MetaboList – November 2018

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Glucose metabolism / lactate


Mannose impairs tumour growth and enhances chemotherapy – Pablo Sierra Gonzalez, James O’Prey, Simone Cardaci, Valentin J. A. Barthet, Jun-ichi Sakamaki, Florian Beaumatin, Antonia Roseweir, David M. Gay, Gillian Mackay, Gaurav Malviya, Elżbieta Kania, Shona Ritchie, Alice D. Baudot, Barbara Zunino, Agata Mrowinska, Colin Nixon, Darren Ennis, Aoisha Hoyle, David Millan, Iain A. McNeish, Owen J. Sansom, Joanne Edwards and Kevin M. Ryan. https://www.nature.com/articles/s41586-018-0729-3

Sodium-glucose transporter 2 is a diagnostic and therapeutic target for early-stage lung adenocarcinoma – Claudio R. Scafoglio , Brendon Villegas, Gihad Abdelhady, Sean T. Bailey, Jie Liu, Aditya S. Shirali, W. Dean Wallace, Clara E. Magyar, Tristan R. Grogan, David Elashoff, Tonya Walser, Jane Yanagawa, Denise R. Aberle, Jorge R. Barrio, Steven M. Dubinett, David B. Shackelford. http://stm.sciencemag.org/content/10/467/eaat5933

Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo – Kevin D. Courtney, Divya Bezwada, Tomoyuki Mashimo, Kumar Pichumani, Vamsidhara Vemireddy, Alexander M. Funk, Jennifer Wimberly, Sarah S. McNeil, Payal Kapur, Yair Lotan, Vitaly Margulis, Jeffrey A. Cadeddu, Ivan Pedrosa, Ralph J. DeBerardinis, Craig R. Malloy, Robert M. Bachoo, Elizabeth A. Maher. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30463-7

Red wine and green tea flavonoids are cis-allosteric activators and competitive inhibitors of GLUT1-mediated sugar uptake – Ogooluwa A Ojelabi, Kenneth P Lloyd, Julie K De Zutter and Anthony Carruthers. http://www.jbc.org/content/early/2018/10/25/jbc.RA118.002326.abstract

Phosphoglucomutase 1 inhibits hepatocellular carcinoma progression by regulating glucose trafficking – Guang-Zhi Jin, Yajuan Zhang, Wen-Ming Cong, Xueyuan Wu, Xiongjun Wang, Siyang Wu, Siyao Wang, Weiping Zhou, Shengxian Yuan, Hong Gao, Guanzhen Yu, Weiwei Yang. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2006483

PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer – Tingting Yang, Chune Ren, Pengyun Qiao, Xue Han, Li Wang et al. https://www.nature.com/articles/s41388-018-0386-x

O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis – Kekoa Taparra, Hailun Wang, Reem Malek, Audrey Lafargue, Mustafa A. Barbhuiya, Xing Wang, Brian W. Simons, Matthew Ballew, Katriana Nugent, Jennifer Groves, Russell D. Williams, Takumi Shiraishi, James Verdone, Gokben Yildirir, Roger Henry, Bin Zhang, John Wong, Ken Kang-Hsin Wang, Barry D. Nelkin, Kenneth J. Pienta, Dean Felsher, Natasha E. Zachara and Phuoc T. Tran. https://www.jci.org/articles/view/94844

Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth – Andrew G Cox, Allison Tsomides, Dean Yimlamai, Katie L Hwang, Joel Miesfeld, Giorgio G Galli, Brendan H Fowl, Michael Fort, Kimberly Y Ma, Mark R Sullivan, Aaron M Hosios, Erin Snay, Min Yuan, Kristin K Brown, Evan C Lien, Sagar Chhangawala, Matthew L Steinhauser, John M Asara, Yariv Houvras, Brian Link, Matthew G Vander Heiden, Fernando D Camargo and Wolfram Goessling. http://EMBOJ.embopress.org/content/37/22/e100294?etoc

TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation – Le Li, Lijia Li, Wei Li, Taiqi Chen, Bin Zou, Lina Zhao, Huili Wang, Xueying Wang, Lina Xu, Xiaohui Liu, Dong Wang, Bo Li, Tak W. Mak, Wenjing Du, Xiaolu Yang and Peng Jiang. https://www.nature.com/articles/s41467-018-07127-8

Antagonism of glycolysis and reductive carboxylation of glutamine potentiates activity of oncolytic adenoviruses in cancer cells – Arthur Dyer, Benjamin Schoeps, Sally Frost, Philip G Jakeman, Eleanor M Scott, Joshua Freedman and Leonard W. Seymour. http://cancerres.aacrjournals.org/content/early/2018/11/13/0008-5472.CAN-18-1326

Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism – Barrett L. Updegraff, Xiaorong Zhou, Yabin Guo, Mahesh S. Padanad, Pei-Hsuan Chen, Chendong Yang, Jessica Sudderth, Carla Rodriguez-Tirado, Luc Girard, John D. Minna, Prashant Mishra, Ralph J. DeBerardinis, Kathryn A. O’Donnell. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31722-4

LDHA in Neuroblastoma Is Associated with Poor Outcome and Its Depletion Decreases Neuroblastoma Growth Independent of Aerobic Glycolysis – Carmen Dorneburg, Matthias Fischer, Thomas F.E. Barth, Wolfgang Mueller-Klieser, Barbara Hero, Judith Gecht, Daniel R. Carter, Katleen de Preter, Benjamin Mayer, Lisa Christner, Frank Speleman, Glenn M. Marshall, Klaus-Michael Debatin and Christian Beltinger. http://clincancerres.aacrjournals.org/content/24/22/5772


Amino acid metabolism


Autophagy maintains tumour growth through circulating arginine – Laura Poillet-Perez, Xiaoqi Xie, Le Zhan, Yang Yang, Daniel W. Sharp, Zhixian Sherrie Hu, Xiaoyang Su, Anurag Maganti, Cherry Jiang, Wenyun Lu, Haiyan Zheng, Marcus W. Bosenberg, Janice M. Mehnert, Jessie Yanxiang Guo, Edmund Lattime, Joshua D. Rabinowitz and Eileen White. https://www.nature.com/articles/s41586-018-0697-7

A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3 – Mylène Tajan, Andreas K. Hock, Julianna Blagih, Neil A. Robertson, Christiaan F. Labuschagne, Flore Kruiswijk, Timothy J. Humpton, Peter D. Adams, Karen H. Vousden. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30448-0

IKKβ activates p53 to promote cancer cell adaptation to glutamine deprivation – Mari B. Ishak Gabra, Ying Yang, Xazmin H. Lowman, Michael A. Reid, Thai Q. Tran and Mei Kong. https://www.nature.com/articles/s41389-018-0104-0

Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting – H. Furkan Alkan, Katharina E. Walter, Alba Luengo, Corina T. Madreiter-Sokolowski, Sarah Stryeck, Allison N. Lau, Wael Al-Zoughbi, Caroline A. Lewis, Craig J. Thomas, Gerald Hoefler, Wolfgang F. Graier, Tobias Madl, Matthew G. Vander Heiden, Juliane G. Bogner-Strauss. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30464-9

Methionine coordinates a hierarchically organized anabolic program enabling proliferation – Adhish S. Walvekar, Rajalakshmi Srinivasan, Ritu Gupta and Sunil Laxman. https://www.molbiolcell.org/doi/10.1091/mbc.E18-08-0515?ai=25zg&ui=2oy6&af=T

Metabolic Reprogramming by Dual AKT/ERK Inhibition through Imipridones Elicits Unique Vulnerabilities in Glioblastoma – Chiaki T. Ishida, Yiru Zhang, Elena Bianchetti, Chang Shu, Trang T.T. Nguyen, Giulio Kleiner, Maria J. Sanchez-Quintero, Catarina M. Quinzii, Mike-Andrew Westhoff, Georg Karpel-Massler, Varun V. Prabhu, Joshua E. Allen and Markus D. Siegelin. http://clincancerres.aacrjournals.org/content/24/21/5392

