MetaboList – December 2019

Special issue of the British Journal of Cancer
Loads of interesting articles and reviews. Edited by Adrian Harris and Christian Frezza
https://www.nature.com/collections/hiciagdefb


Glucose/lactate metabolism


Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells – Pei-Hsuan Chen, Ling Cai Kenneth Huffman, Chendong Yang, Jiyeon Kim, Brandon Faubert, Lindsey Boroughs, Bookyung Ko, Jessica Sudderth, Elizabeth A. McMillan, Luc Girard, Dong Chen, Michael Peyton, Misty D. Shields, Bo Yao, David S. Shames, Hyun Seok Kim, Brenda Timmons, Ikuo Sekine, Rebecca Britt, Stephanie Weber, Lauren A. Byers, John V. Heymach, Jing Chen, Michael A. White, John D. Minna, Guanghua Xiao, Ralph J. DeBerardinis. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30683-5

Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer – Alba Luengo, Keene L. Abbott, Shawn M. Davidson, Aaron M. Hosios, Brandon Faubert, Sze Ham Chan, Elizaveta Freinkman, Lauren G. Zacharias, Thomas P. Mathews, Clary B. Clish, Ralph J. DeBerardinis, Caroline A. Lewis and Matthew G. Vander Heiden. https://www.nature.com/articles/s41467-019-13419-4

KRAS4A directly regulates hexokinase-1 – Caroline R. Amendola, James P. Mahaffey, Seth J. Parker, Ian M. Ahearn, Wei-Ching Chen, Mo Zhou, Helen Court, Jie Shi, Sebastian L. Mendoza, Michael J. Morten, Eli Rothenberg, Eyal Gottlieb, Youssef Z. Wadghiri, Richard Possemato, Stevan R. Hubbard, Allan Balmain, Alec C. Kimmelman and Mark R. Philips. https://www.nature.com/articles/s41586-019-1832-9

A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer – Ke Huang, Qian Liang, Ye Zhou, Lu-lu Jiang, Wei-ming Gu, Ming-yu Luo, Ya-bin Tang, Yang Wang, Wei Lu, Min Huang, Sheng-zhe Zhang, Guang-lei Zhuang, Qing Dai, Qian-cheng Shen, Jian Zhang, Hui-min Lei, Liang Zhu, De-yong Ye, Hong-zhuan Chen, Lu Zhou, Ying Shen. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30517-0

Primary prostate cancer educates bone stroma through exosomal pyruvate kinase M2 to promote bone metastasis – Jinlu Dai, June Escara-Wilke, Jill M. Keller, Younghun Jung, Russell S. Taichman, Kenneth J. Pienta and Evan T. Keller. https://rupress.org/jem/article-abstract/216/12/2883/132527

Aurora-A mediated phosphorylation of LDHB promotes glycolysis and tumor progression by relieving the substrate-inhibition effect – Aoxing Cheng, Peng Zhang, Bo Wang, Dongdong Yang, Xiaotao Duan, Yongliang Jiang, Tian Xu, Ya Jiang, Jiahui Shi, Chengtao Ding, Gao Wu, Zhihong Sang, Qiang Wu, Hua Wang, Mian Wu, Zhiyong Zhang, Xin Pan, Yue-yin Pan, Ping Gao, Huafeng Zhang, Cong-zhao Zhou, Jing Guo and Zhenye Yang. https://www.nature.com/articles/s41467-019-13485-8

Glycolytic suppression dramatically changes the intracellular metabolic profile of multiple cancer cell lines in a mitochondrial metabolism-dependent manner – Reika Shiratori, Kenta Furuichi, Masashi Yamaguchi, Natsumi Miyazaki, Haruna Aoki, Hiroji Chibana, Kousei Ito and Shigeki Aoki. https://www.nature.com/articles/s41598-019-55296-3

The TGFβ1-FOXM1-HMGA1-TGFβ1 positive feedback loop increases the cisplatin resistance of non-small cell lung cancer by inducing G6PD expression – Zhang R, Tao F, Ruan S, Hu M, Hu Y, Fang Z, Mei L, Gong C. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895501/

