MetaboList – September 2018

 


Glucose metabolism/glycolytic enzymes


Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization – William J. Sullivan, Peter J. Mullen, Ernst W. Schmid, Aimee Flores, Milica Momcilovic, Mark S. Sharpley, David Jelinek, Andrew E. Whiteley, Matthew B. Maxwell, Blake R. Wilde, Utpal Banerjee, Hilary A. Coller, David B. Shackelford, Daniel Braas, Donald E. Ayer, Thomas Q. de Aguiar Vallim, William E. Lowry, Heather R. Christofk. https://www.cell.com/cell/fulltext/S0092-8674(18)31033-X

GAPDH inhibits intracellular pathways during starvation for cellular energy homeostasis – Jia-Shu Yang, Jia-Wei Hsu, Seung-Yeol Park, Jian Li, William M. Oldham, Galina V. Beznoussenko, Alexander A. Mironov, Joseph Loscalzo & Victor W. Hsu. https://www.nature.com/articles/s41586-018-0475-6

CARM1 Methylates GAPDH to Regulate Glucose Metabolism and Is Suppressed in Liver Cancer – Xing-Yu Zhong, Xiu-Ming Yuan, Ying-Ying Xu, Miao Yin, Wei-Wei Yan, Shao-Wu Zou, Li-Ming Wei, Hao-Jie Lu, Yi-Ping Wang, Qun-Ying Lei. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31370-6

Ras Suppresses TXNIP Expression by Restricting Ribosome Translocation – Zhizhou Ye, Donald E. Ayer. https://mcb.asm.org/content/38/20/e00178-18?etoc

LncRNA–FEZF1-AS1 Promotes Tumor Proliferation and Metastasis in Colorectal Cancer by Regulating PKM2 Signaling – Zehua Bian, Jiwei Zhang, Min Li, Yuyang Feng, Xue Wang, Jia Zhang, Surui Yao, Guoying Jin, Jun Du, Weifeng Han, Yuan Yin, Shenglin Huang, Bojian Fei, Jian Zou and Zhaohui Huang. http://clincancerres.aacrjournals.org/content/24/19/4808

Metabolic Imaging Detects Low Levels of Glycolytic Activity That Vary with Levels of c-Myc Expression in Patient-Derived Xenograft Models of Glioblastoma – Richard Mair, Alan J. Wright, Susana Ros, De-en Hu, Tom Booth, Felix Kreis, Jyotsna Rao, Colin Watts and Kevin M. Brindle. http://cancerres.aacrjournals.org/content/78/18/5408

Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination – Nina M. S. Gustafsson, Katarina Färnegårdh, Nadilly Bonagas, Anna Huguet Ninou, Petra Groth, Elisee Wiita, Mattias Jönsson, Kenth Hallberg, Jemina Lehto, Rosa Pennisi, Jessica Martinsson, Carina Norström, Jessica Hollers, Johan Schultz, Martin Andersson, Natalia Markova, Petra Marttila, Baek Kim, Martin Norin, Thomas Olin & Thomas Helleday. https://www.nature.com/articles/s41467-018-06287-x

Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer – Wei Li, Takashi Tanikawa, Ilona Kryczek, Houjun Xia, Gaopeng Li, Ke Wu, Shuang Wei, Lili Zhao, Linda Vatan, Bo Wen, Pan Shu, Duxin Sun, Celina Kleer, Max Wicha, Michael Sabel, Kaixiong Tao, Guobin Wang, Weiping Zou. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30306-1


Nucleotides


Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures – Joo Sang Lee, Lital Adler, Hiren Karathia, Narin Carmel, Shiran Rabinovich, Noam Auslander, Rom Keshet, Noa Stettner, Alon Silberman, Lilach Agemy, Daniel Helbling, Raya Eilam, Qin Sun, Alexander Brandis, Sergey Malitsky, Maxim Itkin, Hila Weiss, Sivan Pinto, Shelly Kalaora, Ronen Levy, Eilon Barnea, Arie Admon, David Dimmock, Noam Stern-Ginossar, Avigdor Scherz, Sandesh C.S. Nagamani, Miguel Unda, David M. Wilson III, Ronit Elhasid, Arkaitz Carracedo, Yardena Samuels, Sridhar Hannenhalli, Eytan Ruppin, Ayelet Erez. https://www.cell.com/cell/fulltext/S0092-8674(18)30913-9

Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers – Fang Huang, Min Ni, Milind D. Chalishazar, Kenneth E. Huffman, Jiyeon Kim, Ling Cai, Xiaolei Shi, Feng Cai, Lauren G. Zacharias, Abbie S. Ireland, Kailong Li, Wen Gu, Akash K. Kaushik, Xin Liu, Adi F. Gazdar, Trudy G. Oliver, John D. Minna, Zeping Hu, Ralph J. DeBerardinis. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30387-5

Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase – Wei-Cheng Lin, Archan Chakraborty, Shih-Chia Huang, Pei-Yu Wang, Ya-Ju Hsieh, Kun-Yi Chien, Yen-Hsien Lee, Chia-Chun Chang, Hsiang-Yu Tang, Yu-Tsun Lin, Chang-Shung Tung, Ji-Dung Luo, Ting-Wen Chen, Tzu-Yang Lin, Mei-Ling Cheng, Yi-Ting Chen, Chau-Ting Yeh, Ji-Long Liu, Li-Ying Sung, Ming-Shi Shiao, Jau-Song Yu, Yu-Sun Chang, Li-Mei Pai. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31261-0

Protein interaction and functional data indicate MTHFD2 involvement in RNA processing and translation – Costas Koufaris and Roland Nilsson. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-018-0185-4


Amino acid metabolism


Role of glutamine synthetase in angiogenesis beyond glutamine synthesis – Guy Eelen, Charlotte Dubois, Anna Rita Cantelmo, Jermaine Goveia, Ulrike Brüning, Michael DeRan, Gopala Jarugumilli, Jos van Rijssel, Giorgio Saladino, Federico Comitani, Annalisa Zecchin, Susana Rocha, Rongyuan Chen, Hongling Huang, Saar Vandekeere, Joanna Kalucka, Christian Lange, Francisco Morales-Rodriguez, Bert Cruys, Lucas Treps, Leanne Ramer, Stefan Vinckier, Katleen Brepoels, Sabine Wyns, Joris Souffreau, Luc Schoonjans, Wouter H. Lamers, Yi Wu, Jurgen Haustraete, Johan Hofkens, Sandra Liekens, Richard Cubbon, Bart Ghesquière, Mieke Dewerchin, Francesco L. Gervasio, Xuri Li, Jaap D. van Buul, Xu Wu & Peter Carmeliet. https://www.nature.com/articles/s41586-018-0466-7

Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes – Constantinos Alexandrou, Saif Sattar Al-Aqbi, Jennifer A. Higgins, William Boyle, Ankur Karmokar, Catherine Andreadi, Jin-Li Luo, David A. Moore, Maria Viskaduraki, Matthew Blades, Graeme I. Murray, Lynne M. Howells, Anne Thomas, Karen Brown, Paul N. Cheng & Alessandro Rufini. https://www.nature.com/articles/s41598-018-30591-7

xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression – Xiangming Ji, Jun Qian, S. M. Jamshedur Rahman, Peter J. Siska, Yong Zou, Bradford K. Harris, Megan D. Hoeksema, Irina A. Trenary, Chen Heidi, Rosana Eisenberg, Jeffrey C. Rathmell, Jamey D. Young & Pierre P. Massion. https://www.nature.com/articles/s41388-018-0307-z

Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation – Gaojian Lian, JN Rashida Gnanaprakasam, Tingting Wang, Ruohan Wu, Xuyong Chen, Lingling Liu, Yuqing Shen, Mao Yang, Jun Yang, Ying Chen, Vasilis Vasiliou, Teresa A Cassel, Douglas R Green, Yusen Liu, Teresa WM Fan, Ruoning Wang. https://elifesciences.org/articles/36158

Glutamate-Weighted Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Detects Glutaminase Inhibition in a Mouse Model of Triple-Negative Breast Cancer – Rong Zhou, Puneet Bagga, Kavindra Nath, Hari Hariharan, David A. Mankoff and Ravinder Reddy. http://cancerres.aacrjournals.org/content/78/19/5521


Redox metabolism/sensing


Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma – Samuel K. McBrayer, Jared R. Mayers, Gabriel J. DiNatale, Diana D. Shi, Januka Khanal, Abhishek A. Chakraborty, Kristopher A. Sarosiek, Kimberly J. Briggs, Alissa K. Robbins, Tomasz Sewastianik, Sarah J. Shareef, Benjamin A. Olenchock, Seth J. Parker, Kensuke Tateishi, Jessica B. Spinelli, Mirazul Islam, Marcia C. Haigis, Ryan E. Looper, Keith L. Ligon, Bradley E. Bernstein, Ruben D. Carrasco, Daniel P. Cahill, John M. Asara, Christian M. Metallo, Neela H. Yennawar, Matthew G. Vander Heiden, William G. Kaelin Jr. https://www.cell.com/cell/fulltext/S0092-8674(18)31099-7

Targeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling – Ming Luo, Li Shang, Michael D. Brooks, Evelyn Jiagge, Yongyou Zhu, Johanna M. Buschhaus, Sarah Conley, Melissa A. Fath, April Davis, Elizabeth Gheordunescu, Yongfang Wang, Ramdane Harouaka, Ann Lozier, Daniel Triner, Sean McDermott, Sofia D. Merajver, Gary D. Luker, Douglas R. Spitz, Max S. Wicha. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30388-7

Redox regulation of type-I inositol trisphosphate receptors in intact mammalian cells – Suresh K. Joseph, Michael Young, Kamil Alzayady, David I. Yule, Mehboob Ali, David M. Booth and György Hajnóczky. http://www.jbc.org/content/early/2018/09/18/jbc.RA118.005624.abstract

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly – Elizabeth C Hinchy, Anja V. Gruszczyk, Robin Willows, Naveenan Navaratnam, Andrew R. Hall, Georgina Bates, Thomas P Bright, Thomas Krieg, David Carling and Michael P. Murphy. http://www.jbc.org/content/early/2018/09/19/jbc.RA118.002579.abstract


Lipid metabolism


Triglycerides Promote Lipid Homeostasis during Hypoxic Stress by Balancing Fatty Acid Saturation – Daniel Ackerman, Sergey Tumanov, Bo Qiu, Evdokia Michalopoulou, Michelle Spata, Andrew Azzam, Hong Xie, M. Celeste Simon, Jurre J. Kamphorst. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31269-5

Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy – Talebi A, Dehairs J, Rambow F, Rogiers A, Nittner D, Derua R, Vanderhoydonc F, Duarte JAG, Bosisio F, Van den Eynde K, Nys K, Pérez MV, Agostinis P, Waelkens E, Van den Oord J, Fendt SM, Marine JC, Swinnen JV. https://www.nature.com/articles/s41467-018-04664-0

Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance – Hideki Iwamoto, Mitsuhiko Abe, Yunlong Yang, Dongmei Cui, Takahiro Seki, Masaki Nakamura, Kayoko Hosaka, Sharon Lim, Jieyu Wu, Xingkang He, Xiaoting Sun, Yongtian Lu, Qingjun Zhou, Weiyun Shi, Takuji Torimura, Guohui Nie, Qi Li, Yihai Cao. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30312-7

Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis – Kalucka J, Bierhansl L, Conchinha NV, Missiaen R, Elia I, Brüning U, Scheinok S, Treps L, Cantelmo AR, Dubois C, de Zeeuw P,  Goveia J, Zecchin A, Taverna F, Morales-Rodriguez F, Brajic A, Conradi LC, Schoors S, Harjes U, Vriens K, Pilz GA, Chen R, Cubbon R, Thienpont B, Cruys B, Wong BW, Ghesquière B, Dewerchin M, De Bock K, Sagaert X, Jessberger S, Jones EAV, Gallez B, Lambrechts D, Mazzone M, Eelen G, Li X, Fendt SM, Carmeliet P. https://www.sciencedirect.com/science/article/pii/S1550413118304595

Canonical Wnt Signaling Remodels Lipid Metabolism in Zebrafish Hepatocytes following Ras Oncogenic Insult – Yuxiao Yao, Shaoyang Sun, Jingjing Wang, Fei Fei, Zhaoru Dong, Ai-Wu Ke, Ruoyu He, Lei Wang, Lili Zhang, Min-Biao Ji, Qiang Li, Min Yu, Guo-Ming Shi, Jia Fan, Zhiyuan Gong and Xu Wang. http://cancerres.aacrjournals.org/content/78/19/5548


Mitochondria/fumarate


Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer – Young Kyuen Im, Ouafa Najyb, Simon-Pierre Gravel, Shawn McGuirk, Ryuhjin Ahn, Daina Z. Avizonis, Valérie Chénard, Valerie Sabourin, Jesse Hudson, Tony Pawson, Ivan Topisirovic, Michael Pollak, Julie St-Pierre and Josie Ursini-Siegel. http://cancerres.aacrjournals.org/content/78/17/4826

Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway – Kiran Kurmi, Sadae Hitosugi, Jia Yu, Felix Boakye-Agyeman, Elizabeth K. Wiese, Thomas R. Larson, Qing Dai, Yuichi J. Machida, Zhenkun Lou, Liewei Wang, Judy C. Boughey, Scott H. Kaufmann, Matthew P. Goetz, Larry M. Karnitz, Taro Hitosugi. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30509-6

Fumarate hydratase loss promotes mitotic entry in the presence of DNA damage after ionising radiation – Timothy I. Johnson, Ana S. H. Costa, Ashley N. Ferguson & Christian Frezza. https://www.nature.com/articles/s41419-018-0912-3


Starvation


Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase – Rana J. T. Al-Baghdadi, Inna A. Nikonorova, Emily T. Mirek, Yongping Wang, Jinhee Park, William J. Belden, Ronald C. Wek & Tracy G. Anthony. https://www.nature.com/articles/s41598-017-01041-7

Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy – Seda Avcioglu Barutcu, Nomeda Girnius, Santiago Vernia & Roger J. Davis. https://www.tandfonline.com/doi/full/10.1080/15548627.2018.1466013

Autophagic reliance promotes metabolic reprogramming in oncogenic KRAS-driven tumorigenesis – Helen Lin, Yiyin Chung, Chun-Ting Cheng, Ching Ouyang, Yong Fu, Ching-Ying Kuo, Kevin K. Chi, Maryam Sadeghi, Peiguo Chu, Hsing-Jien Kung, Chien-Feng Li, Kirsten H. Limesand & David K. Ann. https://www.tandfonline.com/doi/full/10.1080/15548627.2018.1450708


mTOR and nutrient sensing


Whi2 is a conserved negative regulator of TORC1 in response to low amino acids – Xianghui Chen, Guiqin Wang, Yu Zhang, Margaret Dayhoff-Brannigan, Nicola L. Diny, Mingjun Zhao, Ge He, Cierra N. Sing, Kyle A. Metz, Zachary D. Stolp, Abdel Aouacheria, Wen-Chih Cheng, J. Marie Hardwick, Xinchen Teng. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007592

mTOR Inhibition via Displacement of Phosphatidic Acid Induces Enhanced Cytotoxicity Specifically in Cancer Cells – Tra-Ly Nguyen, Marie-Julie Nokin, Maxim Egorov, Mercedes Tomé, Clément Bodineau, Carmelo Di Primo, Lætitia Minder, Joanna Wdzieczak-Bakala, Maria Concepcion Garcia-Alvarez, Jérôme Bignon, Odile Thoison, Bernard Delpech, Georgiana Surpateanu, Yves-Michel Frapart, Fabienne Peyrot, Kahina Abbas, Silvia Terés, Serge Evrard, Abdel-Majid Khatib, Pierre Soubeyran, Bogdan I. Iorga, Raúl V. Durán and Pascal Collin. http://cancerres.aacrjournals.org/content/78/18/5384

Phospholipase D-Dependent mTORC1 Activation by Glutamine – Elyssa Bernfeld, Deepak Menon, Vishaldeep Vaghela, Ismat Zerin, Promie Faruque, Maria A. Frias and David A. Foster. http://www.jbc.org/content/early/2018/09/07/jbc.RA118.004972.abstract

mTORC2 modulates the amplitude and duration of GFAT1 Ser243 phosphorylation to maintain flux through the hexosamine pathway during starvation – Joseph G. Moloughney1, Nicole M. Vega-Cotto1, Sharon Liu1, Chadni Patel1,Peter K. Kim2, Chang-chih Wu1, Danielle Albaciete1, Cedric Magaway1,Austin Chang1, Swati Rajput1, Xiaoyang Su3, Guy Werlen1 and Estela Jacinto. http://www.jbc.org/content/early/2018/09/10/jbc.RA118.003991.abstract


Drugs: metformin, etomoxir, 2-DG


Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo – Anila K. Madiraju, Yang Qiu, Rachel J. Perry, Yasmeen Rahimi, Xian-Man Zhangn Dongyan Zhang, João-Paulo G. Camporez, Gary W. Cline, Gina M. Butrico, Bruce E. Kemp, Gregori Casals, Gregory R. Steinberg, Daniel F. Vatner, Kitt F. Petersen & Gerald I. Shulman. https://www.nature.com/articles/s41591-018-0125-4

Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase – Roger W. Hunter, Curtis C. Hughey, Louise Lantier, Elias I. Sundelin, Mark Peggie, Elton Zeqiraj, Frank Sicheri, Niels Jessen, David H. Wasserman & Kei Sakamoto. https://www.nature.com/articles/s41591-018-0159-7

Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis – Ajit S. Divakaruni, Wei Yuan Hsieh, Lucía Minarrieta, Tin N. Duong, Kristen K.O. Kim, Brandon R. Desousa, Alexander Y. Andreyev, Caitlyn E. Bowman, Kacey Caradonna, Brian P. Dranka, David A. Ferrick, Marc Liesa, Linsey Stiles, George W. Rogers, Daniel Braas, Theodore P. Ciaraldi, Michael J. Wolfgang, Tim Sparwasser, Luciana Berod, Steven J. Bensinger, Anne N. Murphy. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30383-8

Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation – Brenda Raud, Dominic G. Roy, Ajit S. Divakaruni, Tatyana N. Tarasenko, Raimo Franke, Eric H. Ma, Bozena Samborska, Wei Yuan Hsieh, Alison H. Wong, Philipp Stüve, Catharina Arnold-Schrauf, Melanie Guderian, Matthias Lochner, Shakuntala Rampertaap, Kimberly Romito, Joseph Monsale, Mark Brönstrup, Steven J. Bensinger, Anne N. Murphy, Peter J. McGuire, Russell G. Jones, Tim Sparwasser, Luciana Berod. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30384-X

Glycolytic Stimulation Is Not a Requirement for M2 Macrophage Differentiation – Feilong Wang, Song Zhang, Ivan Vuckovic, Ryounghoon Jeon, Amir Lerman, Clifford D. Folmes, Petras P. Dzeja, Joerg Herrmann. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30513-8

Metabolic Targeting of Breast Cancer Cells With the 2-Deoxy-D-Glucose and the Mitochondrial Bioenergetics Inhibitor MDIVI-1 – Federico Lucantoni, Heiko Dussmann and Jochen H. M. Prehn. https://www.frontiersin.org/articles/10.3389/fcell.2018.00113/full


Miscellaneous


Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions – Pedro Latorre-Muro, Josue Baeza, Eric A. Armstrong, Ramón Hurtado-Guerrero, Francisco Corzana, Lindsay E. Wu, David A. Sinclair, Pascual López-Buesa, José A. Carrodeguas, John M. Denu. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30600-2

High-Fat Diet-Induced Inflammation Accelerates Prostate Cancer Growth via IL6 Signaling – Takuji Hayashi, Kazutoshi Fujita, Satoshi Nojima, Yujiro Hayashi, Kosuke Nakano, Yu Ishizuya, Cong Wang, Yoshiyuki Yamamoto, Toshiro Kinouchi, Kyosuke Matsuzaki, Kentaro Jingushi, Taigo Kato, Atsunari Kawashima, Akira Nagahara, Takeshi Ujike, Motohide Uemura, Maria Del Carmen Rodriguez Pena, Jennifer B. Gordetsky, Eiichi Morii, Kazutake Tsujikawa, George J. Netto and Norio Nonomura. http://clincancerres.aacrjournals.org/content/24/17/4309

CD38 is methylated in prostate cancer and regulates extracellular NAD+ – Jack Mottahedeh, Michael C. Haffner, Tristan R. Grogan,Takao Hashimoto, Preston D. Crowell, Himisha Beltran, Andrea Sboner, Rohan Bareja,David Esopi, William B. Isaacs, Srinivasan Yegnasubramanian, Matthew B. Rettig, David A. Elashoff, Elizabeth A. Platz, Angelo M. De Marzo, Michael A. Teitell and Andrew S. Goldstein. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-018-0186-3

Heterozygous IDH1R132H/WT created by “single base editing” inhibits human astroglial cell growth by downregulating YAP – Shuang Wei, Jie Wang, Olutobi Oyinlade, Ding Ma, Shuyan Wang, Lisa Kratz, Bachchu Lal, Qingfu Xu, Senquan Liu, Sagar R. Shah, Hao Zhang, Yunqing Li, Alfredo Quiñones-Hinojosa, Heng Zhu, Zhi-yong Huang, Linzhao Cheng, Jiang Qian & Shuli Xia. https://www.nature.com/articles/s41388-018-0334-9

Extracellular Citrate and Cancer Metabolism (Letter) – Philippe Icard, Ludovic Fournel, Marco Alifano and Hubert Lincet. http://cancerres.aacrjournals.org/content/78/17/5176

