MetaboList – February 2019


Glucose metabolism, glycolytic enzymes


GAPDH Expression Predicts the Response to R-CHOP, the Tumor Metabolic Status, and the Response of DLBCL Patients to Metabolic Inhibitors – Johanna Chiche, Julie Reverso-Meinietti, Annabelle Mouchotte, Camila Rubio-Patiño, Rana Mhaidly, Elodie Villa, Jozef P. Bossowski, Emma Proics, Manuel Grima-Reyes, Agnès Paquet, Konstantina Fragaki, Sandrine Marchetti, Josette Briere, Damien Ambrosetti, Jean-François Michiels, Thierry Jo Molina, Christiane Copie-Bergman, Jacqueline Lehmann-Che, Isabelle Peyrottes, Frederic Peyrade, Eric de Kerviler, Bruno Taillan, Georges Garnier, Els Verhoeyen, Véronique Paquis-Flucklinger, Laetitia Shintu, Vincent Delwail, Celine Delpech-Debiais, Richard Delarue, André Bosly, Tony Petrella, Gabriel Brisou, Bertrand Nadel, Pascal Barbry, Nicolas Mounier, Catherine Thieblemont, Jean-Ehrland Ricci. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30066-X

Fasting plasma glucose is an independent predictor of survival in patients with locally advanced non-small cell lung cancer treated with concurrent chemoradiotherapy – Milana Bergamino, Antonio J. Rullan, Maria Saigí, Inmaculada Peiró, Eduard Montanya, Ramón Palmero, José Carlos Ruffinelli, Arturo Navarro, María Dolores Arnaiz, Isabel Brao, Samantha Aso, Susana Padrones, Felipe Cardenal and Ernest Nadal. https://bmccancer.biomedcentral.com/articles/10.1186/s12885-019-5370-5

Tissue-specific regulation of p53 by PKM2 is redox dependent and provides a therapeutic target for anthracycline-induced cardiotoxicity – Bruno Saleme, Vikram Gurtu, Yongneng Zhang, Adam Kinnaird, Aristeidis E. Boukouris, Keshav Gopal, John R. Ussher and Gopinath Sutendra. http://stm.sciencemag.org/content/11/478/eaau8866

MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1 – Ying Yang, Mari B. Ishak Gabra, Eric A. Hanse, Xazmin H. Lowman, Thai Q. Tran, Haiqing Li, Neta Milman, Juan Liu, Michael A. Reid, Jason W. Locasale, Ziv Gil and Mei Kong. https://www.nature.com/articles/s41467-019-08759-0

Tissue-specific regulation of p53 by PKM2 is redox dependent and provides a therapeutic target for anthracycline-induced cardiotoxicity – Bruno Saleme, Vikram Gurtu, Yongneng Zhang, Adam Kinnaird, Aristeidis E. Boukouris, Keshav Gopal, John R. Ussher and Gopinath Sutendra. http://stm.sciencemag.org/content/11/478/eaau8866

IL-8-induced O-GlcNAc modification via GLUT3 and GFAT regulates cancer stem cell-like properties in colon and lung cancer cells – Masahiro Shimizu and Nobuyuki Tanaka. https://www.nature.com/articles/s41388-018-0533-4

Succinylation-dependent mitochondrial translocation of PKM2 promotes cell survival in response to nutritional stress – Hailong Qi, Xianling Ning, Chang Yu, Xin Ji, Yan Jin,  Michael A. McNutt and Yuxin Yin. https://www.nature.com/articles/s41419-018-1271-9


Amino acid metabolism / one carbon


HIF1α Suppresses Tumor Cell Proliferation through Inhibition of Aspartate Biosynthesis – Florinda Meléndez-Rodríguez, Andrés A. Urrutia, Doriane Lorendeau, Gianmarco Rinaldi, Olga Roche, Nuray Böğürcü-Seidel, Marta Ortega Muelas, Claudia Mesa-Ciller, Guillermo Turiel, Antonio Bouthelier, Pablo Hernansanz-Agustín, Ainara Elorza, Elia Escasany, Qilong Oscar Yang Li, Mar Torres-Capelli, Daniel Tello, Esther Fuertes, Enrique Fraga, Antonio Martínez-Ruiz, Belen Pérez, Jose Miguel Giménez-Bachs, Antonio S. Salinas-Sánchez, Till Acker, Ricardo Sánchez Prieto, Sarah-Maria Fendt, Katrien De Bock, Julián Aragonés. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30143-3

