MetaboList – March 2019


Glucose metabolism


Breast cancer cells rely on environmental pyruvate to shape the metastatic niche – Ilaria Elia, Matteo Rossi, Steve Stegen, Dorien Broekaert, Ginevra Doglioni, Marit van Gorsel, Ruben Boon, Carmen Escalona-Noguero, Sophie Torrekens, Catherine Verfaillie, Erik Verbeken, Geert Carmeliet and Sarah-Maria Fendt. https://www.nature.com/articles/s41586-019-0977-x

Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells – Bai Cui, Yuanyuan Luo, Pengfei Tian, Fei Peng, Jinxin Lu, Yongliang Yang, Qitong Su, Bing Liu, Jiachuan Yu, Xi Luo, Liu Yin, Wei Cheng, Fan An, Bin He, Dapeng Liang, Sijin Wu, Peng Chu, Luyao Song, Xinyu Liu, Huandong Luo, Jie Xu, Yujia Pan, Yang Wang, Dangsheng Li, Peng Huang, Qingkai Yang, Lingqiang Zhang, Binhua P. Zhou, Suling Liu, Guowang Xu, Eric W.-F. Lam, Keith W. Kelley and Quentin Liu. https://www.jci.org/articles/view/121685

Epigenetic loss of the endoplasmic reticulum-associated degradation inhibitor SVIP induces cancer cell metabolic reprogramming – Pere Llinàs-Arias, Margalida Rosselló-Tortella, Paula Lopez-Serra, Montserrat Pérez-Salvia, Fernando Setién, Silvia Marin, Juan P. Muñoz, Alexandra Junza, Jordi Capellades, Maria E. Calleja-Cervantes, Humberto J. Ferreira, Manuel Castro de Moura, Marina Srbic, Anna Martínez-Cardús, Carolina de la Torre, Alberto Villanueva, Marta Cascante, Oscar Yanes, Antonio Zorzano, Catia Moutinho and Manel Esteller. https://insight.jci.org/articles/view/125888#

Tristetraprolin-mediated hexokinase 2 expression regulation contributes to glycolysis in cancer cells – Dong Jun Kim, Mai-Tram Vo, Seong Hee Choi, Ji-Heon Lee, So Yeon Jeong, Chung Hwan Hong, Jong Soo Kim, Unn Hwa Lee, Hyung-Min Chung, Byung Ju Lee, Wha Ja Cho and Jeong Woo Park. https://www.molbiolcell.org/doi/10.1091/mbc.E18-09-0606

High-fructose corn syrup enhances intestinal tumor growth in mice – Marcus D. Goncalves, Changyuan Lu, Jordan Tutnauer, Travis E. Hartman, Seo-Kyoung Hwang, Charles J Murphy, Chantal Pauli, Roxanne Morris, Sam Taylor, Kaitlyn Bosch, Sukjin Yang, Yumei Wang, Justin Van Riper, H Carl Lekaye, Jatin Roper, Young Kim, Qiuying Chen, Steven S. Gross, Kyu Y. Rhee, Lewis C. Cantley, Jihye Yun. http://science.sciencemag.org/content/363/6433/1345

Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance – Ruilong Liu, Wenfeng Li, Bangbao Tao, Xiongjun Wang, Zhuo Yang, Yajuan Zhang, Chenyao Wang, Rongzhi Liu, Hong Gao, Ji Liang and Weiwei Yang. https://www.nature.com/articles/s41467-019-08921-8


Glutamine metabolism


Glutamine synthetase is necessary for sarcoma adaptation to glutamine deprivation and tumor growth – Sameer H. Issaq, Arnulfo Mendoza, Stephen D. Fox and Lee J. Helman. https://www.nature.com/articles/s41389-019-0129-z

Spatial-fluxomics provides a subcellular-compartmentalized view of reductive glutamine metabolism in cancer cells – Won Dong Lee, Dzmitry Mukha, Elina Aizenshtein and Tomer Shlomi. https://www.nature.com/articles/s41467-019-09352-1

Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma – Shuo Qie, Akihiro Yoshida, Stuart Parnham, Natalia Oleinik, Gyda C. Beeson, Craig C. Beeson, Besim Ogretmen, Adam J. Bass, Kwok-Kin Wong, Anil K. Rustgi and J. Alan Diehl. https://www.nature.com/articles/s41467-019-09179-w

