MetaboList – July 2019


Cysteine / Glutathione / antioxidants


Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1 – Luca Lignitto, Sarah E. LeBoeuf, Harrison Homer, Shaowen Jiang, Manor Askenazi, Triantafyllia R. Karakousi, Harvey I. Pass, Arjun J. Bhutkar, Aristotelis Tsirigos, Beatrix Ueberheide, Volkan I. Sayin, Thales Papagiannakopoulos, Michele Pagano. https://www.cell.com/cell/fulltext/S0092-8674(19)30631-2

BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis – Clotilde Wiel, Kristell Le Gal, Mohamed X. Ibrahim, Chowdhury Arif Jahangir, Muhammad Kashif, Haidong Yao, Dorian V. Ziegler, Xiufeng Xu, Tanushree Ghosh, Tanmoy Mondal, Chandrasekhar Kanduri, Per Lindahl, Volkan I. Sayin, Martin O. Bergo. https://www.cell.com/cell/fulltext/S0092-8674(19)30633-6

Epigenetic regulation of ferroptosis by H2B monoubiquitination and p53 – Yufei Wang, Lu Yang, Xiaojun Zhang, Wen Cui, Yanping Liu, Qin‐Ru Sun, Qing He, Shiyan Zhao,Guo‐An Zhang, Yequan Wang, Su Chen. https://www.embopress.org/doi/10.15252/embr.201847563

Brief Report: Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II – Courtney L. Jones, Brett M. Stevens, Angelo D’Alessandro, Rachel Culp-Hill, Julie A. Reisz, Shanshan Pei, Annika Gustafson, Nabilah Khan, James DeGregori, Daniel A. Pollyea and Craig T. Jordan. http://bloodjournal.org/content/134/4/389.abstract


Other amino acids


Dietary methionine influences therapy in mouse cancer models and alters human metabolism – Xia Gao, Sydney M. Sanderson, Ziwei Dai, Michael A. Reid, Daniel E. Cooper, Min Lu, John P. Richie Jr, Amy Ciccarella, Ana Calcagnotto, Peter G. Mikhael, Samantha J. Mentch, Juan Liu, Gene Ables, David G. Kirsch, David S. Hsu, Sailendra N. Nichenametla and Jason W. Locasale. https://www.nature.com/articles/s41586-019-1437-3

Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer – Marina Bacci, Nicla Lorito, Luigi Ippolito, Matteo Ramazzotti, Simone Luti, Simone Romagnoli, Matteo Parri, Francesca Bianchini, Federica Cappellesso, Federico Virga, Qiong Gao, Bruno M. Simões, Elisabetta Marangoni, Lesley-Ann Martin, Giuseppina Comito, Manuela Ferracin, Elisa Giannoni, Massimiliano Mazzone, Paola Chiarugi and Andrea Morandi. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30768-5

Targeting Glutamine Metabolism and Redox State for Leukemia Therapy – Mark A. Gregory, Travis Nemkov, Hae J. Park, Vadym Zaberezhnyy, Sarah Gehrke, Biniam Adane, Craig T. Jordan, Kirk C. Hansen, Angelo D’Alessandro and James DeGregori. http://clincancerres.aacrjournals.org/content/25/13/4079

Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors – Yuetong Wang, Jian Zhang, Shengxiang Ren, Dan Sun, Hsin-Yi Huang, Hua Wang, Yujuan Jin, Fuming Li, Chao Zheng, Liu Yang, Lei Deng, Zhonglin Jiang, Tao Jiang, Xiangkun Han, Shenda Hou, Chenchen Guo, Fei Li, Dong Gao, Jun Qin, Daming Gao, Luonan Chen, Shu-Hai Lin, Kwok-Kin Wong, Cheng Li, Liang Hu, Caicun Zhou, Hongbin Ji. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30792-2

Glutamine Synthetase Promotes Radiation Resistance via Facilitating Nucleotide Metabolism and Subsequent DNA Damage Repair – Shujun Fu, Zhi Li, Lanbo Xiao, Wenfeng Hu, Lu Zhang, Bowen Xie, Qin Zhou, Junju He, Yanfang Qiu, Ming Wen, Yanni Peng, Jie Gao, Rong Tan, Yuezhen Deng, Liang Weng, Lun-Quan Sun. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30886-1


