MetaboList – May 2019

To subscribe: http://eepurl.com/cvQCw9


Cystine / Glutathione


Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance – Jonathan K. M. Lim, Alberto Delaidelli, Sean W. Minaker, Hai-Feng Zhang, Milena Colovic, Hua Yang, Gian Luca Negri, Silvia von Karstedt, William W. Lockwood, Paul Schaffer, Gabriel Leprivier and Poul H. Sorensen. https://www.pnas.org/content/116/19/9433.abstract?etoc

Cystine–glutamate antiporter xCT deficiency suppresses tumor growth while preserving antitumor immunity – Michael D. Arensman, Xiaoran S. Yang, Danielle M. Leahy, Lourdes Toral-Barza, Mary Mileski, Edward C. Rosfjord, Fang Wang, Shibing Deng, Jeremy S. Myers, Robert T. Abraham and Christina H. Eng. https://www.pnas.org/content/116/19/9533.abstract?etoc

Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer – Yun Pyo Kang, Laura Torrente, Aimee Falzone, Cody M Elkins, Min Liu, John M Asara, Christian C Dibble, Gina DeNicola. https://elifesciences.org/articles/45572

Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion – Isaac S. Harris, Jennifer E. Endress, Jonathan L. Coloff, Laura M. Selfors, Samuel K. McBrayer, Jennifer M. Rosenbluth, Nobuaki Takahashi, Sabin Dhakal, Vidyasagar Koduri, Matthew G. Oser, Nathan J. Schauer, Laura M. Doherty, Andrew L. Hong, Yun Pyo Kang, Scott T. Younger, John G. Doench, William C. Hahn, Sara J. Buhrlage, Gina M. DeNicola, William G. Kaelin Jr., Joan S. Brugge. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30020-8


Other amino acids


Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression [liver] – Russell E. Ericksen, Siew Lan Lim, Eoin McDonnell, Wai Ho Shuen, Maya Vadiveloo, Phillip J. White, Zhaobing Ding, Royston Kwok, Philip Lee, George K. Radda, Han Chong Toh, Matthew D. Hirschey, Weiping Han. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30757-5

Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations – Adeola O. Adebayo Michael, Sungjin Ko, Junyan Tao, Akshata Moghe, Hong Yang, Meng Xu, Jacquelyn O. Russell, Tirthadipa Pradhan-Sundd, Silvia Liu, Sucha Singh, Minakshi Poddar, Jayvir S. Monga, Pin Liu, Michael Oertel, Sarangarajan Ranganathan, Aatur Singhi, Sandra Rebouissou, Jessica Zucman-Rossi, Silvia Ribback, Diego Calvisi, Natalia Qvartskhava, Boris Görg, Dieter Häussinger, Xin Chen, Satdarshan P. Monga. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30186-X

Dual inhibition of glutaminase and carnitine palmitoyltransferase decreases growth and migration of glutaminase inhibition–resistant triple-negative breast cancer cells – Larissa Menezes dos Reis, Douglas Adamoski, Rodolpho Ornitz Oliveira Souza, Carolline Fernanda Rodrigues Ascenção, Krishina Ratna Sousa de Oliveira, Felipe Corrêa-da-Silva, Fábio Malta de Sá Patroni, Marília Meira Dias, Sílvio Roberto Consonni, Pedro Manoel Mendes de Moraes-Vieira, Ariel Mariano Silber and Sandra Martha Gomes Dias. http://www.jbc.org/content/early/2019/04/30/jbc.RA119.008180.abstract

A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma – Peter E. Hall, Rachel Lewis, Nelofer Syed, Richard Shaffer, Jane Evanson, Stephen Ellis, Matthew Williams, Xiaoxing Feng, Amanda Johnston, Jim A. Thomson, Fiona P. Harris, Raj Jena, Tomasz Matys, Sarah Jefferies, Kate Smith, Bor-Wen Wu, John S. Bomalaski, Timothy Crook, Kevin O’Neill, Dimitris Paraskevopoulos, Ramsay S. Khadeir, Michael Sheaff, Simon Pacey, Piers N. Plowman and Peter W. Szlosarek. http://clincancerres.aacrjournals.org/content/25/9/2708