Does Tumor FDG-PET-Avidity Represent Enhanced Glycolytic Metabolism in Non-Small Cell Lung Cancer? – Kernstine KH, Faubert B, Do QN, Rogers TJ, Hensley CT, Cai L, Torrealba J, Oliver D, Waschmann JW, Lenkinski RE, Malloy CR, Deberardinis RJ. https://www.annalsthoracicsurgery.org/article/S0003-4975(19)31875-2/abstract

Decreased FBP1 expression rewires metabolic processes affecting aggressiveness of glioblastoma – Beomseok Son, Sungmin Lee, Hyunwoo Kim, Hyunkoo Kang, Jaewan Jeon, Sunmi Jo, Ki Moon Seong, Su-Jae Lee, HyeSook Youn and BuHyun Youn. https://www.nature.com/articles/s41388-019-0974-4

Metabolic heterogeneity confers differences in melanoma metastatic potential – Alpaslan Tasdogan, Brandon Faubert, Vijayashree Ramesh, Jessalyn M. Ubellacker, Bo Shen, Ashley Solmonson, Malea M. Murphy, Zhimin Gu, Wen Gu, Misty Martin, Stacy Y. Kasitinon, Travis Vandergriff, Thomas P. Mathews, Zhiyu Zhao, Dirk Schadendorf, Ralph J. DeBerardinis and Sean J. Morrison. https://www.nature.com/articles/s41586-019-1847-2


Amino acids


Plasma membrane V-ATPase controls oncogenic RAS-induced macropinocytosis – Craig Ramirez, Andrew D. Hauser, Emily A. Vucic and Dafna Bar-Sagi. https://www.nature.com/articles/s41586-019-1831-x

A Covalent Small Molecule Inhibitor of Glutamate-Oxaloacetate Transaminase 1 Impairs Pancreatic Cancer Growth – Tomohiro Yoshida, Shingo Yamasaki, Osamu Kaneko, Naofumi Taoka, Yusuke Tomimoto, Ichiji Namatame, Toshiko Yahata, Sadao Kuromitsu, Lewis C Cantley, Costas A Lyssiotis. https://www.sciencedirect.com/science/article/pii/S0006291X19322582

SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis – Kai Su Greene, Michael J. Lukey, Xueying Wang, Bryant Blank, Joseph E. Druso, Miao-chong J. Lin, Clint A. Stalnecker, Chengliang Zhang, Yashira Negrón Abril, Jon W. Erickson, Kristin F. Wilson, Hening Lin, Robert S. Weiss and Richard A. Cerione. https://www.pnas.org/content/116/52/26625.abstract?etoc


Lipid metabolism


ASPP2 inhibits tumor growth by repressing the mevalonate pathway in hepatocellular carcinoma – Beibei Liang, Rui Chen, Shaohua Song, Hao Wang, Guowei Sun, Hao Yang, Wei Jing, Xuyu Zhou, Zhiren Fu, Gang Huang and Jian Zhao. https://www.nature.com/articles/s41419-019-2054-7

CD36-Mediated Metabolic Rewiring of Breast Cancer Cells Promotes Resistance to HER2-Targeted Therapies – William W. Feng, Owen Wilkins, Scott Bang, Matthew Ung, Jiaqi Li, Jennifer An, Carmen del Genio, Kaleigh Canfield, James DiRenzo, Wendy Wells, Arti Gaur, R. Brooks Robey, Jessie Yanxiang Guo, Ryan L. Powles, Christos Sotiriou, Lajos Pusztai, Maria Febbraio, Chao Cheng, William B. Kinlaw, Manabu Kurokawa. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31479-2

Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic Plasticity – Yurena Vivas-García, Paola Falletta, Jana Liebing, Pakavarin Louphrasitthiphol, Yongmei Feng, Jagat Chauhan, David A. Scott, Nicole Glodde, Ana Chocarro-Calvo, Sarah Bonham, Andrei L. Osterman, Roman Fischer, Ze’ev Ronai, Custodia García-Jiménez, Michael Hölzel, Colin R. Goding. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30792-0

