MetaboList – September 2019


Glucose metabolism / glycolytic enzymes


GAPDH Overexpression in the T Cell Lineage Promotes Angioimmunoblastic T Cell Lymphoma through an NF-κB-Dependent Mechanism – Laura Mondragón, Rana Mhaidly, Gian Marco De Donatis, Marie Tosolini, Pascal Dao, Anthony R. Martin, Caroline Pons, Johanna Chiche, Marie Jacquin, Véronique Imbert, Emma Proïcs, Laurent Boyer, Anne Doye, Frédéric Luciano, Jaap G. Neels, Frédéric Coutant, Nicole Fabien, Laura Sormani, Camila Rubio-Patiño, Jozef P. Bossowski, Florian Muller, Sandrine Marchetti, Elodie Villa, Jean-François Peyron, Philippe Gaulard, François Lemonnier, Vahid Asnafi, Laurent Genestier, Rachid Benhida, Jean-Jacques Fournié, Thierry Passeron, Jean-Ehrland Ricci, Els Verhoeyen. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30335-6

Therapeutic Targeting of Aldolase A Interactions Inhibits Lung Cancer Metastasis and Prolongs Survival – Yu-Chan Chang, Jean Chiou, Yi-Fang Yang, Chia-Yi Su, Yuan-Feng Lin, Chia-Ning Yang, Pei-Jung Lu, Ming-Shyan Huang, Chih-Jen Yang and Michael Hsiao. https://cancerres.aacrjournals.org/content/79/18/4754

Targeting a moonlighting function of aldolase induces apoptosis in cancer cells – Agnieszka Gizak, Janusz Wiśniewski, Paul Heron, Piotr Mamczur, Jurgen Sygusch and Dariusz Rakus. https://www.nature.com/articles/s41419-019-1968-4

6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase-2 Regulates TP53-Dependent Paclitaxel Sensitivity in Ovarian and Breast Cancers – Hailing Yang, Zhang Shu, Yongying Jiang, Weiqun Mao, Lan Pang, Abena Redwood, Sabrina L. Jeter-Jones, Nicholas B. Jennings, Argentina Ornelas, Jinhua Zhou, Cristian Rodriguez-Aguayo, Geoffrey Bartholomeusz, LaKesla R. Iles, Niki M. Zacharias, Steven W. Millward, Gabriel Lopez-Berestein, Xiao-Feng Le, Ahmed A. Ahmed, Helen Piwnica-Worms, Anil K. Sood, Robert C. Bast and Zhen Lu. https://clincancerres.aacrjournals.org/content/25/18/5702

The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose – Quentin Defenouillère, Agathe Verraes, Clotilde Laussel, Anne Friedrich, Joseph Schacherer, Sébastien Léon. https://stke.sciencemag.org/content/12/597/eaaw8000

Nitric oxide maintains endothelial redox homeostasis through PKM2 inhibition – Mauro Siragusa, Janina Thöle, Sofia‐Iris Bibli, Bert Luck, Annemarieke E Loot, Kevin de Silva, Ilka Wittig, Juliana Heidler, Heike Stingl, Voahanginirina Randriamboavonjy, Karin Kohlstedt, Bernhard Brüne, Andreas Weigert, Beate Fisslthaler, Ingrid Fleming. https://www.embopress.org/doi/abs/10.15252/embj.2018100938

Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma – Sarah A. Best, Sheryl Ding, Ariena Kersbergen, Xueyi Dong, Ji-Ying Song, Yi Xie, Boris Reljic, Kaiming Li, James E. Vince, Vivek Rathi, Gavin M. Wright, Matthew E. Ritchie and Kate D. Sutherland. https://www.nature.com/articles/s41467-019-12164-y

CD36 inhibits β-catenin/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis – Yuan Fang, Zhi-Yong Shen, Yi-Zhi Zhan, Xiao-Chuang Feng, Ke-Li Chen, Yong-Sheng Li, Hai-Jun Deng, Su-Ming Pan, De-Hua Wu and Yi Ding. https://www.nature.com/articles/s41467-019-11662-3

