MetaboList – June 2019


Resources


The landscape of cancer cell line metabolism – Haoxin Li, Shaoyang Ning, Mahmoud Ghandi, Gregory V. Kryukov, Shuba Gopal, Amy Deik, Amanda Souza, Kerry Pierce, Paula Keskula, Desiree Hernandez, Julie Ann, Dojna Shkoza, Verena Apfel, Yilong Zou, Francisca Vazquez, Jordi Barretina, Raymond A. Pagliarini, Giorgio G. Galli, David E. Root, William C. Hahn, Aviad Tsherniak, Marios Giannakis, Stuart L. Schreiber, Clary B. Clish, Levi A. Garraway and William R. Sellers. https://www.nature.com/articles/s41591-019-0404-8

Metabolic reprogramming and Notch activity distinguish between non-small cell lung cancer subtypes – Katherine Sellers, Thaddeus D. Allen, Michael Bousamra II, JinLian Tan, Andrés Méndez-Lucas, Wei Lin, Nourdine Bah, Yelena Chernyavskaya, James I. MacRae, Richard M. Higashi, Andrew N. Lane, Teresa W.-M. Fan and Mariia O. Yuneva. https://www.nature.com/articles/s41416-019-0464-z

Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer – Nan Jin, Aiwei Bi, Xiaojing Lan, Jun Xu, Xiaomin Wang, Yingluo Liu, Ting Wang, Shuai Tang, Hanlin Zeng, Ziqi Chen, Minjia Tan, Jing Ai, Hua Xie, Tao Zhang, Dandan Liu, Ruimin Huang, Yue Song, Elaine Lai-Han Leung, Xiaojun Yao, Jian Ding, Meiyu Geng, Shu-Hai Lin and Min Huang. https://www.nature.com/articles/s41467-019-10427-2

Improving the metabolic fidelity of cancer models with a physiological cell culture medium – Johan Vande Voorde, Tobias Ackermann, Nadja Pfetzer, David Sumpton, Gillian Mackay, Gabriela Kalna, Colin Nixon, Karen Blyth, Eyal Gottlieb and Saverio Tardito. https://advances.sciencemag.org/content/5/1/eaau7314


Glucose metabolism


Discovery of Small-Molecule Selective mTORC1 Inhibitors via Direct Inhibition of Glucose Transporters – Seong A. Kang, David J. O’Neill, Andreas W. Machl, Seung Hahm, George P. Vlasuk, Eddine Saiah. https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(19)30178-3

Gluconeogenesis of Cancer Cells Is Disrupted by Citrate – Philippe Icard, Zherui Wu, Marco Alifano, Ludovic Fournel. https://www.cell.com/trends/cancer/fulltext/S2405-8033(19)30066-4

The natural product antroalbol H promotes phosphorylation of liver kinase B1 (LKB1) at threonine 189 and thereby enhances cellular glucose uptake – Fang Wang, Xiaoyan Yang, Yanting Lu, Zhenghui Li, Yuhui Xu, Jing Hu, Jikai Liu and Wenyong Xiong. http://www.jbc.org/content/early/2019/05/21/jbc.RA118.007231.abstract

A non-catalytic function of carbonic anhydrase IX contributes to the glycolytic phenotype and pH regulation in human breast cancer cells – Mam Y. Mboge, Zhijuan Chen, Daniel Khokhar, Alyssa Wolff, Lingbao Ai, CoyD. Heldermon, Murat Bozdag, Fabrizio Carta, Claudiu T. Supuran, Kevin D. Brown, Robert McKenna, Christopher J. Frost and Susan C. Frost. http://www.biochemj.org/content/476/10/1497?etoc

High Glucose Triggers Nucleotide Imbalance through O-GlcNAcylation of Key Enzymes and Induces KRAS Mutation in Pancreatic Cells – Chun-Mei Hu, Sui-Chih Tien, Ping-Kun Hsieh, Yung-Ming Jeng, Ming-Chu Chang, Yu-Ting Chang, Yi-Ju Chen, Yu-Ju Chen, Eva Y.-H.P. Lee, Wen-Hwa Lee. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30069-5

Increased 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 activity in response to EGFR signaling contributes to non-small cell lung cancer cell survival – Nadiia Lypova, Sucheta Telang, Jason Chesney and Yoannis Imbert-Fernandez. http://www.jbc.org/content/early/2019/05/23/jbc.RA119.007784.abstract