Glucose metabolism / metabolic enzymes


Discovery of Small-Molecule Selective mTORC1 Inhibitors via Direct Inhibition of Glucose Transporters – Kang SA, O’Neill DJ, Machl AW, Lumpkin CJ, Galda SN, Sengupta S, Mahoney SJ, Howell JJ, Molz L, Hahm S, Vlasuk GP, Saiah E. https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(19)30178-3

Phenotypic selection with an intrabody library reveals an anti-apoptotic function of PKM2 requiring Mitofusin-1 – Liu, T., Kuwana, T., Zhang, H., Vander Heiden, M. G., Lerner, R. A. and Newmeyer, D. D. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2004413

Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation – Jamie A Macpherson, Alina Theisen, Laura Masino, Louise Fets, Paul C Driscoll, Vesela Encheva, Ambrosius P Snijders, Stephen R. Martin, Jens Kleinjung,. Perdita E Barran, Franca Fraternali, Dimitrios Anastasiou. https://elifesciences.org/articles/45068

UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis – Xiongjun Wang, Ruilong Liu, Wencheng Zhu, Huiying Chu, Hua Yu, Ping Wei, Xueyuan Wu, Hongwen Zhu, Hong Gao, Ji Liang, Guohui Li and Weiwei Yang. https://www.nature.com/articles/s41586-019-1340-y

Inhibition of Glucose Transporters and Glutaminase Synergistically Impairs Tumor Cell Growth – Elena S. Reckzeh, George Karageorgis, Melanie Schwalfenberg, Javier Ceballos, Jessica Nowacki, Marcus C.M. Stroet, Aylin Binici, Lena Knauer, Silke Brand, Axel Choidas, Carsten Strohmann, Slava Ziegler, Herbert Waldmann. https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(19)30206-5

A positive feedback loop between Myc and aerobic glycolysis sustains tumor growth in a Drosophila tumor model – Kenneth Kin Lam Wong, Jenny Zhe Liao, Esther M Verheyen. https://elifesciences.org/articles/46315

A Warburg effect targeting vector designed to increase the uptake of compounds by cancer cells demonstrates glucose and hypoxia dependent uptake – Alexandra Glenister, Michela I. Simone, Trevor W. Hambley. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217712


Lipid metabolism


HCF-1 Regulates De Novo Lipogenesis through a Nutrient-Sensitive Complex with ChREBP – Elizabeth A. Lane, Dong Wook Choi, Luisa Garcia-Haro, Zebulon G. Levine, Meghan Tedoldi, Suzanne Walker, Nika N. Danial. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30391-0

Inhibition of hepatocellular carcinoma by metabolic normalization – Huabo Wang, Jie Lu, James Dolezal, Sucheta Kulkarni, Weiqi Zhang,Angel Chen, Joanna Gorka, Jordan A. Mandel, Edward V. Prochownik. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0218186

Lipogenic SREBP-1a/c transcription factors activate expression of the iron regulator hepcidin, revealing cross-talk between lipid and iron metabolisms – Alus M. Xiaoli, Ziyi Song and Fajun Yang. http://www.jbc.org/content/early/2019/07/03/jbc.RA119.009644.abstract


Nucleotides


De novo synthesis of serine and glycine fuels purine nucleotide biosynthesis in  human lung cancer tissues – Teresa W. M. Fan, Ronald C. Bruntz, Ye Yang, Huan Song, Yelena Chernyavskaya, Pan  Deng, Yan Zhang, Parag P. Shah, Levi J. Beverly, Zhen Qi, Angela L. Mahan, Richard M.  Higashi, Chi V. Dang and Andrew N. Lane. http://www.jbc.org/content/early/2019/07/23/jbc.RA119.008743.abstract