Dual Inhibition of GLUT1 and the ATR/CHK1 Kinase Axis Displays Synergistic Cytotoxicity in KRAS-Mutant Cancer Cells – Johanna Erber, Joachim D. Steiner, Jörg Isensee, Leonard A. Lobbes, André Toschka, Filippo Beleggia, Anna Schmitt, Rainer W. J. Kaiser, Florian Siedek, Thorsten Persigehl, Tim Hucho and Hans C. Reinhardt. https://cancerres.aacrjournals.org/content/79/19/4855

PFKFB3 inhibition reprograms malignant pleural mesothelioma to nutrient stress-induced macropinocytosis and ER stress as independent binary adaptive responses – Sayantani Sarkar Bhattacharya, Prabhu Thirusangu, Ling Jin, Debarshi Roy, Deokbeom Jung, Yinan Xiao, Julie Staub, Bhaskar Roy, Julian R. Molina and Viji Shridhar. https://www.nature.com/articles/s41419-019-1916-3

Lactate and pyruvate promote oxidative stress resistance through hormetic ROS signaling – Arnaud Tauffenberger, Hubert Fiumelli, Salam Almustafa and Pierre J. Magistretti. https://www.nature.com/articles/s41419-019-1877-6


Amino acids


Cellular redox state constrains serine synthesis and nucleotide production to impact cell proliferation – Frances F. Diehl, Caroline A. Lewis, Brian P. Fiske and Matthew G. Vander Heiden. https://www.nature.com/articles/s42255-019-0108-x

Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation – Zhimin Gu, Yuxuan Liu, Feng Cai, McKenzie Patrick, Jakub Zmajkovic, Hui Cao, Yuannyu Zhang, Alpaslan Tasdogan, Mingyi Chen, Le Qi, Xin Liu, Kailong Li, Junhua Lyu, Kathryn E. Dickerson, Weina Chen, Min Ni, Matthew E. Merritt, Sean J. Morrison, Radek C. Skoda, Ralph J. DeBerardinis and Jian Xu. https://cancerdiscovery.aacrjournals.org/content/9/9/1228

Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer – Michael J. Lukey, Ahmad A. Cluntun, William P. Katt, Miao-chong J. Lin, Joseph E. Druso, Sekar Ramachandran, Jon W. Erickson, Henry H. Le, Zhihan-Emily Wang, Bryant Blank, Kai Su Greene, Richard A. Cerione. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31131-3

MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer – Niranjan Venkateswaran, M. Carmen Lafita-Navarro, Yi-Heng Hao, Jessica A Kilgore, Lizbeth Perez-Castro, Jonathan Braverman, Nofit Borenstein-Auerbach, Min Kim, Nicholas P. Lesner, Prashant Mishra, Thomas Brabletz, Jerry W. Shay, Ralph J. DeBerardinis, Noelle S. Williams, Omer H. Yilmaz and Maralice Conacci-Sorrell. http://genesdev.cshlp.org/content/33/17-18/1236.abstract?etoc

Unbiased Metabolic Profiling Predicts Sensitivity of High MYC-Expressing Atypical Teratoid/Rhabdoid Tumors to Glutamine Inhibition with 6-Diazo-5-Oxo-L-Norleucine – Sabrina Z. Wang, Brad Poore, Jesse Alt, Antoinette Price, Sariah J. Allen, Allison R. Hanaford, Harpreet Kaur, Brent A. Orr, Barbara S. Slusher, Charles G. Eberhart, Eric H. Raabe and Jeffrey A. Rubens. https://clincancerres.aacrjournals.org/content/25/19/5925