Lactate


Oncogenic KRAS signaling activates mTORC1 through COUP‐TFII‐mediated lactate production – Jun‐Kyu Byun, Mihyang Park, Jae Won Yun, Jaebon Lee, Jae Sun Kim, Sung Jin Cho, You Mie Lee, In‐Kyu Lee, Yeon‐Kyung Choi, Keun‐Gyu Park. http://embor.embopress.org/content/20/6/e47451?etoc

High extracellular lactate causes reductive carboxylation in breast tissue cell lines grown under normoxic conditions – Arthur Nathan Brodsky, Daniel C. Odenwelder, Sarah W. Harcum. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213419


Amino acids


Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting – Mark R. Sullivan, Katherine R. Mattaini, Emily A. Dennstedt, Anna A. Nguyen, Sharanya Sivanand, Montana F. Reilly, Katrina Meeth, Alexander Muir, Alicia M. Darnell, Marcus W. Bosenberg, Caroline A. Lewis, Matthew G. Vander Heiden. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30125-1

Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells – Kim R. Kampen, Laura Fancello, Tiziana Girardi, Gianmarco Rinaldi, Mélanie Planque, Sergey O. Sulima, Fabricio Loayza-Puch, Benno Verbelen, Stijn Vereecke, Jelle Verbeeck, Joyce Op de Beeck, Jonathan Royaert, Pieter Vermeersch, David Cassiman, Jan Cools, Reuven Agami, Mark Fiers, Sarah-Maria Fendt and Kim De Keersmaecker. https://www.nature.com/articles/s41467-019-10508-2

Mitochondrial GPT2 plays a pivotal role in metabolic adaptation to the perturbation of mitochondrial glutamine metabolism – Minjoong Kim, Jihye Gwak, Sunsook Hwang, Seungyeon Yang and Seung Min Jeong. https://www.nature.com/articles/s41388-019-0751-4


Lipid metabolism


Cholesterol Induces Epithelial-to-Mesenchymal Transition of Prostate Cancer Cells by Suppressing Degradation of EGFR through APMAP – Siyuan Jiang, Xuetong Wang, Dalong Song, XiaoJun Liu, Yinmin Gu, Zhiyuan Xu, Xiaodong Wang, Xiaolu Zhang, Qinong Ye, Zhou Tong, BingXue Yan, Jie Yu, Yunzhao Chen, Minxuan Sun, Yang Wang and Shan Gao. http://cancerres.aacrjournals.org/content/79/12/3063

Increased Cholesterol Biosynthesis Is a Key Characteristic of Breast Cancer Stem Cells Influencing Patient Outcome – Sidse Ehmsen, Martin H. Pedersen, Guisong Wang, Mikkel G. Terp, Amina Arslanagic, Brian L. Hood, Thomas P. Conrads, Rikke Leth-Larsen, Henrik J. Ditzel. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30743-0

Sorafenib kills liver cancer cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids via the ATP-AMPK-mTOR-SREBP1 signaling pathway – Ge Liu, Shan Kuang, Ruobing Cao, Ju Wang, Quancai Peng and Chaomin Sun. https://www.fasebj.org/doi/abs/10.1096/fj.201802619RR?ai=ts&ui=ly8&af=T

Metabolic adaptability in metastatic breast cancer by AKR1B10-dependent balancing of glycolysis and fatty acid oxidation – Antoinette van Weverwijk, Nikolaos Koundouros, Marjan Iravani, Matthew Ashenden, Qiong Gao, George Poulogiannis, Ute Jungwirth and Clare M. Isacke. https://www.nature.com/articles/s41467-019-10592-4

HCF-1 Regulates De Novo Lipogenesis through a Nutrient-Sensitive Complex with ChREBP – Lane EA, Choi DW, Garcia-Haro L, Levine ZG, Tedoldi M, Walker S, Danial NN. https://www.sciencedirect.com/science/article/abs/pii/S1097276519303910?via%3Dihub


Nucleotides and folate


MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation – Sara Sdelci, André F. Rendeiro, Philipp Rathert, Wanhui You, Jung-Ming G. Lin, Anna Ringler, Gerald Hofstätter, Herwig P. Moll, Bettina Gürtl, Matthias Farlik, Sandra Schick, Freya Klepsch, Matthew Oldach, Pisanu Buphamalai, Fiorella Schischlik, Peter Májek, Katja Parapatics, Christian Schmidl, Michael Schuster, Thomas Penz, Dennis L. Buckley, Otto Hudecz, Richard Imre, Shuang-Yan Wang, Hans Michael Maric, Robert Kralovics, Keiryn L. Bennett, Andre C. Müller, Karl Mechtler, Jörg Menche, James E. Bradner, Georg E. Winter, Kristaps Klavins, Emilio Casanova, Christoph Bock, Johannes Zuber and Stefan Kubicek. https://www.nature.com/articles/s41588-019-0413-z

