MetaboList – December 2018


Amino acid metabolism


Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism – Michael A. Reid, Annamarie E. Allen, Shiyu Liu, Maria V. Liberti, Pei Liu, Xiaojing Liu, Ziwei Dai, Xia Gao, Qian Wang, Ying Liu, Luhua Lai and Jason W. Locasale. https://www.nature.com/articles/s41467-018-07868-6

Methionine coordinates a hierarchically organized anabolic program enabling proliferation – Adhish S. Walvekar, Rajalakshmi Srinivasan, Ritu Gupta and Sunil Laxman. https://www.molbiolcell.org/doi/10.1091/mbc.E18-08-0515?ai=s5&ui=2oy6&af=T

p53-mediated adaptation to serine starvation is retained by a common tumour-derived mutant – Timothy J. Humpton, Andreas K. Hock, Oliver D. K. Maddocks and Karen H. Vousden. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-018-0191-6

Efficacy of arginine depletion by ADI-PEG20 in an intracranial model of GBM – Justyna Magdalena Przystal, Nabil Hajji, Combiz Khozoie, Alexander Renziehausen, Qingyu Zeng, Fernando Abaitua, Amin Hajitou, Keittisak Suwan, Elizabeth Want, John Bomalaski, Peter Szlosarek, Kevin O’Neill, Tim Crook and Nelofer Syed. https://www.nature.com/articles/s41419-018-1195-4


Lipid metabolism


p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression – Sung-Hwan Moon, Chun-Hao Huang, Shauna L. Houlihan, Kausik Regunath, William A. Freed-Pastor, John P. Morris IV, Darjus F. Tschaharganeh, Edward R. Kastenhuber, Anthony M. Barsotti, Rachel Culp-Hill, Wen Xue, Yu-Jui Ho, Timour Baslan, Xiang Li, Allison Mayle, Elisa de Stanchina, Lars Zender, David R. Tong, Angelo D’Alessandro, Scott W. Lowe, Carol Prives. https://www.cell.com/cell/fulltext/S0092-8674(18)31503-4#%20

CAMKK2 Promotes Prostate Cancer Independently of AMPK via Increased Lipogenesis – Lucy Penfold, Angela Woods, Phillip Muckett, Alexander Yu. Nikitin, Tera R. Kent, Shuai Zhang, Rebecca Graham, Alice Pollard and David Carling. http://cancerres.aacrjournals.org/content/78/24/6747

PPARγ is dispensable for clear cell renal cell carcinoma progression – Danielle J.Sanchez, David J.Steger, NicolasSkuli, AnkitaBansal, CelesteSimon. https://www.sciencedirect.com/science/article/pii/S2212877818304393


Nucleotides


Microtubule-directed transport of purine metabolons drives their cytosolic transit to mitochondria – Chung Yu Chan, Anthony M. Pedley, Doory Kim, Chenglong Xia, Xiaowei Zhuang and Stephen J. Benkovic. https://www.pnas.org/content/115/51/13009?etoc=

SIRT6 deacetylase activity regulates NAMPT activity and NAD(P)(H)pools in cancer cells – Giovanna Sociali, Alessia Grozio, Irene Caffa, Susanne Schuster,  Pamela Becherini, Patrizia Damonte, Laura Sturla, Chiara Fresia, Mario Passalacqua, Francesca Mazzola, Nadia Raffaelli, Antje Garten, Wieland Kiess, Michele Cea, Alessio Nencioni and Santina Bruzzone. https://www.fasebj.org/doi/abs/10.1096/fj.201800321R?ai=ts&ui=ly8&af=T

Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism – Michael A. Reid, Annamarie E. Allen, Shiyu Liu, Maria V. Liberti, Pei Liu, Xiaojing Liu, Ziwei Dai, Xia Gao, Qian Wang, Ying Liu, Luhua Lai and Jason W. Locasale. https://www.nature.com/articles/s41467-018-07868-6


Mitochondria


MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo – Erol C. Bayraktar, Lou Baudrier, Ceren Özerdem, Caroline A. Lewis, Sze Ham Chan, Tenzin Kunchok, Monther Abu-Remaileh, Andrew L. Cangelosi, David M. Sabatini, Kıvanç Birsoy, and Walter W. Chen. https://www.pnas.org/content/116/1/303?etoc=