Lipid metabolism


The MYC Oncogene Cooperates with Sterol-Regulated Element-Binding Protein to Regulate Lipogenesis Essential for Neoplastic Growth – Arvin M. Gouw, Katherine Margulis, Natalie S. Liu, Sudha J. Raman, Anthony Mancuso, Georgia G. Toal, Ling Tong, Adriane Mosley, Annie L. Hsieh, Delaney K. Sullivan, Zachary E. Stine, Brian J. Altman, Almut Schulze, Chi V. Dang, Richard N. Zare, Dean W. Felsher. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30385-7

Glioma Stem Cell–Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis to Support EGFR Signaling – Ryan C. Gimple, Reilly L. Kidwell, Leo J.Y. Kim, Tengqian Sun, Anthony D. Gromovsky, Qiulian Wu, Megan Wolf, Deguan Lv, Shruti Bhargava, Li Jiang, Briana C. Prager, Xiuxing Wang, Qing Ye, Zhe Zhu, Guoxin Zhang, Zhen Dong, Linjie Zhao, Derrick Lee, Junfeng Bi, Andrew E. Sloan, Paul S. Mischel, J. Mark Brown, Hu Cang, Tao Huan, Stephen C. Mack, Qi Xie and Jeremy N. Rich. https://cancerdiscovery.aacrjournals.org/content/9/9/1248

Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis – Rajni Kumari, Ruhi S. Deshmukh and Sanjeev Das. https://www.nature.com/articles/s41467-019-12194-6


Nucleotides / one carbon


Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation – Liang Wei Wang, Hongying Shen, Luis Nobre, Ina Ersing, Joao A. Paulo, Stephen Trudeau, Zhonghao Wang, Nicholas A. Smith, Yijie Ma, Bryn Reinstadler, Jason Nomburg, Thomas Sommermann, Ellen Cahir-McFarland, Steven P. Gygi, Vamsi K. Mootha, Michael P. Weekes, Benjamin E. Gewurz. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30306-7

Cell-Cycle–Dependent Phosphorylation of PRPS1 Fuels Nucleotide Synthesis and Promotes Tumorigenesis – Xiaoqian Jing, Xiong-jun Wang, Tao Zhang, Wencheng Zhu, Yi Fang, Haoxuan Wu, Xinyu Liu, Ding Ma, Xiaopin Ji, Yimei Jiang, Kun Liu, Xianze Chen, Yi Shi, Yaqi Zhang, Minmin Shi, Weihua Qiu and Ren Zhao. https://cancerres.aacrjournals.org/content/79/18/4650


Mitochondria


α-Ketoglutarate links p53 to cell fate during tumour suppression – John P. Morris IV, Jossie J. Yashinskie, Richard Koche, Rohit Chandwani, Sha Tian, Chi-Chao Chen, Timour Baslan, Zoran S. Marinkovic, Francisco J. Sánchez-Rivera, Steven D. Leach, Carlos Carmona-Fontaine, Craig B. Thompson, Lydia W. S. Finley and Scott W. Lowe. https://www.nature.com/articles/s41586-019-1577-5

Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis – Sean C. Tompkins, Ryan D. Sheldon, Adam J. Rauckhorst, Maria F. Noterman, Shane R. Solst, Jane L. Buchanan, Kranti A. Mapuskar, Alvin D. Pewa, Lawrence R. Gray, Lalita Oonthonpan, Arpit Sharma, Diego A. Scerbo, Adam J. Dupuy, Douglas R. Spitz, Eric B. Taylor. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31014-9

Mitochondrial supercomplex assembly promotes breast and endometrial tumorigenesis by metabolic alterations and enhanced hypoxia tolerance – Kazuhiro Ikeda, Kuniko Horie-Inoue, Takashi Suzuki, Rutsuko Hobo, Norie Nakasato, Satoru Takeda and Satoshi Inoue. https://www.nature.com/articles/s41467-019-12124-6

Mitochondria supply ATP to the ER through a mechanism antagonized by cytosolic Ca2+ – Jing Yong, Helmut Bischof, Sandra Burgstaller, Marina Siirin, Anne Murphy, Roland Malli, Randal J Kaufman. https://elifesciences.org/articles/49682

