MetaboList – January 2019


Nucleotides


Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells – Bajzikova M, Kovarova J, Coelho AR, Boukalova S, Oh S, Rohlenova K, Svec D, Hubackova S, Endaya B, Judasova K, Bezawork-Geleta A, Kluckova K, Chatre L, Zobalova R, Novakova A, Vanova K, Ezrova Z, Maghzal GJ, Magalhaes Novais S, Olsinova M, Krobova L, An YJ, Davidova E, Nahacka Z, Sobol M, Cunha-Oliveira T, Sandoval-Acuña C, Strnad H, Zhang T, Huynh T, Serafim TL, Hozak P, Sardao VA, Koopman WJH, Ricchetti M, Oliveira PJ, Kolar F, Kubista M, Truksa J, Dvorakova-Hortova K, Pacak K, Gurlich R, Stocker R, Zhou Y, Berridge MV, Park S, Dong L, Rohlena J, Neuzil J. https://www.sciencedirect.com/science/article/pii/S1550413118306466

AICAr suppresses cell proliferation by inducing NTP and dNTP pool imbalances in acute lymphoblastic leukemia cells – Lijuan Du, Fan Yang, Houshun Fang, Huiying Sun, Yao Chen, Yan Xu, Hui Li, Liang Zheng and Bin-Bing S. Zhou. https://www.fasebj.org/doi/abs/10.1096/fj.201801559RR?ai=ts&ui=ly8&af=T


Lipids / Acetyl-CoA


Acetyl-CoA metabolism supports multi-step pancreatic tumorigenesis – Alessandro Carrer, Sophie Trefely, Steven Zhao, Sydney Campbell, Robert J Norgard, Kollin C Schultz, Simone Sidoli, Joshua L.D. Parris, Hayley C Affronti, Sharanya Sivanand, Shaun Egolf, Yogev Sela, Marco Trizzino, Alessandro Gardini, Benjamin A Garcia, Nathaniel W Snyder, Ben Z. Stanger and Kathryn Wellen. http://cancerdiscovery.aacrjournals.org/content/early/2019/01/09/2159-8290.CD-18-0567

Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma – James S.V. Lally, Sarani Ghoshal, Danielle K. DePeralta, Omeed Moaven, Lan Wei, Ricard Masia, Derek J. Erstad, Naoto Fujiwara, Vivian Leong, Vanessa P. Houde, Alexander E. Anagnostopoulos, Alice Wang, Lindsay A. Broadfield, Rebecca J. Ford, Robert A. Foster, Jamie Bates, Hailing Sun, Ting Wang, Henry Liu, Adrian S. Ray, Asish K. Saha, Jeremy Greenwood, Sathesh Bhat, Geraldine Harriman, Wenyan Miao, Jennifer L. Rocnik, William F. Westlin, Paola Muti, Theodoros Tsakiridis, H. James Harwood Jr., Rosana Kapeller, Yujin Hoshida, Kenneth K. Tanabe, Gregory R. Steinberg, Bryan C. Fuchs. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30521-7

Autophagy modulates lipid metabolism to maintain metabolic flexibility for Lkb1-deficient Kras-driven lung tumorigenesis – Vrushank Bhatt, Khoosheh Khayati, Zhixian Sherrie Hu, Amy Lee, Wali Kamran, Xiaoyang Su and Jessie Yanxiang Guo. http://genesdev.cshlp.org/content/33/3-4/150.abstract?etoc

Induction of 3-hydroxy-3-methylglutaryl-CoA reductase mediates statin resistance in breast cancer cells – Andy Göbel, Dorit Breining, Martina Rauner, Lorenz C. Hofbauer and Tilman D. Rachner. https://www.nature.com/articles/s41419-019-1322-x

Hypoxia Restrains Lipid Utilization via Protein Kinase A and Adipose Triglyceride Lipase Downregulation through Hypoxia-Inducible Factor – Ji Seul Han, Jung Hyun Lee, Jinuk Kong, Yul Ji, Jiwon Kim, Sung Sik Choe  and Jae Bum Kim. http://mcb.asm.org/content/39/2/e00390-18.abstract?etoc

Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer – Giorgia Zadra, Caroline F. Ribeiro, Paolo Chetta, Yeung Ho, Stefano Cacciatore, Xueliang Gao, Sudeepa Syamala, Clyde Bango, Cornelia Photopoulos, Ying Huang, Svitlana Tyekucheva, Debora C. Bastos, Jeremy Tchaicha, Brian Lawney, Takuma Uo, Laura D’Anello, Alfredo Csibi, Radha Kalekar, Benjamin Larimer, Leigh Ellis, Lisa M. Butler, Colm Morrissey, Karen McGovern, Vito J. Palombella, Jeffery L. Kutok, Umar Mahmood, Silvano Bosari, Julian Adams, Stephane Peluso, Scott M. Dehm, Stephen R. Plymate and Massimo Loda. https://www.pnas.org/content/116/2/631

Lipid and Glucose Metabolism in Hepatocyte Cell Lines and Primary Mouse Hepatocytes: A comprehensive resource for in vitro studies of hepatic metabolism – Shilpa R. Nagarajan , Moumita Paul-Heng , James R Krycer , Daniel Fazakerley , Alexandra F. Sharland and Andrew J. Hoy. https://www.physiology.org/doi/abs/10.1152/ajpendo.00365.2018

Extracellular Fatty Acids are the Major Contributor to Lipid Synthesis in Prostate Cancer – Seher Balaban, Zeyad D Nassar, Alison Y. Zhang, Elham Hosseini-Beheshti, Margaret M. Centenera, Mark Schreuder, Hui-Ming Lin, Atqiya Aishah, Bianca Varney, Frank Liu-Fu, Lisa S. Lee, Shilpa R. Nagarajan, Robert F. Shearer, Rae-Anne Hardie, Nikki L. Raftopulos, Meghna S. Kakani, Darren N. Saunders, Jeff Holst, Lisa G Horvath, Lisa M. Butler and Andrew J. Hoy. http://mcr.aacrjournals.org/content/early/2019/01/15/1541-7786.MCR-18-0347


Glucose metabolism, lactate


FOXK1 and FOXK2 regulate aerobic glycolysis – Valentina Sukonina, Haixia Ma, Wei Zhang, Stefano Bartesaghi, Santhilal Subhash, Mikael Heglind, Håvard Foyn, Matthias J. Betz, Daniel Nilsson, Martin E. Lidell, Jennifer Naumann, Saskia Haufs-Brusberg, Henrik Palmgren, Tanmoy Mondal, Muheeb Beg, Mark P. Jedrychowski, Kjetil Taskén, Alexander Pfeifer, Xiao-Rong Peng, Chandrasekhar Kanduri and Sven Enerbäck. https://www.nature.com/articles/s41586-019-0900-5

The FOXC1/FBP1 signaling axis promotes colorectal cancer proliferation by enhancing the Warburg effect – Qingguo Li, Ping Wei, Jitao Wu, Meng Zhang, Guichao Li, Yaqi Li, Ye Xu, Xinxiang Li, Dacheng Xie, Sanjun Cai, Keping Xie and Dawei Li. https://www.nature.com/articles/s41388-018-0469-8

Lactic Acid Accumulation in the Tumor Microenvironment Suppresses 18F-FDG Uptake – Silvan Türkcan, Louise Kiru, Dominik J. Naczynski, Laura S. Sasportas and Guillem Pratx. http://cancerres.aacrjournals.org/content/79/2/410

Ketoconazole and Posaconazole Selectively Target HK2-expressing Glioblastoma Cells – Sameer Agnihotri, Sheila Mansouri, Kelly Burrell, Mira Li, Yasin Mamatjan, Jeff Liu, Romina Nejad, Sushil Kumar, Shahrzad Jalali, Sanjay K. Singh, Alenoush Vartanian, Eric Xueyu Chen, Shirin Karimi, Olivia Singh, Severa Bunda, Alireza Mansouri, Kenneth D. Aldape and Gelareh Zadeh. http://clincancerres.aacrjournals.org/content/25/2/844