CAB39L elicited an anti-Warburg effect via a LKB1-AMPK-PGC1α axis to inhibit gastric tumorigenesis – Weilin Li, Chi Chun Wong, Xiaoming Zhang, Wei Kang, Geicho Nakatsu et al. https://www.nature.com/articles/s41388-018-0402-1

Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity – Caroline Giessner, Virginie Millet, Konrad J Mostert, Thomas Gensollen, Thien-Phong Vu Manh, Marc Garibal, Binta Dieme, Noudjoud Attaf-Bouabdallah, Lionel Chasson, Nicolas Brouilly, Caroline Laprie, Tom Lesluyes, Jean Yves Blay, Laetitia Shintu, Jean Charles Martin, Erick Strauss  Correspondence email, Franck Galland,Philippe Naquet. http://www.life-science-alliance.org/content/1/4/e201800073


Glucose metabolism / lactate


2‐Deoxy‐D‐glucose has distinct and cell line‐specific effects on the survival of different cancer cells upon antitumor drug treatment – Polina Maximchik, Alibek Abdrakhmanov, Evgeniya Inozemtseva, Pyotr A. Tyurin‐Kuzmin, Boris Zhivotovsky, Vladimir Gogvadze. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14687

Transport-exclusion pharmacology to localize lactate dehydrogenase activity within cells – Xiangfeng Niu, Ying-Jr Chen, Peter A. Crawford and Gary J. Patti. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-018-0192-5

A Trace Amount of Galactose, a Major Component of Milk Sugar, Allows Maturation of Glycoproteins during Sugar Starvation – Sasaoka N, Imamura H, Kakizuka A. https://www.sciencedirect.com/science/article/pii/S2589004218302256?via%3Dihub

Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells – Don Benjamin, Dimitri Robay, Sravanth K. Hindupur, Jens Pohlmann, Marco Colombi, Mahmoud Y. El-Shemerly, Sauveur-Michel Maira, Christoph Moroni, Heidi A. Lane, Michael N. Hall. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31806-0


Starvation


ULK1 O-GlcNAcylation Is Crucial for Activating VPS34 via ATG14L during Autophagy Initiation – Ki Eun Pyo, Chang Rok Kim, Minkyoung Lee, Jong-Seo Kim, Keun Il Kim, Sung Hee Baek. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31805-9

Regulated proteolysis of p62/SQSTM1 enables differential control of autophagy and nutrient sensing – Julia Sanchez-Garrido, Vanessa Sancho-Shimizu, and Avinash R. Shenoy. http://stke.sciencemag.org/content/11/559/eaat6903

Arginine methylation of SIRT7 couples glucose sensing with mitochondria biogenesis – Wei‐Wei Yan, Yun‐Liu Liang, Qi‐Xiang Zhang, Di Wang, Ming‐Zhu Lei, Jia Qu, Xiang‐Huo He, Qun‐Ying Lei and Yi‐Ping Wang. http://embor.embopress.org/content/19/12/e46377?etoc

GPx1 is involved in the induction of protective autophagy in pancreatic cancer cells in response to glucose deprivation – Qingcai Meng, Jin Xu, Chen Liang, Jiang Liu, Jie Hua, Yiyin Zhang, Quanxing Ni, Si Shi and Xianjun Yu. https://www.nature.com/articles/s41419-018-1244-z


Metformin


Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides – Laura Hulea, Simon-Pierre Gravel, Masahiro Morita, Marie Cargnello, Oro Uchenunu, Young Kyuen Im, Camille Lehuédé, Eric H. Ma, Matthew Leibovitch, Shannon McLaughlan, Marie-José Blouin, Maxime Parisotto, Vasilios Papavasiliou, Cynthia Lavoie, Ola Larsson, Michael Ohh, Tiago Ferreira, Celia Greenwood, Gaëlle Bridon, Daina Avizonis, Gerardo Ferbeyre, Peter Siegel, Russell G. Jones, William Muller, Josie Ursini-Siegel, Julie St-Pierre, Michael Pollak, Ivan Topisirovic. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30566-7