Critical role of ASCT2-mediated amino acid metabolism in promoting leukaemia development and progression – Fang Ni, Wen-Mei Yu, Zhiguo Li, Douglas K. Graham, Lingtao Jin, Sumin Kang, Michael R. Rossi, Shiyong Li, Hal E. Broxmeyer and Cheng-Kui Qu. https://www.nature.com/articles/s42255-019-0039-6

Ablation of the ASCT2 (SLC1A5) gene encoding a neutral amino acid transporter reveals transporter plasticity and redundancy in cancer cells – Angelika Bröer, Gregory Gauthier-Coles, Farid Rahimi, Michelle van Geldermalsen, Dieter Dorsch, Ansgar Wegener, Jeff Holst and Stefan Bröer. http://www.jbc.org/content/294/11/4012.abstract.html

BAG3 promotes autophagy and glutaminolysis via stabilizing glutaminase – Song Zhao, Jia-Mei Wang, Jing Yan, Da-Lin Zhang, Bao-Qin Liu, Jing-Yi Jiang, Chao Li, Si Li, Xiao-Na Meng and Hua-Qin Wang. https://www.nature.com/articles/s41419-019-1504-6

p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake – Xazmin H. Lowman, Eric A. Hanse, Ying Yang, Mari B. Ishak Gabra, Thai Q. Tran, Haiqing Li, Mei Kong. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30208-6


Amino acid metabolism: other


SOX12 promotes colorectal cancer cell proliferation and metastasis by regulating asparagine synthesis – Feng Du, Jie Chen, Hao Liu, Yanhui Cai, Tianyu Cao, Weili Han, Xiaofang Yi, Meirui Qian, Dean Tian,Yongzhan Nie, Kaichun Wu, Daiming Fan and Limin Xia. https://www.nature.com/articles/s41419-019-1481-9

The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism – Giulia Guiducci, Alessio Paone, Angela Tramonti, Giorgio Giardina, Serena Rinaldo, Amani Bouzidi, Maria C Magnifico, Marina Marani, Javier A Menendez, Alessandro Fatica, Alberto Macone, Alexandros Armaos, Gian G Tartaglia, Roberto Contestabile, Alessandro Paiardini, Francesca Cutruzzolà. https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz129/5365575

TAp73 Modifies Metabolism and Positively Regulates Growth of Cancer Stem–Like Cells in a Redox-Sensitive Manner – Tanveer Sharif, Cathleen Dai, Emma Martell, Mohammad Saleh Ghassemi-Rad, Mark Robert Hanes, Patrick J. Murphy, Barry E. Kennedy, Chitra Venugopal, Minomi Subapanditha, Carman A. Giacomantonio, Paola Marcato, Sheila K. Singh and Shashi Gujar. http://clincancerres.aacrjournals.org/content/25/6/2001

IDO1 and Kynurenine Pathway Metabolites Activate PI3K-Akt Signaling in the Neoplastic Colon Epithelium to Promote Cancer Cell Proliferation and Inhibit Apoptosis – Kumar S. Bishnupuri, David M. Alvarado, Alexander N. Khouri, Mark Shabsovich, Baosheng Chen, Brian K. Dieckgraefe and Matthew A. Ciorba. http://cancerres.aacrjournals.org/content/79/6/1138

Endogenous arginase 2 as a potential biomarker for PEGylated arginase 1 treatment in xenograft models of squamous cell lung carcinoma – Sze-Kwan Lam, Sheng Yan, Shi Xu, Kin-Pong U, Paul Ning-Man Cheng and James Chung-Man Ho. https://www.nature.com/articles/s41389-019-0128-0

Urea cycle sustains cellular energetics upon EGFR inhibition in EGFR mutant NSCLC – Catherine Pham-Danis, Sarah Gehrke, Etienne Danis, Andrii I Rozhok, Michael W Daniels, Dexiang Gao, Christina Collins, Jose T Di Paola, Angelo D’Alessandro and James DeGregori. http://mcr.aacrjournals.org/content/early/2019/02/26/1541-7786.MCR-18-1068.long

p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis – Le Li, Youxiang Mao, Lina Zhao, Lijia Li, Jinjun Wu, Mengjia Zhao, Wenjing Du, Li Yu and Peng Jiang. https://www.nature.com/articles/s41586-019-0996-7


