MetaboList – February 2020

 


Glucose metabolism


Mechanical regulation of glycolysis via cytoskeleton architecture – Jin Suk Park, Christoph J. Burckhardt, Rossana Lazcano, Luisa M. Solis, Tadamoto Isogai, Linqing Li, Christopher S. Chen, Boning Gao, John D. Minna, Robert Bachoo, Ralph J. DeBerardinis and Gaudenz Danuser. https://www.nature.com/articles/s41586-020-1998-1

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy – Nobu Oshima, Ryo Ishida, Shun Kishimoto, Kristin Beebe, Jeffrey R. Brender, Kazutoshi Yamamoto, Daniel Urban, Ganesha Rai, Michelle S. Johnson, Gloria Benavides, Giuseppe L. Squadrito, Dan Crooks, Joseph Jackson, Abhinav Joshi, Bryan T. Mott, Jonathan H. Shrimp, Michael A. Moses, Min-Jung Lee, Akira Yuno, Tobie D. Lee, Xin Hu, Tamara Anderson, Donna Kusewitt, Helen H. Hathaway, Ajit Jadhav, Didier Picard, Jane B. Trepel, James B. Mitchell, Gordon M. Stott, William Moore, Anton Simeonov, Larry A. Sklar, Jeffrey P. Norenberg, W. Marston Linehan, David J. Maloney, Chi V. Dang, Alex G. Waterson, Matthew Hall, Victor M. Darley-Usmar, Murali C. Krishna, Leonard M. Neckers. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30054-1

Systematic Identification of Regulators of Oxidative Stress Reveals Non-canonical Roles for Peroxisomal Import and the Pentose Phosphate Pathway – Michael M. Dubreuil, David W. Morgens, Kanji Okumoto, Masanori Honsho, Kévin Contrepois, Brittany Lee-McMullen, Gavin McAllister Traber, Ria S. Sood, Scott J. Dixon, Michael P. Snyder, Yukio Fujiki, Michael C. Bassik. https://www.sciencedirect.com/science/article/pii/S221112472030022X

Secreted Pyruvate Kinase M2 Promotes Lung Cancer Metastasis through Activating the Integrin Beta1/FAK Signaling Pathway – Caihong Wang, Shaosen Zhang, Jie Liu, Yang Tian, Boyuan Ma, Siran Xu, Yan Fu, Yongzhang Luo. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30052-8

MTR4 drives liver tumorigenesis by promoting cancer metabolic switch through alternative splicing – Lili Yu, Jinchul Kim, Lei Jiang, Bingbing Feng, Yue Ying, Kai-yuan Ji, Qingshuang Tang, Wancheng Chen, Taoyi Mai, Wenlong Dou, Jianlong Zhou, Le-yang Xiang, Yang-fan He, Dinghua Yang, Qingjiao Li, Xuemei Fu and Yang Xu. https://www.nature.com/articles/s41467-020-14437-3

Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis – Sabine Ruegenberg, Moritz Horn, Christian Pichlo, Kira Allmeroth, Ulrich Baumann and Martin S. Denzel. https://www.nature.com/articles/s41467-020-14524-5

GLUT5-mediated fructose utilization drives lung cancer growth by stimulating fatty acid synthesis and AMPK/mTORC1 signaling – Wen-Lian Chen, Xing Jin, Mingsong Wang, Dan Liu, Qin Luo, Hechuan Tian, Lili Cai, Lifei Meng, Rui Bi, Lei Wang, Xiao Xie, Guanzhen Yu, Lihui Li, Changsheng Dong, Qiliang Cai, Wei Jia, Wenyi Wei and Lijun Jia. https://insight.jci.org/articles/view/131596#

CAIX forms a transport metabolon with monocarboxylate transporters in human breast cancer cells – Samantha Ames, Jacob T. Andring, Robert McKenna and Holger M. Becker. https://www.nature.com/articles/s41388-019-1098-6


ROS / Amino acids


Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids – Sarah E. LeBoeuf, Warren L. Wu, Triantafyllia R. Karakousi, Burcu Karadal, S. RaElle Jackson, Shawn M. Davidson, Kwok-Kin Wong, Sergei B. Koralov, Volkan I. Sayin, Thales Papagiannakopoulos. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30619-9

Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer – Eric C. Cheung, Gina M. DeNicola, Colin Nixon, Karen Blyth, Christiaan F. Labuschagne, David A. Tuveson, Karen H. Vousden. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30582-3


Lipid metabolism


Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis  – Jose A. Viscarra, Yuhui Wang, Hai P. Nguyen, Yoon Gi Choi and Hei Sook Sul. https://www.nature.com/articles/s41467-020-14617-1

Statin-induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects – Zhihua Jiao, Huaqing Cai, Yu Long, Orit Katarina Sirka, Veena Padmanaban, Andrew J. Ewald, and Peter N. Devreotes. https://www.pnas.org/content/117/8/4158.abstract?etoc


Mitochondria


Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier – Claire L. Bensard, Dona R. Wisidagama, Kristofor A. Olson, Jordan A. Berg, Nathan M. Krah, John C. Schell, Sara M. Nowinski, Sarah Fogarty, Alex J. Bott, Peng Wei, Katja K. Dove, Jason M. Tanner, Vanja Panic, Ahmad Cluntun, Sandra Lettlova, Christian S. Earl, David F. Namnath, Karina Vázquez-Arreguín, Claudio J. Villanueva, Dean Tantin, L. Charles Murtaugh, Kimberley J. Evason, Gregory S. Ducker, Carl S. Thummel, Jared Rutter. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30609-6

A novel KDM5A/MPC-1 signaling pathway promotes pancreatic cancer progression via redirecting mitochondrial pyruvate metabolism – Jiujie Cui, Ming Quan, Dacheng Xie, Yong Gao, Sushovan Guha, Michael B. Fallon, Jingde Chen and Keping Xie. https://www.nature.com/articles/s41388-019-1051-8

The Amuvatinib Derivative, N-(2H-1,3-Benzodioxol-5-yl)-4-{thieno[3,2-d]pyrimidin-4-yl}piperazine-1-carboxamide, Inhibits Mitochondria and Kills Tumor Cells under Glucose Starvation – Marciano R, David HB, Akabayov B, Rotblat B. https://www.mdpi.com/1422-0067/21/3/1041


Starvation / AMPK


Regulation of Nucleotide Metabolism and Germline Proliferation in Response to Nucleotide Imbalance and Genotoxic Stresses by EndoU Nuclease – Fan Jia, Congwu Chi, Min Han. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30075-9

Energy-stress-mediated AMPK activation inhibits ferroptosis – Hyemin Lee, Fereshteh Zandkarimi, Yilei Zhang, Jitendra Kumar Meena, Jongchan Kim, Li Zhuang, Siddhartha Tyagi, Li Ma, Thomas F. Westbrook, Gregory R. Steinberg, Daisuke Nakada, Brent R. Stockwell and Boyi Gan. https://www.nature.com/articles/s41556-020-0461-8

TLR9 and beclin 1 crosstalk regulates muscle AMPK activation in exercise – Yang Liu, Phong T. Nguyen, Xun Wang, Yuting Zhao, Corbin E. Meacham, Zhongju Zou, Bogdan Bordieanu, Manuel Johanns, Didier Vertommen, Tobias Wijshake, Herman May, Guanghua Xiao, Sanae Shoji-Kawata, Mark H. Rider, Sean J. Morrison, Prashant Mishra and Beth Levine. https://www.nature.com/articles/s41586-020-1992-7


mTOR


Glutamine and asparagine activate mTORC1 independently of Rag GTPases – Delong Meng, Qianmei Yang, Huanyu Wang, Chase H. Melick, Rishika Navlani, Anderson R. Frank and Jenna L. Jewell. http://www.jbc.org/content/early/2020/02/04/jbc.AC119.011578.abstract

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control – Wenjian Gan, Xiaoming Dai, Xiangpeng Dai, Jun Xie, Shasha Yin, Junjie Zhu, Chen Wang, Yuchen Liu, Jianping Guo, Min Wang, Jing Liu, Jia Hu, Ryan J. Quinton, Neil J. Ganem, Pengda Liu, John M. Asara, Pier Paolo Pandolfi, Yingzi Yang, Zhigang He, Guangping Gao and Wenyi Wei. https://www.nature.com/articles/s41556-020-0463-6

DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1/2 signals – Xiaoyu Chen, Xiufang Xiong, Danrui Cui, Fei Yang, Dongping Wei, Haomin Li, Jianfeng Shu, Yanli Bi, Xiaoqing Dai, Longyuan Gong, Yi Sun and Yongchao Zhao. https://www.nature.com/articles/s41388-019-1085-y

Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition – Evdokia Michalopoulou, Francesca R. Auciello, Vinay Bulusu, David Strachan, Andrew D. Campbell, Jacqueline Tait-Mulder, Saadia A. Karim, Jennifer P. Morton, Owen J. Sansom, Jurre J. Kamphorst. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30105-4


Hypoxia


NER-factor DDB2 regulates HIF1α and hypoxia-response genes in HNSCC – Prashant V. Bommi, Vaibhav Chand, Nishit K. Mukhopadhyay, Pradip Raychaudhuri and Srilata Bagchi. https://www.nature.com/articles/s41388-019-1105-y


Metformin, phenformin


GDF15 mediates the effects of metformin on body weight and energy balance – Anthony P. Coll, Michael Chen, Pranali Taskar, Debra Rimmington, Satish Patel, John A. Tadross, Irene Cimino, Ming Yang, Paul Welsh, Samuel Virtue, Deborah A. Goldspink, Emily L. Miedzybrodzka, Adam R. Konopka, Raul Ruiz Esponda, Jeffrey T.-J. Huang, Y. C. Loraine Tung, Sergio Rodriguez-Cuenca, Rute A. Tomaz, Heather P. Harding, Audrey Melvin, Giles S. H. Yeo, David Preiss, Antonio Vidal-Puig, Ludovic Vallier, K. Sreekumaran Nair, Nicholas J. Wareham, David Ron, Fiona M. Gribble, Frank Reimann, Naveed Sattar, David B. Savage, Bernard B. Allan and Stephen O’Rahilly. https://www.nature.com/articles/s41586-019-1911-y

Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module – Laura Di Magno, Simona Manni, Fiorella Di Pastena, Sonia Coni, Alberto Macone, Sara Cairoli, Manolo Sambucci, Paola Infante, Marta Moretti, Marialaura Petroni, Carmine Nicoletti, Carlo Capalbo, Enrico De Smaele, Lucia Di Marcotullio, Giuseppe Giannini, Luca Battistini, Bianca Maria Goffredo, Egidio Iorio, Enzo Agostinelli, Marella Maroder, Gianluca Canettieri. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30033-4

Metformin Abrogates Age-Associated Ovarian Fibrosis – Curtis W. McCloskey, David P. Cook, Brendan S. Kelly, Feryel Azzi, Christian H. Allen, Amanda Forsyth, Jeremy Upham, Katey J. Rayner, Douglas A. Gray, Robert W. Boyd, Sangeeta Murugkar, Bryan Lo, Dominique Trudel, Mary K. Senterman and Barbara C. Vanderhyden. https://clincancerres.aacrjournals.org/content/26/3/632


Cancer Immunometabolism


CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors – Haiping Wang, Fabien Franco, Yao-Chen Tsui, Xin Xie, Marcel P. Trefny, Roberta Zappasodi, Syed Raza Mohmood, Juan Fernández-García, Chin-Hsien Tsai, Isabell Schulze, Florence Picard, Etienne Meylan, Roy Silverstein, Ira Goldberg, Sarah-Maria Fendt, Jedd D. Wolchok, Taha Merghoub, Camilla Jandus, Alfred Zippelius and Ping-Chih Ho. https://www.nature.com/articles/s41590-019-0589-5

Short-term starvation reduces IGF-1 levels to sensitize lung tumors to PD-1 immune checkpoint blockade – Daniel Ajona, Sergio Ortiz-Espinosa, Teresa Lozano, Francisco Exposito, Alfonso Calvo, Karmele Valencia, Miriam Redrado, Ana Remírez, Fernando Lecanda, Diego Alignani, Juan J. Lasarte, Irati Macaya, Yaiza Senent, Cristina Bértolo, Cristina Sainz, Ignacio Gil-Bazo, Iñaki Eguren-Santamaría, Jose M. Lopez-Picazo, Alvaro Gonzalez, Jose L. Perez-Gracia, Carlos E. de Andrea, Silvestre Vicent, Miguel F. Sanmamed, Luis M. Montuenga and Ruben Pio. https://www.nature.com/articles/s43018-019-0007-9