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells – Courtney L. Jones, Brett M. Stevens, Angelo D’Alessandro, Julie A. Reisz, Rachel Culp-Hill, Travis Nemkov, Shanshan Pei, Nabilah Khan, Biniam Adane, Haobin Ye, Anna Krug, Dominik Reinhold, Clayton Smith, James DeGregori, Daniel A. Pollyea, Craig T. Jordan. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30471-9


Lipid metabolism


CPT1A-mediated fatty acid oxidation promotes colorectal cancer cell metastasis by inhibiting anoikis – Ying-nan Wang, Zhao-lei Zeng, Jiahuan Lu, Yun Wang, Ze-xian Liu, Ming-ming He, Qi Zhao, Zi-xian Wang, Ting Li, Yun-xin Lu, Qi-nian Wu, Kai Yu, Feng Wang, Heng-Ying Pu, Bo Li, Wei-hua Jia, Ming shi, Dan Xie, Tie-bang Kang, Peng Huang, Huai-qiang Ju and Rui-hua Xu. https://www.nature.com/articles/s41388-018-0384-z

De novo lipogenesis represents a therapeutic target in mutant Kras non-small cell lung cancer – Anju Singh, Christian Ruiz, Kavita Bhalla, John A. Haley, Qing Kay Li, George Acquaah-Mensah, Emily Montal, Kuladeep R. Sudini, Ferdinandos Skoulidis, Ignacio I. Wistuba, Vassiliki Papadimitrakopoulou, John V. Heymach, Laszlo G. Boros, Edward Gabrielson, Julian Carretero, Kwok-Kin Wong, John D. Haley, Shyam Biswal and Geoffrey D. Girnun. https://www.fasebj.org/doi/abs/10.1096/fj.201800204?ai=s4&ui=ly8&af=T


Nucleotides


Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis – Naiara Santana-Codina, Anjali A. Roeth, Yi Zhang, Annan Yang, Oksana Mashadova, John M. Asara, Xiaoxu Wang, Roderick T. Bronson, Costas A. Lyssiotis, Haoqiang Ying and Alec C. Kimmelman. https://www.nature.com/articles/s41467-018-07472-8?

Metabolomics and proteomics identify the toxic form and the associated cellular binding targets of the anti-proliferative drug AICAR [yeast] – Delphine C Douillet, Benoît Pinson, Johanna Ceschin, Hans C Hürlimann, Christelle Saint-Marc, Damien Laporte, Stéphane Claverol, Manfred Konrad, Marc Bonneu and Bertrand Daignan-Fornier. http://www.jbc.org/content/early/2018/11/26/jbc.RA118.004964.abstract


Mitochondria


Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells – Yuxiang Zheng, Ting-Yu Lin, Gina Lee, Marcia N. Paddock, Jessica Momb, Zhe Cheng, Qian Li, Dennis L. Fei, Benjamin D. Stein, Shivan Ramsamooj, Guoan Zhang, John Blenis, Lewis C. Cantley. https://www.cell.com/cell/fulltext/S0092-8674(18)31253-4

Tissue-specific kinase expression and activity regulates flux through the pyruvate dehydrogenase complex – Alla Klyuyeva, Alina Tuganova, Natalia Y. Kedishvili and Kirill M Popov. http://www.jbc.org/content/early/2018/11/27/jbc.RA118.006433.abstract


AMPK


The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance – Fei Han, Chien-Feng Li, Zhen Cai, Xian Zhang, Guoxiang Jin, Wei-Na Zhang, Chuan Xu, Chi-Yun Wang, John Morrow, Shuxing Zhang, Dazhi Xu, Guihua Wang and Hui-Kuan Lin. https://www.nature.com/articles/s41467-018-07188-9

STIM2 interacts with AMPK and regulates calcium-induced AMPK activation – Anoop Singh Chauhan, Xiaoguang Liu, Ji Jing, Hyemin Lee, Raj Kumar Yadav, Jindou Liu, Yubin Zhou and Boyi Gan. https://www.fasebj.org/doi/abs/10.1096/fj.201801225R?ai=ts&ui=ly8&af=T

Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states – Yan Yan, X. Edward Zhou, Scott J Novick, Simon J. Shaw, Yingwu Li, Joseph S. Brunzelle, Yasumichi Hitoshi, Patrick R. Griffin, H. Eric Xu and Karsten Melcher. http://www.jbc.org/content/early/2018/11/26/jbc.RA118.004883.abstract


Nutrient sensing / starvation


A C9orf72–CARM1 axis regulates lipid metabolism under glucose starvation-induced nutrient stress – Yang Liu, Tao Wang, Yon Ju Ji, Kenji Johnson, Honghe Liu, Kaitlin Johnson, Scott Bailey, Yongwon Suk, Yu-Ning Lu, Mingming Liu and Jiou Wang. http://genesdev.cshlp.org/content/32/21-22/1380.abstract?etoc

Amino acids stimulate the endosome-to-Golgi trafficking through Ragulator and small GTPase Arl5 – Meng Shi, Bing Chen, Divyanshu Mahajan, Boon Kim Boh, Yan Zhou, Bamaprasad Dutta, Hieng Chiong Tie, Siu Kwan Sze, Geng Wu and Lei Lu. https://www.nature.com/articles/s41467-018-07444-y


Hypoxia and HIF


p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression – Ivano Amelio, Mara Mancini, Varvara Petrova, Rob A. Cairns, Polina Vikhreva, Sara Nicolai, Alberto Marini, Alexey A. Antonov, John Le Quesne, Juvenal D. Baena Acevedo, Kate Dudek, Gabriella Sozzi, Ugo Pastorino, Richard A. Knight, Tak W. Mak and Gerry Melino. http://www.pnas.org/content/early/2018/10/29/1808314115

Hypoxia-induced LncRNA-BX111 promotes metastasis and progression of pancreatic cancer through regulating ZEB1 transcription – Shi-jiang Deng, Heng-yu Chen, Zeng Ye, Shi-chang Deng, Shuai Zhu Zhu Zeng, Chi He, Ming-liang Liu, Kang Huang, Jian-xin Zhong, Feng-yu Xu, Qiang Li, Yang Liu, Chun-you Wang and Gang Zhao. https://www.nature.com/articles/s41388-018-0382-1

Notch signaling promotes a HIF2a-driven hypoxic response in multiple tumor cell types – Anders P. Mutvei, Sebastian K.-J. Landor, Rhys Fox, Eike-Benjamin Braune, Yat Long Tsoi, Yee Peng Phoon, Cecilia Sahlgren, Johan Hartman, Jonas Bergh, Shaobo Jin and Urban Lendahl. https://www.nature.com/articles/s41388-018-0400-3

Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy – Hao Geng, Changhui Xue, Janet Mendonca, Xiao-Xin Sun, Qiong Liu, Patrick N. Reardon, Yingxiao Chen, Kendrick Qian, Vivian Hua, Alice Chen, Freddy Pan, Julia Yuan, Sang Dang, Tomasz M. Beer, Mu-Shui Dai, Sushant K. Kachhap and David Z. Qian. https://www.nature.com/articles/s41467-018-07411-7?


IDH


Lack of evidence for substrate channeling or flux between wildtype and mutant isocitrate dehydrogenase to produce the oncometabolite 2-hydroxyglutarate – Joseph P. Dexter, Patrick S. Ward, Tathagata Dasgupta, Aaron M. Hosios, Jeremy Gunawardena and Matthew G. Vander Heiden. http://www.jbc.org/content/early/2018/10/31/jbc.RA118.004278.abstract

D-2-Hydroxyglutarate Is an Intercellular Mediator in IDH-Mutant Gliomas Inhibiting Complement and T Cells – Lingjun Zhang, Mia D. Sorensen, Bjarne W. Kristensen, Guido Reifenberger, Thomas M. McIntyre and Feng Lin. http://clincancerres.aacrjournals.org/content/24/21/5381