Tristetraprolin-mediated hexokinase 2 expression regulation contributes glycolysis in cancer cells – Dong Jun Kim, Mai-Tram Vo, Seong Hee Choi, Ji-Heon Lee, So Yeon Jeong, Chung Hwan Hong, Jong Soo Kim, Unn Hwa Lee, Hyung-Min Chung, Byung Ju Lee, Wha Ja Cho and Jeong Woo Park. https://www.molbiolcell.org/doi/abs/10.1091/mbc.E18-09-0606

High-Throughput Screening Identified Compounds Sensitizing Tumor Cells to Glucose Starvation in Culture and VEGF Inhibitors In Vivo – Ran Marciano, Manu Prasad, Tal Ievy, Sapir Tzadok , Gabriel Leprivier, Moshe Elkabets and Barak Rotblat. https://www.mdpi.com/2072-6694/11/2/156/htm

Tumoral microvesicle–activated glycometabolic reprogramming in  fibroblasts promotes the progression of oral squamous cell carcinoma – Erhui Jiang, Zhi Xu, Meng Wang, Tinglin Yan, Chunming Huang, Xiaocheng Zhou, Qing Liu, Lin Wang, Yang Chen, Hui Wang, Ke Liu, Zhe Shao and Zhenjun Shang. https://www.fasebj.org/doi/abs/10.1096/fj.201802226R?ai=ts&ui=ly8&af=T

LDHA and LDHB are dispensable for aerobic glycolysis in neuroblastoma cells while promoting their aggressiveness – Christian Beltinger. http://www.jbc.org/content/294/1/66.full.html

Reply to Beltinger: Double genetic disruption of lactate dehydrogenases A and B is required to ablate the “Warburg effect” restricting tumor growth to oxidative metabolism – Jacques Pouysségur and Maša Ždralević. http://www.jbc.org/content/294/1/67.full.html


Amino acid metabolism


Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy – Thomas Bertero, William M. Oldham, Eloise M. Grasset, Isabelle Bourget, Etienne Boulter, Sabrina Pisano, Paul Hofman, Floriant Bellvert, Guerrino Meneguzzi, Dmitry V. Bulavin, Soline Estrach, Chloe C. Feral, Stephen Y. Chan, Alexandre Bozec, Cedric Gaggioli. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30577-1

Ablation of the ASCT2 (SLC1A5) gene encoding a neutral amino acid transporter reveals transporter plasticity and redundancy in cancer cells – Angelika Bröer, Gregory Gauthier-Coles, Farid Rahimi, Michelle van Geldermalsen, Dieter Dorsch, Ansgar Wegener, Jeff Holst and Stefan Bröer. http://www.jbc.org/content/early/2019/01/11/jbc.RA118.006378.abstract

Acid-Induced Downregulation of ASS1 Contributes to the Maintenance of Intracellular pH in Cancer – Alon Silberman, Omer Goldman, Odeya Boukobza Assayag, Adi Jacob, Shiran Rabinovich, Lital Adler, Joo Sang Lee, Rom Keshet, Alona Sarver, Julia Frug, Noa Stettner, Sivan Galai, Erez Persi, Keren Bahar Halpern, Yehudit Zaltsman-Amir, Ben Pode-Shakked, Raya Eilam, Yair Anikster, Sandesh C.S. Nagamani, Igor Ulitsky, Eytan Ruppin and Ayelet Erez. http://cancerres.aacrjournals.org/content/79/3/518


Mitochondria


Mitochondrial complex III is necessary for endothelial cell proliferation during angiogenesis – Lauren P. Diebold, Hyea Jin Gil, Peng Gao, Carlos A. Martinez, Samuel E. Weinberg and Navdeep S. Chandel. https://www.nature.com/articles/s42255-018-0011-x

Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer – David A. Bader, Sean M. Hartig […] Sean E. McGuire. https://www.nature.com/articles/s42255-018-0002-y

PML-Regulated Mitochondrial Metabolism Enhances Chemosensitivity in Human Ovarian Cancers – Géraldine Gentric, Yann Kieffer, Virginie Mieulet, Oumou Goundiam, Claire Bonneau, Fariba Nemati, Ilse Hurbain, Graca Raposo, Tatiana Popova, Marc-Henri Stern, Valérie Lallemand-Breitenbach, Sebastian Müller, Tatiana Cañeque, Raphaël Rodriguez, Anne Vincent-Salomon, Hugues de Thé, Rodrigue Rossignol, Fatima Mechta-Grigoriou. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30567-9

Metabolic reprogramming of oncogene-addicted cancer cells to OXPHOS as a mechanism of drug resistance – Hirpara J, Eu JQ, Tan JKM, Wong AL, Clement MV, Kong LR, Ohi N, Tsunoda T, Qu J, Goh BC, Pervaiz S.. https://www.sciencedirect.com/science/article/pii/S2213231718310747?via%3Dihub

Tissue-specific expression and post-transcriptional regulation of the  ATPase inhibitory factor 1 (IF1) in human and mouse tissues – Pau B. Esparza-Moltó, Cristina Nuevo-Tapioles, Margarita Chamorro, Laura Nájera, Laura Torresano, Fulvio Santacatterina and José M. Cuezva. https://www.fasebj.org/doi/abs/10.1096/fj.201800756R?ai=s4&ui=ly8&af=T

The novel function of tumor protein D54 in regulating pyruvate dehydrogenase and metformin cytotoxicity in breast cancer – Yongxian Zhuang, Reynold C. Ly, Carleigh V. Frazier, Jia Yu, Sisi Qin, Xiao-Yang Fan, Matthew P. Goetz, Judy C. Boughey, Richard Weinshilboum and Liewei Wang. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-018-0193-4


Starvation / nutrient sensing


Introns are mediators of cell response to starvation – Julie Parenteau, Laurine Maignon, Mélodie Berthoumieux, Mathieu Catala, Vanessa Gagnon and Sherif Abou Elela. https://www.nature.com/articles/s41586-018-0859-7

Arg78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases – Kuang Shen, Max L. Valenstein, Xin Gu and David M. Sabatini. http://www.jbc.org/content/early/2019/01/16/jbc.AC119.007382.abstract

RagC phosphorylation autoregulates mTOR complex 1 – Guang Yang, Sean J Humphrey, Danielle S Murashige, Deanne Francis, Qiao‐Ping Wang, Kristen C Cooke, G Gregory Neely and David E James. http://EMBOJ.embopress.org/content/38/3/e99548?etoc

Role of Mitochondria in Ferroptosis – Minghui Gao, Junmei Yi, Jiajun Zhu, Alexander M. Minikes, Prashant Monian, Craig B. Thompson, Xuejun Jiang. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30936-5

Headcase and Unkempt Regulate Tissue Growth and Cell Cycle Progression in Response to Nutrient Restriction – Naren Li, Qinfang Liu, Yulan Xiong, Jianzhong Yu. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)32046-1?dgcid=raven_jbs_etoc_email


mTOR


Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A – Sung Min Son, So Jung Park, Huikyong Lee, Farah Siddiqi, Jong Eun Lee, Fiona M. Menzies, David C. Rubinsztein. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30514-X

Spatially Distinct Pools of TORC1 Balance Protein Homeostasis – Riko Hatakeyama, Marie-Pierre Péli-Gulli, Zehan Hu, Malika Jaquenoud, Guillermo Miguel Garcia Osuna, Alessandro Sardu, Jörn Dengjel, Claudio De Virgilio. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30934-1?

