeh, Rui Kang, Daolin Tang. https://www.cell.com/current-biology/fulltext/S0960-9822(18)30764-4

CARM1 suppresses de novo serine synthesis by promoting PKM2 activity – Tharindumala Abeywardana, Myungeun Oh, Lei Jiang, Ying Yang, Mei Kong, Jikui Song and Yanzhong Yang. http://www.jbc.org/content/early/2018/08/21/jbc.RA118.004512.abstract

The NAD+ Salvage Pathway Supports PHGDH-Driven Serine Biosynthesis – Patrick Murphy, Michael A. Giacomantonio, Joao A. Paulo, Robert A. Everley, Barry E. Kennedy, Gopal P. Pathak, Derek R. Clements, Youra Kim, Cathleen Dai, Tanveer Sharif, Steven P. Gygi, Shashi Gujar. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31219-1

Increased glutamine anabolism sensitizes non-small cell lung cancer to gefitinib treatment – Liang Wang, Wen Peng, Tianming Wu, Pengchi Deng & Ying-Lan Zhao. https://www.nature.com/articles/s41420-018-0086-x


Lipid metabolism


Adipocyte-Derived Lipids Mediate Melanoma Progression via FATP Proteins – Maomao Zhang, Julie S. Di Martino, Robert L. Bowman, Nathaniel R. Campbell, Sanjeethan C. Baksh, Theresa Simon-Vermot, Isabella S. Kim, Pearce Haldeman, Chandrani Mondal, Vladimir Yong-Gonzales, Mohsen Abu-Akeel, Taha Merghoub, Drew R. Jones, Xiphias Ge Zhu, Arshi Arora, Charlotte E. Ariyan, Kivanç Birsoy, Jedd D. Wolchok, Katherine S. Panageas, Travis Hollmann, Jose Javier Bravo-Cordero and Richard M. White. http://cancerdiscovery.aacrjournals.org/content/8/8/1006

Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation – Ulrike Bruning, Francisco Morales-Rodriguez, Joanna Kalucka, Jermaine Goveia, Federico Taverna, Karla C.S. Queiroz, Charlotte Dubois, Anna Rita Cantelmo, Rongyuan Chen, Stefan Loroch, Evy Timmerman, Vanessa Caixeta, Katarzyna Bloch, Lena-Christin Conradi, Lucas Treps, An Staes, Kris Gevaert, Andrew Tee, Mieke Dewerchin, Clay F. Semenkovich, Francis Impens, Birgit Schilling, Eric Verdin, Johannes V. Swinnen, Jordan L. Meier, Rhushikesh A. Kulkarni, Albert Sickmann, Bart Ghesquière, Luc Schoonjans, Xuri Li, Massimiliano Mazzone, Peter Carmeliet. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30462-5

Heterogeneity of fatty acid metabolism in breast cancer cells underlies differential sensitivity to palmitate‐induced apoptosis – Seher Balaban Lisa S Lee Bianca Varney Atqiya Aishah Quanqing Gao Robert F Shearer Darren N Saunders Thomas Grewal Andrew J. Hoy. https://febs.onlinelibrary.wiley.com/doi/abs/10.1002/1878-0261.12368

Fatostatin induces pro- and anti-apoptotic lipid accumulation in breast cancer – Viktor Brovkovych, Yasir Izhar, Jeanne M. Danes, Oleskii Dubrovskyi, Isin T. Sakallioglu, Lauren M. Morrow, G. Ekin Atilla-Gokcumen & Jonna Frasor. https://www.nature.com/articles/s41389-018-0076-0

Inhibition of cholesterol biosynthesis overcomes enzalutamide resistance in castration-resistant prostate cancer (CRPC) – Yifan Kong, Lijun Cheng, Fengyi Mao, Zhuangzhuang Zhang, Yanquan Zhang, Elia Farah, Jacob Bosler, Yunfeng Bai, Nihal Ahmad, Shihuan Kuang, Lang Li and Xiaoqi Liu. http://www.jbc.org/content/early/2018/08/08/jbc.RA118.004442.abstract