A phase 2 trial of neoadjuvant metformin in combination with trastuzumab and chemotherapy in women with early HER2-positive breast cancer: the METTEN study – Martin-Castillo B, Pernas S, Dorca J, Álvarez I, Martínez S, Pérez-Garcia JM, Batista-López N, Rodríguez-Sánchez CA, Amillano K, Domínguez S, Luque M, Stradella A, Morilla I, Viñas G, Cortés J, Cuyàs E, Verdura S, Fernández-Ochoa Á, Fernández-Arroyo S, Segura-Carretero A, Joven J, Pérez E, Bosch N, Garcia M, López-Bonet E, Saidani S, Buxó M, Menendez JA. http://www.impactjournals.com/oncotarget/misc/linkedout.php?pii=26286

Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals – Elbere I, Silamikelis I, Ustinova M, Kalnina I, Zaharenko L, Peculis R, Konrade I, Ciuculete DM, Zhukovsky C, Gudra D, Radovica-Spalvina I, Fridmanis D, Pirags V, Schiöth HB, Klovins J. https://www.ncbi.nlm.nih.gov/pubmed/30545422


Cancer immunometabolism


Dietary Protein Restriction Reprograms Tumor-Associated Macrophages and Enhances Immunotherapy – Ashley Orillion, Nur P. Damayanti, Li Shen, Remi Adelaiye-Ogala, Hayley Affronti, May Elbanna, Sreenivasulu Chintala, Michael Ciesielski, Luigi Fontana, Chinghai Kao, Bennett D. Elzey, Timothy L. Ratliff, David E. Nelson, Dominic Smiraglia, Scott I. Abrams and Roberto Pili. http://clincancerres.aacrjournals.org/content/24/24/6383

Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression – Christopher M. Rice, Luke C. Davies, Jeff J. Subleski, Nunziata Maio, Marieli Gonzalez-Cotto, Caroline Andrews, Nimit L. Patel, Erika M. Palmieri, Jonathan M. Weiss, Jung-Min Lee, Christina M. Annunziata, Tracey A. Rouault, Scott K. Durum and Daniel W. McVicar. https://www.nature.com/articles/s41467-018-07505-2

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism – Marc O. Johnson, Melissa M. Wolf, Matthew Z. Madden, Gabriela Andrejeva, Ayaka Sugiura, Diana C. Contreras, Damian Maseda, Maria V. Liberti, Katelyn Paz, Rigel J. Kishton, Matthew E. Johnson, Aguirre A. de Cubas, Pingsheng Wu, Gongbo Li, Yongliang Zhang, Dawn C. Newcomb, Andrew D. Wells, Nicholas P. Restifo, W. Kimryn Rathmell, Jason W. Locasale, Marco L. Davila, Bruce R. Blazar, Jeffrey C. Rathmell. https://www.cell.com/cell/fulltext/S0092-8674(18)31309-6?dgcid=raven_jbs_etoc_email


Liver cancer


An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma – Hanyong Sun, Weiqin Yang, Yuan Tian, Xuezhen Zeng, Jingying Zhou, Myth T. S. Mok, Wenshu Tang, Yu Feng, Liangliang Xu, Anthony W. H. Chan, Joanna H. Tong, Yue-Sun Cheung, Paul B. S. Lai, Hector K. S. Wang, Shun-Wa Tsang, King-Lau Chow, Mengying Hu, Rihe Liu, Leaf Huang, Bing Yang, Pengyuan Yang, Ka-Fai To, Joseph J. Y. Sung, Grace L. H. Wong, Vincent W. S. Wong and Alfred S. L. Cheng. https://www.nature.com/articles/s41467-018-07402-8

Metabolic network-based stratification of hepatocellular carcinoma reveals three distinct tumor subtypes – Gholamreza Bidkhori, Rui Benfeitas, Martina Klevstig, Cheng Zhang, Jens Nielsen, Mathias Uhlen, Jan Boren and Adil Mardinoglu. https://www.pnas.org/content/115/50/E11874?etoc=

Identification of the Consistently Altered Metabolic Targets in Human Hepatocellular Carcinoma – Nwosu ZC, Megger DA, Hammad S, Sitek B, Roessler S, Ebert MP, Meyer C, Dooley S. https://www.cmghjournal.org/article/S2352-345X(17)30086-3/fulltext

Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours – Nwosu ZC, Battello N, Rothley M, Piorońska W, Sitek B, Ebert MP, Hofmann U, Sleeman J, Wölfl S, Meyer C, Megger DA, Dooley S. https://jeccr.biomedcentral.com/articles/10.1186/s13046-018-0872-6

p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression – Sung-Hwan Moon, Chun-Hao Huang, Shauna L. Houlihan, Kausik Regunath, William A. Freed-Pastor, John P. Morris IV, Darjus F. Tschaharganeh, Edward R. Kastenhuber, Anthony M. Barsotti, Rachel Culp-Hill, Wen Xue, Yu-Jui Ho, Timour Baslan, Xiang Li, Allison Mayle, Elisa de Stanchina, Lars Zender, David R. Tong, Angelo D’Alessandro, Scott W. Lowe, Carol Prives. https://www.cell.com/cell/fulltext/S0092-8674(18)31503-4#%20


Miscellaneous


Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway – Kiran Kurmi, Sadae Hitosugi, Jia Yu, Felix Boakye-Agyeman, Elizabeth K. Wiese, Thomas R. Larson, Qing Dai, Yuichi J. Machida, Zhenkun Lou, Liewei Wang, Judy C. Boughey, Scott H. Kaufmann, Matthew P. Goetz, Larry M. Karnitz, Taro Hitosugi. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30509-6

Spatially resolved metabolomics to discover tumor-associated metabolic alterations – Chenglong Sun, Tiegang Li, Xiaowei Song, Luojiao Huang, Qingce Zang, Jing Xu, Nan Bi, Guanggen Jiao, Yanzeng Hao, Yanhua Chen, Ruiping Zhang, Zhigang Luo, Xin Li, Luhua Wang, Zhonghua Wang, Yongmei Song, Jiuming He and Zeper Abliz. https://www.pnas.org/content/116/1/52?etoc=

Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD – Daniel Garcia, Kristina Hellberg, Amandine Chaix, Martina Wallace, Sébastien Herzig, Mehmet G. Badur, Terry Lin, Maxim N. Shokhirev, Antonio F.M. Pinto, Debbie S. Ross, Alan Saghatelian, Satchidananda Panda, Lukas E. Dow, Christian M. Metallo, Reuben J. Shaw. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31966-1

A Transient Pseudosenescent Secretome Promotes Tumor Growth after Antiangiogenic Therapy Withdrawal – Michalis Mastri, Amanda Tracz, Christina R. Lee, Melissa Dolan, Kristopher Attwood, James G. Christensen, Song Liu, John M.L. Ebos. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31928-4


Reviews


Metabolic Reprogramming of Non-Hodgkin’s B-Cell Lymphomas and Potential Therapeutic Strategies – Jean-Ehrland Ricci and Johanna Chiche. https://www.frontiersin.org/articles/10.3389/fonc.2018.00556/full

The lysosome as a cellular centre for signalling, metabolism and quality control – Rosalie E. Lawrence and Roberto Zoncu. https://www.nature.com/articles/s41556-018-0244-7

mTOR as a central hub of nutrient signalling and cell growth – Joungmok Kim and Kun-Liang Guan. https://www.nature.com/articles/s41556-018-0205-1

The emerging link between cancer, metabolism, and circadian rhythms – Selma Masri and Paolo Sassone-Corsi. https://www.nature.com/articles/s41591-018-0271-8

NAD Metabolism in Cancer Therapeutics – Keisuke Yaku, Keisuke Okabe, Keisuke Hikosaka and Takashi Nakagawa. https://www.frontiersin.org/articles/10.3389/fonc.2018.00622/full


Comments


HER2 Signaling Hijacks the Creatine Shuttle to Fuel Breast Cancer Cell Growth – Issam Ben-Sahra, Alexandre Puissant. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30686-7

Probing mitochondrial metabolism in vivo – Gregory S. McElroy and Navdeep S. Chandel. https://www.pnas.org/content/116/1/20?etoc=

Parasitic Behavior of Leukemic Cells in Systemic Host Metabolism – Julie Leca, Thorsten Berger, Tak Wah Mak. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30688-0

New developments of Metformin in the clinical cancer area – Lev M. Berstein. https://impactjournals.us9.list-manage.com/track/click?u=133779c099e52b6fa9d4dec2e&id=3043c292d9&e=923b339f12

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