Metformin Inhibits Progression of Head and Neck Squamous Cell Carcinoma by Acting Directly on Carcinoma-Initiating Cells – Xingyu Wu, Huwate Yeerna, Yusuke Goto, Toshinori Ando, Victoria H. Wu, Xuefeng Zhang, Zhiyong Wang, Panomwat Amornphimoltham, Anne N. Murphy, Pablo Tamayo, Qianming Chen, Scott M. Lippman and J. Silvio Gutkind. https://cancerres.aacrjournals.org/content/79/17/4360


Starvation / nutrient sensing


Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK – Mengqi Li, Chen-Song Zhang, Yue Zong, Jin-Wei Feng, Teng Ma, Meiqin Hu, Zhizhong Lin, Xiaotong Li, Changchuan Xie, Yaying Wu, Dong Jiang, Ying Li, Cixiong Zhang, Xiao Tian, Wen Wang, Yanyan Yang, Jie Chen, Jiwen Cui, Yu-Qing Wu, Xin Chen, Qing-Feng Liu, Jianfeng Wu, Shu-Yong Lin, Zhiyun Ye, Ying Liu, Hai-Long Piao, Li Yu, Zhuan Zhou, Xiao-Song Xie, D. Grahame Hardie, Sheng-Cai Lin. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30258-X

Acetyl-CoA flux regulates the proteome and acetyl-proteome to maintain intracellular metabolic crosstalk – Inca A. Dieterich, Alexis J. Lawton, Yajing Peng, Qing Yu, Timothy W. Rhoads, Katherine A. Overmyer, Yusi Cui, Eric A. Armstrong, Porsha R. Howell, Maggie S. Burhans, Lingjun Li, John M. Denu, Joshua J. Coon, Rozalyn M. Anderson and Luigi Puglielli. https://www.nature.com/articles/s41467-019-11945-9

Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2 – Tsuyoshi Osawa, Teppei Shimamura, Kyoko Saito, Yoko Hasegawa, Naoko Ishii, Miyuki Nishida, Ritsuko Ando, Ayano Kondo, Muyassar Anwar, Rika Tsuchida, Shinjiro Hino, Akihisa Sakamoto, Kaori Igarashi, Kaori Saitoh, Keiko Kato, Keiko Endo, Shotaro Yamano, Yasuharu Kanki, Yoshihiro Matsumura, Takashi Minami, Toshiya Tanaka, Motonobu Anai, Youichiro Wada, Hideki Wanibuchi, Mitsuhiro Hayashi, Akinobu Hamada, Masayuki Yoshida, Shinichi Yachida, Mitsuyoshi Nakao, Juro Sakai, Hiroyuki Aburatani, Masabumi Shibuya, Kentaro Hanada, Satoru Miyano, Tomoyoshi Soga, Tatsuhiko Kodama. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31149-0

ALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis – Jia-Shu Yang, Jia-Wei Hsu, Seung-Yeol Park, Stella Y. Lee, Jian Li, Ming Bai, Claudia Alves, William Tseng, Xavier Michelet, I-Cheng Ho and Victor W. Hsu. https://www.nature.com/articles/s41467-019-11932-0

Age modulates liver responses to asparaginase-induced amino acid stress in mice – Inna A. Nikonorova, Qiaoqiao Zhu, Christina C. Signore, Emily T. Mirek, William O. Jonsson, Bo Kong, Grace L. Guo, William J. Belden and Tracy G. Anthony. http://www.jbc.org/content/294/38/13864.abstract.html


mTOR


Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid–induced mTORC1 signaling – Arunas Kvainickas, Heike Nägele, Wenjing Qi, Ladislav Dokládal, Ana Jimenez-Orgaz, Luca Stehl, Dipak Gangurde, Qian Zhao, Zehan Hu, Jörn Dengjel, Claudio De Virgilio, Ralf Baumeister and Florian Steinberg. http://jcb.rupress.org/content/218/9/3019?etoc