Canonical Wnt is inhibited by targeting one-carbon metabolism through methotrexate or methionine deprivation – Lauren V. Albrecht, Maggie H. Bui, and Edward M. De Robertis. https://www.pnas.org/content/116/8/2987.abstract?etoc

Mapping Metabolic Events in the Cancer Cell Cycle Reveals Arginine Catabolism in the Committed SG2M Phase – Irena Roci, Jeramie D. Watrous, Kim A. Lagerborg, Lorenzo Lafranchi, Arne Lindqvist, Mohit Jain, Roland Nilsson. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30088-9


Lipid metabolism


Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity – Kim Vriens, Stefan Christen, Sweta Parik, Dorien Broekaert, Kazuaki Yoshinaga, Ali Talebi, Jonas Dehairs, Carmen Escalona-Noguero, Roberta Schmieder, Thomas Cornfield, Catriona Charlton, Laura Romero-Pérez, Matteo Rossi, Gianmarco Rinaldi, Martin F. Orth, Ruben Boon, Axelle Kerstens, Suet Ying Kwan, Brandon Faubert, Andrés Méndez-Lucas, Charlotte C. Kopitz, Ting Chen, Juan Fernandez-Garcia, João A. G. Duarte, Arndt A. Schmitz, Patrick Steigemann, Mustapha Najimi, Andrea Hägebarth, Jo A. Van Ginderachter, Etienne Sokal, Naohiro Gotoh, Kwok-Kin Wong, Catherine Verfaillie, Rita Derua, Sebastian Munck, Mariia Yuneva, Laura Beretta, Ralph J. DeBerardinis, Johannes V. Swinnen, Leanne Hodson, David Cassiman, Chris Verslype, Sven Christian, Sylvia Grünewald, Thomas G. P. Grünewald and Sarah-Maria Fendt. https://www.nature.com/articles/s41586-019-0904-1

Tumor metastasis to lymph nodes requires YAP-dependent metabolic adaptation – Choong-kun Lee, Seung-hwan Jeong, Cholsoon Jang, Hosung Bae, Yoo Hyung Kim, Intae Park, Sang Kyum Kim, Gou Young Koh. http://science.sciencemag.org/content/363/6427/644


Nucleotides


Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer – Christopher J. Halbrook, Corbin Pontious, Ilya Kovalenko, Laura Lapienyte, Stephan Dreyer, Ho-Joon Lee, Galloway Thurston, Yaqing Zhang, Jenny Lazarus, Peter Sajjakulnukit, Hanna S. Hong, Daniel M. Kremer, Barbara S. Nelson, Samantha Kemp, Li Zhang, David Chang, Andrew Biankin, Jiaqi Shi, Timothy L. Frankel, Howard C. Crawford, Jennifer P. Morton, Marina Pasca di Magliano, Costas A. Lyssiotis. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30065-8

NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression – Chunjing Bian, Chao Zhang, Tao Luo, Aditi Vyas, Shih-Hsun Chen, Chao Liu, Muzaffer Ahmad Kassab, Ying Yang, Mei Kong and Xiaochun Yu. https://www.nature.com/articles/s41467-019-08530-5


Mitochondria


Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses – Ivana Kurelac, Luisa Iommarini, Renaud Vatrinet, Laura Benedetta Amato, Monica De Luise, Giulia Leone, Giulia Girolimetti, Nikkitha Umesh Ganesh, Victoria Louise Bridgeman, Luigi Ombrato, Marta Columbaro, Moira Ragazzi, Lara Gibellini, Manuela Sollazzo, Rene Gunther Feichtinger, Silvia Vidali, Maurizio Baldassarre, Sarah Foriel, Michele Vidone, Andrea Cossarizza, Daniela Grifoni, Barbara Kofler, Ilaria Malanchi, Anna Maria Porcelli and Giuseppe Gasparre. https://www.nature.com/articles/s41467-019-08839-1