Lipid metabolism


Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death – Javier Garcia-Bermudez, Lou Baudrier, Erol Can Bayraktar, Yihui Shen, Konnor La, Rohiverth Guarecuco, Burcu Yucel, Danilo Fiore, Bernardo Tavora, Elizaveta Freinkman, Sze Ham Chan, Caroline Lewis, Wei Min, Giorgio Inghirami, David M. Sabatini and Kıvanç Birsoy. https://www.nature.com/articles/s41586-019-0945-5

Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP – Patrizia Romani, Irene Brian, Giulia Santinon, Arianna Pocaterra, Matteo Audano, Silvia Pedretti, Samuel Mathieu, Mattia Forcato, Silvio Bicciato, Jean-Baptiste Manneville, Nico Mitro and Sirio Dupont. https://www.nature.com/articles/s41556-018-0270-5

Statins affect human glioblastoma and other cancers through TGF-β inhibition – Aizhen Xiao, Breanna Brenneman, Desiree Floyd, Laurey Comeau, Kelsey Spurio, Inan Olmez, Jeongwu Lee, Ichiro Nakano, Jakub Godlewski, Agnieszka Bronisz, Noritaka Kagaya, Kazuo Shin-ya and Benjamin Purow. http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=26733&path[]=83070

A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma – Saiful E. Syafruddin, Paulo Rodrigues, Erika Vojtasova, Saroor A. Patel, M. Nazhif Zaini, Johanna Burge, Anne Y. Warren, Grant D. Stewart, Tim Eisen, Dóra Bihary, Shamith A. Samarajiwa and Sakari Vanharanta. https://www.nature.com/articles/s41467-019-09116-x


Nucleotides 


Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase – Gerta Hoxhaj, Issam Ben-Sahra, Sophie E. Lockwood, Rebecca C. Timson, Vanessa Byles, Graham T. Henning, Peng Gao, Laura M. Selfors, John M. Asara, Brendan D. Manning. http://science.sciencemag.org/content/363/6431/1088

NAD+ metabolism governs the proinflammatory senescence-associated secretome – Timothy Nacarelli, Lena Lau, Takeshi Fukumoto, Joseph Zundell, Nail Fatkhutdinov, Shuai Wu, Katherine M. Aird, Osamu Iwasaki, Andrew V. Kossenkov, David Schultz, Ken-ichi Noma, Joseph A. Baur, Zachary Schug, Hsin-Yao Tang, David W. Speicher, Gregory David and Rugang Zhang. https://www.nature.com/articles/s41556-019-0287-4

NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism – Li Chen, Zhaoyue Zhang, Atsushi Hoshino, Henry D. Zheng, Michael Morley, Zoltan Arany and Joshua D. Rabinowitz. https://www.nature.com/articles/s42255-019-0043-x


Mitochondria


MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network – Rana Elkholi, Ioana Abraham-Enachescu, Andrew P. Trotta, Camila Rubio-Patiño, Jarvier N. Mohammed, Mark P.A. Luna-Vargas, Jesse D. Gelles, Joshua R. Kaminetsky, Madhavika N. Serasinghe, Cindy Zou, Sumaira Ali, Gavin P. McStay, Cathie M. Pfleger, Jerry Edward Chipuk. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30102-9

Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism – Jiyoung Lee, Ali E. Yesilkanal, Joseph P. Wynne, Casey Frankenberger, Juan Liu, Jielin Yan, Mohamad Elbaz, Daniel C. Rabe, Felicia D. Rustandy, Payal Tiwari, Elizabeth A. Grossman, Peter C. Hart, Christie Kang, Sydney M. Sanderson, Jorge Andrade, Daniel K. Nomura, Marcelo G. Bonini, Jason W. Locasale and Marsha Rich Rosner. https://www.nature.com/articles/s41586-019-1005-x

Enhancing folic acid metabolism suppresses defects associated with loss of Drosophila mitofusin – Juan Garrido-Maraver, Ivana Celardo, Ana C. Costa, Susann Lehmann, Samantha H. Y. Loh and L. Miguel Martins. https://www.nature.com/articles/s41419-019-1496-2

