MetaboList – January 2020

 


Starvation / nutrient sensing


Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1 – Ina Yoon, Miso Nam, Hoi Kyoung Kim, Hee-Sun Moon, Sungmin Kim, Jayun Jang, Ji Ae Song, Seung Jae Jeong, Sang Bum Kim, Seongmin Cho, YounHa Kim, Jihye Lee, Won Suk Yang, Hee Chan Yoo, Kibum Kim, Min-Sun Kim, Aerin Yang, Kyukwang Cho, Hee-Sung Park, Geum-Sook Hwang, Kwang Yeon Hwang, Jung Min Han, Jong Hyun Kim, Sunghoon Kim. https://science.sciencemag.org/content/367/6474/205

Local Fatty Acid Channeling into Phospholipid Synthesis Drives Phagophore Expansion during Autophagy – Maximilian Schütter, Patrick Giavalisco, Susanne Brodesser, Martin Graef. https://www.cell.com/cell/fulltext/S0092-8674(19)31331-5

Glucose stimulates microRNA-199 expression in murine pancreatic β-cells – Joao Pedro Werneck-de-Castro, Manuel Blandino-Rosano, Denise Hilfiker-Kleiner and Ernesto Bernal-Mizrachi. http://www.jbc.org/content/early/2019/12/26/jbc.RA119.010356.abstract

The nutrient sensor OGT regulates Hipk stability and tumorigenic-like activities in Drosophila – Kenneth Kin Lam Wong, Ta-Wei Liu, Jessica M. Parker, Donald A. R. Sinclair, Yi-Yun Chen, Kay-Hooi Khoo, David J. Vocadlo and Esther M. Verheye.
https://www.pnas.org/content/117/4/2004.abstract?etoc


mTOR


Loss of TSC complex enhances gluconeogenesis via upregulation of Dlk1-Dio3 locus miRNAs – Dritan Liko, Andrzej Rzepiela, Vanja Vukojevic, Mihaela Zavolan and Michael N. Hall. https://www.pnas.org/content/117/3/1524.abstract?etoc

Anabolic SIRT4 Exerts Retrograde Control over TORC1 Signaling by Glutamine Sparing in the Mitochondria – Eisha Shaw, Manasi Talwadekar, Zeenat Rashida, Nitya Mohan, Aishwarya Acharya, Subhash Khatri, Sunil Laxman and Ullas Kolthur-Seetharam. http://mcb.asm.org/content/40/2/e00212-19.abstract?etoc

AMPKα1 confers survival advantage of colorectal cancer cells under metabolic stress by promoting redox balance through the regulation of glutathione reductase phosphorylation – Ying-Nan Wang, Yun-Xin Lu, Jie Liu, Ying Jin, Hui-Chang Bi, Qi Zhao, Ze-Xian Liu, Ying-Qin Li, Jia-Jia Hu, Hui Sheng, Yi-Ming Jiang, Chao Zhang, Feng Tian, Yang Chen, Zhi-Zhong Pan, Gong Chen, Zhao-Lei Zeng, Kai-Yan Liu, Marcia Ogasawara, Jin-Ping Yun, Huai-Qiang Ju, Jian-Xiong Feng, Dan Xie, Song Gao, Wei-Hua Jia, Scott Kopetz, Rui-Hua Xu and Feng Wang. https://www.nature.com/articles/s41388-019-1004-2

mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress – Naomi X. Y. Ling, Adrian Kaczmarek, Ashfaqul Hoque, Elizabeth Davie, Kevin R. W. Ngoei, Kaitlin R. Morrison, William J. Smiles, Gabriella M. Forte, Tingting Wang, Shervi Lie, Toby A. Dite, Christopher G. Langendorf, John W. Scott, Jonathan S. Oakhill and Janni Petersen. https://www.nature.com/articles/s42255-019-0157-1

A two-pore channel protein required for regulating mTORC1 activity on starvation – Fu-Sheng Chang, Yuntao Wang, Phillip Dmitriev, Julian Gross, Antony Galione and Catherine Pears [Dictyostelium]. https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-019-0735-4

Homeostasis of branched-chain amino acids is critical for the activity of TOR signaling in Arabidopsis – Pengfei Cao, Sang-Jin Kim, Anqi Xing, Craig A Schenck, Lu Liu, Nan Jiang, Jie Wang, Robert L Last, Federica Brandizzi. https://elifesciences.org/articles/50747