SKA1 induces de novo MTX‐resistance in osteosarcoma through inhibiting FPGS transcription – Wenxi Yu, Daliu Min, Feng Lin, Shuier Zheng,  Lina Tang,  Aina He,  Haiyan Hu, Zan Shen. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14808

Inhibition of nucleotide synthesis promotes replicative senescence of human mammary epithelial cells – Alireza Delfarah, Sydney Parrish, Jason A. Junge, Jesse Yang, Frances Seo, Si Li, John Mac, Pin Wang, Scott E. Fraser and Nicholas A. Graham. http://www.jbc.org/content/early/2019/05/28/jbc.RA118.005806.abstract?papetoc


Mitochondria


Inhibition of ERRα Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer – Sunghee Park, Rachid Safi, Xiaojing Liu, Robert Baldi, Wen Liu, Juan Liu, Jason W. Locasale, Ching-yi Chang, Donald P. McDonnell. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30695-3

Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer through reduced expression of SDHC – Gro V. Røsland, Sissel E. Dyrstad, Deusdedit Tusubira, Reham Helwa,Tuan Zea Tan, Maria L. Lotsberg, Ina K. N. Pettersen, Anna Berg, Charlotte Kindt, Fredrik Hoel, Kirstine Jacobsen, Ari J. Arason, Agnete S. T. Engelsen, Henrik J. Ditzel, Per E. Lønning, Camilla Krakstad, Jean P. Thiery, James B. Lorens, Stian Knappskog and Karl J. Tronstad. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-019-0197-8

Structural, biochemical and biophysical characterization of recombinant human fumarate hydratase – Mariana A. Ajalla Aleixo  Victor L. Rangel  Joane K. Rustiguel  Ricardo A. P. de Pádua  Maria Cristina Nonato. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14782

AIF-regulated oxidative phosphorylation supports lung cancer development – Shuan Rao, Laura Mondragón, Blanka Pranjic, Toshikatsu Hanada, Gautier Stoll, Thomas Köcher, Peng Zhang, Alexander Jais, Alexander Lercher, Andreas Bergthaler, Daniel Schramek, Katharina Haigh, Valentina Sica, Marion Leduc, Nazanine Modjtahedi, Tsung-Pin Pai, Masahiro Onji, Iris Uribesalgo, Reiko Hanada, Ivona Kozieradzki, Rubina Koglgruber, Shane J. Cronin, Zhigang She, Franz Quehenberger, Helmut Popper, Lukas Kenner, Jody J. Haigh, Oliver Kepp, Malgorzata Rak, Kaican Cai, Guido Kroemer and Josef M. Penninger. https://www.nature.com/articles/s41422-019-0181-4

Suppression of fumarate hydratase activity increases the efficacy of cisplatin-mediated chemotherapy in gastric cancer – Hong-En Yu, Feng Wang, Fang Yu, Zhao-Lei Zeng, Yun Wang, Yun-Xin Lu, Ying Jin, De-Shen Wang, Miao-Zhen Qiu, Heng-Ying Pu, Tie-Bang Kang, Dan Xie, Huai-Qiang Ju, Rui-Hua Xu and Hui-Yan Luo. https://www.nature.com/articles/s41419-019-1652-8


Starvation


AMPK directly activates mTORC2 to promote cell survival during acute energetic stress – Dubek Kazyken, Brian Magnuson, Cagri Bodur, Hugo A. Acosta-Jaquez, Deqiang Zhang, Xin Tong, Tammy M. Barnes, Gabrielle K. Steinl, Nicole E. Patterson, Christopher H. Altheim, Naveen Sharma, Ken Inoki, Gregory D. Cartee, Dave Bridges, Lei Yin, Steven M. Riddle and Diane C. Fingar. https://stke.sciencemag.org/content/12/585/eaav3249

CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress – Qidong Li, Yichun Wang, Shuang Wu, Zhong Zhou, Xiaojuan Ding, Ronghua Shi, Rick F. Thorne, Xu Dong Zhang, Wanglai Hu, Mian Wu. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30249-9