Global phosphoproteomic analysis reveals ARMC10 as an AMPK substrate that regulates mitochondrial dynamics OPEN – Zhen Chen, Caoqi Lei, Chao Wang, Nan Li, Mrinal Srivastava, Mengfan Tang, Huimin Zhang, Jong Min Choi, Sung Yun Jung, Jun Qin and Junjie Chen. https://www.nature.com/articles/s41467-018-08004-0


Hypoxia


Hypoxia Restrains Lipid Utilization via Protein Kinase A and Adipose Triglyceride Lipase Downregulation through Hypoxia-Inducible Factor – Ji Seul Han, Jung Hyun Lee, Jinuk Kong, Yul Ji, Jiwon Kim, Sung Sik Choe and Jae Bum Kim. http://mcb.asm.org/content/39/2/e00390-18.abstract?etoc

Tamoxifen mechanically reprograms the tumor microenvironment via HIF‐1A and reduces cancer cell survival – Ernesto Cortes, Dariusz Lachowski, Benjamin Robinson, Muge Sarper, Jaakko S Teppo, Stephen D Thorpe, Tyler J Lieberthal, Kazunari Iwamoto, David A Lee, Mariko Okada‐Hatakeyama, Markku T Varjosalo and Armando E del Río Hernández. http://EMBOr.embopress.org/content/20/1/e46557?etoc

Inherent DNA‐binding specificities of the HIF‐1α and HIF‐2α transcription factors in chromatin – James A Smythies, Min Sun, Norma Masson, Rafik Salama, Peter D Simpson, Elizabeth Murray, Viviana Neumann, Matthew E Cockman, Hani Choudhry, Peter J Ratcliffe and David R Mole. http://EMBOr.embopress.org/content/20/1/e46401?etoc

Hypoxia-inducible factor (HIF)-prolyl hydroxylase 3 (PHD3) maintains high HIF2A mRNA levels in clear cell renal cell carcinoma – Petra Miikkulainen, Heidi Högel, Fatemeh Seyednasrollah, Krista Rantanen, Laura L. Elo and Panu M. Jaakkola. http://www.jbc.org/content/early/2019/01/07/jbc.RA118.004902.abstract

Physioxic human cell culture improves viability, metabolism, and mitochondrial morphology while reducing DNA damage – Sara Timpano, Brianna D. Guild, Erin J. Specker, Gaelan Melanson, Philip J. Medeiros, Shannon L. J. Sproul and James Uniacke. https://www.fasebj.org/doi/abs/10.1096/fj.201802279R

Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia – Yuanyuan Wang, Changsen Bai, Yuxia Ruan, Miao Liu, Qiaoyun Chu, Li Qiu, Chuanzhen Yang and Binghui Li. https://www.nature.com/articles/s41467-018-08033-9

Hypoxia-induced autophagy of stellate cells inhibits expression and secretion of lumican into microenvironment of pancreatic ductal adenocarcinoma – Xinqun Li, Yeonju Lee, Ya’an Kang, Bingbing Dai, Mayrim Rios Perez, Michael Pratt, Eugene J. Koay, Michael Kim, Rolf A. Brekken and Jason B. Fleming. https://www.nature.com/articles/s41418-018-0207-3

Molecular landmarks of tumor hypoxia across cancer types – Vinayak Bhandari, Christianne Hoey, Lydia Y. Liu, Emilie Lalonde, Jessica Ray, Julie Livingstone ,Robert Lesurf, Yu-Jia Shiah,Tina Vujcic, Xiaoyong Huang, Shadrielle M. G. Espiritu, Lawrence E. Heisler, Fouad Yousif, Vincent Huang,Takafumi N. Yamaguchi,Cindy Q. Yao, Veronica Y. Sabelnykova, Michael Fraser, Melvin L. K. Chua,Theodorus van der Kwast, Stanley K. Liu, Paul C. Boutros and Robert G. Bristow. https://www.nature.com/articles/s41588-018-0318-2