Protein kinase N controls a lysosomal lipid switch to facilitate nutrient signalling via mTORC1 – Alexander Wallroth, Philipp A. Koch, Andrea L. Marat, Eberhard Krause and Volker Haucke. https://www.nature.com/articles/s41556-019-0377-3

Regulation of GSK3 cellular location by FRAT modulates mTORC1-dependent cell growth and sensitivity to rapamycin – Long He, Dennis Liang Fei, Michal J. Nagiec, Anders P. Mutvei, Andreas Lamprakis, Bo Yeon Kim and John Blenis. https://www.pnas.org/content/116/39/19523.abstract?etoc


AMPK


Negative regulation of AMPKα1 by PIM2 promotes aerobic glycolysis and tumorigenesis in endometrial cancer – Xue Han, Chune Ren, Tingting Yang, Pengyun Qiao, Li Wang, Aifang Jiang, Yuhan Meng, Zhijun Liu, Yu Du and Zhenhai Yu. https://www.nature.com/articles/s41388-019-0898-z

Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling – Nan Li, Yifan Wang, Shinya Neri, Yuanli Zhen, Lon Wolf R. Fong, Yawei Qiao, Xu Li, Zhen Chen, Clifford Stephan, Weiye Deng, Rui Ye, Wen Jiang, Shuxing Zhang, Yonghao Yu, Mien-Chie Hung, Junjie Chen & Steven H. Lin. https://www.nature.com/articles/s41467-019-12377-1


Hypoxia / HIF


Cell Clustering Promotes a Metabolic Switch that Supports Metastatic Colonization – Christiaan F. Labuschagne, Eric C. Cheung, Julianna Blagih, Marie-Charlotte Domart, Karen H. Vousden. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30387-0

Volumetric Optoacoustic Imaging Unveils High-Resolution Patterns of Acute and Cyclic Hypoxia in a Murine Model of Breast Cancer – Avihai Ron, Xosé Luís Deán-Ben, Sven Gottschalk and Daniel Razansky. https://cancerres.aacrjournals.org/content/79/18/4767

HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species – Hilary E. Nicholson, Zeshan Tariq, Benjamin E. Housden, Rebecca B. Jennings, Laura A. Stransky, Norbert Perrimon, Sabina Signoretti and William G. Kaelin Jr. https://stke.sciencemag.org/content/12/601/eaay0482


Cancer Immunometabolism


Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy – Kathrin Renner, Christina Bruss, Annette Schnell, Gudrun Koehl, Holger M. Becker, Matthias Fante, Ayse-Nur Menevse, Nathalie Kauer, Raquel Blazquez, Lisa Hacker, Sonja-Maria Decking, Toszka Bohn, Stephanie Faerber, Katja Evert, Lisa Aigle, Sabine Amslinger, Maria Landa, Oscar Krijgsman, Elisa A. Rozeman, Christina Brummer, Peter J. Siska, Katrin Singer, Stefanie Pektor, Matthias Miederer, Katrin Peter, Eva Gottfried, Wolfgang Herr, Ibtisam Marchiq, Jacques Pouyssegur, William R. Roush, SuFey Ong, Sarah Warren, Tobias Pukrop, Philipp Beckhove, Sven A. Lang, Tobias Bopp, Christian U. Blank, John L. Cleveland, Peter J. Oefner, Katja Dettmer, Mark Selby, Marina Kreutz. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31123-4

Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence – Michal Harel, Rona Ortenberg, Siva Karthik Varanasi, Kailash Chandra Mangalhara, Mariya Mardamshina, Ettai Markovits, Erez N. Baruch, Victoria Tripple, May Arama-Chayoth, Eyal Greenberg, Anjana Shenoy, Ruveyda Ayasun, Naama Knafo, Shihao Xu, Liat Anafi, Gali Yanovich-Arad, Georgina D. Barnabas, Shira Ashkenazi, Michal J. Besser, Jacob Schachter, Marcus Bosenberg, Gerald S. Shadel, Iris Barshack, Susan M. Kaech, Gal Markel, Tamar Geiger. ttps://www.cell.com/cell/fulltext/S0092-8674(19)30900-6