Tumor-Derived Lactic Acid Contributes to the Paucity of Intratumoral ILC2s – Marek Wagner, Kafi N. Ealey, Hiroe Tetsu, Tsuyoshi Kiniwa, Yasutaka Motomura, Kazuyo Moro, Shigeo Koyasu. https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30137-6


Reviews


Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer – Sharanya Sivanand, Matthew G. Vander Heiden. https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30581-1?dgcid=raven_jbs_etoc_email

Stable Isotopes for Tracing Mammalian-Cell Metabolism In Vivo – Juan Fernández-García, Patricia Altea-Manzano, Erica Pranzini, Sarah-Maria Fendt. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(19)30263-4

Metabolite Repair Enzymes Control Metabolic Damage in Glycolysis – Guido T. Bommer, Emile Van Schaftingen, Maria Veiga-da-Cunha. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(19)30176-8

Metformin in Gynecologic Cancers: Opening a New Window for Prevention and Treatment? – Ainhoa Madariaga, Pamela J. Goodwin and Amit M. Oza. https://clincancerres.aacrjournals.org/content/26/3/523

The SLC25 Mitochondrial Carrier Family: Structure and Mechanism – Jonathan J. Ruprecht, Edmund R.S. Kunji. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(19)30229-4

Cell cycle regulators in cancer cell metabolism – Leal-Esteban LC, Fajas L. https://www.sciencedirect.com/science/article/abs/pii/S0925443920300600

Mitochondrial functions and rare diseases – L.Dard, W.Blanchard, C.Hubert, D.Lacombe, R.Rossignol. https://www.sciencedirect.com/science/article/pii/S0098299719301177

Mechanistic Links between Obesity, Insulin, and Cancer – Rachel J. Perry, Gerald I. Shulman. https://www.cell.com/trends/cancer/fulltext/S2405-8033(19)30261-4

Metabolic Regulation of Cell Fate and Function – Shohini Ghosh-Choudhary, Jie Liu, Toren Finkel. https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(19)30219-3

Serine–glycine-one-carbon metabolism: vulnerabilities in MYCN-amplified neuroblastoma – Erhu Zhao, Jianbing Hou and Hongjuan Cui. https://www.nature.com/articles/s41389-020-0200-9

Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities – Binlu Huang, Bao-liang Song and Chenqi Xu. https://www.nature.com/articles/s42255-020-0174-0


Comments


We need to talk about the Warburg effect – Ralph J. DeBerardinis and Navdeep S. Chandel. https://www.nature.com/articles/s42255-020-0172-2

Dynamic ROS Regulation by TIGAR: Balancing Anti-cancer and Pro-metastasis Effects – Sarah-Maria Fendt, Sophia Y. Lunt. https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30048-9

Dietary Methionine in T Cell Biology and Autoimmune Disease – Shuang Tang, Xiaoling Li, Jason W. Locasale. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30007-3

Glucose Starvation Blocks Translation at Multiple Levels – Chen-Song Zhang, D. Grahame Hardie, Sheng-Cai Lin. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30005-X

Tension in tumour cells keeps metabolism high – Nadia M. E. Ayad, Valerie M. Weaver. https://www.nature.com/articles/d41586-020-00314-y

Histone Lactylation: A New Role for Glucose Metabolism – Maria V. Liberti, Jason W. Locasale. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(19)30265-8

Surviving stress during metastasis – Sarah Seton-Rogers. https://www.nature.com/articles/s41568-020-0243-4

Starving tumours – Anna Dart. https://www.nature.com/articles/s41568-020-0244-3

Mechanosensing metabolically moves cancer cells – Wei Wong. https://stke.sciencemag.org/content/13/619/eabb2935

An SLC1A5 Variant Transports Glutamine to Mitochondria in Cancer Cells – https://cancerdiscovery.aacrjournals.org/content/10/2/173.2

Isoform-Specific KRAS–Hexokinase 1 Interaction Affects Metabolism – https://cancerdiscovery.aacrjournals.org/content/10/2/OF10

One thought on “MetaboList – February 2020

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