Effects of cancer-associated point mutations on the structure, function, and stability of succinate dehydrogenase A – Zhi-Fa Cao, Nan Ni, Weihao Zhuang, Fei Ye, Yuehong Wu, Jieqiong Qiu, Yeqing Wu, Qing Sheng and Wen-Bin Ou. http://www.jbc.org/content/early/2019/02/06/jbc.RA118.006266.abstract

Metabolic and oncogenic adaptations to pyruvate dehydrogenase inactivation in fibroblasts – Huabo Wang, Jie Lu, Sucheta Kulkarni, Weiqi Zhang, Joanna E. Gorka, Jordan A. Mandel, Eric S. Goetzman and Edward V. Prochownik. http://www.jbc.org/content/early/2019/02/12/jbc.RA118.005200.abstract

Increased mitochondrial respiration promotes survival from endoplasmic reticulum stress – Jeffrey Knupp, Peter Arvan and Amy Chang. https://www.nature.com/articles/s41418-018-0133-4

Metabolic reprogramming in breast cancer results in distinct mitochondrial bioenergetics between luminal and basal subtypes – Paola Lunetti, Mariangela Di Giacomo, Daniele Vergara, Stefania De Domenico, Michele Maffia, Vincenzo Zara, Loredana Capobianco, Alessandra Ferramosca. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14756


Glutathione/Redox


Assessment of Tumor Redox Status through (S)-4-(3-[18F]fluoropropyl)-L-Glutamic Acid PET Imaging of System xc− Activity – Patrick N. McCormick, Hannah E. Greenwood, Matthias Glaser, Oliver D.K. Maddocks, Thibault Gendron, Kerstin Sander, Gayatri Gowrishankar, Aileen Hoehne, Tong Zhang, Adam J. Shuhendler, David Y. Lewis, Mathias Berndt, Norman Koglin, Mark F. Lythgoe, Sanjiv S. Gambhir, Erik Årstad and Timothy H. Witney. http://cancerres.aacrjournals.org/content/79/4/853

AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer – Shawn P. Kubli, Christian Bassi, Cecilia Roux, Andrew Wakeham, Christoph Göbl, Wenjing Zhou, Soode Moghadas Jafari, Bryan Snow, Lisa Jones, Luis Palomero, Kelsie L. Thu, Luca Cassetta, Daniel Soong, Thorsten Berger, Parameswaran Ramachandran, Shakiba P. Baniasadi, Gordon Duncan, Moshit Lindzen, Yosef Yarden, Carmen Herranz, Conxi Lazaro, Mandy F. Chu, Jillian Haight, Paul Tinto, Jennifer Silvester, David W. Cescon, Anna Petit, Sven Pettersson, Jeffrey W. Pollard, Tak W. Mak, Miguel A. Pujana, Paola Cappello and Chiara Gorrini. https://www.pnas.org/content/116/9/3604.abstract?etoc


Starvation


Metformin and glucose starvation decrease the migratory ability of hepatocellular carcinoma cells: targeting AMPK activation to control migration – Anabela C. Ferretti, Florencia Hidalgo, Facundo M. Tonucci, Evangelina Almada, Alejandro Pariani, María C. Larocca and Cristián Favre. https://www.nature.com/articles/s41598-019-39556-w

Analysis of autophagy activated during changes in carbon source availability in yeast cells – Ryo Iwama and Yoshinori Ohsumi. http://www.jbc.org/content/early/2019/02/12/jbc.RA118.005698.abstract

SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress – Mengli Zhang, Jian Wu, Renqiang Sun, Xiaoting Tao, Xiaoxia Wang, Qi Kang, Hui Wang, Lei Zhang, Peng Liu, Jinye Zhang, Yukun Xia, Yuzheng Zhao, Yi Yang, Yue Xiong, Kun-Liang Guan, Yunzeng Zou, Dan Ye. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211796


Hypoxia


OCT4B mediates hypoxia-induced cancer dissemination – Sheng-Chieh Lin, Chi-Hsiu Chung, Chih-Hung Chung, Ming-Han Kuo, Cheng-Han Hsieh, Yu-Fan Chiu, Yi-Shing Shieh, Yu-Ting Chou and Cheng-Wen Wu. https://www.nature.com/articles/s41388-018-0487-6