Dynamic Regulation of ME1 Phosphorylation and Acetylation Affects Lipid Metabolism and Colorectal Tumorigenesis – Yahui Zhu, Li Gu, Xi Lin, Cheng Liu, Bingjun Lu, Kaisa Cui, Feng Zhou, Qiu Zhao, Edward V. Prochownik, Chengpeng Fan, Youjun Li. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30793-2


Nucleotides


Inhibition of tRNA Gene Transcription by the Immunosuppressant Mycophenolic Acid – Aneta Jurkiewicz, Ewa Leśniewska, Małgorzata Cieśla, Neuton Gorjão, Theodoros Kantidakis, Robert J. White, Magdalena Boguta and Damian Graczyk. http://mcb.asm.org/content/40/1/e00294-19.abstract?etoc

The Folate Pathway Inhibitor Pemetrexed Pleiotropically Enhances Effects of Cancer Immunotherapy – David A. Schaer, Sandaruwan Geeganage, Nelusha Amaladas, Zhao Hai Lu, Erik R. Rasmussen, Andreas Sonyi, Darin Chin, Andrew Capen, Yanxia Li, Catalina M. Meyer, Bonita D. Jones, Xiaodong Huang, Shuang Luo, Carmine Carpenito, Kenneth D. Roth, Alexander Nikolayev, Bo Tan, Manisha Brahmachary, Krishna Chodavarapu, Frank C. Dorsey, Jason R. Manro, Thompson N. Doman, Gregory P. Donoho, David Surguladze, Gerald E. Hall, Michael Kalos and Ruslan D. Novosiadly. https://clincancerres-aacrjournals-org.sire.ub.edu/content/25/23/7175

PCK1 and DHODH drive colorectal cancer liver metastatic colonization and hypoxic growth by promoting nucleotide synthesis – Norihiro Yamaguchi, Ethan M Weinberg, Alexander Nguyen, Maria V Liberti, Hani Goodarzi, Yelena Y Janjigian, Philip B Paty, Leonard B Saltz, T Peter Kingham, Jia Min Loo, Elisa de Stanchina, Sohail F Tavazoie. https://elifesciences.org/articles/52135


Mitochondria


BRCA1 Deficiency Upregulates NNMT, Which Reprograms Metabolism and Sensitizes Ovarian Cancer Cells to Mitochondrial Metabolic Targeting Agents – Arun Kanakkanthara, Kiran Kurmi, Thomas L. Ekstrom, Xiaonan Hou, Emma R. Purfeerst, Ethan P. Heinzen, Cristina Correia, Catherine J. Huntoon, Daniel O’Brien, Andrea E. Wahner Hendrickson, Sean C. Dowdy, Hu Li, Ann L. Oberg, Taro Hitosugi, Scott H. Kaufmann, S. John Weroha and Larry M. Karnitz. https://cancerres.aacrjournals.org/content/79/23/5920

Acidosis-induced metabolic reprogramming in tumor cells enhances the anti-proliferative activity of the PDK inhibitor dichloroacetate – Schoonjans CA, Joudiou N, Brusa D, Corbet C, Feron O, Gallez B. https://www.sciencedirect.com/science/article/abs/pii/S0304383519306056

The mitochondrial carrier Citrin plays a role in regulating cellular energy during carcinogenesis – Shiran Rabinovich, Alon Silberman, Lital Adler, Shani Agron, Smadar Levin-Zaidman, Amir Bahat, Ziv Porat, Efrat Ben-Zeev, Inbal Geva, Maxim Itkin, Sergey Malitsky, Adam Buchaklian, Daniel Helbling, David Dimmock and Ayelet Erez. https://www.nature.com/articles/s41388-019-0976-2


Metformin


Combination of Metformin and Gefitinib as First-Line Therapy for Nondiabetic Advanced NSCLC Patients with EGFR Mutations: A Randomized, Double-Blind Phase II Trial – Li Li, Liyan Jiang, Yubo Wang, Yizhuo Zhao, Xiao-Ju Zhang, Guoming Wu, Xiangdong Zhou, Jianguo Sun, Jun Bai, Biyong Ren, Kun Tian, Zhi Xu, Hua-liang Xiao, Qi Zhou, Rui Han, Hengyi Chen, Haidong Wang, Zhenzhou Yang, Chan Gao, Shangli Cai and Yong He. https://clincancerres.aacrjournals.org/content/25/23/6967

Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss – Emily A. Day, Rebecca J. Ford, Brennan K. Smith, Pedrum Mohammadi-Shemirani, Marisa R. Morrow, Robert M. Gutgesell, Rachel Lu, Amogelang R. Raphenya, Mostafa Kabiri, Andrew G. McArthur, Natalia McInnes, Sibylle Hess, Guillaume Paré, Hertzel C. Gerstein and Gregory R. Steinberg. https://www.nature.com/articles/s42255-019-0146-4

Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk – Peter C. Hart, Hilary A. Kenny, Niklas Grassl, Karen M. Watters, Lacey M. Litchfield, Fabian Coscia, Ivana Blaženović, Lisa Ploetzky, Oliver Fiehn, Matthias Mann, Ernst Lengyel, Iris L. Romero. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31570-0

Hypoxia and hyperglycaemia determine why some endometrial tumours fail to respond to metformin – Sivalingam VN, Latif A, Kitson S, McVey R, Finegan KG, Marshall K, Lisanti MP, Sotgia F, Stratford IJ, Crosbie EJ. https://www.nature.com/articles/s41416-019-0627-y

Metabolic Rewiring in Response to Biguanides Is Mediated by mROS/HIF-1a in Malignant Lymphocytes – Hamidullah Khan, Ashish Anshu, Aman Prasad, Sushmita Roy, Justin Jeffery, Wasakorn Kittipongdaja, David T. Yang, Stefan M. Schieke. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31478-0

Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks – Benjamin D. Stein, Diego Calzolari, Kristina Hellberg, Ying S. Hu, Lin He, Chien-Min Hung, Erin Q. Toyama, Debbie S. Ross, Björn F. Lillemeier, Lewis C. Cantley, John R. Yates III, Reuben J. Shaw. https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31450-0


Starvation / AMPK


AMPK regulates ESCRT-dependent microautophagy of proteasomes concomitant with proteasome storage granule assembly during glucose starvation – Jianhui Li, Michal Breker, Morven Graham, Maya Schuldiner, Mark Hochstrasser. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008387

TFEB controls retromer expression in response to nutrient availability – Rachel Curnock, Alessia Calcagni, Andrea Ballabio, Peter J. Cullen. http://jcb.rupress.org/content/218/12/3954?etoc

Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutrient stress – Zhiyuan You, Wen-Xue Jiang, Ling-Yun Qin, Zhou Gong, Wei Wan, Jin Li, Yusha Wang, Hongtao Zhang, Chao Peng, Tianhua Zhou, Chun Tang and Wei Liu. https://www.nature.com/articles/s41467-019-13718-w

TIPRL potentiates survival of lung cancer by inducing autophagy through the eIF2α-ATF4 pathway – Su-Jin Jeon, Jun-Ho Ahn, Debasish Halder, Hyun-Soo Cho, Jung-Hwa Lim, Soo Young Jun, Jeong-Ju Lee, Ji-Yong Yoon, Min-Hyuk Choi, Cho-Rok Jung, Jin-Man Kim and Nam-Soon Kim. https://www.nature.com/articles/s41419-019-2190-0

γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A – Xue Gao, Liang Zhao, Shuangping Liu, Yuancheng Li, Siyuan Xia, Dong Chen, Mei Wang, Shaoxiong Wu, Qing Dai, Hieu Vu, Lauren Zacharias, Ralph DeBerardinis, Esther Lim, Christian Metallo, Titus J. Boggon, Sagar Lonial, Ruiting Lin, Hui Mao, Yaozhu Pan, Changliang Shan, Jing Chen. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30692-6


Hypoxia and HIF


KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis – Xu Qian, Xinjian Li, Zhumei Shi, Xiaoming Bai, Yan Xia, Yanhua Zheng, Daqian Xu, Feng Chen, Yongping You, Jing Fang, Zhibin Hu, Qin Zhou, Zhimin Lu. https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30724-5

HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells – Albertus T. J. Wierenga, Alan Cunningham, Ayşegül Erdem, Nuria Vilaplana Lopera, Annet Z. Brouwers-Vos, Maurien Pruis, André B. Mulder, Ulrich L. Günther, Joost H. A. Martens, Edo Vellenga and Jan Jacob Schuringa. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-019-0206-y

Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils – Karim Mahiddine, Adam Blaisdell, Stephany Ma, Amandine Créquer-Grandhomme, Clifford A. Lowell and Adrian Erlebacher. https://www.jci.org/articles/view/130952


Miscellaneous


PGC1α Suppresses Prostate Cancer Cell Invasion through ERRα Transcriptional Control – Lorea Valcarcel-Jimenez, Alice Macchia, Eva Crosas-Molist, Ariane Schaub-Clerigué, Laura Camacho, Natalia Martín-Martín, Paolo Cicogna, Cristina Viera-Bardón, Sonia Fernández-Ruiz, Irene Rodriguez-Hernandez, Ivana Hermanova, Ianire Astobiza, Ana R. Cortazar, Jon Corres-Mendizabal, Antonio Gomez-Muñoz, Victoria Sanz-Moreno, Verónica Torrano and Arkaitz Carracedo. https://cancerres.aacrjournals.org/content/79/24/6153

SGLT2 inhibition slows tumor growth in mice by reversing hyperinsulinemia – Ali R. Nasiri, Marcos R. Rodrigues, Zongyu Li, Brooks P. Leitner and Rachel J. Perry. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-019-0203-1

Cerebrospinal fluid-based metabolomics to characterize different types of brain tumors – Wang FX, Chen K, Huang FQ, Alolga RN, Ma J, Wu ZX, Fan Y, Ma G, Guan M. https://link.springer.com/article/10.1007%2Fs00415-019-09665-7

Untargeted LC-HRMS-based metabolomics to identify novel biomarkers of metastatic colorectal cancer – Martín-Blázquez A, Díaz C, González-Flores E, Franco-Rivas D, Jiménez-Luna C, Melguizo C, Prados J, Genilloud O, Vicente F, Caba O, Pérez Del Palacio J. https://www.nature.com/articles/s41598-019-55952-8

A systematic flux analysis approach to identify metabolic vulnerabilities in human breast cancer cell lines – Sheree D. Martin and Sean L. McGee. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-019-0207-x


Reviews / comments


Mitochondrial TCA cycle metabolites control physiology and disease – Inmaculada Martínez-Reyes and Navdeep S. Chandel. https://www.nature.com/articles/s41467-019-13668-3

A Tumor Agnostic Therapeutic Strategy for Hexokinase 1–Null/Hexokinase 2–Positive Cancers – Shili Xu and Harvey R. Herschman. https://cancerres.aacrjournals.org/content/79/23/5907

The Metabolic Interplay between Cancer and Other Diseases – Anne Le, Sunag Udupa, Cissy Zhang. https://www.cell.com/trends/cancer/fulltext/S2405-8033(19)30219-5

Metabolic Regulation of Macrophage Polarization in Cancer – Kamiya Mehla, Pankaj K. Singh. https://www.cell.com/trends/cancer/fulltext/S2405-8033(19)30200-6

Sweet Temptation: From Sugar Metabolism to Gene Regulation – Giulia Notarangelo, Marcia C. Haigis. https://www.cell.com/immunity/fulltext/S1074-7613(19)30489-3

The Mitochondrion as an Emerging Therapeutic Target in Cancer – Katherine G. Roth, Isa Mambetsariev, Prakash Kulkarni, Ravi Salgia. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(19)30171-6

The impact of oncogenic RAS on redox balance and implications for cancer development – Jonathan K. M. Lim and Gabriel Leprivier. https://www.nature.com/articles/s41419-019-2192-y

Glutamine Skipping the Q into Mitochondria – Zachary E. Stine, Chi V. Dang. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(19)30295-3

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s