Glucose metabolism


The quantitative relationship between isotopic and net contributions of lactate and glucose to the TCA cycle – Minfeng Ying, Cheng Guo and Xun Hu. http://www.jbc.org/content/early/2019/04/30/jbc.RA119.007841.abstract

Long Noncoding RNA MALAT1 Regulates Cancer Glucose Metabolism by Enhancing mTOR-Mediated Translation of TCF7L2 – Pushkar Malakar, Ilan Stein, Amijai Saragovi, Roni Winkler, Noam Stern-Ginossar, Michael Berger, Eli Pikarsky and Rotem Karni. http://cancerres.aacrjournals.org/content/79/10/2480

Characterization of the molecular changes associated with the overexpression of a novel epithelial cadherin splice variant mRNA in a breast cancer model using proteomics and bioinformatics approaches: identification of changes in cell metabolism and an increased expression of lactate dehydrogenase B – Marina Rosso, Lara Lapyckyj, María José Besso, Marta Monge, Jaume Reventós, Francesc Canals, Jorge Oswaldo Quevedo Cuenca, María Laura Matos and Mónica Hebe Vazquez-Levin. https://www.nature.com/articles/s41586-019-1126-2

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis – Mohamed Elgendy, Marco Cirò, Amir Hosseini, Jakob Weiszmann, Luca Mazzarella, Elisa Ferrari, Riccardo Cazzoli, Giuseppe Curigliano, Andrea DeCensi, Bernardo Bonanni, Alfredo Budillon, Pier Giuseppe Pelicci, Veerle Janssens, Manfred Ogris, Manuela Baccarini, Luisa Lanfrancone, Wolfram Weckwerth, Marco Foiani, Saverio Minucci. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30152-7

p53/BNIP3-dependent mitophagy limits glycolytic shift in radioresistant cancer – Hyo Won Chang, Mi Ra Kim, Hyang Ju Lee, Hye Min Lee, Gui Chul Kim, Yoon Sun Lee, Hae Yun Nam, Myungjin Lee, Hye Jin Jang, Kyung Eun Lee, Jong Cheol Lee, Youngro Byun, Seong Who Kim and Sang Yoon Kim. https://www.nature.com/articles/s41388-019-0697-6


Lipid metabolism


Acyl-CoA-Binding Protein Drives Glioblastoma Tumorigenesis by Sustaining Fatty Acid Oxidation – Ceren Duman, Kaneschka Yaqubi, Angelika Hoffmann, Azer Aylin Acikgöz, Andrey Korshunov, Martin Bendszus, Christel Herold-Mende, Hai-Kun Liu, Julieta Alfonso. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30188-3

Free Fatty Acids Rewire Cancer Metabolism in Obesity-Associated Breast Cancer via Estrogen Receptor and mTOR Signaling – Zeynep Madak-Erdogan, Shoham Band, Yiru C. Zhao, Brandi P. Smith, Eylem Kulkoyluoglu-Cotul, Qianying Zuo, Ashlie Santaliz Casiano, Kinga Wrobel, Gianluigi Rossi, Rebecca L. Smith, Sung Hoon Kim, John A. Katzenellenbogen, Mariah L. Johnson, Meera Patel, Natascia Marino, Anna Maria V. Storniolo and Jodi A. Flaws. http://cancerres.aacrjournals.org/content/79/10/2494

The mevalonate coordinates energy input and cell proliferation – Li Gong, Yi Xiao, Fan Xia, Pei Wu, Tingting Zhao, Shulin Xie, Ran Wang, Qiaocheng Wen, Wensu Zhou, Huilan Xu, Lingyan Zhu, Zeqi Zheng, Tianlun Yang, Zihua Chen and Qiong Duan. https://www.nature.com/articles/s41419-019-1544-y


Nucleotides


Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts – Mark A. Eckert, Fabian Coscia, Agnieszka Chryplewicz, Jae Won Chang, Kyle M. Hernandez, Shawn Pan, Samantha M. Tienda, Dominik A. Nahotko, Gang Li, Ivana Blaženović, Ricardo R. Lastra, Marion Curtis, S. Diane Yamada, Ruth Perets, Stephanie M. McGregor, Jorge Andrade, Oliver Fiehn, Raymond E. Moellering, Matthias Mann and Ernst Lengyel. https://www.nature.com/articles/s41586-019-1173-8