Nucleotides


Metabolomic profiling of human lung tumor tissues: nucleotide metabolism as a candidate for therapeutic interventions and biomarkers – Paula Moreno, Carla Jiménez‐Jiménez, Martín Garrido‐Rodríguez, Mónica Calderón‐Santiago, Susana Molina, Maribel Lara‐Chica, Feliciano Priego‐Capote, Ángel Salvatierra, Eduardo Muñoz, Marco A Calzado. https://febs.onlinelibrary.wiley.com/doi/abs/10.1002/1878-0261.12369


Mitochondria


Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway – Kiran Kurmi, Sadae Hitosugi, Jia Yu, Felix Boakye-Agyeman, Elizabeth K. Wiese, Thomas R. Larson, Qing Dai, Yuichi J. Machida, Zhenkun Lou, Liewei Wang, Judy C. Boughey, Scott H. Kaufmann, Matthew P. Goetz, Larry M. Karnitz, Taro Hitosugi. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30507-2

The Metabolomic Bioenergetic Signature of Opa1-Disrupted Mouse Embryonic Fibroblasts Highlights Aspartate Deficiency – Bocca C, Kane MS, Veyrat-Durebex C, Chupin S, Alban J, Kouassi Nzoughet J, Le Mao M, Chao de la Barca JM, Amati-Bonneau P, Bonneau D, Procaccio V, Lenaers G, Simard G, Chevrollier A, Reynier P. https://www.nature.com/articles/s41598-018-29972-9

p53-inducible DPYSL4 associates with mitochondrial supercomplexes and regulates energy metabolism in adipocytes and cancer cells – Hidekazu Nagano, Naoko Hashimoto, Akitoshi Nakayama, Sawako Suzuki, Yui Miyabayashi, Azusa Yamato, Seiichiro Higuchi, Masanori Fujimoto, Ikki Sakuma, Minako Beppu, Masataka Yokoyama, Yutaka Suzuki, Sumio Sugano, Kazuhiro Ikeda, Ichiro Tatsuno, Ichiro Manabe, Koutaro Yokote, Satoshi Inoue, and Tomoaki Tanaka. http://www.pnas.org/content/115/33/8370?etoc

ACP Acylation Is an Acetyl-CoA-Dependent Modification Required for Electron Transport Chain Assembly – Jonathan G. Van Vranken, Sara M. Nowinski, Katie J. Clowers, Mi-Young Jeong, Yeyun Ouyang, Jordan A. Berg, Jeremy P. Gygi, Steven P. Gygi, Dennis R. Winge, Jared Rutter. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30514-8

Mitochondria-targeted drugs stimulate mitophagy and abrogate colon cancer cell proliferation – Kathleen A. Boyle, Jonathan Van Wickle, R. Blake Hill, Adriano Marchese, Balaraman Kalyanaraman and Michael B. Dwinell. http://www.jbc.org/content/early/2018/08/07/jbc.RA117.001469.abstract

Mitochondrial Complex I Activity Is Required for Maximal Autophagy – Hala Elnakat Thomas, Yu Zhang, Jonathan A. Stefely, Sonia R. Veiga, George Thomas, Sara C. Kozma, Carol A. Mercer. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31234-8?

Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity – Caroline Giessner, Virginie Millet, Konrad J Mostert, Thomas Gensollen, Thien-Phong Vu Manh, Marc Garibal, Binta Dieme, Noudjoud Attaf-Bouabdallah, Lionel Chasson, Nicolas Brouilly, Caroline Laprie, Tom Lesluyes, Jean Yves Blay, Laetitia Shintu, Jean Charles Martin, Erick Strauss, Franck Galland, Philippe Naquet. http://www.life-science-alliance.org/content/1/4/e201800073