Cisplatin resistance involves a metabolic reprogramming through ROS and PGC-1α in NSCLC which can be overcome by OXPHOS inhibition – Alberto Cruz-Bermúdez, Raquel Laza-Briviesca, Ramiro J. Vicente-Blanco,Aránzazu García-Grande, Maria José Coronado, Sara Laine-Menéndez, Sara Palacios-Zambrano, M. Rocío Moreno-Villa, Asunción Martin Ruiz-Valdepeñas, Cristina Lendinez, Atocha Romero, Fernando Franco, Virginia Calvo, Cristina Alfaro, Paloma Martin Acosta, Clara Salas, José Miguel Garcia, Mariano Provencio. https://www.sciencedirect.com/science/article/pii/S089158491831582X

CHCHD4 confers metabolic vulnerabilities to tumour cells through its control of the mitochondrial respiratory chain – Luke W. Thomas, Jenna M. Stephen, Cinzia Esposito, Simon Hoer, Robin Antrobus, Afshan Ahmed, Hasan Al-Habib and Margaret Ashcroft. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-019-0194-y

S100A4 alters metabolism and promotes invasion of lung cancer cells by up-regulating mitochondrial complex I protein NDUFS2 – Lili Liu, Lei Qi, Teresa Knifley, Dava W. Piecoro, Piotr Rychahou, Jinpeng Liu, Mihail I. Mitov, Jeremiah Martin, Chi Wang, Jianrong Wu, Heidi L. Weiss, D. Allan Butterfield, B. Mark Evers, Kathleen L. O’Connor and Min Chen. http://www.jbc.org/content/early/2019/03/18/jbc.RA118.004365.abstract


Cancer metabolism and epigenetics


Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis – Alessandro Carrer, Sophie Trefely, Steven Zhao, Sydney L. Campbell, Robert J. Norgard, Kollin C. Schultz, Simone Sidoli, Joshua L.D. Parris, Hayley C. Affronti, Sharanya Sivanand, Shaun Egolf, Yogev Sela, Marco Trizzino, Alessandro Gardini, Benjamin A. Garcia, Nathaniel W. Snyder, Ben Z. Stanger and Kathryn E. Wellen. http://cancerdiscovery.aacrjournals.org/content/9/3/416

Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer – Miguel Reina-Campos, Juan F. Linares, Angeles Duran, Thekla Cordes, Antoine L’Hermitte, Mehmet G. Badur, Munveer S. Bhangoo, Phataraporn K. Thorson, Alicia Richards, Tarmo Rooslid, Dolores C. Garcia-Olmo, Syongh Y. Nam-Cha, Antonio S. Salinas-Sanchez, Ken Eng, Himisha Beltran, David A. Scott, Christian M. Metallo, Jorge Moscat, Maria T. Diaz-Meco. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30052-2


AMPK


Cellular energy stress induces AMPK-mediated regulation of glioblastoma cell proliferation by PIKE-A phosphorylation – Shuai Zhang, Hao Sheng, Xiaoya Zhang, Qi Qi, Chi Bun Chan, Leilei Li, Changliang Shan and Keqiang Ye. https://www.nature.com/articles/s41419-019-1452-1

AMPK is down-regulated by the CRL4A-CRBN axis through the polyubiquitination of AMPKα isoforms – Eunju Kwon, Xian Li, Yifeng Deng, Hyeun Wook Chang and Dong Young Kim. https://www.fasebj.org/doi/abs/10.1096/fj.201801766RRR

Synthetic energy sensor AMPfret deciphers adenylate-dependent AMPK activation mechanism – Martin Pelosse, Cécile Cottet-Rousselle, Cécile M. Bidan, Aurélie Dupont, Kapil Gupta, Imre Berger and Uwe Schlattner. https://www.nature.com/articles/s41467-019-08938-z


mTOR / GCN2


mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53 – Seung Hee Jung, Hyun Jung Hwang, Donghee Kang, Hyun A. Park, Hyung Chul Lee, Daecheol Jeong, Keunwook Lee, Heon Joo Park, Young-Gyu Ko and Jae-Seon Lee. https://www.nature.com/articles/s41388-018-0521-8

