MetaboList – August 2019


Resources


Metabolic landscape of the tumor microenvironment at single cell resolution – Zhengtao Xiao, Ziwei Dai and Jason W. Locasale. https://www.nature.com/articles/s41467-019-11738-0


Glucose and lactate metabolism


p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas – Meng-Hsiung Hsieh, Joshua H. Choe, Jashkaran Gadhvi, Yoon Jung Kim, Marcus A. Arguez, Madison Palmer, Haleigh Gerold, Chance Nowak, Hung Do, Simbarashe Mazambani, Jordan K. Knighton, Matthew Cha, Justin Goodwin, Min Kyu Kang, Ji Yun Jeong, Shin Yup Lee, Brandon Faubert, Zhenyu Xuan, E. Dale Abel, Claudio Scafoglio, David B. Shackelford, John D. Minna, Pankaj K. Singh, Vladimir Shulaev, Leonidas Bleris, Kenneth Hoyt, James Kim, Masahiro Inoue, Ralph J. DeBerardinis, Tae Hoon Kim, Jung-whan Kim. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30924-6

LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc – Jiayin Tang, Tingting Yan, Yujie Bao, Chaoqin Shen, Chenyang Yu, Xiaoqiang Zhu, Xianglong Tian, Fangfang Guo, Qian Liang, Qiang Liu, Ming Zhong, Jinxian Chen, Zhizheng Ge, Xiaobo Li, Xiaoyu Chen, Yun Cui, Yingxuan Chen, Weiping Zou, Haoyan Chen, Jie Hong and Jing-Yuan Fang. https://www.nature.com/articles/s41467-019-11447-8

Inhibition of phosphoenolpyruvate carboxykinase blocks lactate utilization and impairs tumor growth in colorectal cancer – Emily D. Montal, Kavita Bhalla, Ruby E. Dewi, Christian F. Ruiz, John A. Haley, Ashley E. Ropell, Chris Gordon, John D. Haley and Geoffrey D. Girnun. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-019-0199-6

Autophagy inhibition elicits emergence from metastatic dormancy by inducing and stabilizing Pfkfb3 expression – Alyssa La Belle Flynn, Benjamin C. Calhoun, Arishya Sharma, Jenny C. Chang, Alexandru Almasan and William P. Schiemann. https://www.nature.com/articles/s41467-019-11640-9

Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice – Shun Kishimoto, Jeffrey R Brender , Daniel R Crooks, Shingo Matsumoto, Tomohiro Seki, Nobu Oshima, Hellmut Merkle, Penghui Lin, Galen Reed,Albert P Chen, Jan Henrik Ardenkjaer-Larsen, Jeeva Munasinghe, Keita Saito, Kazutoshi Yamamoto, Peter L Choyke, James Mitchell, Andrew N Lane,Teresa Fan, W Marston Linehan, Murali C Krishna. https://elifesciences.org/articles/46312

Targeting tumor phenotypic plasticity and metabolic remodeling in adaptive cross-drug tolerance – Aaron Goldman, Sachin Khiste, Elizaveta Freinkman, Andrew Dhawan, Biswanath Majumder, Jayanta Mondal, Anthony B. Pinkerton, Elliot Eton, Ragini Medhi, Vineethkrishna Chandrasekar, M. Mamunur Rahman, Takaharu Ichimura, Kodaganur S. Gopinath, Pradip Majumder, Mohammad Kohandel and Shiladitya Sengupta. https://stke.sciencemag.org/content/12/595/eaas8779


Cystine / Glutathione / NRF2


The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase – Viraj R. Sanghvi, Josef Leibold, Marco Mina, Prathibha Mohan, Marjan Berishaj, Zhuoning Li, Matthew M. Miele, Nathalie Lailler, Chunying Zhao, Elisa de Stanchina, Agnes Viale, Leila Akkari, Scott W. Lowe, Giovanni Ciriello, Ronald C. Hendrickson, Hans-Guido Wendel. https://www.cell.com/cell/fulltext/S0092-8674(19)30830-X

GSTZ1‐1 Deficiency Activates NRF2/IGF1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone – Fan Yang, Jingjing Li, Haijun Deng, Yihao Wang, Chong Lei, Qiujie Wang, Jin Xiang, Li Liang, Jie Xia, Xuanming Pan, Xiaosong Li, Quanxin Long, Lei Chang, Ping Xu, Ailong Huang, Kai Wang, Ni Tang. https://www.embopress.org/doi/10.15252/embj.2019101964

