MetaboList – October 2018

Glucose metabolism, glycolytic enzymes

Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals – Xiaojing Liu, Daniel E. Cooper, Ahmad A. Cluntun, Marc O. Warmoes, Steven Zhao, Michael A. Reid, Juan Liu, Peder J. Lund, Mariana Lopes, Benjamin A. Garcia, Kathryn E. Wellen, David G. Kirsch and Jason W. Locasale.

Real-Time Imaging of Mitochondrial ATP Dynamics Reveals the Metabolic Setting of Single Cells – Maria R. Depaoli, Felix Karsten, Corina T. Madreiter-Sokolowski, Christiane Klec, Benjamin Gottschalk, Helmut Bischof, Emrah Eroglu, Markus Waldeck-Weiermair, Thomas Simmen, Wolfgang F. Graier and Roland Malli.

A metabolite-derived protein modification integrates glycolysis with KEAP1–NRF2 signalling – Michael J. Bollong, Gihoon Lee, John S. Coukos, Hwayoung Yun, Claudio Zambaldo, Jae Won Chang, Emily N. Chin, Insha Ahmad, Arnab K. Chatterjee, Luke L. Lairson, Peter G. Schultz and Raymond E. Moellering.

Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells – Haobin Ye, Biniam Adane, Nabilah Khan, Erica Alexeev, Nichole Nusbacher, Mohammad Minhajuddin, Brett M. Stevens, Amanda C. Winters, Xi Lin, John M. Ashton, Enkhtsetseg Purev, Lianping Xing, Daniel A. Pollyea, Catherine A. Lozupone, Natalie J. Serkova, Sean P. Colgan and Craig T. Jordan.

Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells – Oliver A. Stone, Mohamed El-Brolosy, Kerstin Wilhelm, Xiaojing Liu, Ana M. Romão, Elisabetta Grillo, Jason K. H. Lai, Stefan Günther, Sylvia Jeratsch, Carsten Kuenne, I-Ching Lee, Thomas Braun, Massimo M. Santoro, Jason W. Locasale, Michael Potente and Didier Y. R. Stainier.

PKM2 is not required for pancreatic ductal adenocarcinoma – Alissandra L Hillis, Allison N Lau, Camille X Devoe, Talya L Dayton, Laura V Danai, Dolores Di Vizio and Matthew G Vander Heiden.

LDH and lactate

Double genetic disruption of lactate dehydrogenases A and B is required to ablate the “Warburg effect” restricting tumor growth to oxidative metabolism – Maša Ždralević, Almut Brand, Lorenza Di Ianni, Katja Dettmer, Jörg Reinders, Katrin Singer, Katrin Peter, Annette Schnell, Christina Bruss, Sonja-Maria Decking, Gudrun Koehl, Blanca Felipe-Abrio, Jérôme Durivault, Pascale Bayer, Marie Evangelista, Thomas O’Brien, Peter J. Oefner, Kathrin Renner, Jacques Pouysségur and Marina Kreutz.

Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival – Gaurav Pathria, David A Scott, Yongmei Feng, Joo Sang Lee, Yu Fujita, Gao Zhang, Avinash D Sahu, Eytan Ruppin, Meenhard Herlyn, Andrei L Osterman and Ze’ev A Ronai.

Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth – Yuan Liu, Ji-Zheng Guo, Ying Liu, Kui Wang, Wencheng Ding, Hui Wang, Xiang Liu, Shengtao Zhou, Xiao-Chen Lu, Hong-Bin Yang, Chenyue Xu, Wei Gao, Li Zhou, Yi-Ping Wang, Weiguo Hu, Yuquan Wei, Canhua Huang and Qun-Ying Lei.

Warburg Effect Metabolism Drives Neoplasia in a Drosophila Genetic Model of Epithelial Cancer – Teresa Eichenlaub, René Villadsen, Flávia C.P. Freitas, Diana Andrejeva, Blanca I. Aldana, Hung Than Nguyen, Ole William Petersen, Jan Gorodkin, Héctor Herranz and Stephen M. Cohen.