Mitochondria


CD38-Driven Mitochondrial Trafficking Promotes Bioenergetic Plasticity in Multiple Myeloma – Christopher R. Marlein, Rachel E. Piddock, Jayna J. Mistry, Lyubov Zaitseva, Charlotte Hellmich, Rebecca H. Horton, Zhigang Zhou, Martin J. Auger, Kristian M. Bowles and Stuart A. Rushworth. http://cancerres.aacrjournals.org/content/79/9/2285

Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma – Liang Zhang , Yixin Yao, Shaojun Zhang, Yang Liu, Hui Guo, Makhdum Ahmed, Taylor Bell, Hui Zhang, Guangchun Han, Elizabeth Lorence, Maria Badillo, Shouhao Zhou, Yuting Sun, M. Emilia Di Francesco, Ningping Feng, Randy Haun, Renny Lan, Samuel G. Mackintosh, Xizeng Mao, Xingzhi Song, Jianhua Zhang, Lan V. Pham, Philip L. Lorenzi, Joseph Marszalek, Tim Heffernan, Giulio Draetta, Philip Jones, Andrew Futreal, Krystle Nomie, Linghua Wang, Michael Wang. https://stm.sciencemag.org/content/11/491/eaau1167

Elevated Heme Synthesis and Uptake Underpin Intensified Oxidative Metabolism and Tumorigenic Functions in Non–Small Cell Lung Cancer Cells – Sagar Sohoni, Poorva Ghosh, Tianyuan Wang, Sarada Preeta Kalainayakan, Chantal Vidal, Sanchareeka Dey, Purna Chaitanya Konduri and Li Zhang. http://cancerres.aacrjournals.org/content/79/10/2511

Extrinsic conditions influence the self-association and structure of IF1, the regulatory protein of mitochondrial ATP synthase – Vytaute Boreikaite, Basile I. M. Wicky, Ian N. Watt, Jane Clarke and John E. Walker. https://www.pnas.org/content/116/21/10354.abstract?etoc

Metformin induces a fasting- and antifolate-mimicking modification of systemic host metabolism in breast cancer patients – Elisabet Cuyàs, Salvador Fernández-Arroyo, Maria Buxó, Sonia Pernas, Joan Dorca, Isabel Álvarez, Susana Martínez, Jose Manuel Pérez-Garcia, Norberto Batista-López, César A. Rodríguez-Sánchez,  Kepa Amillano, Severina Domínguez , Maria Luque, Idoia Morilla, Agostina Stradella, Gemma Viñas, Javier Cortés, Sara Verdura , Joan Brunet, Eugeni López-Bonet, Margarita Garcia, Samiha Saidani, Jorge Joven, Begoña Martin-Castillo, Javier A. Menendez. https://www.aging-us.com/article/101960/text

Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis – Gang Cheng, Qi Zhang, Jing Pan, Yongik Lee, Olivier Ouari, Micael Hardy, Monika Zielonka, Charles R. Myers, Jacek Zielonka, Katherine Weh, Andrew C. Chang, Guoan Chen, Laura Kresty, Balaraman Kalyanaraman and Ming You. https://www.nature.com/articles/s41467-019-10042-1


Starvation


eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response – Lillian R. Kenner, Aditya A. Anand, Henry C. Nguyen, Alexander G. Myasnikov, Carolin J. Klose, Lea A. McGeever, Jordan C. Tsai, Lakshmi E. Miller-Vedam, Peter Walter, Adam Frost. https://science.sciencemag.org/content/364/6439/491

Structural basis for eIF2B inhibition in integrated stress response – Kazuhiro Kashiwagi, Takeshi Yokoyama, Madoka Nishimoto, Mari Takahashi, Ayako Sakamoto, Mayumi Yonemochi, Mikako Shirouzu, Takuhiro Ito. https://science.sciencemag.org/content/364/6439/495


mTOR


The Ion Transporter NKCC1 Links Cell Volume to Cell Mass Regulation by Suppressing mTORC1 – Wael L. Demian, Avinash Persaud, Chong Jiang, Étienne Coyaud, Shixuan Liu, Andras Kapus, Ran Kafri, Brian Raught, Daniela Rotin. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30499-1

GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor – Jenna L Jewell , Vivian Fu, Audrey W Hong, Fa-Xing Yu, Delong Meng, Chase H Melick, Huanyu Wang, Wai-Ling Macrina Lam, Hai-Xin Yuan, Susan S Taylor, Kun-Liang Guan. https://elifesciences.org/articles/43038?