Glucose metabolism


Targeting tumor-intrinsic hexosamine biosynthesis sensitizes pancreatic cancer to anti-PD1 therapy – Nikita S. Sharma, Vineet K. Gupta, Vanessa T. Garrido, Roey Hadad, Brittany C. Durden, Kousik Kesh, Bhuwan Giri, Anthony Ferrantella, Vikas Dudeja, Ashok Saluja and Sulagna Banerjee. https://www.jci.org/articles/view/127515

A synthetic lethal drug combination mimics glucose deprivation-induced cancer cell death in the presence of glucose – James H Joly, Alireza Delfarah, Philip S Phung, Sydney Parrish and Nicholas A. Graham. http://www.jbc.org/content/early/2019/12/30/jbc.RA119.011471.abstract

O-GlcNAcase targets pyruvate kinase M2 to regulate tumor growth – Jay Prakash Singh, Kevin Qian, Jeong-Sang Lee, Jinfeng Zhou, Xuemei Han, Bichen Zhang, Qunxiang Ong, Weiming Ni, Mingzuo Jiang, Hai-Bin Ruan, Min-Dian Li, Kaisi Zhang, Zhaobing Ding, Philip Lee, Kamini Singh, Jing Wu, Raimund I. Herzog, Susan Kaech, Hans-Guido Wendel, John R. Yates III, Weiping Han, Robert S. Sherwin, Yongzhan Nie and Xiaoyong Yang. https://www.nature.com/articles/s41388-019-0975-3

Hyperpolarized MRI of Human Prostate Cancer Reveals Increased Lactate with Tumor Grade Driven by Monocarboxylate Transporter 1 – Kristin L. Granlund, Sui-Seng Tee, Hebert A. Vargas, Serge K. Lyashchenko, Ed Reznik, Samson Fine, Vincent Laudone, James A. Eastham, Karim A. Touijer, Victor E. Reuter, Mithat Gonen, Ramon E. Sosa, Duane Nicholson, YanWei W. Guo, Albert P. Chen, James Tropp, Fraser Robb, Hedvig Hricak, Kayvan R. Keshari. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30498-X


Amino acids


Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy – Barbara S. Nelson, Lin Lin, Daniel M. Kremer, Cristovão M. Sousa, Cecilia Cotta-Ramusino, Amy Myers, Johanna Ramos, Tina Gao, Ilya Kovalenko, Kari Wilder-Romans, Joseph Dresser, Mary Davis, Ho-Joon Lee, Zeribe C. Nwosu, Scott Campit, Oksana Mashadova, Brandon N. Nicolay, Zachary P. Tolstyka, Christopher J. Halbrook, Sriram Chandrasekaran, John M. Asara, Howard C. Crawford, Lewis C. Cantley, Alec C. Kimmelman, Daniel R. Wahl and Costas A. Lyssiotis. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-019-0202-2

Cysteine catabolism and the serine biosynthesis pathway support pyruvate production during pyruvate kinase knockdown in pancreatic cancer cells – Lei Yu, Shao Thing Teoh, Elliot Ensink, Martin P. Ogrodzinski, Che Yang, Ana I. Vazquez and Sophia Y. Lunt. https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-019-0205-z

Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy – Hayley C. Affronti, Aryn M. Rowsam, Anthony J. Pellerite, Spencer R. Rosario, Mark D. Long, Justine J. Jacobi, Anna Bianchi-Smiraglia, Christoph S. Boerlin, Bryan M. Gillard, Ellen Karasik, Barbara A. Foster, Michael Moser, John H. Wilton, Kristopher Attwood, Mikhail A. Nikiforov, Gissou Azabdaftari, Roberto Pili, James G. Phillips, Robert A. Casero Jr. and Dominic J. Smiraglia. https://www.nature.com/articles/s41467-019-13950-4

Serine racemase enhances growth of colorectal cancer by producing pyruvate from serine – Kenji Ohshima, Satoshi Nojima, Shinichiro Tahara, Masako Kurashige, Keisuke Kawasaki, Yumiko Hori, Moyu Taniguchi, Yutaka Umakoshi, Daisuke Okuzaki, Naoki Wada, Jun-ichiro Ikeda, Eiichiro Fukusaki and Eiichi Morii. https://www.nature.com/articles/s42255-019-0156-2