Extracellular Citrate and Cancer Metabolism (Response) – Maria E. Mycielska and Edward K. Geissler. http://cancerres.aacrjournals.org/content/78/17/5177


Reviews


Nutrient Sensing in Cancer – Margaret E. Torrence and Brendan D. Manning. https://www.annualreviews.org/doi/full/10.1146/annurev-cancerbio-030617-050329

Rewiring urea cycle metabolism in cancer to support anabolism – Rom Keshet, Peter Szlosarek, Arkaitz Carracedo & Ayelet Erez. https://www.nature.com/articles/s41568-018-0054-z

The Effects of Cholesterol-Derived Oncometabolites on Nuclear Receptor Function in Cancer – Sandrine Silvente-Poirot, Florence Dalenc and Marc Poirot. http://cancerres.aacrjournals.org/content/78/17/4803

Hidden features: exploring the non-canonical functions of metabolic enzymes – Peiwei Huangyang, M. Celeste Simon. http://dmm.biologists.org/content/11/8/dmm033365

Emerging evidence for targeting mitochondrial metabolic dysfunction in cancer therapy – Yueming Zhu, Angela Elizabeth Dean, Nobuo Horikoshi, Collin Heer, Douglas R. Spitz, and David Gius. https://www.jci.org/articles/view/120844

Nutrient scavenging in cancer – Brendan T. Finicle, Vaishali Jayashankar & Aimee L. Edinger. https://www.nature.com/articles/s41568-018-0048-x

Amino acid transporters revisited: New views in health and disease – Palanivel Kandasamy, Gergely Gyimesi, Yoshikatsu Kanai, Matthias A. Hediger. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(18)30101-4

Fructose 2,6-Bisphosphate in Cancer Cell Metabolism – Ramon Bartrons, Helga Simon-Molas, Ana Rodríguez-García, Esther Castaño, Àurea Navarro-Sabaté, Anna Manzano, and Ubaldo E. Martinez-Outschoorn. https://www.frontiersin.org/articles/10.3389/fonc.2018.00331/full

Interplay between adenylate metabolizing enzymes and AMP‐activated protein kinase – Marcella Camici, Simone Allegrini, Maria Grazia Tozzi. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14508

Hypusine, a polyamine-derived amino acid critical for eukaryotic translation – Myung Hee Park1 and Edith C Wolff. http://www.jbc.org/content/early/2018/09/26/jbc.TM118.003341.abstract


Comments


A Glycolysis Outsider Steps into the Cancer Spotlight – Marcus D. Goncalves, Lewis C. Cantley. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30399-1

Metabolic Frugality Marks Cancer Cells for Immune Targeting – Lucas B. Sullivan. https://www.cell.com/cell/fulltext/S0092-8674(18)31039-0

The Golgi stacking protein GORASP2/GRASP55 serves as an energy sensor to promote autophagosome maturation under glucose starvation – Xiaoyan Zhang & Yanzhuang Wang. https://www.tandfonline.com/doi/full/10.1080/15548627.2018.1491214

Mitochondrial Genome Transfer to Tumor Cells Breaks The Rules and Establishes a New Precedent in Cancer Biology – Michael V. Berridge, Carole Crasso & Jiri Neuzil. https://www.tandfonline.com/doi/full/10.1080/23723556.2015.1023929

Autophagy-deficient tumor cells rely on extracellular amino acids to survive upon glutamine deprivation – Nan Zhang, Xin Yang, Fengjie Yuan, Wei-Guo Zhu & Ying Zhao. https://www.tandfonline.com/doi/full/10.1080/15548627.2018.1493314

It takes two to tango: IDH mutation and glutaminase inhibition in glioma – Qing Zhang. http://stm.sciencemag.org/content/10/460/eaav0344

Excess Fumarate or Succinate Impairs Homologous Recombinationhttp://cancerdiscovery.aacrjournals.org/content/8/9/OF7

Hyperglycemia Results in TET2 Destabilization to Promote Tumorigenesishttp://cancerdiscovery.aacrjournals.org/content/8/9/1058.1

IDH Mutations Suppress T Cell–Mediated Antitumor Immunityhttp://cancerdiscovery.aacrjournals.org/content/8/9/OF17

Disrupting Histidine Catabolism Reduces Methotrexate Sensitivityhttp://cancerdiscovery.aacrjournals.org/content/8/9/OF18

Epigenetic control by sugarhttps://www.nature.com/articles/s41568-018-0052-1

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s