Genetic Ablation of the Cystine Transporter xCT in PDAC Cells Inhibits mTORC1, Growth, Survival, and Tumor Formation via Nutrient and Oxidative Stresses – Boutaina Daher, Scott K. Parks, Jerome Durivault, Yann Cormerais, Hanane Baidarjad, Eric Tambutte, Jacques Pouysségur and Milica Vučetić. https://cancerres.aacrjournals.org/content/79/15/3877


Other amino acids


MYC-Driven Small-Cell Lung Cancer is Metabolically Distinct and Vulnerable to Arginine Depletion – Milind D. Chalishazar, Sarah J. Wait, Fang Huang, Abbie S. Ireland, Anandaroop Mukhopadhyay, Younjee Lee, Sophia S. Schuman, Matthew R. Guthrie, Kristofer C. Berrett, Jeffery M. Vahrenkamp, Zeping Hu, Marek Kudla, Katarzyna Modzelewska, Guoying Wang, Nicholas T. Ingolia, Jason Gertz, David H. Lum, Sabina C. Cosulich, John S. Bomalaski, Ralph J. DeBerardinis and Trudy G. Oliver. https://clincancerres.aacrjournals.org/content/25/16/5107

Arginine Starvation and Docetaxel Induce c-Myc–Driven hENT1 Surface Expression to Overcome Gemcitabine Resistance in ASS1-Negative Tumors – Bethany C. Prudner, Richa Rathore, Anthony M. Robinson, Abigail Godec, Samuel F. Chang, William G. Hawkins, Angela C. Hirbe and Brian A. Van Tine. https://clincancerres.aacrjournals.org/content/25/16/5122

Age modulates liver responses to asparaginase-induced amino acid stress in mice – Inna A. Nikonorova, Qiaoqiao Zhu, Christina C. Signore, Emily T. Mirek, William O. Jonsson, Bo Kong, Grace L. Guo, William J. Belden and Tracy G. Anthony. http://www.jbc.org/content/early/2019/08/14/jbc.RA119.009864.abstract

Metabolic Reprogramming by MYCN Confers Dependence on the Serine-Glycine-One-Carbon Biosynthetic Pathway – Yingfeng Xia, Bingwei Ye, Jane Ding, Yajie Yu, Ahmet Alptekin, Muthusamy Thangaraju, Puttur D. Prasad, Zhi-Chun Ding, Eun Jeong Park, Jeong-Hyeon Choi, Bei Gao, Oliver Fiehn, Chunhong Yan, Zheng Dong, Yunhong Zha and Han-Fei Ding. https://cancerres.aacrjournals.org/content/79/15/3837

Folate can promote the methionine-dependent reprogramming of glioblastoma cells towards pluripotency – Racha Zgheib, Shyue-Fang Battaglia-Hsu, Sébastien Hergalant, Maelle Quéré, Jean-Marc Alberto, Céline Chéry, Pierre Rouyer, Guillaume Gauchotte, Jean-Louis Guéant and Farès Namour. https://www.nature.com/articles/s41419-019-1836-2

Targeting HIBCH to reprogram valine metabolism for the treatment of colorectal cancer – Yunlong Shan, Yuan Gao, Wei Jin, Minmin Fan, Ying Wang, Yanhong Gu, Chenxiao Shan, Lijun Sun, Xin Li, Biao Yu, Qiong Luo and Qiang Xu. https://www.nature.com/articles/s41419-019-1832-6


Polyamines


Lysine harvesting is an antioxidant strategy and triggers underground polyamine metabolism – Viridiana Olin-Sandoval, Jason Shu Lim Yu, Leonor Miller-Fleming, Mohammad Tauqeer Alam, Stephan Kamrad, Clara Correia-Melo, Robert Haas, Joanna Segal, David Alejandro Peña Navarro, Lucia Herrera-Dominguez, Oscar Méndez-Lucio, Jakob Vowinckel, Michael Mülleder and Markus Ralser. https://www.nature.com/articles/s41586-019-1442-6