Hypoxia


ADAR1 promotes robust hypoxia signaling via distinct regulation of multiple HIF‐1α‐inhibiting factors – Chung‐Pei Ma, Hsuan Liu, Ian Yi‐Feng Chang, Wan‐Cheng Wang, Yi‐Tung Chen, Shao‐Min Wu, Hui‐Wen Chen, Yu‐Ping Kuo, Chieh‐Tien Shih, Chuan‐Yun Li and Bertrand Chin‐Ming Tan. http://EMBOr.embopress.org/content/20/5/e47107?etoc

A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension  – Swati Dabral, Christian Muecke, Chanil Valasarajan, Mario Schmoranzer, Astrid Wietelmann, Gregg L. Semenza, Michael Meister, Thomas Muley, Tamina Seeger-Nukpezah, Christos Samakovlis, Norbert Weissmann, Friedrich Grimminger, Werner Seeger, Rajkumar Savai and Soni S. Pullamsetti. https://www.nature.com/articles/s41467-019-10044-z


Cancer Immunometabolism


Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment – Xingzhe Ma, Enguang Bi, Yong Lu, Pan Su, Chunjian Huang, Lintao Liu, Qiang Wang, Maojie Yang, Matthew F. Kalady, Jianfei Qian, Aijun Zhang, Anisha A. Gupte, Dale J. Hamilton, Chengyun Zheng, Qing Yi. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30186-X

Acetate Promotes T Cell Effector Function during Glucose Restriction – Jing Qiu, Matteo Villa, David E. Sanin, Michael D. Buck, David O’Sullivan, Reagan Ching, Mai Matsushita, Katarzyna M. Grzes, Frances Winkler, Chih-Hao Chang, Jonathan D. Curtis, Ryan L. Kyle, Nikki Van Teijlingen Bakker, Mauro Corrado, Fabian Haessler, Francesca Alfei, Joy Edwards-Hicks, Leonard B. Maggi Jr., Dietmar Zehn, Takeshi Egawa, Bertram Bengsch, Ramon I. Klein Geltink, Thomas Jenuwein, Edward J. Pearce, Erika L. Pearce. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30487-5

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy – Weimin Wang, Michael Green, Jae Eun Choi, Miguel Gijón, Paul D. Kennedy, Jeffrey K. Johnson, Peng Liao, Xueting Lang, Ilona Kryczek, Amanda Sell, Houjun Xia, Jiajia Zhou, Gaopeng Li, Jing Li, Wei Li, Shuang Wei, Linda Vatan, Hongjuan Zhang, Wojciech Szeliga, Wei Gu, Rebecca Liu, Theodore S. Lawrence, Candice Lamb, Yuri Tanno, Marcin Cieslik, Everett Stone, George Georgiou, Timothy A. Chan, Arul Chinnaiyan and Weiping Zou. https://www.nature.com/articles/s41586-019-1170-y


Miscellaneous


Intra-Tumoral Metabolic Zonation and Resultant Phenotypic Diversification Are Dictated by Blood Vessel Proximity – Saran Kumar, Husni Sharife, Tirzah Kreisel, Maxim Mogilevsky, Libat Bar-Lev, Myriam Grunewald, Elina Aizenshtein, Rotem Karni, Iddo Paldor, Tomer Shlomi, Eli Keshet. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30187-1

Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity – Kevin H. Lin, Abigail Xie, Justine C. Rutter, Yeong-ran Ahn, Julia M. Lloyd-Cowden, Amanda G. Nichols, Ryan S. Soderquist, Timothy R. Koves, Deborah M. Muoio, Nancie J. MacIver, Jatinder K. Lamba, Timothy S. Pardee, Chad M. McCall, David A. Rizzieri, Kris C. Wood. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30011-7

Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases – Grant M. Fischer, Ali Jalali, David A. Kircher, Won-Chul Lee, Jennifer L. McQuade, Lauren E. Haydu, Aron Y. Joon, Alexandre Reuben, Mariana P. de Macedo, Fernando C. L. Carapeto, Chendong Yang, Anuj Srivastava, Chandrashekar R. Ambati, Arun Sreekumar, Courtney W. Hudgens, Barbara Knighton, Wanleng Deng, Sherise D. Ferguson, Hussein A. Tawbi, Isabella C. Glitza, Jeffrey E. Gershenwald, Y. N. Vashisht Gopal, Patrick Hwu, Jason T. Huse, Jennifer A. Wargo, P. Andrew Futreal, Nagireddy Putluri, Alexander J. Lazar, Ralph J. DeBerardinis, Joseph R. Marszalek, Jianjun Zhang, Sheri L. Holmen, Michael T. Tetzlaff and Michael A. Davies. http://cancerdiscovery.aacrjournals.org/content/9/5/628

mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1–induced collagen biosynthesis – Brintha Selvarajah, Ilan Azuelos, Manuela Platé, Delphine Guillotin, Ellen J. Forty, Greg Contento, Hannah V. Woodcock, Matthew Redding, Adam Taylor, Gino Brunori, Pascal F. Durrenberger, Riccardo Ronzoni, Andy D. Blanchard, Paul F. Mercer, Dimitrios Anastasiou and Rachel C. Chambers. https://stke.sciencemag.org/content/12/582/eaav3048


Reviews


Metabolic interventions in the immune response to cancer – David O’Sullivan, David E. Sanin, Edward J. Pearce and Erika L. Pearce. https://www.nature.com/articles/s41577-019-0140-9

Prostate cancer-specific hallmarks of amino acids metabolism: Towards a paradigm of precision medicine – Vladislav Strmiska, Petr Michalek, Tomas Eckschlager, Marie Stiborova, Vojtech Adam, Sona Krizkova, Zbynek Heger. https://www.sciencedirect.com/science/article/abs/pii/S0304419X18301999

Pyruvate kinase M2: A multifarious enzyme in non-canonical localization to promote cancer progression – Sajid Amin, Peng Yang, Zhuoyu Li. https://www.sciencedirect.com/science/article/abs/pii/S0304419X18301951

A critical review of the role of M2PYK in the Warburg effect – Robert A. Harris, Aron W. Fenton. https://www.sciencedirect.com/science/article/abs/pii/S0304419X18302002

Targeting acidity in cancer and diabetes – Robert J. Gillies, Christian Pilot, Yoshinori Marunaka, Stefano Fais. https://www.sciencedirect.com/science/article/abs/pii/S0304419X19300058

Lipid metabolism in cancer cells under metabolic stress – Rimsha Munir, Jan Lisec, Johannes V. Swinnen and Nousheen Zaid. https://www.nature.com/articles/s41416-019-0451-4

Role of branched-chain amino acid–catabolizing enzymes in intertissue signaling, metabolic remodeling, and energy homeostasis – Dipsikha Biswa, Luke Duffley and Thomas Pulinilkunnil. https://www.fasebj.org/doi/abs/10.1096/fj.201802842RR

Interconnection between Metabolism and Cell Cycle in Cancer – Philippe Icard, Ludovic Fournel, Zherui Wu, Marco Alifano, Hubert Lincet. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(18)30273-1


Comments


Teaching an Old Drug New Tricks – Milica Momcilovic, David B. Shackelford. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30203-X

Macrophage-Derived Nucleosides Reduce the Efficacy of Gemcitabine – http://cancerdiscovery.aacrjournals.org/content/9/5/574.2

NAD Kinase Is an AKT Substrate – http://cancerdiscovery.aacrjournals.org/content/9/5/576.1

Pyruvate Mediates ECM Remodeling in the Lung Metastatic Niche – http://cancerdiscovery.aacrjournals.org/content/9/5/575.2

Metabolic Checkpoint of Immune Cells in Melanoma Brain Metastases – Colt A. Egelston and Kim Margolin. http://cancerdiscovery.aacrjournals.org/content/9/5/581

Stromal Support of Metabolic Function through Mitochondrial Transfer in Multiple Myeloma – Lawrence H. Boise and Mala Shanmugam. http://cancerres.aacrjournals.org/content/79/9/2102

 

6th Annual ISCaM Meeting (International Society for Cancer Metabolism, www.iscams.org) | 17-19th October 2019 at Bom Jesus do Monte, Braga, Portugal.

Last day for abstract submission!!!

https://www.lab52.pt/iscam2019/

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