Acetylation regulates ribonucleotide reductase activity and cancer cell growth – Guo Chen, Yin Luo, Kurt Warncke, Youwei Sun, David S. Yu, Haian Fu, Madhusmita Behera, Suresh S. Ramalingam, Paul W. Doetsch, Duc M. Duong, Michael Lammers, Walter J. Curran and Xingming Deng. https://www.nature.com/articles/s41467-019-11214-9

BCL-2 family protein BOK is a positive regulator of uridine metabolism in mammals – Rahul Srivastava, Zhipeng Cao, Christina Nedeva, Samara Naim, Daniel Bachmann, Tatiana Rabachini, Lahiru Gangoda, Sanjay Shahi, Jason Glab, Joseph Menassa, Laura Osellame, Tao Nelson, Yuniel Fernandez-Marrero, Fiona Brown, Andrew Wei, Francine Ke, Lorraine O’Reilly, Marcel Doerflinger, Cody Allison, Andrew Kueh, Rob Ramsay, Brian J. Smith, Suresh Mathivanan, Thomas Kaufmann and Hamsa Puthalakath. https://www.pnas.org/content/116/31/15469.abstract?etoc


Mitochondria


Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia – Irène Baccelli, Yves Gareau, Bernhard Lehnertz, Stéphane Gingras, Jean-François Spinella, Sophie Corneau, Nadine Mayotte, Simon Girard, Mélanie Frechette, Valérie Blouin-Chagnon, Koryne Leveillé, Isabel Boivin, Tara MacRae, Jana Krosl, Clarisse Thiollier, Vincent-Philippe Lavallée, Evgeny Kanshin, Thierry Bertomeu, Jasmin Coulombe-Huntington, Corinne St-Denis, Marie-Eve Bordeleau, Geneviève Boucher, Philippe P. Roux, Sébastien Lemieux, Mike Tyers, Pierre Thibault, Josée Hébert, Anne Marinier, Guy Sauvageau. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30294-6

CHCHD4 regulates tumour proliferation and EMT-related phenotypes, through respiratory chain-mediated metabolism – Luke W. Thomas, Cinzia Esposito, Jenna M. Stephen, Ana S. H. Costa, Christian Frezza, Thomas S. Blacker, Gyorgy Szabadkai and Margaret Ashcroft. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-019-0200-4

Cardiolipin-induced activation of pyruvate dehydrogenase links mitochondrial lipid biosynthesis to TCA cycle function – Yiran Li, Wenjia Lou, Vaishnavi Raja, Simone Denis, Wenxi Yu, Michael W. Schmidtke, Christian A. Reynolds, Michael Schlame, Riekelt H. Houtkooper and Miriam L. Greenberg. http://www.jbc.org/content/294/30/11568.abstract.html


Starvation / metabolic stress


ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression – Feven Tameire, Ioannis I. Verginadis, Nektaria Maria Leli, Christine Polte, Crystal S. Conn, Rani Ojha, Carlo Salas Salinas, Frank Chinga, Alexandra. M. Monroy, Weixuan Fu, Paul Wang, Andrew Kossenkov, Jiangbin Ye, Ravi K. Amaravadi, Zoya Ignatova, Serge Y. Fuchs, J. Alan Diehl, Davide Ruggero and Constantinos Koumenis. https://www.nature.com/articles/s41556-019-0347-9

EGFR-Pak Signaling Selectively Regulates Glutamine Deprivation-Induced Macropinocytosis – Szu-Wei Lee, Yijuan Zhang, Michael Jung, Nathalia Cruz, Basheer Alas, Cosimo Commisso. https://www.cell.com/developmental-cell/fulltext/S1534-5807(19)30485-X

LIMS1 Promotes Pancreatic Cancer Cell Survival under Oxygen–Glucose Deprivation Conditions by Enhancing HIF1A Protein Translation – Chongbiao Huang, Yang Li, Zengxun Li, Yang Xu, Na Li, Yi Ge, Jie Dong, Antao Chang, Tiansuo Zhao, Xiuchao Wang, Hongwei Wang, Shengyu Yang, Keping Xie, Jihui Hao and He Ren. http://clincancerres.aacrjournals.org/content/25/13/4091