Isoform Switching as a Mechanism of Acquired Resistance to Mutant Isocitrate Dehydrogenase Inhibition – James J. Harding, Maeve A. Lowery, Alan H. Shih, Juan Schvartzman, Shengqi Hou, Christopher Famulare, Minal Patel, Mikhail Roshal, Richard K. Do, Ahmet Zehir, Daoqi You, S. Duygu Selcuklu, Agnes Viale, Martin S. Tallman, David M. Hyman, Ed Reznik, Lydia W.S. Finley, Elli Papaemmanuil, Alessandra Tosolini, Mark G. Frattini, Kyle J. MacBeth, Guowen Liu, Bin Fan, Sung Choe, Bin Wu, Yelena Y. Janjigian, Ingo K. Mellinghoff, Luis A. Diaz, Ross L. Levine, Ghassan K. Abou-Alfa, Eytan M. Stein and Andrew M. Intlekofer. http://cancerdiscovery.aacrjournals.org/content/8/12/1540


Metformin


Metformin Inhibits Prostate Cancer Progression by Targeting Tumor-Associated Inflammatory Infiltration – Qiuli Liu, Dali Tong, Gaolei Liu, Jie Gao, Lin-ang Wang, Jing Xu, Xingxia Yang, Qiubo Xie, Yiqiang Huang, Jian Pang, Luofu Wang, Yong He, Dianzheng Zhang, Qiang Ma, Weihua Lan and Jun Jiang. http://clincancerres.aacrjournals.org/content/24/22/5622

Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer – Simon R. Lord, Wei-Chen Cheng, Dan Liu, Edoardo Gaude, Syed Haider, Tom Metcalf, Neel Patel, Eugene J. Teoh, Fergus Gleeson, Kevin Bradley, Simon Wigfield, Christos Zois, Daniel R. McGowan, Mei-Lin Ah-See, Alastair M. Thompson, Anand Sharma, Luc Bidaut, Michael Pollak, Pankaj G. Roy, Fredrik Karpe, Tim James, Ruth English, Rosie F. Adams, Leticia Campo, Lisa Ayers, Cameron Snell, Ioannis Roxanis, Christian Frezza, John D. Fenwick, Francesca M. Buffa, Adrian L. Harris. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30522-9


Cancer immunometabolism


Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages – Toszka Bohn, Steffen Rapp, Natascha Luther, Matthias Klein, Till-Julius Bruehl Nobuhiko Kojima, Pamela Aranda Lopez, JennifeHahlbrock, Sabine Muth, Shogo Endo, Stefanie Pektor, Almut Brand, Kathrin Renner, Vanessa Popp, Katharina Gerlach, Dennis Vogel, Christina Lueckel, Danielle Arnold-Schild, Jacques Pouyssegur, Marina Kreutz, Magdalena Huber, Jochem Koenig, Benno Weigmann, Hans-Christian Probst, Esther von Stebut, Christian Becker, Hansjoerg Schild, Edgar Schmitt and Tobias Bopp. https://www.nature.com/articles/s41590-018-0226-8

Metabolic reprogramming of natural killer cells in obesity limits antitumor responses – Xavier Michelet, Lydia Dyck, Andrew Hogan, Roisin M. Loftus, Danielle Duquette, Kevin Wei, Semir Beyaz, Ali Tavakkoli, Cathriona Foley, Raymond Donnelly, Cliona O’Farrelly, Mathilde Raverdeau, Ashley Vernon, William Pettee, Donal O’Shea, Barbara S. Nikolajczyk, Kingston H. G. Mills, Michael B. Brenner, David Finlay and Lydia Lynch. https://www.nature.com/articles/s41590-018-0251-7


Exercise, obesity


Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade – Ziming Wang, Ethan G. Aguilar, […] Arta M. Monjazeb. https://www.nature.com/articles/s41591-018-0221-5

Switch to low-fat diet improves outcome of acute lymphoblastic leukemia in obese mice – Jonathan Tucci, Waseem Alhushki, Ting Chen, Xia Sheng, Yong-Mi Kim and Steven D. Mittelman. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-018-0189-0