Lipid metabolism / Statins


Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress – Irem Kaymak, Carina R. Maier, Werner Schmitz, Andrew D. Campbell, Beatrice Dankworth, Carsten P. Ade, Susanne Walz, Madelon Paauwe, Charis Kalogirou, Hecham Marouf, Mathias T. Rosenfeldt, David M. Gay, Grace H. McGregor, Owen J. Sansom and Almut Schulze. https://cancerres.aacrjournals.org/content/80/2/189

Targeting the Metabolic Response to Statin-Mediated Oxidative Stress Produces a Synergistic Antitumor Response – Grace H. McGregor, Andrew D. Campbell, Sigrid K. Fey, Sergey Tumanov, David Sumpton, Giovanny Rodriguez Blanco, Gillian Mackay, Colin Nixon, Alexei Vazquez, Owen J. Sansom and Jurre J. Kamphorst. https://cancerres.aacrjournals.org/content/80/2/175

Altered Gene Expression along the Glycolysis–Cholesterol Synthesis Axis Is Associated with Outcome in Pancreatic Cancer – Joanna M. Karasinska, James T. Topham, Steve E. Kalloger, Gun Ho Jang, Robert E. Denroche, Luka Culibrk, Laura M. Williamson, Hui-Li Wong, Michael K.C. Lee, Grainne M. O’Kane, Richard A. Moore, Andrew J. Mungall, Malcolm J. Moore, Cassia Warren, Andrew Metcalfe, Faiyaz Notta, Jennifer J. Knox, Steven Gallinger, Janessa Laskin, Marco A. Marra, Steven J.M. Jones, Daniel J. Renouf and David F. Schaeffer. https://clincancerres.aacrjournals.org/content/26/1/135

MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer – Jessica C. Casciano, Caroline Perry, Adam J. Cohen-Nowak, Katelyn D. Miller, Johan Vande Voorde, Qifeng Zhang, Susan Chalmers, Mairi E. Sandison, Qin Liu, Ann Hedley, Tony McBryan, Hsin-Yao Tang, Nicole Gorman, Thomas Beer, David W. Speicher, Peter D. Adams, Xuefeng Liu, Richard Schlegel, John G. McCarron, Michael J. O. Wakelam, Eyal Gottlieb, Andrew V. Kossenkov and Zachary T. Schug. https://www.nature.com/articles/s41416-019-0711-3

Dysregulation of very-long-chain fatty acid metabolism causes membrane saturation and induction of the unfolded protein response – Yagmur Micoogullari, Sankha S. Basu, Jessie Ang, Nina Weisshaar, Nicholas D. Schmitt, Walid M. Abdelmoula, Begona Lopez, Jeffrey N. Agar, Nathalie Agar and John Hanna. https://www.molbiolcell.org/doi/10.1091/mbc.E19-07-0392?ai=s5&ui=2oy6&af=T

Deciphering the Elevated Lipid via CD36 in Mantle Cell Lymphoma with Bortezomib Resistance Using Synchrotron-Based Fourier Transform Infrared Spectroscopy of Single Cells – Sudjit Luanpitpong ,Montira Janan ,Kanjana Thumanu , Jirarat Poohadsuan ,Napachai Rodboon , Phatchanat Klaihmon and Surapol Issaragrisil. https://doi.org/10.3390/cancers11040576


Mitochondria


A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells – Hee Chan Yoo, Seung Joon Park, Miso Nam, Juwon Kang, Kibum Kim, Joo Hye Yeo, Joon-Ki Kim, Yunkyung Heo, Hee Seung Lee, Myeong Youl Lee, Chang Woo Lee, Jong Soon Kang, Yun-Hee Kim, Jinu Lee, Junjeong Choi, Geum-Sook Hwang, Seungmin Bang, Jung Min Han. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30664-3

O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth – Hao Nie, Haixing Ju, Jiayi Fan, Xiaoliu Shi, Yaxian Cheng, Xiaohui Cang, Zhiguo Zheng, Xiaotao Duan and Wen Yi. https://www.nature.com/articles/s41467-019-13601-8

Dichloroacetate restores colorectal cancer chemosensitivity through the p53/miR-149-3p/PDK2-mediated glucose metabolic pathway – Yu Liang, Lidan Hou, Linjing Li, Lei Li, Liming Zhu, Yu Wang, Xin Huang, Yichao Hou, Danxi Zhu, Huimin Zou, Yan Gu, Xiaoling Weng, Yingying Wang, Yue Li, Tianqi Wu, Mengfei Yao, Isabelle Gross, Christian Gaiddon, Meng Luo, Jianhua Wang and Xiangjun Meng. https://www.nature.com/articles/s41388-019-1035-8