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation – Daniel J. Puleston, Michael D. Buck, Ramon I. Klein Geltink, Ryan L. Kyle, George Caputa, David O’Sullivan, Alanna M. Cameron, Angela Castoldi, Yaarub Musa, Agnieszka M. Kabat, Ying Zhang, Lea J. Flachsmann, Cameron S. Field, Annette E. Patterson, Stefanie Scherer, Francesca Alfei, Francesc Baixauli, S. Kyle Austin, Beth Kelly, Mai Matsushita, Jonathan D. Curtis, Katarzyna M. Grzes, Matteo Villa, Mauro Corrado, David E. Sanin, Jing Qiu, Nora Pällman, Katelyn Paz, Maria Elena Maccari, Bruce R. Blazar, Gerhard Mittler, Joerg M. Buescher, Dietmar Zehn, Sabine Rospert, Edward J. Pearce, Stefan Balabanov, Erika L. Pearce. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30243-8

Supramolecular trap for catching polyamines in cells as an anti-tumor strategy – Junyi Chen, Hanzhi Ni, Zhao Meng, Jing Wang, Xiayang Huang, Yansheng Dong, Chao Sun, Yadan Zhang, Lei Cui, Jian Li, Xueshun Jia, Qingbin Meng and Chunju Li. https://www.nature.com/articles/s41467-019-11553-7


Lipid metabolism


Acyl-CoA-Binding Protein Drives Glioblastoma Tumorigenesis by Sustaining Fatty Acid Oxidation – Ceren Duman, Kaneschka Yaqubi, Angelika Hoffmann, Azer Aylin Acikgöz, Andrey Korshunov, Martin Bendszus, Christel Herold-Mende, Hai-Kun Liu, Julieta Alfonso. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30188-3

Targeting of lipid metabolism with a metabolic inhibitor cocktail eradicates peritoneal metastases in ovarian cancer cells – Chen RR, Yung MMH, Xuan Y, Zhan S, Leung LL, Liang RR, Leung THY, Yang H, Xu D, Sharma R, Chan KKL, Ngu SF, Ngan HYS, Chan DW. https://doi.org/10.1038/s42003-019-0508-1

mTOR direct crosstalk with STAT5 promotes de novo lipid synthesis and induces hepatocellular carcinoma – Ting Li, Jun Weng, Yue Zhang, Kangyan Liang, Gongbo Fu, Yang Li, Xiaochun Bai and Yi Gao. https://www.nature.com/articles/s41419-019-1828-2


Nucleotides


Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming – Raquel Buj, Chi-Wei Chen, Erika S. Dahl, Kelly E. Leon, Rostislav Kuskovsky, Natella Maglakelidze, Maithili Navaratnarajah, Gao Zhang, Mary T. Doan, Helen Jiang, Michael Zaleski, Lydia Kutzler, Holly Lacko, Yiling Lu, Gordon B. Mills, Raghavendra Gowda, Gavin P. Robertson, Joshua I. Warrick, Meenhard Herlyn, Yuka Imamura, Scot R. Kimball, David J. DeGraff, Nathaniel W. Snyder, Katherine M. Aird. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31000-9

Targeting pyrimidine synthesis accentuates molecular therapy response in glioblastoma stem cells – Xiuxing Wang , Kailin Yang, Qiulian Wu, Leo J. Y. Kim, Andrew R. Morton, Ryan C. Gimple, Briana C. Prager, Yu Shi, Wenchao Zhou, Shruti Bhargava, Zhe Zhu, Li Jiang, Weiwei Tao, Zhixin Qiu, Linjie Zhao, Guoxing Zhang, Xiqing Li, Sameer Agnihotri, Paul S. Mischel, Stephen C. Mack, Shideng Bao, Jeremy N. Rich. https://stm.sciencemag.org/content/11/504/eaau4972

IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma – Satoshi Kofuji, Akiyoshi Hirayama, Alexander Otto Eberhardt, Risa Kawaguchi, Yuki Sugiura, Oltea Sampetrean, Yoshiki Ikeda, Mikako Warren, Naoya Sakamoto, Shuji Kitahara, Hirofumi Yoshino, Daisuke Yamashita, Kazutaka Sumita, Kara Wolfe, Lisa Lange, Satsuki Ikeda, Hiroko Shimada, Noriaki Minami, Akshiv Malhotra, Shin Morioka, Yuki Ban, Maya Asano, Victoria L. Flanary, Annmarie Ramkissoon, Lionel M. L. Chow, Juri Kiyokawa, Tomoyuki Mashimo, Greg Lucey, Sergey Mareninov, Tatsuya Ozawa, Nobuyuki Onishi, Koichi Okumura, Jumpei Terakawa, Takiko Daikoku, Trisha Wise-Draper, Nazanin Majd, Kaori Kofuji, Mika Sasaki, Masaru Mori, Yonehiro Kanemura, Eric P. Smith, Dimitrios Anastasiou, Hiroaki Wakimoto, Eric C. Holland, William H. Yong, Craig Horbinski, Ichiro Nakano, Ralph J. DeBerardinis, Robert M. Bachoo, Paul S. Mischel, Wataru Yasui, Makoto Suematsu, Hideyuki Saya, Tomoyoshi Soga, Ingrid Grummt, Holger Bierhoff and Atsuo T. Sasaki. https://www.nature.com/articles/s41556-019-0363-9


Mitochondria


Drp1 Promotes KRas-Driven Metabolic Changes to Drive Pancreatic Tumor Growth – Sarbajeet Nagdas, Jennifer A. Kashatus, Aldo Nascimento, Syed S. Hussain, Riley E. Trainor, Sarah R. Pollock, Sara J. Adair, Alex D. Michaels, Hiromi Sesaki, Edward B. Stelow, Todd W. Bauer, David F. Kashatus. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30928-3

Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers – Nilanjana Chatterjee, Evangelos Pazarentzos, Manasi K. Mayekar, Philippe Gui, David V. Allegakoen, Gorjan Hrustanovic, Victor Olivas, Luping Lin, Erik Verschueren, Jeffrey R. Johnson, Matan Hofree, Jenny J. Yan, Billy W. Newton, John V. Dollen, Charles H. Earnshaw, Jennifer Flanagan, Elton Chan, Saurabh Asthana, Trey Ideker, Wei Wu, Junji Suzuki, Benjamin A. Barad, Yuriy Kirichok, James S. Fraser, William A. Weiss, Nevan J. Krogan, Asmin Tulpule, Amit J. Sabnis, Trever G. Bivona. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30967-2

Mutant p53-dependent mitochondrial metabolic alterations in a mesenchymal stem cell-based model of progressive malignancy – Giuseppe Lonetto, Gabriela Koifman, Alon Silberman, Ayush Attery, Hilla Solomon, Smadar Levin-Zaidman, Naomi Goldfinger, Ziv Porat, Ayelet Erez and Varda Rotter. https://www.nature.com/articles/s41418-018-0227-z

UCP2 Deficiency Increases Colon Tumorigenesis by Promoting Lipid Synthesis and Depleting NADPH for Antioxidant Defenses – Esther Aguilar, Pauline Esteves, Tiphaine Sancerni, Véronique Lenoir, Thomas Aparicio, Frédéric Bouillaud, Renaud Dentin, Carina Prip-Buus, Daniel Ricquier, Claire Pecqueur, Sandra Guilmeau, Marie-Clotilde Alves-Guerra. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31013-7

Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1 – Leilei Zhang, Jie Zhang, Zhiwei Ye, Yefim Manevich, Lauren E. Ball, Jennifer R. Bethard, Yu-Lin Jiang, Ann-Marie Broome, Annamarie C. Dalton, Gavin Y. Wang, Danyelle M. Townsend and Kenneth D. Tew. https://cancerres.aacrjournals.org/content/79/16/4072


Starvation / ATF4 / AMPK


Impaired Mitochondrial ATP Production Downregulates Wnt Signaling via ER Stress Induction – Roberto Costa, Roberta Peruzzo, Magdalena Bachmann, Giulia Dalla Montà, Mattia Vicario, Giulia Santinon, Andrea Mattarei, Enrico Moro, Rubén Quintana-Cabrera, Luca Scorrano, Massimo Zeviani, Francesca Vallese, Mario Zoratti, Cristina Paradisi, Francesco Argenton, Marisa Brini, Tito Calì, Sirio Dupont, Ildikò Szabò, Luigi Leanza. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30954-4

AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR – Caterina Collodet, Marc Foretz, Maria Deak, Laurent Bultot, Sylviane Metairon, Benoit Viollet, Gregory Lefebvre, Frederic Raymond, Alice Parisi, Gabriele Civiletto, Philipp Gut, Patrick Descombes and Kei Sakamoto. https://www.fasebj.org/doi/abs/10.1096/fj.201900841R?ai=ts&ui=ly8&af=T


mTOR


Oncogenic Rag GTPase signalling enhances B cell activation and drives follicular lymphoma sensitive to pharmacological inhibition of mTOR – Ana Ortega-Molina, Nerea Deleyto-Seldas, Joaquim Carreras, Alba Sanz, Cristina Lebrero-Fernández, Camino Menéndez, Andrew Vandenberg, Beatriz Fernández-Ruiz, Leyre Marín-Arraiza, Celia de la Calle Arregui, Ana Belén Plata-Gómez, Eduardo Caleiras, Alba de Martino, Nuria Martínez-Martín, Kevin Troulé, Elena Piñeiro-Yáñez, Naoya Nakamura, Shamzah Araf, Gabriel D. Victora, Jessica Okosun, Jude Fitzgibbon and Alejo Efeyan. https://www.nature.com/articles/s42255-019-0098-8

mTORC1/AMPK responses define a core gene set for developmental cell fate switching [in Dictyostelium] – Pundrik Jaiswal and Alan R. Kimmel. https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-019-0673-1


Hypoxia


Hypoxic ER stress suppresses β-catenin expression and promotes cooperation between the transcription factors XBP1 and HIF1α for cell survival – Zhixiong Xia, Shiyong Wu, Xin Wei, Yifei Liao, Ping Yi, Yong Liu, Jianmiao Liu and Jianfeng Liu. http://www.jbc.org/content/early/2019/07/26/jbc.RA119.008353.abstract

The Pro-Oncogenic Adaptor CIN85 Acts as an Inhibitory Binding Partner of Hypoxia-Inducible Factor Prolyl Hydroxylase 2 – Nina Kozlova, Daniela Mennerich, Anatoly Samoylenko, Elitsa Y. Dimova, Peppi Koivunen, Ekaterina Biterova, Kati Richter, Antti Hassinen, Sakari Kellokumpu, Aki Manninen, Ilkka Miinalainen, Virpi Glumoff, Lloyd Ruddock, Lyudmyla Borysivna Drobot and Thomas Kietzmann. https://cancerres.aacrjournals.org/content/79/16/4042


IDH


Targeting IDH1 as a Prosenescent Therapy in High-grade Serous Ovarian Cancer – Erika S. Dahl, Raquel Buj, Kelly E. Leon, Jordan M. Newell, Yuka Imamura, Benjamin G. Bitler, Nathaniel W. Snyder and Katherine M. Aird. https://mcr.aacrjournals.org/content/17/8/1710.long


Cancer Immunometabolism


Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity – Paramita Chakraborty, Silvia G. Vaena, Krishnamurthy Thyagarajan, Shilpak Chatterjee, Amir Al-Khami, Shanmugam Panneer Selvam, Hung Nguyen, Inhong Kang, Megan W. Wyatt, Uday Baliga, Zachariah Hedley, Rose N. Ngang, Beichu Guo, Gyda C. Beeson, Shahid Husain, Chrystal M. Paulos, Craig C. Beeson, Michael J. Zilliox, Elizabeth G. Hill, Meenal Mehrotra, Xue-Zhong Yu, Besim Ogretmen, Shikhar Mehrotra. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30941-6

Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8+ T Cell-Derived Interferon-γ – Chang Liu, Maria Chikina, Rahul Deshpande, Ashley V. Menk, Ting Wang, Tracy Tabib, Erin A. Brunazzi, Kate M. Vignali, Ming Sun, Donna B. Stolz, Robert A. Lafyatis, Wei Chen, Greg M. Delgoffe, Creg J. Workman, Stacy G. Wendell, Dario A.A. Vignali. https://www.cell.com/immunity/fulltext/S1074-7613(19)30287-0

Acidity promotes tumour progression by altering macrophage phenotype in prostate cancer – El-Kenawi A, Gatenbee C, Robertson-Tessi M, Bravo R, Dhillon J, Balagurunathan Y, Berglund A, Visvakarma N, Ibrahim-Hashim A, Choi J, Luddy K, Gatenby R, Pilon-Thomas S, Anderson A, Ruffell B, Gillies R. https://www.nature.com/articles/s41416-019-0542-2