T Cell Activation Depends on Extracellular Alanine – Noga Ron-Harel, Jonathan M. Ghergurovich, Giulia Notarangelo, Arlene H. Sharpe, Joshua D. Rabinowitz, Marcia C. Haigis. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31074-5?dgcid=raven_jbs_etoc_email

AMPK Alpha-1 Intrinsically Regulates the Function and Differentiation of Tumor Myeloid-Derived Suppressor Cells – Jimena Trillo-Tinoco, Rosa A. Sierra, Eslam Mohamed, Yu Cao, Álvaro de Mingo-Pulido, Danielle L. Gilvary, Carmen M. Anadon, Tara Lee Costich, Sheng Wei, Elsa R. Flores, Brian Ruffell, José R. Conejo-Garcia and Paulo C. Rodriguez. https://cancerres.aacrjournals.org/content/79/19/5034


Miscellaneous


High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program – David P. Labbé, Giorgia Zadra, […]Myles Brown. https://www.nature.com/articles/s41467-019-12298-z

PPARδ Mediates the Effect of Dietary Fat in Promoting Colorectal Cancer Metastasis – Dingzhi Wang, Lingchen Fu, Jie Wei, Ying Xiong and Raymond N. DuBois. https://cancerres.aacrjournals.org/content/79/17/4480

Endogenous Hyperinsulinemia Contributes to Pancreatic Cancer Development – Anni M.Y. Zhang, Jamie Magrill, Twan J.J. de Winter, Xiaoke Hu, Søs Skovsø, David F. Schaeffer, Janel L. Kopp, James D. Johnson. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30376-6

Mutant IDH Sensitizes Gliomas to Endoplasmic Reticulum Stress and Triggers Apoptosis via miR-183-Mediated Inhibition of Semaphorin 3E – Ying Zhang, Stefan Pusch, James Innes, Kastytis Sidlauskas, Matthew Ellis, Joanne Lau, Tedani El-Hassan, Natasha Aley, Francesca Launchbury, Angela Richard-Loendt, Jasper deBoer, Sheng Chen, Lei Wang, Andreas von Deimling, Ningning Li and Sebastian Brandner. https://cancerres.aacrjournals.org/content/79/19/4994


Reviews


Mechanisms and Implications of Metabolic Heterogeneity in Cancer – Jiyeon Kim, Ralph J. DeBerardinis. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30442-5

Hallmarks of Endothelial Cell Metabolism in Health and Disease – Xuri Li, Xiaodong Sun, Peter Carmeliet. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30440-1

Metabolic implications of organelle–mitochondria communication – Isabel Gordaliza‐Alaguero, Carlos Cantó, Antonio Zorzano. https://www.embopress.org/doi/abs/10.15252/embr.201947928


Comments


Epigenetic Control of Fatty-Acid Metabolism Sustains Glioma Stem Cells – Hayley C. Affronti and Kathryn E. Wellen. https://cancerdiscovery.aacrjournals.org/content/9/9/1161

United They Stand, Divided They Fall – Isaac S. Harris, Joan S. Brugge. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30496-6

Monitoring Oxygenation Levels Deep in the Tumor Core: Noninvasive Imaging of Hypoxia, Now in Real-Time 3D – Alexander L. Klibanov and Song Hu. https://cancerres.aacrjournals.org/content/79/18/4577

Membrane Lipid Remodeling Takes Center Stage in Growth Factor Receptor-Driven Cancer Development – Johannes V. Swinnen, Jonas Dehairs, Ali Talebi. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30445-0

Essentiality of non-essential amino acids for tumour cells and tumorigenesis – Chi V. Dang. https://www.nature.com/articles/s42255-019-0113-0

Bone Marrow: An Immunometabolic Refuge during Energy Depletion – Emily L. Goldberg, Vishwa Deep Dixit. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30496-6

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