The cystine/glutamate antiporter xCT is a key regulator of EphA2 S897 phosphorylation under glucose-limited conditions – Koji Teramoto, Hironori Katoh. https://www.sciencedirect.com/science/article/pii/S0898656819301196


mTOR / nutrient sensing


Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling – Jae Woo Jung, Stephani Joy Y. Macalino, Minghua Cui, Ji Eon Kim, Hye-Jin Kim, Dae-Geun Song, Seo Hee Nam, Semi Kim, Sun Choi, Jung Weon Lee. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30133-0

A Novel mTORC1/2 Inhibitor (MTI-31) Inhibits Tumor Growth, Epithelial–Mesenchymal Transition, Metastases, and Improves Antitumor Immunity in Preclinical Models of Lung Cancer – Qianwen Zhang, Yan Zhang, Yaqing Chen, Jianchang Qian, Xuesai Zhang and Ker Yu. http://clincancerres.aacrjournals.org/content/25/12/3630

Reciprocal regulation of TORC signaling and tRNA modifications by Elongator enforces nutrient-dependent cell fate – Julie Candiracci, Valerie Migeot, Yok-Hian Chionh, Fanelie Bauer, Thomas Brochier, Brandon Russell, Kazuhiro Shiozaki, Peter Dedon and Damien Hermand. https://advances.sciencemag.org/content/5/6/eaav0184


Hypoxia


Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer – Matteo Morotti, Esther Bridges, Alessandro Valli, Hani Choudhry, Helen Sheldon, Simon Wigfield, Nicki Gray, Christos E. Zois, Fiona Grimm, Dylan Jones, Eugene J. Teoh, Wei-Chen Cheng, Simon Lord, Dimitrios Anastasiou, Syed Haider, Alan McIntyre, Deborah C. I. Goberdhan, Francesca Buffa and Adrian L. Harris. https://www.pnas.org/content/116/25/12452.abstract?etoc

Hypoxia induces cancer cell-specific chromatin interactions and increases MALAT1 expression in breast cancer cells – Joshua K. Stone, Jung-Hyun Kim, Lana Vukadin, Alexander Richard, Hannah K. Giannini, Ssang-Taek Steve Lim, Ming Tan and Eun-Young Erin Ahn. http://www.jbc.org/content/early/2019/06/05/jbc.RA118.006889.abstract

Hypoxia-induced tumor exosomes promote M2-like macrophage polarization of infiltrating myeloid cells and microRNA-mediated metabolic shift – Jung Eun Park, Bamaprasad Dutta, Shun Wilford Tse, Nikhil Gupta, Chee Fan Tan, Jee Keem Low, Kheng Wei Yeoh, Oi Lian Kon, James P. Tam and Siu Kwan Sze. https://www.nature.com/articles/s41388-019-0782-x

Targeting the Temporal Dynamics of Hypoxia-Induced Tumor-Secreted Factors Halts Tumor Migration – Manjulata Singh, Xiao-Jun Tian, Vera S. Donnenberg, Alan M. Watson, JingYu Zhang, Laura P. Stabile, Simon C. Watkins, Jianhua Xing and Shilpa Sant. http://cancerres.aacrjournals.org/content/79/11/2962


Cancer Immunometabolism


Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression – Pieter Goossens, Juan Rodriguez-Vita, Anders Etzerodt, Marion Masse, Olivia Rastoin, Victoire Gouirand, Thomas Ulas, Olympia Papantonopoulou, Miranda Van Eck, Nathalie Auphan-Anezin, Magali Bebien, Christophe Verthuy, Thien Phong Vu Manh, Martin Turner, Marc Dalod, Joachim L. Schultze, Toby Lawrence. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30128-7

Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer – Payal Tiwari, Ariane Blank, Chang Cui, Kelly Q. Schoenfelt, Guolin Zhou, Yanfei Xu, Galina Khramtsova, Funmi Olopade, Ajay M. Shah, Seema A. Khan, Marsha Rich Rosner and Lev Becker. http://jem.rupress.org/content/216/6/1345?etoc