Metabolic stress activates an ERK/hnRNPK/DDX3X pathway in pancreatic β cells – Austin L. Good, Matthew W. Haemmerle, Alexis U. Oguh, Nicolai M.Doliba, Doris A.Stoffers. https://www.sciencedirect.com/science/article/pii/S2212877819304703


mTOR


Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition – Clive Yik-Sham Chung, Hijai R. Shin, Charles A. Berdan, Breanna Ford, Carl C. Ward, James A. Olzmann, Roberto Zoncu and Daniel K. Nomura. https://www.nature.com/articles/s41589-019-0308-4

mTORC1 suppresses PIM3 expression via miR-33 encoded by the SREBP loci – Kelsey I, Zbinden M, Byles V, Torrence M, Manning BD. https://www.nature.com/articles/s41598-017-16398-y

Kaposi sarcoma-associated herpesvirus miRNAs suppress CASTOR1-mediated mTORC1 inhibition to promote tumorigenesis – Li T, Ju E, Gao SJ. https://www.jci.org/articles/view/127166

A novel rapamycin analog is highly selective for mTORC1 in vivo – Katherine H. Schreiber, Sebastian I. Arriola Apelo, Deyang Yu, Jacqueline A. Brinkman, Michael C. Velarde, Faizan A. Syed, Chen-Yu Liao, Emma L. Baar, Kathryn A. Carbajal, Dawn S. Sherman, Denise Ortiz, Regina Brunauer, Shany E. Yang, Stelios T. Tzannis, Brian K. Kennedy and Dudley W. Lamming. https://www.nature.com/articles/s41467-019-11174-0


Hypoxia


Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants – Norma Masson, Thomas P. Keeley, Beatrice Giuntoli, Mark D. White, Mikel Lavilla Puerta, Pierdomenico Perata, Richard J. Hopkinson, Emily Flashman, Francesco Licausi, Peter J. Ratcliffe. https://science.sciencemag.org/content/365/6448/65


Cancer Immunometabolism


Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma – Malgorzata Czystowska-Kuzmicz, Anna Sosnowska, Dominika Nowis, Kavita Ramji, Marta Szajnik, Justyna Chlebowska-Tuz, Ewa Wolinska, Pawel Gaj, Magdalena Grazul, Zofia Pilch, Abdessamad Zerrouqi, Agnieszka Graczyk-Jarzynka, Karolina Soroczynska, Szczepan Cierniak, Robert Koktysz, Esther Elishaev, Slawomir Gruca, Artur Stefanowicz, Roman Blaszczyk, Bartlomiej Borek, Anna Gzik, Theresa Whiteside and Jakub Golab. https://www.nature.com/articles/s41467-019-10979-3


Miscellaneous


Magnetic Resonance Imaging Is More Sensitive Than PET for Detecting Treatment-Induced Cell Death–Dependent Changes in Glycolysis – Richard L. Hesketh, Jiazheng Wang, Alan J. Wright, David Y. Lewis, Alice E. Denton, Richard Grenfell, Jodi L. Miller, Robert Bielik, Marcel Gehrung, Maria Fala, Susana Ros, Bangwen Xie, De-en Hu and Kevin M. Brindle. http://cancerres.aacrjournals.org/content/79/14/3557

Changes in the turnover of the cellular proteome during metabolic reprogramming: A role for mtROS in proteostasis – Garcia A, Martinez-Reyes I, Cuezva JM. https://pubs.acs.org/doi/10.1021/acs.jproteome.9b00239

Loss of GCN5L1 in cardiac cells disrupts glucose metabolism and promotes cell death via reduced Akt/mTORC2 signaling – Janet R. Manning, Dharendra Thapa, Manling Zhang, Michael W. Stoner, Javier Traba, Catherine Corey, Sruti Shiva, Michael N. Sack, Iain Scott. http://www.biochemj.org/content/476/12/1713?etoc

Cancer-associated fibroblasts promote prostate cancer malignancy via metabolic rewiring and mitochondrial transfer – Luigi Ippolito, Andrea Morandi, Maria Letizia Taddei, Matteo Parri, Giuseppina Comito, Alessandra Iscaro, Maria Rosaria Raspollini, Francesca Magherini, Elena Rapizzi, Julien Masquelier, Giulio G. Muccioli, Pierre Sonveaux, Paola Chiarugi and Elisa Giannoni. https://www.nature.com/articles/s41388-019-0805-7