Cancer Immunometabolism


Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage – Evi Goulielmaki, Anna Ioannidou, Maria Tsekrekou, Kalliopi Stratigi, Ioanna K. Poutakidou, Katerina Gkirtzimanaki, Michalis Aivaliotis, Konstantinos Evangelou, Pantelis Topalis, Janine Altmüller, Vassilis G. Gorgoulis, Georgia Chatzinikolaou and George A. Garinis. https://www.nature.com/articles/s41467-019-13894-9


Miscellaneous


Subcellular metabolic pathway kinetics are revealed by correcting for artifactual post harvest metabolism – Sophie Trefely, JoyceLiu, Katharina Huber, Mary T. Doan, Helen Jiang, Jay Singh, Elianavon Krusenstiern, Anna Bostwick, Peining Xu, Juliane G.Bogner-Strauss, Kathryn E. Wellen, Nathaniel W.Snyder. https://www.sciencedirect.com/science/article/pii/S221287781930907X

Role of KEAP1/NFE2L2 Mutations in the Chemotherapeutic Response of Patients with Non–Small Cell Lung Cancer – Youngtae Jeong, Jessica A. Hellyer, Henning Stehr, Ngoc T. Hoang, Xiaomin Niu, Millie Das, Sukhmani K. Padda, Kavitha Ramchandran, Joel W. Neal, Heather Wakelee and Maximilian Diehn. https://clincancerres.aacrjournals.org/content/26/1/274

The creatine–phosphagen system is mechanoresponsive in pancreatic adenocarcinoma and fuels invasion and metastasis – Vassilis Papalazarou, Tong Zhang, Nikki R. Paul, Amelie Juin, Marco Cantini, Oliver D. K. Maddocks, Manuel Salmeron-Sanchez and Laura M. Machesky. https://www.nature.com/articles/s42255-019-0159-z

Genomic Profiling Identifies Association of IDH1/IDH2 Mutation with Longer Relapse-Free and Metastasis-Free Survival in High-Grade Chondrosarcoma – Guo Gord Zhu, Khedoudja Nafa, Narasimhan Agaram, Ahmet Zehir, Ryma Benayed, Justyna Sadowska, Laetitia Borsu, Ciara Kelly, William D. Tap, Nicola Fabbri, Edward Athanasian, Patrick J. Boland, John H. Healey, Michael F. Berger, Marc Ladanyi and Meera Hameed. https://clincancerres.aacrjournals.org/content/26/2/419


Reviews


The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism – Gerta Hoxhaj and Brendan D. Manning. https://www.nature.com/articles/s41568-019-0216-7

Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer – Marteinn Thor Snaebjornsson, Sudha Janaki-Raman, Almut Schulze. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30617-5

Targeting Extracellular Nutrient Dependencies of Cancer Cells – Javier Garcia-Bermudez, Robert T Williams, Rohiverth Guarecuco, Kıvanç Birsoy. https://www.sciencedirect.com/science/article/pii/S2212877819309433

The Role of Metabolic Plasticity in Blood and Brain Stem Cell Pathophysiology – Catherine J. Libby, Jonathan McConathy, Victor Darley-Usmar and Anita B. Hjelmeland. https://cancerres.aacrjournals.org/content/80/1/5

Metabolic Subtyping for Novel Personalized Therapies Against Pancreatic Cancer – Kamiya Mehla and Pankaj K. Singh. https://clincancerres.aacrjournals.org/content/26/1/6

Tumor microenvironment differences between primary tumor and brain metastases – Cacho-Díaz B, García-Botello DR, Wegman-Ostrosky T, Reyes-Soto G, Ortiz-Sánchez E, Herrera-Montalvo LA. https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-019-02189-8

Targeting citrate as a novel therapeutic strategy in cancer treatment – Lan Huang, Cindy Wang, Huaxi Xu, Guangyong Peng. https://www.sciencedirect.com/science/article/pii/S0304419X19301593

Dietary patterns and cancer risk – Susan E. Steck and E. Angela Murphy
https://www.nature.com/articles/s41568-019-0227-4

Loads of reviews and primary articles at the special issue in Cancers:
“Metabolic Reprogramming and Vulnerabilities in Cancer” – Guest Editor(s): Deepak Nagrath, Costas Lyssiotis. https://www.mdpi.com/journal/cancers/special_issues/metabolic-reprogram

Including:

Hodakoski, C.; Hopkins, B.D.; Zhang, G.; Su, T.; Cheng, Z.; Morris, R.; Rhee, K.Y.; Goncalves, M.D.; Cantley, L.C. Rac-Mediated Macropinocytosis of Extracellular Protein Promotes Glucose Independence in Non-Small Cell Lung Cancer.