IDH


Mutant and Wild-Type Isocitrate Dehydrogenase 1 Share Enhancing Mechanisms Involving Distinct Tyrosine Kinase Cascades in Cancer – Dong Chen, Siyuan Xia, Mei Wang, Ruiting Lin, Yuancheng Li, Hui Mao, Mike Aguiar, Christopher A. Famulare, Alan H. Shih, Cameron W. Brennan, Xue Gao, Yaozhu Pan, Shuangping Liu, Jun Fan, Lingtao Jin, Lina Song, An Zhou, Joydeep Mukherjee, Russell O. Pieper, Ashutosh Mishra, Junmin Peng, Martha Arellano, William G. Blum, Sagar Lonial, Titus J. Boggon, Ross L. Levine and Jing Chen. http://cancerdiscovery.aacrjournals.org/content/9/6/756

Isocitrate dehydrogenase 1-mutated cancers are sensitive to the green tea polyphenol epigallocatechin-3-gallate – Tom H. Peeters, Krissie Lenting, Vincent Breukels, Sanne A. M. van Lith, Corina N. A. M. van den Heuvel, Remco Molenaar, Arno van Rooij, Ron Wevers, Paul N. Span, Arend Heerschap and William P. J. Leenders. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-019-0198-7

Tissue 2-Hydroxyglutarate as a Biomarker for Isocitrate Dehydrogenase Mutations in Gliomas – Hao-Wen Sim, Romina Nejad, Wenjiang Zhang, Farshad Nassiri, Warren Mason, Kenneth D. Aldape, Gelareh Zadeh and Eric X. Chen. http://clincancerres.aacrjournals.org/content/25/11/3366


Miscellaneous


Probabilistic controllability approach to metabolic fluxes in normal and cancer tissues – Jean-Marc Schwartz, Hiroaki Otokuni, Tatsuya Akutsu and Jose C. Nacher. https://www.nature.com/articles/s41467-019-10616-z


Reviews


Metabolic regulation of cell growth and proliferation – Jiajun Zhu and Craig B. Thompson. https://www.nature.com/articles/s41580-019-0123-5

Determinants of nutrient limitation in cancer – Sullivan MR, Vander Heiden MG. https://www.tandfonline.com/doi/full/10.1080/10409238.2019.1611733

Role of tumor and host autophagy in cancer metabolism – Laura Poillet-Perez and Eileen White. http://genesdev.cshlp.org/content/33/11-12/610.abstract

Gluconeogenesis in cancer cells – Repurposing of a starvation-induced metabolic pathway? – Gabriele Grasmann, Elisabeth Smolle, Horst Olschewski, Katharina Leithner. https://www.sciencedirect.com/science/article/pii/S0304419X19300150

Interactions in the (Pre)metastatic Niche Support Metastasis Formation – Ginevra Doglioni, Sweta Parik and Sarah-Maria Fendt. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491570/

Hypoxia- and MicroRNA-Induced Metabolic Reprogramming of Tumor-Initiating Cells – Pit Ullmann, Martin Nurmik, Rubens Begaj, Serge Haan and Elisabeth Letellier. https://www.mdpi.com/2073-4409/8/6/528

Macropinocytosis in Cancer: A Complex Signaling Network – Yijuan Zhang, Cosimo Commisso. https://www.cell.com/trends/cancer/fulltext/S2405-8033(19)30072-X

Cell Culture Medium Formulation and Its Implications in Cancer Metabolism – Tobias Ackermann, Saverio Tardito. https://www.cell.com/trends/cancer/fulltext/S2405-8033(19)30080-9


Comments


Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword – Curtis C. Hughey, Peter A. Crawford. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30253-0

Lactate jump‐starts mTORC1 in cancer cells – Don Benjamin and Michael N Hall. http://EMBOr.embopress.org/content/20/6/e48302?etoc

Fatty Acids Corrupt Neutrophils in Cancer – Max D. Wellenstein, Karin E. de Visser. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30249-1

Kinase Networks Regulate Metabolism: I’D(H1) Never Have Guessed! – Sarah Horton and Brian J.P. Huntly. http://cancerdiscovery.aacrjournals.org/content/9/6/699

Glutamine-fuelled OXPHOS — a new target in MCL – Conor A. Bradley. https://www.nature.com/articles/s41568-019-0161-5

Context determines which pathway to use for NAD synthesis – Ulrike Harjes. https://www.nature.com/articles/s41568-019-0157-1

Amplifying mTORC2 signals through AMPK during energetic stress – Estela Jacinto. https://stke.sciencemag.org/content/12/585/eaax5855

Tumor Cells Scavenge Cholesterol from Tumor-Associated Macrophages – http://cancerdiscovery.aacrjournals.org/content/9/6/691.2

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