IDH


IDH2 inhibition enhances proteasome inhibitor responsiveness in hematological malignancies – Elisa Bergaggio, Chiara Riganti, Giulia Garaffo, Nicoletta Vitale, Elisabetta Mereu, Cecilia Bandini, Elisa Pellegrino, Verdiana Pullano, Paola Omedè, Katia Todoerti, Luciano Cascione, Valentina Audrito, Anna Riccio, Antonio Rossi, Francesco Bertoni, Silvia Deaglio, Antonino Neri, Antonio Palumbo and Roberto Piva. http://bloodjournal.org/content/133/2/156.abstract?etoc

Methylation-dependent Tissue Factor Suppression Contributes to the Reduced Malignancy of IDH1-mutant Gliomas – Dusten Unruh, Snezana Mirkov, Brian Wray, Michael Drumm, Jonathan Lamano, Yuping D. Li, Qazi F. Haider, Rodrigo Javier, Kathleen McCortney, Amanda Saratsis, Denise M. Scholtens, Jann N. Sarkaria, C. David James and Craig Horbinski. http://clincancerres.aacrjournals.org/content/25/2/747


Cancer Immunometabolism


Uncoupling protein 2 reprograms the tumor microenvironment to support the anti-tumor immune cycle – Wan-Chen Cheng, Yao-Chen Tsui, Simone Ragusa, Viktor H. Koelzer, Marco Mina, Fabien Franco, Heinz Läubli, Benjamin Tschumi, Daniel Speiser, Pedro Romero, Alfred Zippelius, Tatiana V. Petrova, Kirsten Mertz, Giovanni Ciriello and Ping-Chih Ho. https://www.nature.com/articles/s41590-018-0290-0

Mitochondrial complex III is essential for suppressive function of regulatory T cells – Samuel E. Weinberg, Benjamin D. Singer, Elizabeth M. Steinert, Carlos A. Martinez, Manan M. Mehta, Inmaculada Martínez-Reyes, Peng Gao, Kathryn A. Helmin, Hiam Abdala-Valencia, Laura A. Sena, Paul T. Schumacker, Laurence A. Turka and Navdeep S. Chandel. https://www.nature.com/articles/s41586-018-0846-z

Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma – Livingstone Fultang, Laura D. Gamble, Luciana Gneo, Andrea M. Berry, Sharon A. Egan, Fenna De Bie, Orli Yogev, Georgina L. Eden, Sarah Booth, Samantha Brownhill, Ashley Vardon, Carmel M. McConville, Paul N. Cheng, Murray D. Norris, Heather C. Etchevers, Jayne Murray, David S. Ziegler, Louis Chesler, Ronny Schmidt, Susan A. Burchill, Michelle Haber, Carmela De Santo and Francis Mussai. http://cancerres.aacrjournals.org/content/79/3/611


Miscellaneous


NCOA4 Maintains Murine Erythropoiesis Via Cell Autonomous And Non-Autonomous Mechanisms – Naiara Santana-Codina, Sebastian Gableske, Maria Quiles del Rey, Beata Małachowska, Mark P. Jedrychowsk, Douglas E. Biancur, Paul J. Schmidt, Mark D. Fleming, Wojciech Fendler, J. Wade Harper, Alec C. Kimmelman, Joseph D. Mancias. http://www.haematologica.org/content/early/2019/01/07/haematol.2018.204123

Low metformin causes a more oxidized mitochondrial NADH/NAD redox state in hepatocytes and inhibits gluconeogenesis by a redox-independent mechanism – Ahmed Alshawi and Loranne Agius. http://www.jbc.org/content/early/2018/12/27/jbc.RA118.006670.abstract

The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons – Brian P. Daniels, Sigal B. Kofman, Julian R. Smith, Geoffrey T. Norris, Annelise G. Snyder, Joseph P. Kolb, Xia Gao, Jason W. Locasale, Jennifer Martinez, Michael Gale Jr., Yueh-Ming Loo, Andrew Oberst. https://www.cell.com/immunity/fulltext/S1074-7613(18)30525-9