3 articles on caloric restriction and the immune system in Cell:

https://www.cell.com/cell/fulltext/S0092-8674(19)30850-5

https://www.cell.com/cell/fulltext/S0092-8674(19)30849-9

https://www.cell.com/cell/fulltext/S0092-8674(19)30847-5


Miscellaneous


The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair – Anthony Kusnadi, Sung Ho Park, Ruoxi Yuan, Tania Pannellini, Eugenia Giannopoulou, David Oliver, Theresa Lu, Kyung-Hyun Park-Min, Lionel B. Ivashkiv. https://www.cell.com/immunity/fulltext/S1074-7613(19)30275-4

Inhibition of Pyruvate Dehydrogenase Kinase Enhances the Antitumor Efficacy of Oncolytic Reovirus – Barry E. Kennedy, John Patrick Murphy, Derek R. Clements, Prathyusha Konda, Namit Holay, Youra Kim, Gopal P. Pathak, Michael A. Giacomantonio, Yassine El Hiani and Shashi Gujar. https://cancerres.aacrjournals.org/content/79/15/3824


Reviews


Acetate Metabolism in Physiology, Cancer, and Beyond – Shree Bose, Vijyendra Ramesh, Jason W. Locasale. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(19)30084-4

Metabolic Regulation of Redox Balance in Cancer – Vinee Purohit, Diane M. Simeone and Costas A. Lyssiotis. https://www.mdpi.com/2072-6694/11/7/955

Mitochondria Plasticity in Cell Fate Regulation – Amir Bahat and Atan Gross. http://www.jbc.org/content/early/2019/08/05/jbc.REV118.000828.abstract

Targeting Metabolic Bottlenecks in Lung Cancer – Volkan I. Sayin, Sarah E. LeBoeuf, Thales Papagiannakopoulos. https://www.cell.com/trends/cancer/fulltext/S2405-8033(19)30118-9

Studying metabolic flux adaptations in cancer through integrated experimental-computational approaches – Shoval Lagziel, Won Dong Lee and Tomer Shlomi. https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-019-0669-x

NAD-Biosynthetic and Consuming Enzymes as Central Players of Metabolic Regulation of Innate and Adaptive Immune Responses in Cancer – Audrito V, Managò A, Gaudino F, Sorci L, Messana VG, Raffaelli N, Deaglio S. https://www.frontiersin.org/articles/10.3389/fimmu.2019.01720/full

Adipocyte and lipid metabolism in cancer drug resistance – Yihai Cao. https://www.jci.org/articles/view/127201

Innate and adaptive resistance mechanisms to arginine deprivation therapies in sarcoma and other cancers – Leonard C. Rogers, Brian A. Van Tine. https://cdrjournal.com/article/view/3194

The Metabolic Basis of Kidney Cancer – Marston Linehan, Laura S. Schmidt, Daniel R. Crooks, Darmood Wei, Ramaprasad Srinivasan, Martin Lang and Christopher J. Ricketts. https://cancerdiscovery.aacrjournals.org/content/9/8/1006

Serine-Glycine-One-Carbon Metabolism: The Hidden Achilles Heel of MYCN-Amplified Neuroblastoma? – Aida Rodriguez Garcia and Marie Arsenian-Henriksson. https://cancerres.aacrjournals.org/content/79/15/3818

Fasting and rapamycin: diabetes versus benevolent glucose intolerance – Mikhail V. Blagosklonny. https://www.nature.com/articles/s41419-019-1822-8


Comments


AGK Unleashes CD8+ T Cell Glycolysis to Combat Tumor Growth – Peipei Zhou, Hongbo Chi. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30381-X

Acyl-CoA-Binding Protein Fuels Gliomagenesis – Junfeng Bi, Paul S. Mischel. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30380-8

EGFR Pathway Links Amino Acid Levels and Induction of Macropinocytosis – Vajira K. Weerasekara, Krushna C. Patra, Nabeel Bardeesy. https://www.cell.com/developmental-cell/fulltext/S1534-5807(19)30626-4

Losing control of nutrient sensing in the germinal centre drives lymphomagenesis – Ulf Klein. https://www.nature.com/articles/s42255-019-0103-2

Drugging OXPHOS Dependency in Cancer– https://cancerdiscovery.aacrjournals.org/content/9/8/OF10

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