Activation of GCN2 by the ribosomal P-stalk – Alison J. Inglis, Glenn R. Masson, Sichen Shao, Olga Perisic, Stephen H. McLaughlin, Ramanujan S. Hegde and Roger L. Williams. https://www.pnas.org/content/116/11/4946.abstract?etoc


Hypoxia


Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate – Abhishek A. Chakraborty, Tuomas Laukka, Matti Myllykoski, Alison E. Ringel, Matthew A. Booker, Michael Y. Tolstorukov, Yuzhong Jeff Meng, Samuel R. Meier, Rebecca B. Jennings, Amanda L. Creech, Zachary T. Herbert, Samuel K. McBrayer, Benjamin A. Olenchock, Jacob D. Jaffe, Marcia C. Haigis, Rameen Beroukhim, Sabina Signoretti, Peppi Koivunen, William G. Kaelin Jr. http://science.sciencemag.org/content/363/6432/1217

Hypoxia induces rapid changes to histone methylation and reprograms chromatin – Michael Batie, Julianty Frost, Mark Frost, James W. Wilson, Pieta Schofield, Sonia Rocha. http://science.sciencemag.org/content/363/6432/1222

Intracellular citrate accumulation by oxidized ATM-mediated metabolism reprogramming via PFKP and CS enhances hypoxic breast cancer cell invasion and metastasis – Meixi Peng, Dan Yang, Yixuan Hou, Shuiqing Liu, Maojia Zhao, Yilu Qin, Rui Chen, Yong Teng and Manran Liu. https://www.nature.com/articles/s41419-019-1475-7

Primary endothelial–specific regulation of hypoxia-inducible factor (HIF)-1 and HIF-2 and their target gene expression profiles during  hypoxia – Rafal Bartoszewski, Adrianna Moszyńska, Marcin Serocki, Aleksandra Cabaj, Andreas Polten, Renata Ochocka, Louis Dell’Italia, Sylwia Bartoszewska, Jarosław Króliczewski, Michał Dąbrowski and James F. Collawn. https://www.fasebj.org/doi/abs/10.1096/fj.201802650RR?ai=ts&ui=ly8&af=T


Miscellaneous


Flura-seq identifies organ-specific metabolic adaptations during early metastatic colonization – Harihar Basnet, Lin Tian, Karuna Ganesh, Yun-Han Huang, Danilo G Macalinao, Edi Brogi, Lydia Finley,  Joan Massagué. https://elifesciences.org/articles/43627


Reviews


Molecular logic of mTORC1 signalling as a metabolic rheostat – Alexander J. Valvezan and Brendan D. Manning. https://www.nature.com/articles/s42255-019-0038-7

Crosstalk between metabolism and circadian clocks – Hans Reinke and Gad Asher. https://www.nature.com/articles/s41580-018-0096-9

The ERK and JNK pathways in the regulation of metabolic reprogramming – Salvatore Papa, Pui Man Choy and Concetta Bubici. https://www.nature.com/articles/s41388-018-0582-8

Reimagining IDO Pathway Inhibition in Cancer Immunotherapy via Downstream Focus on the Tryptophan–Kynurenine–Aryl Hydrocarbon Axis – Brian W. Labadie, Riyue Bao and Jason J. Luke. http://clincancerres.aacrjournals.org/content/25/5/1462


Comments


Histone modifiers are oxygen sensors – Paolo Gallipoli, Brian J. P. Huntly. http://science.sciencemag.org/content/363/6432/1148

Serine and Methionine Metabolism: Vulnerabilities in Lethal Prostate Cancer – Xia Gao, Jason W. Locasale, Michael A. Reid. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30109-6

NAD-biosynthetic pathways regulate innate immunity – Leah K. Billingham and Navdeep S. Chandel. https://www.nature.com/articles/s41590-019-0353-x

B cell lymphoma R-CHOPped by metabolic inhibitors – Ming Yang. http://stm.sciencemag.org/content/11/485/eaax3456

Metabolism Drives Carcinogenesis and Maintenance of Pancreatic Tumors – Christopher J. Halbrook, Barbara S. Nelson and Costas A. Lysstiotis. http://cancerdiscovery.aacrjournals.org/content/9/3/326

Cell scientist to watch – Kivanc Birsoy. http://jcs.biologists.org/content/132/5/jcs230540?etoc

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