Sanford-Crane, H.; Abrego, J.; Sherman, M.H. Fibroblasts as Modulators of
Local and Systemic Cancer Metabolism.

Choi, B.-H.; Coloff, J.L. The Diverse Functions of Non-Essential Amino Acids in Cancer.

Combs, J.A.; DeNicola, G.M. The Non-Essential Amino Acid Cysteine Becomes Essential for Tumor Proliferation and Survival.

Villa, E.; Ali, E.S.; Sahu, U.; Ben-Sahra, I. Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides.

Bott, A.J.; Maimouni, S.; Zong, W.-X. The Pleiotropic Effects of Glutamine Metabolism in Cancer.

Jiang, J.; Srivastava, S.; Zhang, J. Starve Cancer Cells of Glutamine: Break the Spell or Make a Hungry Monster?

Purohit, V.; Simeone, D.M.; Lyssiotis, C.A. Metabolic Regulation of Redox Balance in Cancer.

Petronek, M.S.; Spitz, D.R.; Buettner, G.R.; Allen, B.G. Linking Cancer Metabolic Dysfunction and Genetic Instability through the Lens of Iron Metabolism.

Sharma, A.; Boise, L.H.; Shanmugam, M. Cancer Metabolism and the Evasion of
Apoptotic Cell Death.

Weinberg, F.; Ramnath, N.; Nagrath, D. Reactive Oxygen Species in the Tumor
Microenvironment: An Overview.

Cockfield, J.A.; Schafer, Z.T. Antioxidant Defenses: A Context-Specific Vulnerability of Cancer Cells.

Zhou, W.; Wahl, D.R. Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance.

Guda, M.R.; Labak, C.M.; Omar, S.I.; Asuthkar, S.; Airala, S.; Tuszynski, J.; Tsung, A.J.; Velpula, K.K. GLUT1 and TUBB4 in Glioblastoma Could be Efficacious Targets.

Naffouje, R.; Grover, P.; Yu, H.; Sendilnathan, A.; Wolfe, K.; Majd, N.; Smith, E.P.; Takeuchi, K.; Senda, T.; Kofuji, S.; Sasaki, A.T. Anti-Tumor Potential of IMP Dehydrogenase Inhibitors: A Century-Long Story.

Ramteke, P.; Deb, A.; Shepal, V.; Bhat, M.K.
Hyperglycemia Associated Metabolic and Molecular Alterations in Cancer Risk, Progression, Treatment, and Mortality.

Yan, L.; Raj, P.; Yao, W.; Ying, H.
Glucose Metabolism in Pancreatic Cancer.

Haley, J.A.; Ruiz, C.F.; Montal, E.D.; Wang, D.; Haley, J.D.; Girnun, G.D.
Decoupling of Nrf2 Expression Promotes Mesenchymal State Maintenance in Non-Small Cell Lung Cancer.

Loponte, S.; Lovisa, S.; Deem, A.K.; Carugo, A.; Viale, A. The Many Facets of
Tumor Heterogeneity: Is Metabolism Lagging Behind?

Natarajan, S.K.; Venneti, S. Glutamine Metabolism in Brain Tumors. Cancers


Comments / other


A sugary input to leucine sensing – Elyssa Lehman, Robert T. Abraham. https://science.sciencemag.org/content/367/6474/146

How to catch a HIF-the work of Gregg Semenza’s lab on hypoxia-inducible factor 1 – Martin J. Spiering. http://www.jbc.org/content/295/3/715.full.html

Conferences:

Lactate: Unconventional roles of a nutrient along tumor landscape
Organizers: Paola Chiarugi, Pierre Sonveaux, Luigi Ippolito. Florence, Italy, May 08-10 2020. http://meetings.embo.org/event/20-lactate

Cancer Immunometabolism 2020. Rehovot, Israel, May 5-6th.
Organizers: Ayelet Erez and Eyal Gottlieb. http://www.weizmann.ac.il/conferences/CIM2020/

Cancer Metabolism and Signaling 2020. Friday, April 17, 2020, New York.
Organizers: Lydia Finley, Steven Gross, Costas Lyssiotis, Sonya Dougal, Kari Fischer. https://www.nyas.org/events/2020/cancer-metabolism-and-signaling/

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