Amino acids / Redox / lipid metabolism

The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma – Heike Miess, Beatrice Dankworth, Arvin M. Gouw, Mathias Rosenfeldt, Werner Schmitz, Ming Jiang, Becky Saunders, Michael Howell, Julian Downward, Dean W. Felsher, Barrie Peck and Almut Schulze.

Biosynthetic energy cost for amino acids decreases in cancer evolution – Hong Zhang, Yirong Wang, Jun Li, Han Chen, Xionglei He, Huiwen Zhang, Han Liang and Jian Lu.

Stable Isotope Labeling Highlights Enhanced Fatty Acid and Lipid Metabolism in Human Acute Myeloid Leukemia – Lucille Stuani, Fabien Riols, Pierre Millard, Marie Sabatier, Aurélie Batut, Estelle Saland, Fanny Viars, Laure Tonini, Sonia Zaghdoudi, Laetitia K. Linares, Jean-Charles Portais, Jean-Emmanuel Sarry and Justine Bertrand-Michel.


Anti-Folate Receptor Alpha–Directed Antibody Therapies Restrict the Growth of Triple-negative Breast Cancer – Anthony Cheung, James Opzoomer, Kristina M. Ilieva, Patrycja Gazinska, Ricarda M. Hoffmann, Hasan Mirza, Rebecca Marlow, Erika Francesch-Domenech, Matthew Fittall, Diana Dominguez Rodriguez, Angela Clifford, Luned Badder, Nirmesh Patel, Silvia Mele, Giulia Pellizzari, Heather J. Bax, Silvia Crescioli, Gyula Petranyi, Daniel Larcombe-Young, Debra H. Josephs, Silvana Canevari, Mariangela Figini, Sarah Pinder, Frank O. Nestle, Cheryl Gillett, James F. Spicer, Anita Grigoriadis, Andrew N.J. Tutt and Sophia N. Karagiannis.

Parallel reaction pathways and noncovalent intermediates in thymidylate synthase revealed by experimental and computational tools – Svetlana A. Kholodar, Ananda K. Ghosh, Katarzyna Świderek, Vicent Moliner and Amnon Kohen.


Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism – Martin Benej, Xiangqian Hong, Sandip Vibhute, Sabina Scott, Jinghai Wu, Edward Graves, Quynh-Thu Le, Albert C. Koong, Amato J. Giaccia, Bing Yu, Shih-Ching Chen, Ioanna Papandreou and Nicholas C. Denko.

Cox2p of yeast cytochrome oxidase assembles as a stand-alone subunit with the Cox1p and Cox3p modules – Leticia Veloso R. Franco, Chen Hsien Su, Gavin P. McStay, George J. Yu and Alexander Tzagoloff.

Starvation / mTOR

Chronic starvation induces noncanonical pro-death stress granules – Lucas C. Reineke, Shebna A. Cheema, Julien Dubrulle and Joel R. Neilson.

The mTOR-S6 kinase pathway promotes stress granule assembly – Aristeidis P. Sfakianos, Laura E. Mellor, Yoke Fei Pang, Paraskevi Kritsiligkou, Hope Needs, Hussein Abou-Hamdan, Laurent Désaubry, Gino B. Poulin, Mark P. Ashe and Alan J. Whitmarsh.

mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux – Wei Wan, Zhiyuan You, Li Zhou, Yinfeng Xu, Chao Peng, Tianhua Zhou, Cong Yi, Yin Shi and Wei Liu.

Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction – Rituraj Pal, Michela Palmieri, Arindam Chaudhury, Tiemo Jürgen Klisch, Alberto di Ronza, Joel R. Neilson, George G. Rodney and Marco Sardiello.

Metabolic reprogramming of murine cardiomyocytes during autophagy requires the extracellular nutrient sensor decorin – Maria A. Gubbiotti, Erin Seifert, Ulrich Rodeck, Jan B. Hoek and Renato V. Iozzo.

Integrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia – Peter van Galen, Nathan Mbong, Antonia Kreso, Erwin M. Schoof, Elvin Wagenblast, Stanley W.K. Ng, Gabriela Krivdova, Liqing Jin, Hiromitsu Nakauchi and John E. Dick.


Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia – Arpita Chowdhury, Abhishek Aich, Gaurav Jain, Katharina Wozny, Christian Lüchtenborg, Magnus Hartmann, Olaf Bernhard, Martina Balleiniger, Ezzaldin Ahmed Alfar, Anke Zieseniss, Karl Toischer, Kaomei Guan, Silvio O. Rizzoli, Britta Brügger, Andrè Fischer, Dörthe M. Katschinski, Peter Rehling and Jan Dudek.

The receptor tyrosine kinase HIR-1 coordinates HIF-independent responses to hypoxia and extracellular matrix injury – Roman Vozdek , Yong Long and Dengke K. Ma.

MicroRNA expression profile during different conditions of hypoxia – Donato Lacedonia, Giulia Scioscia, Grazia Pia Palladino, Crescenzio Gallo, Giovanna Elisiana Carpagnano, Roberto Sabato and Maria Pia Foschino Barbaro.

Oxygen-Enhanced and Dynamic Contrast-Enhanced Optoacoustic Tomography Provide Surrogate Biomarkers of Tumor Vascular Function, Hypoxia, and Necrosis – Michal R. Tomaszewski, Marcel Gehrung, James Joseph, Isabel Quiros-Gonzalez, Jonathan A. Disselhorst and Sarah E. Bohndiek.

Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment – Jie Lan, Haiquan Lu, Debangshu Samanta, Shaima Salman, You Lu and Gregg L. Semenza.

The p38α Stress Kinase Suppresses Aneuploidy Tolerance by Inhibiting Hif-1α – Susana Simões-Sousa, Samantha Littler, Sarah L. Thompson, Paul Minshall, Helen Whalley, Bjorn Bakker, Klaudyna Belkot, Daniela Moralli, Daniel Bronder, Anthony Tighe, Diana C.J. Spierings, Nourdine Bah, Joshua Graham, Louisa Nelson, Catherine M. Green, Floris Foijer, Paul A. Townsend and Stephen S. Taylor.

Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen – Mathieu Deygas, Rudy Gadet, Germain Gillet, Ruth Rimokh, Philippe Gonzalo and Ivan Mikaelian.


Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Sells – Mehmet G. Badur, Thangaselvam Muthusamy, Seth J. Parker, Shenghong Ma, Samuel K. McBrayer, Thekla Cordes, Jose H. Magana, Kun-Liang Guan and Christian M. Metallo.

Metformin sensitizes endometrial cancer cells to chemotherapy through IDH1-induced Nrf2 expression via an epigenetic mechanism – Mingzhu Bai, Linlin Yang, Hong Liao, Xiaoyan Liang, Bingying Xie, Ji Xiong, Xiang Tao, Xiong Chen, Yali Cheng, Xiaojun Chen, Youji Feng, Zhenbo Zhang and Wenxin Zheng.

IDH1R132H is intrinsically tumor-suppressive but functionally attenuated by the glutamate-rich cerebral environment – Patricia D. B. Tiburcio, Bing Xiao, Yi Chai, Sydney Asper, Sheryl R. Tripp, David L. Gillespie, Randy L. Jensen and L. Eric Huang.[]=26203&path[]=81692

Cancer immunometabolism

IRE1α–XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity – Minkyung Song, Tito A. Sandoval, Chang-Suk Chae, Sahil Chopra, Chen Tan, Melanie R. Rutkowski, Mahesh Raundhal, Ricardo A. Chaurio, Kyle K. Payne, Csaba Konrad, Sarah E. Bettigole, Hee Rae Shin, Michael J. P. Crowley, Juan P. Cerliani, Andrew V. Kossenkov, Ievgen Motorykin, Sheng Zhang, Giovanni Manfredi, Dmitriy Zamarin, Kevin Holcomb, Paulo C. Rodriguez, Gabriel A. Rabinovich, Jose R. Conejo-Garcia, Laurie H. Glimcher and Juan R. Cubillos-Ruiz.


Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells – Saar Vandekeere, Charlotte Dubois, Joanna Kalucka, Mark R. Sullivan, Melissa García-Caballero, Jermaine Goveia, Rongyuan Chen, Frances F. Diehl, Libat Bar-Lev, Joris Souffreau, Andreas Pircher, Saran Kumar, Stefan Vinckier, Yoshio Hirabayashi, Shigeki Furuya, Luc Schoonjans, Guy Eelen, Bart Ghesquière, Eli Keshet, Xuri Li, Matthew G. Vander Heiden, Mieke Dewerchin and Peter Carmeliet.

An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State – Clair Crewe, Nolwenn Joffin, Joseph M. Rutkowski, Min Kim, Fang Zhang, Dwight A. Towler, Ruth Gordillo and Philipp E. Scherer.

C16-ceramide is a natural regulatory ligand of p53 in cellular stress response – Baharan Fekry, Kristen A. Jeffries, Amin Esmaeilniakooshkghazi, Zdzislaw M. Szulc, Kevin J. Knagge, David R. Kirchner, David A. Horita, Sergey A. Krupenko and Natalia I. Krupenko.

Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases – Jacob Lauwring Andersen, Borbala Gesser, Erik Daa Funder, Christine Juul Fælled Nielsen, Helle Gotfred-Rasmussen, Mads Kirchheiner Rasmussen, Rachel Toth, Kurt Vesterager Gothelf, J. Simon C. Arthur, Lars Iversen and Poul Nissen.


Emerging Technologies to Image Tissue Metabolism – Vasilis Ntziachristos, Miguel A. Pleitez, Silvio Aime and Kevin M. Brindle.

Impact of Mitochondrial Fatty Acid Synthesis on Mitochondrial Biogenesis – Sara M. Nowinski, Jonathan G. Van Vranken, Katja K. Dove and Jared Rutter.

The Different Routes to Metastasis via Hypoxia-Regulated Programs – Ana Rita Nobre, David Entenberg, Yarong Wang, John Condeelis and Julio A. Aguirre-Ghiso.

Targeting the IDH2 Pathway in Acute Myeloid Leukemia – Maria L. Amaya and Daniel A. Pollyea.

No Parkin Zone: Mitophagy without Parkin – Elodie Villa, Sandrine Marchetti and Jean-Ehrland Ricci.

Polyamine metabolism and cancer: treatments, challenges and opportunities – Robert A. Casero Jr, Tracy Murray Stewart and Anthony E. Pegg.

Fasting and cancer: molecular mechanisms and clinical application – Alessio Nencioni, Irene Caffa, Salvatore Cortellino and Valter D. Longo.

Cancer pharmacoprevention: Targeting polyamine metabolism to manage risk factors for colon cancer – Eugene W. Gerner, Elizabeth Bruckheimer and Alfred Cohen.

The Krebs Cycle Connection: Reciprocal Influence Between Alternative Splicing Programs and Cell Metabolism – Giuseppe Biamonti, Lucia Maita and Alessandra Montecucco.

Mevalonate Metabolism in Cancer Stemness and Trained Immunity – Georg Gruenbacher and Martin Thurnher.

Roles of polyamines in translation – Thomas E. Dever and Ivaylo P. Ivanov.

Metabolic Pathways in Kidney Cancer: Current Therapies and Future Directions – W. Kimryn Rathmell, Jeffrey C. Rathmell and W. Marston Linehan.

Cancer Metabolism: the Known, Unknowns – Dang CV.

Editorial for this issue of BBA-Reviews on cancer with many more interesting reviews:


AMPK Regulates the Epigenome through Phosphorylation of TET2 – Eleanor C. Fiedler and Reuben J. Shaw.

ATF4‐amino acid circuits: a recipe for resistance in melanoma – Mario R Fernandez and John L Cleveland.


Metabolic Signaling. Methods and Protocols

Editors: Sarah-Maria Fendt and Sophia Y. Lunt

Springer Protocols


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