Starvation / nutrient sensing


The UPR Activator ATF6 Responds to Proteotoxic and Lipotoxic Stress by Distinct Mechanisms – Arvin B. Tam, Lindsay S. Roberts, Vivek Chandra, Io Guane Rivera, Daniel K. Nomura, Douglass J. Forbes, Maho Niwa. https://www.cell.com/developmental-cell/fulltext/S1534-5807(18)30329-0

Nutrient Deprivation Elicits a Transcriptional and Translational Inflammatory Response Coupled to Decreased Protein Synthesis – Paulo A. Gameiro, Kevin Struhl. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31111-2

A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase–Ragulator lysosomal scaffold – Rosalie E. Lawrence, Kelvin F. Cho, Ronja Rappold, Anna Thrun, Marie Tofaute. https://www.nature.com/articles/s41556-018-0148-6

Feedback regulation of TORC1 by its downstream effectors Npr1 and Par33 – Natalia V. Varlakhanova, Bryan A. Tornabene, and Marijn G. J. Ford. https://www.molbiolcell.org/doi/10.1091/mbc.E18-03-0158?ai=25zg&ui=2oy6&af=T

Cholesterol depletion enhances TGF-β Smad signaling by increasing c-Jun expression through a PKR-dependent mechanism – Keren E. Shapira, Marcelo Ehrlichand, Yoav I. Henis. https://www.molbiolcell.org/doi/10.1091/mbc.E18-03-0175?ai=25zg&ui=2oy6&af=T


Cancer immunometabolism


Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1 – Jong-Ho Cha, Wen-Hao Yang, Weiya Xia, Yongkun Wei, Li-Chuan Chan, Seung-Oe Lim, Chia-Wei Li, Taewan Kim, Shih-Shin Chang, Heng-Huan Lee, Jennifer L. Hsu, Hung-Ling Wang, Chu-Wei Kuo, Wei-Chao Chang, Sirwan Hadad, Colin A. Purdie, Aaron M. McCoy, Shirong Cai, Yizheng Tu, Jennifer K. Litton, Elizabeth A. Mittendorf, Stacy L. Moulder, William F. Symmans, Alastair M. Thompson, Helen Piwnica-Worms, Chung-Hsuan Chen, Kay-Hooi Khoo, Mien-Chie Hung. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30599-9

Hexokinase 2 is dispensable for T cell-dependent immunity – Manan M. Mehta, Samuel E. Weinberg, Elizabeth M. Steinert, Krishan Chhiba, Carlos Alberto Martinez, Peng Gao, Harris R. Perlman, Paul Bryce, Nissim Hay and Navdeep S. Chandel. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-018-0184-5

Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α-Dependent Intensification of Oxidative Stress and Tumor Cell Death – Tsadik Habtetsion, Zhi-Chun Ding, Wenhu Pi, Tao Li, Chunwan Lu, Tingting Chen, Caixia Xi, Helena Spartz, Kebin Liu, Zhonglin Hao, Nahid Mivechi, Yuqing Huo, Bruce R. Blazar, David H. Munn, Gang Zhou. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30319-X

Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression – Jingjing Cong, Xianwei Wang, Xiaohu Zheng, Dong Wang, Binqing Fu, Rui Sun, Zhigang Tian, Haiming Wei. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30443-1


Miscellaneous


Myc and ChREBP Transcription Factors Cooperatively Regulate Normal and Neoplastic Hepatocyte Proliferation in Mice – Huabo Wang, James M. Dolezal, Sucheta Kulkarni, Jie Lu, Jordan Mandel, Laura E. Jackson, Frances Alencastro, Andrew W. Duncan and Edward V. Prochownik. http://www.jbc.org/content/early/2018/08/07/jbc.RA118.004099.abstract

Metabolic reprogramming of acute lymphoblastic leukemia cells in response to glucocorticoid treatment – Matheus Dyczynski, Mattias Vesterlund, Ann-Charlotte Björklund, Vasilios Zachariadis, Jerry Janssen, Hector Gallart-Ayala, Evangelia Daskalaki, Craig E. Wheelock, Janne Lehtiö, Dan Grandér, Katja Pokrovskaja Tamm, Roland Nilsson. https://www.nature.com/articles/s41419-018-0625-7