Differential Oxygenation in Tumor Microenvironment Modulates Macrophage and Cancer Cell Crosstalk: Novel Experimental Setting and Proof of Concept – Noelia Campillo, Bryan Falcones, Jordi Otero, Roser Colina, David Gozal, Daniel Navajas, Ramon Farré and Isaac Almendros. https://www.frontiersin.org/articles/10.3389/fonc.2019.00043/full

HIF1α Suppresses Tumor Cell Proliferation through Inhibition of Aspartate Biosynthesis – Florinda Meléndez-Rodríguez, […] Julián Aragonés. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30143-3


IDH


Molecular remission and response patterns in patients with mutant-IDH2 acute myeloid leukemia treated with enasidenib – Eytan M. Stein, Courtney D. DiNardo, Amir T. Fathi, Daniel A. Pollyea, Richard M. Stone, Jessica K. Altman, Gail J. Roboz, Manish R. Patel, Robert Collins, Ian W. Flinn, Mikkael A. Sekeres, Anthony S. Stein, Hagop M. Kantarjian, Ross L. Levine, Paresh Vyas, Kyle J. MacBeth, Alessandra Tosolini, Jason VanOostendorp, Qiang Xu, Ira Gupta, Thomas Lila, Alberto Risueno, Katharine E. Yen, Bin Wu, Eyal C. Attar, Martin S. Tallman and Stéphane de Botton. http://bloodjournal.org/content/133/7/676.abstract?etoc

IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response – Felipe J. Núñez , Flor M. Mendez, Padma Kadiyala, Mahmoud S. Alghamri, Masha G. Savelieff, Maria B. Garcia-Fabiani, Santiago Haase, Carl Koschmann, Anda-Alexandra Calinescu, Neha Kamran, Meghna Saxena, Rohin Patel, Stephen Carney, Marissa Z. Guo, Marta Edwards, Mats Ljungman, Tingting Qin, Maureen A. Sartor, Rebecca Tagett, Sriram Venneti, Jacqueline Brosnan-Cashman, Alan Meeker, Vera Gorbunova, Lili Zhao, Daniel M. Kremer, Li Zhang, Costas A. Lyssiotis, Lindsey Jones, Cameron J. Herting, James L. Ross, Dolores Hambardzumyan, Shawn Hervey-Jumper, Maria E. Figueroa, Pedro R. Lowenstein, Maria G. Castro. http://stm.sciencemag.org/content/11/479/eaaq1427


Cancer Immunometabolism


Tumor-Associated Macrophages Enhance Tumor Hypoxia and Aerobic Glycolysis – Hoibin Jeong, Sehui Kim, Beom-Ju Hong, Chan-Ju Lee, Young-Eun Kim, Seoyeon Bok, Jung-Min Oh, Seung-Hee Gwak, Min Young Yoo, Min Sun Lee, Seock-Jin Chung, Joan Defrêne, Philippe Tessier, Martin Pelletier, Hyeongrin Jeon, Tae-Young Roh, Bumju Kim, Ki Hean Kim, Ji Hyeon Ju, Sungjee Kim, Yoon-Jin Lee, Dong-Wan Kim, Il Han Kim, Hak Jae Kim, Jong-Wan Park, Yun-Sang Lee, Jae Sung Lee, Gi Jeong Cheon, Irving L. Weissman, Doo Hyun Chung, Yoon Kyung Jeon and G-One Ahn. http://cancerres.aacrjournals.org/content/79/4/795

Tumor cell oxidative metabolism as a barrier to PD-1 blockade immunotherapy in melanoma – Najjar YG, Menk AV, Sander C, Rao U, Karunamurthy A, Bhatia R, Zhai S, Kirkwood JM, Delgoffe GM. https://insight.jci.org/articles/view/124989

Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses – Ivana Kurelac, Luisa Iommarini, Renaud Vatrinet, Laura Benedetta Amato, Monica De Luise, Giulia Leone, Giulia Girolimetti, Nikkitha Umesh Ganesh, Victoria Louise Bridgeman, Luigi Ombrato, Marta Columbaro, Moira Ragazzi, Lara Gibellini, Manuela Sollazzo, Rene Gunther Feichtinger, Silvia Vidali, Maurizio Baldassarre, Sarah Foriel, Michele Vidone, Andrea Cossarizza, Daniela Grifoni, Barbara Kofler, Ilaria Malanchi, Anna Maria Porcelli and Giuseppe Gasparre. https://www.nature.com/articles/s41467-019-08839-1