Reviews


Exploiting metabolic vulnerabilities of Non small cell lung carcinoma – Blanca Majem, Ernest Nadal, Cristina Muñoz Pinedo. https://www.sciencedirect.com/science/article/pii/S1084952118301861

Mitochondrial DNA: the overlooked oncogenome? – Payam A. Gammage and Christian Frezza. https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-019-0668-y

Metabolic Regulation of Redox Balance in Cancer – Vinee Purohit, Diane M. Simeone and Costas A. Lyssiotis. https://www.mdpi.com/2072-6694/11/7/955

Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer – Neha M. Akella, Lorela Ciraku and Mauricio J. Reginato. https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-019-0671-3

mTOR as a central regulator of lifespan and aging – David Papadopoli, Karine Boulay, Lawrence Kazak, Michael Pollak, Frédérick A. Mallette, Ivan Topisirovic, Laura Hulea. https://f1000research.com/articles/8-998/v1

Exploiting metabolic vulnerabilities for personalized therapy in acute myeloid leukemia – Stuani L, Sabatier M, Sarry JE. https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-019-0670-4

Allosteric, transcriptional and post-translational control of mitochondrial energy metabolism – Qutuba G. Karwi, Alice R. Jörg and Gary D. Lopaschuk. http://www.biochemj.org/content/476/12/1695?etoc

Macrophages and Metabolism in the Tumor Microenvironment – Ilio Vitale, Gwenola Manic, Lisa M. Coussens, Guido Kroemer, Lorenzo Galluzzi. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30304-3

The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde? – Diana Vara-Ciruelos, Fiona M. Russell and D. Grahame Hardie. https://royalsocietypublishing.org/doi/full/10.1098/rsob.190099

Thirty sweet years of GLUT4 – Amira Klip, Timothy E. McGraw and David E. James. http://www.jbc.org/content/early/2019/06/07/jbc.REV119.008351.abstract

Role of branched-chain amino acid–catabolizing enzymes in intertissue signaling, metabolic remodeling, and energy homeostasis – Dipsikha Biswas, Luke Duffley and Thomas Pulinilkunnil. https://www.fasebj.org/doi/abs/10.1096/fj.201802842RR


Comments/other


Blood Vessel Proximity Shapes Cancer Cell Metabolism – Federico Virga, Manuel Ehling, Massimiliano Mazzone. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30314-6

Metabolic signal curbs cancer-cell migration – Lydia W. S. Finley. https://www.nature.com/articles/d41586-019-01934-9

BACH1 Orchestrates Lung Cancer Metastasis – Nicole M. Anderson, M. Celeste Simon. https://www.cell.com/cell/fulltext/S0092-8674(19)30683-X

c-Myc steers translation in lymphoma – Marie Cargnello and Ivan Topisirovic. http://jem.rupress.org/content/216/7/1471?etoc

Metabolic vulnerabilities of metastasizing cancer cells – Sarah-Maria Fendt. https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-019-0672-2

Viral hijacking of cellular metabolism – Shivani K. Thaker, James Ch’ng and Heather R. Christofk. https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-019-0678-9

ER stress boosts respiration – Paulina Strzyz. https://www.nature.com/articles/s41580-019-0139-x

New Roles for Glycogen in Tumor Progression – Patricia Dauer, Ernst Lengyel. https://www.cell.com/trends/cancer/fulltext/S2405-8033(19)30079-2

NAD Metabolic Dependency Determines Therapeutic Sensitivity in Cancer – http://cancerdiscovery.aacrjournals.org/content/9/7/OF14

Blood Vessel Proximity Generates Metabolic Gradients in Glioblastoma – http://cancerdiscovery.aacrjournals.org/content/9/7/OF13

Sarah-Maria Fendt: Driving scientific discovery through collaboration – http://jem.rupress.org/content/216/7/1467

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