Clonal heterogeneity of acute myeloid leukemia treated with the IDH2 inhibitor enasidenib – Lynn Quek, Muriel D. David, […] Paresh Vyas. https://www.nature.com/articles/s41591-018-0115-6

Circulating Adipose Fatty Acid Binding Protein Is a New Link Underlying Obesity-Associated Breast/Mammary Tumor Development – Jiaqing Hao, Yuwen Zhang, Xiaofang Yan, Fei Yan, Yanwen Sun, Jun Zeng, Sabine Waigel, Yanhui Yin, Mostafa M. Fraig, Nejat K. Egilmez, Jill Suttles, Maiying Kong, Shujun Liu, Margot P. Cleary, Edward Sauter, Bing Li. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30449-2


Reviews


Biological Role and Therapeutic Potential of IDH Mutations in Cancer – Matthew S. Waitkus, Bill H. Diplas, Hai Yan. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30182-X

No Parkin Zone: Mitophagy without Parkin – Elodie Villa, Sandrine Marchetti, Jean-Ehrland Ricci. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(18)30125-9

Translating In Vitro T Cell Metabolic Findings to In VivoTumor Models of Nutrient Competition – Christopher Ecker and James L. Riley. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30452-2?dgcid=raven_jbs_etoc_email

The different axes of the mammalian mitochondrial unfolded protein response – Christian Münch. https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-018-0548-x

RAS signalling in energy metabolism and rare human diseases – Dard, N. Bellance, D. Lacombe, R. Rossignol. https://www.sciencedirect.com/science/article/pii/S0005272818301063

Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies – Alexander Muir, Laura V. Danai, Matthew G. Vander Heiden. http://dmm.biologists.org/content/11/8/dmm035758

Regulation of chromatin and gene expression by metabolic enzymes and metabolites – Xinjian Li, Gabor Egervari, Yugang Wang, Shelley L. Berger & Zhimin Lu. https://www.nature.com/articles/s41580-018-0029-7

Perspectives on IDH Mutation in Diffuse Gliomas – Yu-Ting Su, Funita P. Phan, Jing Wu. https://www.cell.com/trends/cancer/fulltext/S2405-8033(18)30152-3

Interplay between YAP/TAZ and Metabolism – Ja Hyun Koo, Kun-Liang Guan. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30453-4

Microenvironmental control of glucose metabolism in tumors by regulation of pyruvate dehydrogenase – Tereza Golias, Martin Kery, Silvia Radenkovic, Ioanna Papandreou. https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.31812#.W3pybxmKn0k.twitter

Metabolic Plasticity of Tumor Cell Mitochondria – Giuseppe Cannino, Francesco Ciscato, Ionica Masgras, Carlos Sánchez-Martín, and Andrea Rasola. https://www.frontiersin.org/articles/10.3389/fonc.2018.00333/full

Understanding lymphocyte metabolism for use in cancer immunotherapy – Sarah MacPherson, Marisa Kilgour, Julian J. Lum. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14454

The big picture: exploring the metabolic cross-talk in cancer – Almut Schulze, Mariia Yuneva. http://dmm.biologists.org/content/11/8/dmm036673


Comments


Lysosomal catch-and-release controls mTORC1 – Aaron M. Hosios & Brendan D. Manning. https://www.nature.com/articles/s41556-018-0188-y

ERADicate Tumor Progression with Metformin – Lena-Sophie Dreher, Thorsten Hoppe. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30635-X

An OXPHOS Inhibitor Has Antitumor Activity in Multiple Tumor Models http://cancerdiscovery.aacrjournals.org/content/8/8/OF13

Second-Site IDH2 Mutations Confer Resistance to Enasidenib In Trans http://cancerdiscovery.aacrjournals.org/content/8/8/913.2

Starving cancer cells to death: Cisplatin-resistant cancer cells are particularly susceptible to starvation-induced death. http://stke.sciencemag.org/content/11/542/eaau9719

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