Antagonism of Glycolysis and Reductive Carboxylation of Glutamine Potentiates Activity of Oncolytic Adenoviruses in Cancer Cells – Arthur Dyer, Benjamin Schoeps, Sally Frost, Philip Jakeman, Eleanor M. Scott, Joshua Freedman, Egon J. Jacobus and Leonard W. Seymour. http://cancerres.aacrjournals.org/content/79/2/331

CD36-triggered cell invasion and persistent tissue colonization by tumor microvesicles during metastasis – Susanne Pfeiler, Manovriti Thakur, Petra Grünauer, Remco T. A. Megens, Urjita Joshi, Raffaele Coletti, Verena Samara, Geraldine Müller-Stoy, Hellen Ishikawa-Ankerhold, Konstantin Stark, Andreas Klingl, Thomas Fröhlich, Georg J. Arnold, Sonja Wörmann, Christiane J. Bruns, Hana Algül, Christian Weber, Steffen Massberg and Bernd Engelmann. https://www.fasebj.org/doi/abs/10.1096/fj.201800985R


Reviews


Gluconeogenesis in Cancer: Function and Regulation of PEPCK, FBPase, and G6Pase – Zhanyu Wang, Chenfang Don. https://www.cell.com/trends/cancer/fulltext/S2405-8033(18)30256-5

Lactate: A Metabolic Driver in the Tumour Landscape – Luigi Ippolito, Andrea Morandi, Elisa Giannoni, Paola Chiarugi. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(18)30227-5

p62/SQSTM1: ‘Jack of all trades’ in health and cancer – Pablo Sánchez‐Martín, Tetsuya Saito, Masaaki Komatsu. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14712

Inflammation and Hypoxia: HIF and PHD Isoform Selectivity – Emily R. Watts, Sarah R. Walmsley. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(18)30202-8

Coupling Krebs cycle metabolites to signalling in immunity and cancer – Dylan G. Ryan, Michael P. Murphy […] Evanna L. Mills. https://www.nature.com/articles/s42255-018-0014-7

6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 and 4: A pair of valves for fine-tuning of glucose metabolism in human cancer – Mei Yi, Yuanyuan Ban, Yixin Tan, Wei Xiong, Guiyuan Li, Bo Xiang. https://www.sciencedirect.com/science/article/pii/S2212877818310342


Comments


The next decade of metabolism – Fredrik Bäckhed, Elisabetta Bugianesi, Heather Christofk, Ivan Dikic, Rana Gupta, William B. Mair, Luke A. J. O’Neill, Markus Ralser, David M. Sabatini and Matthias Tschöp. https://www.nature.com/articles/s42255-018-0022-7

Glucose-Regulated TET2 Activity Links Cancer to Diabetes – Hari R. Singh, Stefan H. Stricker. https://www.cell.com/trends/cancer/fulltext/S2405-8033(18)30239-5

Think We Understand the Role of DRP1 in Mitochondrial Biology? Zinc Again! – Jerry Edward Chipuk. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)31100-6

METABOLISM – Sabotaging the host – Maria Giuseppina Baratta. https://www.nature.com/articles/s41568-018-0078-4

mTORC1 goes sensorlesshttp://stke.sciencemag.org/content/12/564/eaaw6411

Autophagy Sustains Tumors by Maintaining Serum Arginine Levelshttp://cancerdiscovery.aacrjournals.org/content/9/1/15.1

Maintaining the tumour’s diet – Ulrike Harjes. https://www-nature-com.sire.ub.edu/articles/s41568-018-0097-1?

2nd Cell Death, Cell Stress and Metabolism Conference
27 May 2019 – 30 May 2019. https://www.fusion-conferences.com/conference94.php

Metabolism in Health and Disease Conference
24 May 2019 – 27 May 2019. https://www.fusion-conferences.com/conference90.php

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