Miscellaneous


Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways – Dongya Jia, Mingyang Lu, Kwang Hwa Jung, Jun Hyoung Park, Linglin Yu, José N. Onuchic, Benny Abraham Kaipparettu and Herbert Levine. https://www.pnas.org/content/116/9/3909.abstract?etoc

AMPK Promotes Xenophagy through Priming of Autophagic Kinases upon Detection of Bacterial Outer Membrane Vesicles – Truc T. Losier, Mercy Akuma, Olivia C. McKee-Muir, Nicholas D. LeBlond, Yujin Suk, Reham M. Alsaadi, Zhihao Guo, Ryan Reshke, Subash Sad, François-Xavier Campbell-Valois, Derrick J. Gibbings, Morgan D. Fullerton, Ryan C. Russell. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30091-9


Reviews


Metabolic signatures of cancer cells and stem cells – Andrew M. Intlekofer and Lydia W. S. Finley. https://www.nature.com/articles/s42255-019-0032-0

Toward a better understanding of folate metabolism in health and disease – Yuxiang Zheng and Lewis C. Cantley. http://jem.rupress.org/content/216/2/253?etoc

Nutrient regulation of signaling and transcription [by O-linked β-GlcNAc; O-GlcNAc] – Gerald W. Hart. http://www.jbc.org/content/294/7/2211.abstract.html

Dynamics and functions of lipid droplets – James A. Olzmann and Pedro Carvalho. https://www.nature.com/articles/s41580-018-0085-z

Immune control by amino acid catabolism during tumorigenesis and therapy   – Henrique Lemos, Lei Huang, George C. Prendergast and Andrew L. Mellor. https://www.nature.com/articles/s41568-019-0106-z

Starvation and Pseudo-Starvation as Drivers of Cancer Metastasis through Translation Reprogramming – Custodia García-Jiménez, Colin R. Goding. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30737-X

p53 tumor suppressor and iron homeostasis – Jin Zhang, Xinbin Chen. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14638


Comments


Tumours use a metabolic twist to make lipids – Marteinn Thor Snaebjornsson, Almut Schulze. https://www.nature.com/articles/d41586-019-00352-1

Glutathione Metabolism: An Achilles’ Heel of ARID1A-Deficient Tumors – Chiara Gorrini, Tak W. Mak. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30051-0

Host Control of Tumor Feeding: Autophagy Holds the Key – Anthony Venida, Rushika M. Perera. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30009-9

AMPK-Mediated Lysosome Biogenesis in Lung Cancer Growth – Krushna C. Patra, Vajira K. Weerasekara, Nabeel Bardeesy. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30748-4

IDH2 inhibition: another piece to the puzzle – Lars Bullinger. http://bloodjournal.org/content/133/7/625?etoc

A PET Glutamate Analogue to Measure Cancer Cell Redox State and Oxidative Stress: Promise and Paradox – Hsiaoju S. Lee, Austin R. Pantel, Rong Zhou and David A. Mankoff. http://cancerres.aacrjournals.org/content/79/4/701

Fasting in oncology: a word of caution – Riccardo Caccialanza, Giuseppe Aprile, Emanuele Cereda and Paolo Pedrazzoli. https://www.nature.com/articles/s41568-018-0098-0

Reply to ‘Fasting in oncology: a word of caution’ – Alessio Nencioni, Irene Caffa, Salvatore Cortellino and Valter D. Longo. https://www.nature.com/articles/s41568-018-0100-x

Mannose Inhibits Tumor Growth and Increases Tumor Chemosensitivity
http://cancerdiscovery.aacrjournals.org/content/9/2/OF6

WITHDRAWN: Effects of cancer-associated point mutations on the structure, function, and stability of succinate dehydrogenase A – Zhi-Fa Cao, Nan Ni, Weihao Zhuang, Fei Ye, Yuehong Wu, Jieqiong Qiu, Yeqing Wu, Qing Sheng and Wen-Bin Ou. http://www.jbc.org/content/early/2019/02/25/jbc.RA118.006266.abstract

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