Exercise inhibits tumor growth and central carbon metabolism in patient-derived xenograft models of colorectal cancer – Min Lu, Sydney M Sanderson, Amelia Zessin, Kathleen A Ashcraft, Lee W Jones, Mark W Dewhirst, Jason W Locasale and David S Hsu. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-018-0190-7

Circulating Adipose Fatty Acid Binding Protein Is a New Link Underlying Obesity-Associated Breast/Mammary Tumor Development – Jiaqing Hao, Yuwen Zhang, Xiaofang Yan, Fei Yan, Yanwen Sun, Jun Zeng, Sabine Waigel, Yanhui Yin, Mostafa M. Fraig, Nejat K. Egilmez, Jill Suttles, Maiying Kong, Shujun Liu, Margot P. Cleary, Edward Sauter, Bing Li. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30449-2


Miscellaneous


Gene Expression Integration into Pathway Modules Reveals a Pan-Cancer Metabolic Landscape – Cankut Cubuk, Marta R. Hidalgo, Alicia Amadoz, Miguel A. Pujana, Francesca Mateo, Carmen Herranz, Jose Carbonell-Caballero and Joaquin Dopazo. http://cancerres.aacrjournals.org/content/78/21/6059

Single-Cell Transcriptome Analysis Reveals Estrogen Signaling Coordinately Augments One-Carbon, Polyamine, and Purine Synthesis in Breast Cancer – Detu Zhu, Zuxianglan Zhao, Guimei Cui, Shiehong Chang, Lingling Hu, Yi Xiang See, Michelle Gek Liang Lim, Dajiang Guo, Xin Chen, Paul Robson, Yumei Luo, Edwin Cheung . https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31714-5

Thermodynamic constraints on the regulation of metabolic fluxes – Ziwei Dai and Jason W. Locasale. http://www.jbc.org/content/early/2018/10/25/jbc.RA118.004372.abstract


Reviews


mTOR signalling and cellular metabolism are mutual determinants in cancer – Dirk Mossmann, Sujin Park and Michael N. Hall. https://www-nature-com.sire.ub.edu/articles/s41568-018-0074-8

Cancer Cachexia: More Than Skeletal Muscle Wasting – Søren Fisker Schmidt, Maria Rohm, Stephan Herzig, Mauricio Berriel Diaz. https://www.cell.com/trends/cancer/fulltext/S2405-8033(18)30219-X

Cell-in-cell phenomena in cancer – Stefano Fais and Michael Overholtzer. https://www.nature.com/articles/s41568-018-0073-9

Chemical biology probes of mammalian GLUT structure and function – Geoffrey D. Holman. http://www.biochemj.org/content/475/22/3511?etoc


Comments/other


Revisiting the Warburg Effect: Some Tumors Hold Their Breath – Sydney M. Sanderson, Jason W. Locasale. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30643-0

Tumors sweeten macrophages with acids – Hiroki Sekine, Masayuki Yamamoto and Hozumi Motohashi. https://www.nature.com/articles/s41590-018-0258-0

Endosomal microautophagy is an integrated part of the autophagic response to amino acid starvation – Hallvard L. Olsvik, Steingrim Svenning, Yakubu Princely Abudu, Andreas Brech, Harald Stenmark, Terje Johansen and Jakob Mejlvang. https://www.tandfonline.com/doi/full/10.1080/15548627.2018.1532265

Metabolic Flexibility in Leukemia—Adapt or Die – Boaz Nachmias, Aaron D. Schimmer. https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30478-1

Obesity gives unexpected boost to anticancer drugshttp://science.sciencemag.org/content/362/6416/734.full

TXNIP-Dependent Extracellular Matrix Remodeling Drives Glycolysishttp://cancerdiscovery.aacrjournals.org/content/8/11/OF9

Biochimica et Biophysica Acta (BBA) – Bioenergetics
20th European Bioenergetics Conference – abstracts -https://www.sciencedirect.com/journal/biochimica-et-biophysica-acta-bba-bioenergetics/vol/1859/suppl/S

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